Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells.

PubWeight™: 1.65‹?› | Rank: Top 3%

🔗 View Article (PMID 21576504)

Published in J Immunol on May 16, 2011

Authors

Olga M Pena1, Jelena Pistolic, Disha Raj, Christopher D Fjell, Robert E W Hancock

Author Affiliations

1: Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

Articles citing this

Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature (2014) 2.75

Macrophage polarization in health and disease. ScientificWorldJournal (2011) 1.46

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med (2016) 1.22

NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data. Nat Protoc (2015) 1.17

Bioenergetic profiles diverge during macrophage polarization: implications for the interpretation of 18F-FDG PET imaging of atherosclerosis. J Nucl Med (2013) 1.13

Elevation in body temperature to fever range enhances and prolongs subsequent responsiveness of macrophages to endotoxin challenge. PLoS One (2012) 1.06

An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation. EBioMedicine (2014) 1.05

Cell elasticity determines macrophage function. PLoS One (2012) 1.05

INVEX--a web-based tool for integrative visualization of expression data. Bioinformatics (2013) 1.04

Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks endotoxemia. PLoS Pathog (2012) 1.00

Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences. Crit Care (2013) 1.00

Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. J Biol Chem (2013) 0.98

Dysregulation of macrophage activation profiles by engineered nanoparticles. ACS Nano (2013) 0.96

Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin. Arterioscler Thromb Vasc Biol (2012) 0.95

Expression of NF-κB p50 in tumor stroma limits the control of tumors by radiation therapy. PLoS One (2012) 0.94

Redox control of microglial function: molecular mechanisms and functional significance. Antioxid Redox Signal (2014) 0.90

Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. Immunology (2014) 0.89

Activation of pattern recognition receptors up-regulates metallothioneins, thereby increasing intracellular accumulation of zinc, autophagy, and bacterial clearance by macrophages. Gastroenterology (2014) 0.89

Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation. PLoS One (2013) 0.88

NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation. Am J Physiol Gastrointest Liver Physiol (2013) 0.88

Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients. PLoS One (2015) 0.87

Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia. Am J Respir Crit Care Med (2016) 0.87

Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages. J Immunol (2013) 0.86

Plasma Tryptophan and the Kynurenine-Tryptophan Ratio are Associated with the Acquisition of Statural Growth Deficits and Oral Vaccine Underperformance in Populations with Environmental Enteropathy. Am J Trop Med Hyg (2016) 0.85

A unique role for p53 in the regulation of M2 macrophage polarization. Cell Death Differ (2014) 0.83

The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis. Nat Commun (2016) 0.83

iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls. Trends Mol Med (2013) 0.82

Lipopolysaccharide modulates neutrophil recruitment and macrophage polarization on lymphatic vessels and impairs lymphatic function in rat mesentery. Am J Physiol Heart Circ Physiol (2015) 0.81

Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour? Pathog Dis (2013) 0.81

Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes. Hum Mol Genet (2015) 0.80

A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells. PLoS One (2014) 0.79

Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro. PLoS One (2014) 0.79

Up-regulation of A20/ABIN1 contributes to inefficient M1 macrophage polarization during Hepatitis C virus infection. Virol J (2015) 0.79

Mitochondrial DAMPs induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction. PLoS One (2014) 0.79

On the origin of myeloid-derived suppressor cells. Oncotarget (2016) 0.78

Identification of biomarkers of response to IFNg during endotoxin tolerance: application to septic shock. PLoS One (2013) 0.78

Receptor-Interacting Protein 140 Orchestrates the Dynamics of Macrophage M1/M2 Polarization. J Innate Immun (2015) 0.78

The Metabolic Prospective and Redox Regulation of Macrophage Polarization. J Clin Cell Immunol (2015) 0.78

Glucocorticoid-induced leucine zipper (GILZ) in immuno suppression: master regulator or bystander? Oncotarget (2015) 0.77

High Pulmonary Levels of IL-6 and IL-1β in Children with Chronic Suppurative Lung Disease Are Associated with Low Systemic IFN-γ Production in Response to Non-Typeable Haemophilus influenzae. PLoS One (2015) 0.77

p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β. J Clin Invest (2016) 0.77

JTD special edition 'Hot Topics in COPD'-The microbiome in COPD. J Thorac Dis (2014) 0.77

Risk Stratification and Prognosis in Sepsis: What Have We Learned from Microarrays? Clin Chest Med (2016) 0.76

Blockade of the T cell immunoglobulin and mucin domain protein 3 pathway exacerbates sepsis-induced immune deviation and immunosuppression. Clin Exp Immunol (2014) 0.76

Endotoxin tolerance in monocytes can be mitigated by α2-interferon. J Leukoc Biol (2015) 0.75

Long-term Monocyte Dysfunction after Sepsis in Humanized Mice Is Related to Persisted Activation of Macrophage-Colony Stimulation Factor (M-CSF) and Demethylation of PU.1, and It Can Be Reversed by Blocking M-CSF In Vitro or by Transplanting Naïve Autologous Stem Cells In Vivo. Front Immunol (2017) 0.75

When host defense goes awry: Modeling sepsis-induced immunosuppression. Drug Discov Today Dis Models (2012) 0.75

Exosomes, your body's answer to immune health. Ann Transl Med (2017) 0.75

Pro-Resolving Molecules-New Approaches to Treat Sepsis? Int J Mol Sci (2017) 0.75

Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance. J Inflamm (Lond) (2016) 0.75

A novel real time imaging platform to quantify macrophage phagocytosis. Biochem Pharmacol (2016) 0.75

The Cytokine Response to Lipopolysaccharide Does Not Predict the Host Response to Infection. J Immunol (2017) 0.75

The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs. Sci Rep (2017) 0.75

Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription. Sci Rep (2017) 0.75

Advanced glycation endproducts induce self- and cross-tolerance in monocytes. Inflamm Res (2017) 0.75

Programming and memory dynamics of innate leukocytes during tissue homeostasis and inflammation. J Leukoc Biol (2017) 0.75

Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes. J Gastrointest Surg (2017) 0.75

The Role of IFN-β during the Course of Sepsis Progression and Its Therapeutic Potential. Front Immunol (2017) 0.75

Articles by these authors

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nat Protoc (2008) 7.92

Peptide antimicrobial agents. Clin Microbiol Rev (2006) 6.04

Pseudomonas Genome Database: improved comparative analysis and population genomics capability for Pseudomonas genomes. Nucleic Acids Res (2010) 5.23

PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods (2011) 5.01

Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. Dev Cell (2002) 4.94

InnateDB: facilitating systems-level analyses of the mammalian innate immune response. Mol Syst Biol (2008) 4.61

Designing antimicrobial peptides: form follows function. Nat Rev Drug Discov (2011) 4.16

Pseudomonas aeruginosa: all roads lead to resistance. Trends Microbiol (2011) 3.49

Cerebral: a Cytoscape plugin for layout of and interaction with biological networks using subcellular localization annotation. Bioinformatics (2007) 3.39

Protein interaction data curation: the International Molecular Exchange (IMEx) consortium. Nat Methods (2012) 3.17

Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa. Mol Microbiol (2003) 3.06

Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa. Genome Res (2008) 3.03

A multibiomarker-based outcome risk stratification model for adult septic shock*. Crit Care Med (2014) 2.94

Recognition of host immune activation by Pseudomonas aeruginosa. Science (2005) 2.84

Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Nucleic Acids Res (2008) 2.71

Cationic host defense (antimicrobial) peptides. Curr Opin Immunol (2005) 2.71

InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curation. Nucleic Acids Res (2012) 2.66

Pseudomonas aeruginosa Genome Database and PseudoCAP: facilitating community-based, continually updated, genome annotation. Nucleic Acids Res (2005) 2.61

The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol (2002) 2.57

Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol (2004) 2.51

The relationship between peptide structure and antibacterial activity. Peptides (2003) 2.51

Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa. J Exp Med (2002) 2.40

Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: comparison with cationic antimicrobial peptides and lipopeptides. Biochim Biophys Acta (2006) 2.35

Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol (2006) 2.32

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses. Pathog Dis (2013) 2.32

Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem (2005) 2.28

Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes. Genome Res (2005) 2.22

Inhibition of LpxC protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis. MBio (2012) 2.15

Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion. Nat Protoc (2007) 2.08

Alternative mechanisms of action of cationic antimicrobial peptides on bacteria. Expert Rev Anti Infect Ther (2007) 2.06

ArrayPipe: a flexible processing pipeline for microarray data. Nucleic Acids Res (2004) 2.03

A physical map of the genome of Atlantic salmon, Salmo salar. Genomics (2005) 2.03

High-throughput generation of small antibacterial peptides with improved activity. Nat Biotechnol (2005) 2.01

Impact of LL-37 on anti-infective immunity. J Leukoc Biol (2004) 2.01

Multifunctional cationic host defence peptides and their clinical applications. Cell Mol Life Sci (2011) 1.99

Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance. J Bacteriol (2008) 1.98

An anti-infective peptide that selectively modulates the innate immune response. Nat Biotechnol (2007) 1.97

The roles of cathelicidin LL-37 in immune defences and novel clinical applications. Curr Opin Hematol (2009) 1.92

Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa. FEMS Microbiol Rev (2009) 1.91

Human host defense peptide LL-37 prevents bacterial biofilm formation. Infect Immun (2008) 1.91

Can innate immunity be enhanced to treat microbial infections? Nat Rev Microbiol (2004) 1.90

Sequence requirements and an optimization strategy for short antimicrobial peptides. Chem Biol (2006) 1.84

Ciprofloxacin induction of a susceptibility determinant in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2005) 1.82

The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization. J Immunol (2004) 1.78

The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A. Antimicrob Agents Chemother (2011) 1.78

A re-evaluation of the role of host defence peptides in mammalian immunity. Curr Protein Pept Sci (2005) 1.78

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen. Genome Res (2005) 1.77

Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS. Antimicrob Agents Chemother (2010) 1.74

Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. Clin Microbiol Rev (2012) 1.74

Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance. Drug Discov Today (2005) 1.74

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides. Nat Chem Biol (2013) 1.73

Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast. Genome Res (2002) 1.72

Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli. Antimicrob Agents Chemother (2002) 1.69

Immunomodulatory activities of small host defense peptides. Antimicrob Agents Chemother (2005) 1.67

Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility. Antimicrob Agents Chemother (2008) 1.67

Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies. Curr Opin Microbiol (2013) 1.63

Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide. Antimicrob Agents Chemother (2012) 1.63

Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages. PLoS One (2009) 1.61

Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins. Antimicrob Agents Chemother (2003) 1.59

AMPer: a database and an automated discovery tool for antimicrobial peptides. Bioinformatics (2007) 1.59

Potential of immunomodulatory host defense peptides as novel anti-infectives. Trends Biotechnol (2009) 1.58

Identification of genes involved in swarming motility using a Pseudomonas aeruginosa PAO1 mini-Tn5-lux mutant library. J Bacteriol (2006) 1.54

Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides. Biopolymers (2008) 1.51

Characterization of a proteolytically stable multifunctional host defense peptidomimetic. Chem Biol (2013) 1.49

Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations. Vaccine (2011) 1.48

INMEX--a web-based tool for integrative meta-analysis of expression data. Nucleic Acids Res (2013) 1.48

Antimicrobial peptide therapeutics for cystic fibrosis. Antimicrob Agents Chemother (2005) 1.44

The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes. J Immunol (2004) 1.41

Intracellular receptor for human host defense peptide LL-37 in monocytes. J Immunol (2009) 1.38

Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B. Eur J Immunol (2007) 1.37

Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways. J Immunol (2007) 1.37

The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis. Infect Immun (2008) 1.36

Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics. Antimicrob Agents Chemother (2010) 1.35

Enabling a systems biology approach to immunology: focus on innate immunity. Trends Immunol (2009) 1.35

Cationic peptides: distribution and mechanisms of resistance. Curr Pharm Des (2002) 1.35

Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides. J Biol Chem (2007) 1.33

Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. ACS Chem Biol (2009) 1.33

Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol (2010) 1.32

Curating the innate immunity interactome. BMC Syst Biol (2010) 1.30

Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall-dependent process. J Biol Chem (2010) 1.28

Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro. Respir Res (2010) 1.26

Fluorescent probes alter miscibility phase boundaries in ternary vesicles. J Phys Chem B (2007) 1.26

The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol (2006) 1.25

Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells. Infect Immun (2005) 1.24

Antimicrobial properties of lactoferrin. Biochimie (2008) 1.24

Structural studies of a peptide with immune modulating and direct antimicrobial activity. Chem Biol (2010) 1.24

Creeping baselines and adaptive resistance to antibiotics. Drug Resist Updat (2011) 1.24

Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2008) 1.24

Identification of novel antibacterial peptides by chemoinformatics and machine learning. J Med Chem (2009) 1.23

ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease. Clin Immunol (2008) 1.23

The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world. J Pharm Sci (2009) 1.23

The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa. Microbiology (2009) 1.23

Role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa. J Bacteriol (2006) 1.22

Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators, including MetR. J Bacteriol (2009) 1.21