Published in Genes Dev on November 01, 2002
On the origin of the beta cell. Genes Dev (2008) 3.34
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. Cell Metab (2015) 2.71
Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. PLoS Biol (2006) 2.26
Dicer is required for maintaining adult pancreas. PLoS One (2009) 1.59
Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev Biol (2009) 1.56
METABOLIC FUNCTIONS OF MYOSTATIN AND GDF11. Immunol Endocr Metab Agents Med Chem (2010) 1.50
Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol (2006) 1.50
Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration. Proc Natl Acad Sci U S A (2006) 1.47
Highly sensitive and specific bioassay for measuring bioactive TGF-beta. BMC Cell Biol (2006) 1.42
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev (2008) 1.32
Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin. Endocrinology (2008) 1.27
Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. Mol Cell Biol (2004) 1.26
Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition. J Clin Invest (2006) 1.26
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci U S A (2008) 1.20
Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol (2006) 1.20
Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb. J Biol Chem (2010) 1.16
Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations. Hum Mol Genet (2008) 1.14
Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. EMBO Rep (2006) 1.13
Establishment of Hox vertebral identities in the embryonic spine precursors. Curr Top Dev Biol (2009) 1.12
Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development (2011) 1.09
B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol (2004) 1.08
ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Mol Cell Biol (2004) 1.06
β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies. Haematologica (2015) 1.06
Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. J Biol Chem (2008) 1.03
MicroRNAs in Human Placental Development and Pregnancy Complications. Int J Mol Sci (2013) 1.00
Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Hum Mol Genet (2008) 0.99
Ovalbumin sensitization and challenge increases the number of lung cells possessing a mesenchymal stromal cell phenotype. Respir Res (2010) 0.95
Pancreas cell fate. Birth Defects Res C Embryo Today (2009) 0.91
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. J Biol Chem (2011) 0.90
Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development. Dev Biol (2010) 0.89
TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol (2008) 0.89
A phase 1 study of ACE-536, a regulator of erythroid differentiation, in healthy volunteers. Am J Hematol (2014) 0.86
Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiation. J Cell Physiol (2012) 0.83
GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation. Nat Commun (2016) 0.81
Gdf11 facilitates temporal progression of neurogenesis in the developing spinal cord. J Neurosci (2011) 0.81
The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy. PLoS One (2015) 0.80
A Tale from TGF-β Superfamily for Thymus Ontogeny and Function. Front Immunol (2015) 0.79
The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo. Mech Dev (2010) 0.78
Tgif1 and Tgif2 Regulate Axial Patterning in Mouse. PLoS One (2016) 0.77
A study of vertebra number in pigs confirms the association of vertnin and reveals additional QTL. BMC Genet (2015) 0.77
The Elusive Philosopher's Stone in Young Blood. Circ Res (2015) 0.76
GDF11 Protects against Endothelial Injury and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice. Mol Ther (2016) 0.75
Developmental Patterning as a Quantitative Trait: Genetic Modulation of the Hoxb6 Mutant Skeletal Phenotype. PLoS One (2016) 0.75
Supt20 is required for development of the axial skeleton. Dev Biol (2016) 0.75
Myostatin-like proteins regulate synaptic function and neuronal morphology. Development (2017) 0.75
The sequence of the human genome. Science (2001) 101.55
How cells read TGF-beta signals. Nat Rev Mol Cell Biol (2000) 8.93
Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci U S A (2001) 6.38
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell (1991) 3.71
Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature (1998) 3.65
Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J (1999) 3.28
Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell (1991) 3.28
nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development (1997) 3.15
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development (1994) 3.12
Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. Nat Genet (1999) 2.90
Different phenotypes for mice deficient in either activins or activin receptor type II. Nature (1995) 2.62
Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell (2001) 2.58
Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature (1993) 2.45
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell (1992) 2.40
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J Cell Biol (1995) 2.36
Nodal signalling in vertebrate development. Nature (2000) 2.20
The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes Dev (2001) 2.17
The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev (1997) 2.09
Genetic dissection of nodal function in patterning the mouse embryo. Development (2001) 2.07
Activin receptor patterning of foregut organogenesis. Genes Dev (2000) 1.91
Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis. Mech Dev (1999) 1.89
Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. J Cell Biol (1999) 1.87
Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol (2002) 1.80
Nodal signaling in early vertebrate embryos: themes and variations. Dev Cell (2001) 1.74
Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins. Development (1994) 1.74
Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev (1999) 1.74
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev (2001) 1.54
The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol (1999) 1.51
Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3. Growth Factors (1995) 1.14
The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development. Development (2001) 0.98
Nodal signaling and the zebrafish organizer. Int J Dev Biol (2001) 0.92
Axis development: the mouse becomes a dachshund. Curr Biol (1999) 0.89
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature (2004) 7.42
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08
Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells (2006) 5.68
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev (2008) 5.58
Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol (2003) 5.27
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol (2006) 5.16
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci (2010) 5.12
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development (2002) 4.72
Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (2010) 4.60
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet (2008) 4.40
DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol (2006) 4.38
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet (2007) 3.63
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61
Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci U S A (2005) 3.52
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem (2002) 3.50
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum Mol Genet (2007) 3.27
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A (2012) 3.03
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev (2008) 2.99
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature (2009) 2.98
Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol (2004) 2.92
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A (2003) 2.54
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med (2007) 2.50
Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol (2006) 2.48
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res (2005) 2.42
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet (2008) 2.35
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A (2013) 2.35
The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol (2004) 2.30
Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc Natl Acad Sci U S A (2004) 2.21
Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol (2007) 2.15
Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation. J Biol Chem (2004) 2.15
Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J (2002) 2.13
Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J Biol Chem (2005) 2.10
DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages. Development (2006) 2.08
Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J Biol Chem (2005) 2.04
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell (2008) 1.99
Structure and function of eukaryotic DNA methyltransferases. Curr Top Dev Biol (2004) 1.91
Neurobehavioral and electroencephalographic abnormalities in Ube3a maternal-deficient mice. Neurobiol Dis (2002) 1.84
De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation. Gene (2002) 1.80
DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev (2006) 1.76
Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation (2008) 1.72
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol (2004) 1.64
Lsh is involved in de novo methylation of DNA. EMBO J (2006) 1.57
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion. Genes Cells (2002) 1.51
De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes. Genesis (2008) 1.51
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 1.51
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol (2012) 1.46
Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development (2006) 1.44
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol (2009) 1.40
BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev (2004) 1.40
Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity. Blood (2007) 1.39
De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation. Development (2004) 1.39
Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. Genes Dev (2003) 1.25
Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo. J Cell Biol (2009) 1.25
Stochastic imprinting in the progeny of Dnmt3L-/- females. Hum Mol Genet (2006) 1.24
Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase. Cell Res (2011) 1.24
Identification of a novel pool of extracellular pro-myostatin in skeletal muscle. J Biol Chem (2008) 1.23
Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun (2008) 1.22
Meiotic and epigenetic aberrations in Dnmt3L-deficient male germ cells. Mol Reprod Dev (2006) 1.21
Preference of DNA methyltransferases for CpG islands in mouse embryonic stem cells. Genome Res (2004) 1.20
Endogenous patterns of BMP signaling during early chick development. Dev Biol (2002) 1.19
Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye. FASEB J (2005) 1.18
Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence. Hum Mol Genet (2007) 1.17
Role for Med12 in regulation of Nanog and Nanog target genes. J Biol Chem (2008) 1.16
Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation. Genes Cells (2010) 1.14
KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation. Stem Cells (2010) 1.14
DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells. Stem Cells (2005) 1.14
Lithography-Free Fabrication of Large Area Subwavelength Antireflection Structures Using Thermally Dewetted Pt/Pd Alloy Etch Mask. Nanoscale Res Lett (2009) 1.12
Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation. Genes Cells (2006) 1.11
Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue. Dev Biol (2006) 1.10
Generation of a floxed allele of the mouse BMP type II receptor gene. Genesis (2005) 1.10
Regulation of activin/nodal signaling by Rap2-directed receptor trafficking. Dev Cell (2008) 1.10
B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol (2004) 1.08
A methyl-CpG-binding protein 2-enhanced green fluorescent protein reporter mouse model provides a new tool for studying the neuronal basis of Rett syndrome. Neuroreport (2008) 1.06
TGF-beta signaling is required for multiple processes during Xenopus tail regeneration. Dev Biol (2008) 1.06
Acetylation of Sirt2 by p300 attenuates its deacetylase activity. Biochem Biophys Res Commun (2008) 1.04
New roles for FoxH1 in patterning the early embryo. Development (2004) 1.03
Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction. Dev Biol (2005) 1.02
Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain. J Neurosci (2011) 1.01
Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation. J Biol Chem (2011) 1.01
Genetic analyses of DNA methyltransferase genes in mouse model system. J Nutr (2002) 1.00
Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development. Hum Mol Genet (2008) 1.00
Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo. Dev Biol (2006) 1.00
The zinc-finger protein CNBP is required for forebrain formation in the mouse. Development (2003) 1.00
Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. FEBS Lett (2005) 0.99
Sox10 controls migration of B16F10 melanoma cells through multiple regulatory target genes. PLoS One (2012) 0.97
Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. J Biol Chem (2008) 0.97
Rapid prototyping of three-dimensional microfluidic mixers in glass by femtosecond laser direct writing. Lab Chip (2012) 0.96
FGF-2 inhibits TNF-α mediated apoptosis through upregulation of Bcl2-A1 and Bcl-xL in ATDC5 cells. BMB Rep (2012) 0.95
Comparative analysis of DNA methylation patterns in transgenic Drosophila overexpressing mouse DNA methyltransferases. Biochem J (2004) 0.94
Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets. Dev Dyn (2007) 0.91
Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron. Dev Dyn (2002) 0.91
Arabidopsis RopGEF4 and RopGEF10 are important for FERONIA-mediated developmental but not environmental regulation of root hair growth. New Phytol (2013) 0.91
Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity. Biochem Biophys Res Commun (2009) 0.91
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis (2003) 0.89