Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin.

PubWeight™: 9.13‹?› | Rank: Top 0.1%

🔗 View Article (PMID 12867029)

Published in Curr Biol on July 15, 2003

Authors

Bernhard Lehnertz1, Yoshihide Ueda, Alwin A H A Derijck, Ulrich Braunschweig, Laura Perez-Burgos, Stefan Kubicek, Taiping Chen, En Li, Thomas Jenuwein, Antoine H F M Peters

Author Affiliations

1: Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, Dr. Bohrgasse 7, A-1030 Vienna, Austria.

Articles citing this

(truncated to the top 100)

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15

Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet (2009) 12.08

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14

Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74

Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35

Epigenetics in cancer. Carcinogenesis (2009) 7.49

The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10

Post-transcriptional regulation of microRNA expression. RNA (2006) 6.76

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71

DNA methylation: roles in mammalian development. Nat Rev Genet (2013) 6.65

Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Genes Dev (2006) 5.15

Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90

Molecular signals of epigenetic states. Science (2010) 4.81

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73

Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol (2009) 4.43

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet (2008) 4.40

Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev (2010) 4.00

Developmental programming of CpG island methylation profiles in the human genome. Nat Struct Mol Biol (2009) 3.96

The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol (2005) 3.93

Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol Cell Biol (2004) 3.76

Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev (2004) 3.67

In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell (2011) 3.67

Mouse centric and pericentric satellite repeats form distinct functional heterochromatin. J Cell Biol (2004) 3.65

Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51

Differential histone modifications mark mouse imprinting control regions during spermatogenesis. EMBO J (2007) 3.46

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol (2009) 3.46

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res (2011) 3.36

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nat Struct Mol Biol (2008) 3.33

DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs. Cell Stem Cell (2011) 3.10

H3K9 methyltransferase G9a and the related molecule GLP. Genes Dev (2011) 3.01

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature (2009) 2.98

Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J (2004) 2.94

Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol (2004) 2.92

In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases. J Biol Chem (2004) 2.86

DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J (2008) 2.81

Mammalian DNA methyltransferases: a structural perspective. Structure (2008) 2.72

In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet (2012) 2.70

Genome-wide association of histone H3 lysine nine methylation with CHG DNA methylation in Arabidopsis thaliana. PLoS One (2008) 2.69

Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol (2008) 2.67

Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. EMBO Rep (2009) 2.50

Locus-specific control of DNA methylation by the Arabidopsis SUVH5 histone methyltransferase. Plant Cell (2006) 2.46

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43

Economy, speed and size matter: evolutionary forces driving nuclear genome miniaturization and expansion. Ann Bot (2005) 2.43

Mammalian cytosine methylation at a glance. J Cell Sci (2009) 2.43

Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res (2010) 2.39

Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA. Mol Cell Biol (2009) 2.34

Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res (2009) 2.31

The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol (2004) 2.30

Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1. Mol Cell Biol (2005) 2.27

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24

Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development. EMBO J (2006) 2.21

Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes Dev (2009) 2.18

Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15

A transcription factor-based mechanism for mouse heterochromatin formation. Nat Struct Mol Biol (2012) 2.15

An unmethylated 3' promoter-proximal region is required for efficient transcription initiation. PLoS Genet (2007) 2.11

Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet (2008) 2.08

The Heterochromatin Protein 1 family. Genome Biol (2006) 2.05

VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization. Genes Dev (2007) 2.01

Linking the epigenetic 'language' of covalent histone modifications to cancer. Br J Cancer (2004) 2.00

Replication-independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep (2004) 1.98

G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J Biol Chem (2008) 1.96

The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha. Mol Endocrinol (2007) 1.95

A family of human zinc finger proteins that bind methylated DNA and repress transcription. Mol Cell Biol (2006) 1.94

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle (2008) 1.90

Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3. Nat Cell Biol (2010) 1.89

DNA methylation and demethylation in mammals. J Biol Chem (2011) 1.89

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep (2009) 1.89

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells. EMBO J (2012) 1.85

Kinetochore and heterochromatin domains of the fission yeast centromere. Chromosome Res (2004) 1.85

SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin. Nat Genet (2011) 1.85

Differential regulation of strand-specific transcripts from Arabidopsis centromeric satellite repeats. PLoS Genet (2005) 1.83

Role of CTCF binding sites in the Igf2/H19 imprinting control region. Mol Cell Biol (2004) 1.79

Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2. Nat Genet (2009) 1.78

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol (2012) 1.77

Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74

DNA methylation in development and human disease. Mutat Res (2008) 1.74

Connections between epigenetic gene silencing and human disease. Mutat Res (2007) 1.72

Regulation of mammalian DNA methyltransferases: a route to new mechanisms. EMBO Rep (2011) 1.71

The retinoblastoma protein regulates pericentric heterochromatin. Mol Cell Biol (2006) 1.68

Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol Cell Biol (2004) 1.67

The role of heterochromatin in centromere function. Philos Trans R Soc Lond B Biol Sci (2005) 1.65

K12-biotinylated histone H4 marks heterochromatin in human lymphoblastoma cells. J Nutr Biochem (2007) 1.64

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. Genome Res (2012) 1.63

Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa. Genome Res (2008) 1.61

Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res (2012) 1.60

Proliferation-dependent and cell cycle regulated transcription of mouse pericentric heterochromatin. J Cell Biol (2007) 1.59

Direct interaction between DNA methyltransferase DIM-2 and HP1 is required for DNA methylation in Neurospora crassa. Mol Cell Biol (2008) 1.58

Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. Mol Cell (2014) 1.58

Partitioning the C. elegans genome by nucleosome modification, occupancy, and positioning. Chromosoma (2009) 1.58

DNA methylation in mammals. Cold Spring Harb Perspect Biol (2014) 1.57

Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus. J Nutr Biochem (2007) 1.57

A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs. EMBO J (2009) 1.56

Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet (2011) 1.56

H3 lysine 9 methylation is maintained on a transcribed inverted repeat by combined action of SUVH6 and SUVH4 methyltransferases. Mol Cell Biol (2005) 1.56

The PHD domain of Np95 (mUHRF1) is involved in large-scale reorganization of pericentromeric heterochromatin. Mol Biol Cell (2008) 1.53

Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing. EMBO J (2010) 1.53

Automethylation of G9a and its implication in wider substrate specificity and HP1 binding. Nucleic Acids Res (2007) 1.52

Articles by these authors

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33

Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Cell (2010) 9.50

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47

Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature (2005) 8.53

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature (2004) 7.42

Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11

The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08

The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01

Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86

Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70

Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells (2006) 5.68

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev (2008) 5.58

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J (2002) 5.33

Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol (2003) 5.27

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol (2006) 5.16

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci (2010) 5.12

Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell (2011) 4.89

Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science (2003) 4.74

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development (2002) 4.72

Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (2010) 4.60

p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53

Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51

An epigenetic road map for histone lysine methylation. J Cell Sci (2003) 4.43

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet (2008) 4.40

DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol (2006) 4.38

A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet (2007) 3.63

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61

Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59

Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci U S A (2005) 3.52

Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51

A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem (2002) 3.50

Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet (2001) 3.46

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46

Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum Mol Genet (2007) 3.27

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev (2006) 3.24

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16

H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. Genome Res (2008) 3.09

Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev (2004) 3.08

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa. Nat Struct Mol Biol (2010) 3.07

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A (2012) 3.03

Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00

Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev (2008) 2.99

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature (2009) 2.98

Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell (2008) 2.96

Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol (2004) 2.92

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (2003) 2.91

In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet (2012) 2.70

Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome. Mol Cell (2007) 2.69

Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27. EMBO J (2006) 2.68

Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell (2007) 2.66

G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A (2003) 2.54

De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med (2007) 2.50

Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol (2006) 2.48

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43

Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res (2005) 2.42

Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41

PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet (2008) 2.37

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet (2008) 2.35

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet (2012) 2.35

The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol (2004) 2.30

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol (2005) 2.27