Published in Cancer Res on August 01, 2004
The antioxidant function of the p53 tumor suppressor. Nat Med (2005) 7.57
HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell (2007) 4.81
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle (2010) 3.15
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A (2010) 3.03
Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol Med (2009) 2.04
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J Clin Invest (2007) 2.03
Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS One (2008) 1.94
Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res (2009) 1.71
Reactive oxygen species in health and disease. J Biomed Biotechnol (2012) 1.52
Metabolic shifts in residual breast cancer drive tumor recurrence. J Clin Invest (2017) 1.38
Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology (2010) 1.23
Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal (2009) 1.11
Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PLoS One (2010) 1.01
The role of tumor suppressor p53 in the antioxidant defense and metabolism. Subcell Biochem (2014) 0.90
ATM localization and gene expression in the adult mouse eye. Mol Vis (2009) 0.85
Micro-RNAs in regenerating lungs: an integrative systems biology analysis of murine influenza pneumonia. BMC Genomics (2014) 0.85
Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice. Food Chem Toxicol (2007) 0.84
A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia. Am J Pathol (2011) 0.83
Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer. Transl Oncol (2009) 0.82
Experimental antioxidant therapy in ataxia telangiectasia. Clin Med Oncol (2008) 0.81
ATM-deficient human neural stem cells as an in vitro model system to study neurodegeneration. DNA Repair (Amst) (2013) 0.81
Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model. Sci Rep (2015) 0.80
The Chemical Interplay between Nitric Oxide and Mitochondrial Cytochrome c Oxidase: Reactions, Effectors and Pathophysiology. Int J Cell Biol (2012) 0.79
NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease. Proc Natl Acad Sci U S A (2015) 0.77
Effects of Antioxidant N-acetylcysteine Against Paraquat-Induced Oxidative Stress in Vital Tissues of Mice. Int J Sci Basic Appl Res (2016) 0.75
No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats. J Toxicol Pathol (2009) 0.75
The protective effects of different treatments on rat salivary glands after radiotherapy. Eur Arch Otorhinolaryngol (2016) 0.75
High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 5.62
Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res (2004) 2.33
Intestinal mucosal inflammation leads to systemic genotoxicity in mice. Cancer Res (2009) 1.90
Quick and easy yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 1.89
Large-scale high-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 1.76
Radiation-induced long-lived extracellular radicals do not contribute to measurement of intracellular reactive oxygen species using the dichlorofluorescein method. Radiat Res (2008) 1.71
Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res (2009) 1.71
Frozen competent yeast cells that can be transformed with high efficiency using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 1.48
Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice. DNA Repair (Amst) (2006) 1.32
New and emerging technologies for genetic toxicity testing. Environ Mol Mutagen (2010) 1.28
Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes. Dev Neurobiol (2008) 1.27
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell (2003) 1.23
Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res (2002) 1.18
Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. Cancer Res (2010) 1.17
Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. Cancer Res (2003) 1.17
Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice. J Nutr (2007) 1.07
Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Mutat Res (2010) 1.06
siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status. Radiat Res (2006) 1.05
Refinement of the dichlorofluorescein assay for flow cytometric measurement of reactive oxygen species in irradiated and bystander cell populations. Radiat Res (2008) 1.04
Detection of Arabidopsis thaliana AtRAD1 cDNA variants and assessment of function by expression in a yeast rad1 mutant. Gene (2002) 1.03
Ionizing radiation and restriction enzymes induce microhomology-mediated illegitimate recombination in Saccharomyces cerevisiae. Nucleic Acids Res (2007) 1.01
Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis (2005) 1.01
Color and shape interactions in the recognition of natural scenes by human and monkey observers. J Vis (2009) 1.00
Involvement of homologous recombination in carcinogenesis. Adv Genet (2007) 0.99
Microtiter plate transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 0.98
Differences in animal housing facilities and diet may affect study outcomes-a plea for inclusion of such information in publications. DNA Repair (Amst) (2006) 0.97
Diesel exhaust particles cause increased levels of DNA deletions after transplacental exposure in mice. Mutat Res (2005) 0.96
Role of homologous recombination in carcinogenesis. Exp Mol Pathol (2003) 0.96
Intestinal bacteria modify lymphoma incidence and latency by affecting systemic inflammatory state, oxidative stress, and leukocyte genotoxicity. Cancer Res (2013) 0.90
High throughput screening of small molecule libraries for modifiers of radiation responses. Int J Radiat Biol (2011) 0.90
N-acetyl cysteine protects against ionizing radiation-induced DNA damage but not against cell killing in yeast and mammals. Mutat Res (2009) 0.90
Increases in oxidative stress in the progeny of X-irradiated cells. Radiat Res (2004) 0.90
Pol3 is involved in nonhomologous end-joining in Saccharomyces cerevisiae. DNA Repair (Amst) (2008) 0.90
Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases. PLoS One (2012) 0.89
Developmental cell death in the liver and newborn lethality of Ku86 deficient mice suppressed by antioxidant N-acetyl-cysteine. DNA Repair (Amst) (2006) 0.88
Characterization of the hyperrecombination phenotype of the pol3-t mutation of Saccharomyces cerevisiae. Genetics (2003) 0.88
Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients. DNA Repair (Amst) (2005) 0.88
Intestinal inflammation induces genotoxicity to extraintestinal tissues and cell types in mice. Int J Cancer (2011) 0.87
Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice. Food Chem Toxicol (2007) 0.84
Adaptive response to gamma radiation in mammalian cells proficient and deficient in components of nucleotide excision repair. Radiat Res (2007) 0.84
Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg. Cancer Res (2010) 0.84
In vivo DNA deletion assay to detect environmental and genetic predisposition to cancer. Methods Mol Biol (2004) 0.84
Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons. Mol Neurodegener (2011) 0.83
Small-animal PET/CT for monitoring the development and response to chemotherapy of thymic lymphoma in Trp53-/- mice. J Nucl Med (2010) 0.83
Promoter-trapping in Saccharomyces cerevisiae by radiation-assisted fragment insertion. Nucleic Acids Res (2002) 0.82
Effects of human Werner helicase on intrachromosomal homologous recombination mediated DNA deletions in mice. Mutat Res (2008) 0.82
Experimental antioxidant therapy in ataxia telangiectasia. Clin Med Oncol (2008) 0.81
Ionizing radiation induces microhomology-mediated end joining in trans in yeast and mammalian cells. Radiat Res (2009) 0.81
The role of tumour necrosis factor-α and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity. Mutagenesis (2011) 0.81
A high G418-resistant neo(R) transgenic mouse and mouse embryonic fibroblast (MEF) feeder layers for cytotoxicity and gene targeting in vivo and in vitro. Drug Chem Toxicol (2011) 0.80
Genetic toxicity assessment: employing the best science for human safety evaluation Part VII: Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment. Toxicol Sci (2007) 0.80
Carcinogenic Cr(VI) and the nutritional supplement Cr(III) induce DNA deletions in yeast and mice. Cancer Res (2006) 0.80
Mouse models for induced genetic instability at endogenous loci. Oncogene (2003) 0.80
Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow. Exp Hematol (2011) 0.80
IL-13 overexpression in mouse lungs triggers systemic genotoxicity in peripheral blood. Mutat Res (2014) 0.80
Detecting carcinogens with the yeast DEL assay. Methods Mol Biol (2004) 0.79
More damaging than we think: systemic effects of intestinal inflammation. Cell Cycle (2009) 0.79
Yeast DEL assay detects clastogens. Mutat Res (2005) 0.79
Ty1 integrase overexpression leads to integration of non-Ty1 DNA fragments into the genome of Saccharomyces cerevisiae. Mol Genet Genomics (2010) 0.79
Intestinal microbiome and lymphoma development. Cancer J (2014) 0.79
2-Dodecylcyclobutanone does not induce mutations in the Salmonella mutagenicity test or intrachromosomal recombination in Saccharomyces cerevisiae. J Food Prot (2004) 0.78
Ku86 deficiency leads to reduced intrachromosomal homologous recombination in vivo in mice. DNA Repair (Amst) (2004) 0.78
9,10-Phenanthrenequinone induces DNA deletions and forward mutations via oxidative mechanisms in the yeast Saccharomyces cerevisiae. Toxicol In Vitro (2007) 0.78
Development of a microtiter plate version of the yeast DEL assay amenable to high-throughput toxicity screening of chemical libraries. Mutat Res (2007) 0.78
Effects of side-stream tobacco smoke and smoke extract on glutathione- and oxidative DNA damage repair-deficient mice and blood cells. Mutat Res (2013) 0.77
Rad1, rad10 and rad52 mutations reduce the increase of microhomology length during radiation-induced microhomology-mediated illegitimate recombination in saccharomyces cerevisiae. Radiat Res (2009) 0.77
Radiation-induced myeloid leukemia in murine models. Hum Genomics (2014) 0.77
Intracellular and extracellular factors influencing Cr(VI) and Cr(III) genotoxicity. Environ Mol Mutagen (2011) 0.77
Cell cycle dependence of ionizing radiation-induced DNA deletions and antioxidant radioprotection in Saccharomyces cerevisiae. Radiat Res (2010) 0.77
Intestinal microbiota reduces genotoxic endpoints induced by high-energy protons. Radiat Res (2014) 0.77
Heat-induced phosphorylation of NBS1 in human skin fibroblast cells. J Cell Biochem (2006) 0.77
Effect of rad50 mutation on illegitimate recombination in Saccharomyces cerevisiae. Mol Genet Genomics (2011) 0.76
The pol3-t hyperrecombination phenotype and DNA damage-induced recombination in Saccharomyces cerevisiae is RAD50 dependent. J Biomed Biotechnol (2009) 0.76
Yeast DEL assay detects protection against radiation-induced cytotoxicity and genotoxicity: adaptation of a microtiter plate version. Radiat Res (2010) 0.76
Effect of benzene and its closed ring metabolites on intrachromosomal recombination in Saccharomyces cerevisiae. Mutat Res (2005) 0.76
Nucleotide excision repair deficiency causes elevated levels of chromosome gain in Saccharomyces cerevisiae. DNA Repair (Amst) (2004) 0.76
Biological aspects of dichlorofluorescein measurement of cellular reactive oxygen species. Radiat Res (2008) 0.75
HNO induces DNA deletions in the yeast S. cerevisiae. Mutat Res (2007) 0.75
Effects of 1 GeV/nucleon ⁵⁶Fe particles on longevity, carcinogenesis and neuromotor ability in Atm-deficient mice. Radiat Res (2010) 0.75
Mouse models for radiation-induced cancers. Mutagenesis (2016) 0.75
Point-source irradiation with eccentric rotation causes inhomogeneous dose distribution. Radiat Res (2006) 0.75
Mutagen X and chlorinated tap water are recombinagenic in yeast. Mutat Res (2004) 0.75