Published in Nature on August 19, 2004
Copper-free click chemistry for dynamic in vivo imaging. Proc Natl Acad Sci U S A (2007) 8.50
Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew Chem Int Ed Engl (2009) 8.15
In vivo imaging of membrane-associated glycans in developing zebrafish. Science (2008) 5.45
Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proc Natl Acad Sci U S A (2006) 4.44
Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem (2008) 3.93
Cu-free click cycloaddition reactions in chemical biology. Chem Soc Rev (2010) 3.89
Copper-free click chemistry in living animals. Proc Natl Acad Sci U S A (2010) 2.76
Imaging the glycome. Proc Natl Acad Sci U S A (2008) 2.62
From mechanism to mouse: a tale of two bioorthogonal reactions. Acc Chem Res (2011) 2.50
Advances in the biology and chemistry of sialic acids. ACS Chem Biol (2010) 1.96
Expanding metabolism for biosynthesis of nonnatural alcohols. Proc Natl Acad Sci U S A (2008) 1.86
Labeling live cells by copper-catalyzed alkyne--azide click chemistry. Bioconjug Chem (2010) 1.86
Probing mucin-type O-linked glycosylation in living animals. Proc Natl Acad Sci U S A (2006) 1.85
A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation. Angew Chem Int Ed Engl (2008) 1.79
In vivo imaging in cancer. Cold Spring Harb Perspect Biol (2010) 1.76
Reactive polymer enables efficient in vivo bioorthogonal chemistry. Proc Natl Acad Sci U S A (2012) 1.74
Therapeutic cell engineering with surface-conjugated synthetic nanoparticles. Nat Med (2010) 1.71
Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides. Proc Natl Acad Sci U S A (2011) 1.65
Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. Proc Natl Acad Sci U S A (2011) 1.61
Ultrabright and bioorthogonal labeling of cellular targets using semiconducting polymer dots and click chemistry. Angew Chem Int Ed Engl (2010) 1.59
Bioorthogonal chemistry: recent progress and future directions. Chem Commun (Camb) (2010) 1.58
Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J (2007) 1.55
Metabolic labeling of sialic acids in living animals with alkynyl sugars. Angew Chem Int Ed Engl (2009) 1.53
Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization. Proc Natl Acad Sci U S A (2005) 1.49
Bringing chemistry to life. Nat Methods (2011) 1.45
Ligand-directed tosyl chemistry for protein labeling in vivo. Nat Chem Biol (2009) 1.43
Click chemistry in complex mixtures: bioorthogonal bioconjugation. Chem Biol (2014) 1.40
A chemical approach for detecting sulfenic acid-modified proteins in living cells. Mol Biosyst (2008) 1.37
A chemical reporter strategy to probe glycoprotein fucosylation. J Am Chem Soc (2006) 1.35
Chemical approaches to perturb, profile, and perceive glycans. Acc Chem Res (2009) 1.33
Growing applications of "click chemistry" for bioconjugation in contemporary biomedical research. Cancer Biother Radiopharm (2009) 1.30
Non-canonical amino acid labeling in vivo to visualize and affinity purify newly synthesized proteins in larval zebrafish. ACS Chem Neurosci (2012) 1.30
A critical examination of Escherichia coli esterase activity. J Biol Chem (2009) 1.18
Thiacycloalkynes for copper-free click chemistry. Angew Chem Int Ed Engl (2012) 1.08
Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells. Chem Sci (2011) 1.08
Targeted metabolic labeling of yeast N-glycans with unnatural sugars. Proc Natl Acad Sci U S A (2010) 1.08
Selective enrichment of sialic acid-containing glycopeptides using titanium dioxide chromatography with analysis by HILIC and mass spectrometry. Nat Protoc (2010) 1.07
Imaging the sialome during zebrafish development with copper-free click chemistry. Chembiochem (2012) 1.05
Carbohydrate post-glycosylational modifications. Org Biomol Chem (2007) 1.02
A synthetic mimic of human Fc receptors: defined chemical modification of cell surfaces enables efficient endocytic uptake of human immunoglobulin-G. J Am Chem Soc (2006) 1.02
Isotope-targeted glycoproteomics (IsoTaG): a mass-independent platform for intact N- and O-glycopeptide discovery and analysis. Nat Methods (2015) 1.01
Uptake, distribution and diffusivity of reactive fluorophores in cells: implications toward target identification. Mol Pharm (2010) 1.00
Endocytic delivery of vancomycin mediated by a synthetic cell surface receptor: rescue of bacterially infected Mammalian cells and tissue targeting in vivo. J Am Chem Soc (2007) 1.00
Copper-Catalyzed Azide-Alkyne Click Chemistry for Bioconjugation. Curr Protoc Chem Biol (2011) 0.98
Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo. Nat Chem (2014) 0.98
Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials. Nano Today (2011) 0.96
A copper-catalyzed, pH-neutral construction of high-enantiopurity peptidyl ketones from peptidic s-acylthiosalicylamides in air at room temperature. Angew Chem Int Ed Engl (2009) 0.96
Imaging beyond the proteome. Chem Commun (Camb) (2012) 0.95
Design strategies for bioorthogonal smart probes. Org Biomol Chem (2014) 0.95
Staudinger ligation of peptides at non-glycyl residues. J Org Chem (2006) 0.94
Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology (2010) 0.94
Imaging cell surface glycosylation in vivo using "double click" chemistry. Bioconjug Chem (2013) 0.94
Fluorination of mammalian cell surfaces via the sialic acid biosynthetic pathway. Bioorg Med Chem Lett (2008) 0.92
Development of benzothiazole 'click-on' fluorogenic dyes. Bioorg Med Chem Lett (2010) 0.92
Real-time bioluminescence imaging of glycans on live cells. J Am Chem Soc (2010) 0.92
Microencapsulation of islets within alginate/poly(ethylene glycol) gels cross-linked via Staudinger ligation. Acta Biomater (2010) 0.92
Chemoselective cross-linking and functionalization of alginate via Staudinger ligation. Biomacromolecules (2009) 0.91
Sialic acid metabolism and sialyltransferases: natural functions and applications. Appl Microbiol Biotechnol (2012) 0.91
Sialic acids attached to O-glycans modulate voltage-gated potassium channel gating. J Biol Chem (2010) 0.90
Bioorthogonal chemistry: implications for pretargeted nuclear (PET/SPECT) imaging and therapy. Am J Nucl Med Mol Imaging (2014) 0.88
A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice. ACS Chem Biol (2013) 0.88
Synthesis of polystyrene microspheres and functionalization with Pd(0) nanoparticles to perform bioorthogonal organometallic chemistry in living cells. Nat Protoc (2012) 0.88
Synthesis and inhibitory activity of oligosaccharide thiazolines as a class of mechanism-based inhibitors for endo-beta-N-acetylglucosaminidases. Bioorg Med Chem (2008) 0.88
In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics. Nat Commun (2016) 0.87
A synthetic approach to abiogenesis. Nat Methods (2014) 0.87
Azide-specific labeling of biomolecules by Staudinger-Bertozzi ligation phosphine derivatives of fluorescent probes suitable for single-molecule fluorescence spectroscopy. Methods Enzymol (2010) 0.86
Modulation of cellular adhesion by glycoengineering. J Med Chem (2010) 0.86
Small molecule probes for plant cell wall polysaccharide imaging. Front Plant Sci (2012) 0.86
Recruiting the host's immune system to target Helicobacter pylori's surface glycans. Chembiochem (2013) 0.85
Recent advances in chemical proteomics: exploring the post-translational proteome. J Chem Biol (2008) 0.84
Monitoring the size and lateral dynamics of ErbB1 enriched membrane domains through live cell plasmon coupling microscopy. PLoS One (2012) 0.84
A strategy for the selective imaging of glycans using caged metabolic precursors. J Am Chem Soc (2010) 0.84
Isotope Targeted Glycoproteomics (IsoTaG) to Characterize Intact, Metabolically Labeled Glycopeptides from Complex Proteomes. Curr Protoc Chem Biol (2016) 0.82
Glycans in pathogenic bacteria--potential for targeted covalent therapeutics and imaging agents. Chem Commun (Camb) (2014) 0.81
A biocompatible "split luciferin" reaction and its application for non-invasive bioluminescent imaging of protease activity in living animals. Curr Protoc Chem Biol (2014) 0.80
(99m)Tc-bioorthogonal click chemistry reagent for in vivo pretargeted imaging. Bioorg Med Chem (2016) 0.80
One-step enzymatic modification of the cell surface redirects cellular cytotoxicity and parasite tropism. ACS Chem Biol (2014) 0.80
In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy. Proc Natl Acad Sci U S A (2016) 0.80
Cell labeling and tracking method without distorted signals by phagocytosis of macrophages. Theranostics (2014) 0.80
Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid. Bioorg Med Chem Lett (2009) 0.80
Surface-bound cytomimetic assembly based on chemoselective and biocompatible immobilization and further modification of intact liposome. Bioconjug Chem (2010) 0.79
Chemical biology: hitting the sweet spot. Nature (2004) 0.79
Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation. J Am Chem Soc (2015) 0.79
Bioorthogonal Chemistry-A Covalent Strategy for the Study of Biological Systems. Sci China Chem (2010) 0.79
Chemistry and material science at the cell surface. Mater Today (Kidlington) (2010) 0.79
Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology. PLoS Pathog (2016) 0.79
Labeling Cell Surface GPIs and GPI-Anchored Proteins through Metabolic Engineering with Artificial Inositol Derivatives. Angew Chem Int Ed Engl (2015) 0.78
Metabolic flux-driven sialylation alters internalization, recycling, and drug sensitivity of the epidermal growth factor receptor (EGFR) in SW1990 pancreatic cancer cells. Oncotarget (2016) 0.78
Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging. Angew Chem Int Ed Engl (2015) 0.78
Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics. Bioconjug Chem (2009) 0.78
Chemical Glycoproteomics. Chem Rev (2016) 0.78
Development of a novel method to evaluate sialylation of glycoproteins and analysis of gp96 sialylation in Hela, SW1990 and A549 cell lines. Biol Res (2015) 0.77
Targeted Ultrasound-Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging using Click Chemistry. Angew Chem Int Ed Engl (2016) 0.77
Azide-reactive liposome for chemoselective and biocompatible liposomal surface functionalization and glyco-liposomal microarray fabrication. Langmuir (2011) 0.77
CMP substitutions preferentially inhibit polysialic acid synthesis. Glycobiology (2007) 0.77
Fluorescent tags to explore cell wall structure and dynamics. Front Plant Sci (2012) 0.77
Multiplex detection of functional G protein-coupled receptors harboring site-specifically modified unnatural amino acids. Biochemistry (2015) 0.77
Tissue-based metabolic labeling of polysialic acids in living primary hippocampal neurons. Proc Natl Acad Sci U S A (2015) 0.76
Copper-free click chemistry for dynamic in vivo imaging. Proc Natl Acad Sci U S A (2007) 8.50
Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew Chem Int Ed Engl (2009) 8.15
Chemistry in living systems. Nat Chem Biol (2005) 7.55
A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems. J Am Chem Soc (2004) 7.51
Glycans in cancer and inflammation--potential for therapeutics and diagnostics. Nat Rev Drug Discov (2005) 6.14
In vivo imaging of membrane-associated glycans in developing zebrafish. Science (2008) 5.45
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation. Proc Natl Acad Sci U S A (2001) 4.88
A comparative study of bioorthogonal reactions with azides. ACS Chem Biol (2006) 4.26
Cu-free click cycloaddition reactions in chemical biology. Chem Soc Rev (2010) 3.89
Second-generation difluorinated cyclooctynes for copper-free click chemistry. J Am Chem Soc (2008) 3.65
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes. Nat Biotechnol (2007) 3.41
A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proc Natl Acad Sci U S A (2003) 2.97
Copper-free click chemistry in living animals. Proc Natl Acad Sci U S A (2010) 2.76
Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J Am Chem Soc (2010) 2.74
Introducing genetically encoded aldehydes into proteins. Nat Chem Biol (2007) 2.65
Imaging the glycome. Proc Natl Acad Sci U S A (2008) 2.62
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proc Natl Acad Sci U S A (2003) 2.62
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation. Proc Natl Acad Sci U S A (2003) 2.56
From mechanism to mouse: a tale of two bioorthogonal reactions. Acc Chem Res (2011) 2.50
The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Biochemistry (2008) 2.40
Investigating cellular metabolism of synthetic azidosugars with the Staudinger ligation. J Am Chem Soc (2002) 2.26
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol (2004) 2.25
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids. Proc Natl Acad Sci U S A (2006) 2.23
Mechanistic investigation of the staudinger ligation. J Am Chem Soc (2005) 2.19
Chemical technologies for probing glycans. Cell (2006) 2.04
A cell nanoinjector based on carbon nanotubes. Proc Natl Acad Sci U S A (2007) 2.00
Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. Proc Natl Acad Sci U S A (2007) 1.98
Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics. Methods Enzymol (2006) 1.93
Probing mucin-type O-linked glycosylation in living animals. Proc Natl Acad Sci U S A (2006) 1.85
A hydrophilic azacyclooctyne for Cu-free click chemistry. Org Lett (2008) 1.84
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc Natl Acad Sci U S A (2009) 1.83
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc Natl Acad Sci U S A (2009) 1.83
Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. Chem Biol (2012) 1.79
A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation. Angew Chem Int Ed Engl (2008) 1.79
The chemistry and biology of mucin-type O-linked glycosylation. Bioorg Med Chem (2005) 1.78
Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling. Chem Biol (2004) 1.78
Visualizing enveloping layer glycans during zebrafish early embryogenesis. Proc Natl Acad Sci U S A (2010) 1.74
Sulfotransferases and sulfatases in mycobacteria. Chem Biol (2002) 1.74
Integrated microfluidic bioprocessor for single-cell gene expression analysis. Proc Natl Acad Sci U S A (2008) 1.73
Metabolic labeling of glycans with azido sugars and subsequent glycan-profiling and visualization via Staudinger ligation. Nat Protoc (2007) 1.73
Imaging cell surface glycans with bioorthogonal chemical reporters. J Am Chem Soc (2007) 1.65
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter. Proc Natl Acad Sci U S A (2010) 1.63
Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. Proc Natl Acad Sci U S A (2011) 1.61
5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice. Mol Microbiol (2006) 1.59
Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjug Chem (2015) 1.58
Symbol nomenclature for glycan representation. Proteomics (2009) 1.56
Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J (2007) 1.55
Sulfate metabolism in mycobacteria. Chembiochem (2006) 1.55
Metabolic labeling of sialic acids in living animals with alkynyl sugars. Angew Chem Int Ed Engl (2009) 1.53
Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers. Chem Commun (Camb) (2008) 1.52
In vivo imaging of Caenorhabditis elegans glycans. ACS Chem Biol (2009) 1.48
Bringing chemistry to life. Nat Methods (2011) 1.45
Trehalose is required for growth of Mycobacterium smegmatis. J Biol Chem (2004) 1.44
Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5'-phosphosulfate reductase. J Mol Biol (2006) 1.42
Noncovalent cell surface engineering: incorporation of bioactive synthetic glycopolymers into cellular membranes. J Am Chem Soc (2008) 1.41
Metabolic oligosaccharide engineering as a tool for glycobiology. Curr Opin Chem Biol (2003) 1.41
Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat Protoc (2012) 1.40
Programmable cell adhesion encoded by DNA hybridization. Angew Chem Int Ed Engl (2006) 1.39
Selective enrichment of azide-containing peptides from complex mixtures. J Proteome Res (2009) 1.38
A chemical reporter strategy to probe glycoprotein fucosylation. J Am Chem Soc (2006) 1.35
Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase. Glycobiology (2005) 1.35
Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem (2008) 1.35
A conserved mechanism for sulfonucleotide reduction. PLoS Biol (2005) 1.34
Membrane proteomics of phagosomes suggests a connection to autophagy. Proc Natl Acad Sci U S A (2008) 1.34
Chemical approaches to perturb, profile, and perceive glycans. Acc Chem Res (2009) 1.33
A decade of bioorthogonal chemistry. Acc Chem Res (2011) 1.32
Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells. J Am Chem Soc (2009) 1.31
Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog. FASEB J (2007) 1.31
Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir (2009) 1.30
(D)-Amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen. ACS Chem Biol (2013) 1.29
Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by beta-cyclodextrin. J Am Chem Soc (2010) 1.29
Synthetic riboswitches that induce gene expression in diverse bacterial species. Appl Environ Microbiol (2010) 1.29
A fluorogenic dye activated by the staudinger ligation. J Am Chem Soc (2003) 1.29
Expanding the diversity of unnatural cell-surface sialic acids. Chembiochem (2004) 1.29
5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria. J Biol Chem (2002) 1.27
Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach. Proc Natl Acad Sci U S A (2002) 1.26
Metabolic labeling of fucosylated glycans in developing zebrafish. ACS Chem Biol (2011) 1.25
Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag. Angew Chem Int Ed Engl (2012) 1.25
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc Natl Acad Sci U S A (2007) 1.25
Interfacing carbon nanotubes with living cells. J Am Chem Soc (2006) 1.25
Reactivity of biarylazacyclooctynones in copper-free click chemistry. J Am Chem Soc (2012) 1.24
An inhibitor of the human UDP-GlcNAc 4-epimerase identified from a uridine-based library: a strategy to inhibit O-linked glycosylation. Chem Biol (2002) 1.22
Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res (2009) 1.20
Synthesis, characterization, and theory of [9]-, [12]-, and [18]cycloparaphenylene: carbon nanohoop structures. J Am Chem Soc (2008) 1.19
Metabolic functionalization of recombinant glycoproteins. Biochemistry (2004) 1.19
A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites. J Am Chem Soc (2003) 1.18
Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications. Angew Chem Int Ed Engl (2009) 1.18
A chemical method for labeling lysine methyltransferase substrates. Chembiochem (2010) 1.18
A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 1.16
Synthetic glycopeptides and glycoproteins as tools for biology. Chem Soc Rev (2004) 1.16
Probing glycosyltransferase activities with the Staudinger ligation. J Am Chem Soc (2004) 1.15
The regulation of sulfur metabolism in Mycobacterium tuberculosis. PLoS Pathog (2011) 1.15
Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition. J Am Chem Soc (2012) 1.15
The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus. Curr Opin Cell Biol (2004) 1.15
Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library. Antimicrob Agents Chemother (2003) 1.14
Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes. Proc Natl Acad Sci U S A (2014) 1.14
Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition. Chembiochem (2010) 1.14
Azido sialic acids can modulate cell-surface interactions. Chembiochem (2004) 1.14
A strategy for functional proteomic analysis of glycosidase activity from cell lysates. Angew Chem Int Ed Engl (2004) 1.14