Published in Nat Biotechnol on October 01, 2010
Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09
Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov (2012) 6.70
A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature (2012) 6.34
Analysing and interpreting DNA methylation data. Nat Rev Genet (2012) 3.77
DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell (2012) 2.45
Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. Nat Genet (2013) 2.41
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell (2012) 2.35
Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation. Cell (2014) 2.27
Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell (2012) 2.15
Tackling the epigenome: challenges and opportunities for collaboration. Nat Biotechnol (2010) 2.04
PBX1 genomic pioneer function drives ERα signaling underlying progression in breast cancer. PLoS Genet (2011) 1.93
Global profiling of DNA methylation erasure in mouse primordial germ cells. Genome Res (2012) 1.78
Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling. Genome Biol (2012) 1.76
Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency. Cell Res (2011) 1.72
Taking the measure of the methylome. Nat Biotechnol (2010) 1.57
Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting. Genome Res (2012) 1.54
RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Mol Cell (2012) 1.52
NuRD and pluripotency: a complex balancing act. Cell Stem Cell (2012) 1.46
Genetic and epigenetic stability of human pluripotent stem cells. Nat Rev Genet (2012) 1.38
Recent advancements in cloning by somatic cell nuclear transfer. Philos Trans R Soc Lond B Biol Sci (2013) 1.33
Interplay between chromatin state, regulator binding, and regulatory motifs in six human cell types. Genome Res (2013) 1.33
Quantitative reconstruction of leukocyte subsets using DNA methylation. Genome Biol (2014) 1.32
Histone h1 depletion impairs embryonic stem cell differentiation. PLoS Genet (2012) 1.32
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci (2013) 1.26
DNA methylation and methylcytosine oxidation in cell fate decisions. Curr Opin Cell Biol (2013) 1.24
Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Res (2012) 1.21
Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment. EMBO J (2013) 1.19
AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes. Nature (2013) 1.18
Stem cell technology for the study and treatment of motor neuron diseases. Regen Med (2011) 1.16
High-resolution mapping of h1 linker histone variants in embryonic stem cells. PLoS Genet (2013) 1.11
Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. J Biol Chem (2010) 1.07
Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell Biosci (2013) 1.07
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function. Blood (2012) 1.05
Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease. Clin Epigenetics (2015) 1.05
Linking cell signaling and the epigenetic machinery. Nat Biotechnol (2010) 1.03
Predicting expression: the complementary power of histone modification and transcription factor binding data. Epigenetics Chromatin (2014) 1.03
Interplay between Epigenetics and Genetics in Cancer. Genomics Inform (2013) 1.03
Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state. Proc Natl Acad Sci U S A (2012) 1.02
Chromatin regulation at the frontier of synthetic biology. Nat Rev Genet (2015) 1.01
High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring. PLoS One (2014) 1.01
Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. PLoS One (2011) 1.01
Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol (2012) 0.99
Epigenetic regulation of skin: focus on the Polycomb complex. Cell Mol Life Sci (2012) 0.99
Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev (2014) 0.97
DNA methylation is crucial for the early development in the Oyster C. gigas. Mar Biotechnol (NY) (2013) 0.97
Lessons learned about human stem cell responses to ionizing radiation exposures: a long road still ahead of us. Int J Mol Sci (2013) 0.96
Epigenetic treatment of solid tumours: a review of clinical trials. Clin Epigenetics (2015) 0.96
Epigenetics: Beyond Chromatin Modifications and Complex Genetic Regulation. Plant Physiol (2014) 0.95
The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA. PLoS One (2011) 0.94
Control of adult stem cells in vivo by a dynamic physiological environment: diet-dependent systemic factors in Drosophila and beyond. Wiley Interdiscip Rev Dev Biol (2012) 0.94
Epigenetic regulation of inflammatory cytokines and associated genes in human malignancies. Mediators Inflamm (2015) 0.93
Molecular features of cellular reprogramming and development. Nat Rev Mol Cell Biol (2016) 0.93
Epigenetic mechanisms in cardiac development and disease. Acta Biochim Biophys Sin (Shanghai) (2012) 0.93
Non-CG Methylation in the Human Genome. Annu Rev Genomics Hum Genet (2015) 0.92
Epigenetic regulation of epidermal differentiation. Cold Spring Harb Perspect Med (2014) 0.91
Genomes, proteomes, and the central dogma. Circ Cardiovasc Genet (2011) 0.91
Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method. Nucleic Acids Res (2013) 0.91
Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation. Nucleic Acids Res (2011) 0.90
Epigenetic control of skin and hair regeneration after wounding. Exp Dermatol (2014) 0.89
EZH2: a pivotal regulator in controlling cell differentiation. Am J Transl Res (2012) 0.89
The polycomb protein Ezh2 impacts on induced pluripotent stem cell generation. Stem Cells Dev (2014) 0.89
Choline nutrition programs brain development via DNA and histone methylation. Cent Nerv Syst Agents Med Chem (2012) 0.89
Integration of 'omics' data in aging research: from biomarkers to systems biology. Aging Cell (2015) 0.88
The epigenome of AML stem and progenitor cells. Epigenetics (2012) 0.87
Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells. Sci Rep (2014) 0.87
Browsing (Epi)genomes: a guide to data resources and epigenome browsers for stem cell researchers. Cell Stem Cell (2013) 0.87
Epigenetic obstacles encountered by transcription factors: reprogramming against all odds. Curr Opin Genet Dev (2012) 0.87
The genetic and epigenetic journey of embryonic stem cells into mature neural cells. Front Genet (2012) 0.87
Epigenetic landscape of pluripotent stem cells. Antioxid Redox Signal (2012) 0.86
The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation. Stem Cells Dev (2013) 0.86
The use of small molecules in somatic-cell reprogramming. Trends Cell Biol (2013) 0.85
Direct conversion of human fibroblasts into functional osteoblasts by defined factors. Proc Natl Acad Sci U S A (2015) 0.85
The histone demethylase Kdm3a is essential to progression through differentiation. Nucleic Acids Res (2012) 0.84
Human embryonic stem cell responses to ionizing radiation exposures: current state of knowledge and future challenges. Stem Cells Int (2012) 0.84
KDM1 class flavin-dependent protein lysine demethylases. Biopolymers (2015) 0.84
Effect of estrogen receptor α binding on functional DNA methylation in breast cancer. Epigenetics (2014) 0.84
Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis. Breast Cancer Res (2012) 0.84
Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine. Biochemistry (2015) 0.83
Unraveling transcription factor interactions with heterochromatin protein 1 using fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy. J Biomed Opt (2013) 0.82
Adeno-associated viral vector-mediated transgene expression is independent of DNA methylation in primate liver and skeletal muscle. PLoS One (2011) 0.82
Epigenetic biomarkers: a step forward for understanding periodontitis. J Periodontal Implant Sci (2013) 0.82
Efficient reprogramming of naïve-like induced pluripotent stem cells from porcine adipose-derived stem cells with a feeder-independent and serum-free system. PLoS One (2014) 0.82
Epigenetic biomarker to support classification into pluripotent and non-pluripotent cells. Sci Rep (2015) 0.82
Lats2 is critical for the pluripotency and proper differentiation of stem cells. Cell Death Differ (2014) 0.82
The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells. Braz J Med Biol Res (2013) 0.82
Transcription factor-mediated epigenetic reprogramming. J Biol Chem (2012) 0.81
Assaying the epigenome in limited numbers of cells. Methods (2014) 0.80
Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation. Front Genet (2016) 0.80
Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells. Stem Cell Res Ther (2012) 0.80
Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. Nucleic Acids Res (2013) 0.80
Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks. Stem Cells (2014) 0.80
Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells. Nat Commun (2016) 0.79
Human factors and pathways essential for mediating epigenetic gene silencing. Epigenetics (2014) 0.79
Prospective in vitro models of channelopathies and cardiomyopathies. Stem Cells Int (2012) 0.79
Understanding the molecular circuitry of cell lineage specification in the early mouse embryo. Genes (Basel) (2011) 0.79
Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges. Int J Mol Sci (2015) 0.79
Reprogramming cancer cells to pluripotency: an experimental tool for exploring cancer epigenetics. Epigenetics (2014) 0.79
A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands. Nucleic Acids Res (2016) 0.79
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
Embryonic stem cell lines derived from human blastocysts. Science (1998) 65.53
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
The language of covalent histone modifications. Nature (2000) 44.92
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
The epigenomics of cancer. Cell (2007) 30.91
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 30.49
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature (2008) 26.78
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature (2010) 23.55
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A (2009) 20.66
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature (2010) 18.63
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Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
Epigenetic reprogramming in mammalian development. Science (2001) 13.42
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature (1999) 12.60
Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet (2009) 12.08
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97
Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
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Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04
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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature (2010) 8.84
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Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell (2007) 8.59
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Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature (2007) 8.33
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Dnmt3L and the establishment of maternal genomic imprints. Science (2001) 7.42
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature (2004) 7.42
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol (2001) 7.20
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
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Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell (2007) 6.62
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Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell (2009) 5.51
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev (2005) 5.50
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell (2009) 5.26
Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis (2003) 5.19
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Capturing pluripotency. Cell (2008) 5.08
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell (2009) 4.64
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JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution. Nat Methods (2010) 4.30
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Nuclear cloning and epigenetic reprogramming of the genome. Science (2001) 3.79
Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol Cell Biol (2004) 3.76