Published in Nat Struct Mol Biol on November 21, 2010
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A (2011) 1.90
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest (2013) 1.72
Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun (2013) 1.13
The dual lives of bidirectional promoters. Biochim Biophys Acta (2012) 0.99
BRCA1 as a nicotinamide adenine dinucleotide (NAD)-dependent metabolic switch in ovarian cancer. Cell Cycle (2014) 0.96
Wounds that will not heal: pervasive cellular reprogramming in cancer. Am J Pathol (2013) 0.96
Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci (2014) 0.96
A novel crosstalk between BRCA1 and poly (ADP-ribose) polymerase 1 in breast cancer. Cell Cycle (2014) 0.94
Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer. Mol Carcinog (2011) 0.94
BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2. Neoplasia (2013) 0.89
The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers. Front Biosci (Landmark Ed) (2014) 0.88
AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes. Int J Biochem Cell Biol (2014) 0.85
BRCA1 and estrogen/estrogen receptor in breast cancer: where they interact? Int J Biol Sci (2014) 0.84
C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. Int J Cell Biol (2013) 0.84
β-HPV 5 and 8 E6 disrupt homology dependent double strand break repair by attenuating BRCA1 and BRCA2 expression and foci formation. PLoS Pathog (2015) 0.82
CtBP1 is expressed in melanoma and represses the transcription of p16INK4a and Brca1. J Invest Dermatol (2013) 0.81
Nicotinamide phosphoribosyltransferase can affect metastatic activity and cell adhesive functions by regulating integrins in breast cancer. DNA Repair (Amst) (2014) 0.80
Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget (2016) 0.79
CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4. Cell Death Dis (2015) 0.78
CtBP2 proteome: Role of CtBP in E2F7-mediated repression and cell proliferation. Genes Cancer (2014) 0.78
The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells. Cancer Cell Int (2011) 0.78
Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1. Circulation (2016) 0.77
BRCA1 Alternative splicing landscape in breast tissue samples. BMC Cancer (2015) 0.77
A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer. BMC Med Genomics (2016) 0.76
Wnt/β-Catenin Mediates AICAR Effect to Increase GATA3 Expression and Inhibit Adipogenesis. J Biol Chem (2015) 0.76
Compartmentation of metabolites in regulating epigenome of cancer. Mol Med (2016) 0.75
TOX3 protein expression is correlated with pathological characteristics in breast cancer. Oncol Lett (2016) 0.75
CtBP1 overexpression in keratinocytes perturbs skin homeostasis. J Invest Dermatol (2013) 0.75
SAT1 and glioblastoma multiforme: Disarming the resistance. Mol Cell Oncol (2015) 0.75
CtBP- an emerging oncogene and novel small molecule drug target: advances in the understanding of its oncogenic action and identification of therapeutic inhibitors. Cancer Biol Ther (2017) 0.75
Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP. Nat Commun (2017) 0.75
Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer (2002) 34.99
A high-resolution map of active promoters in the human genome. Nature (2005) 24.35
Dynamic regulation of nucleosome positioning in the human genome. Cell (2008) 15.60
Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet (1998) 15.09
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer (2004) 10.31
Cancer statistics, 1999. CA Cancer J Clin (1999) 9.18
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell (2005) 8.95
Breaking barriers to transcription elongation. Nat Rev Mol Cell Biol (2006) 8.18
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene (2009) 8.01
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell (2009) 6.26
Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev (2004) 6.08
An abundance of bidirectional promoters in the human genome. Genome Res (2004) 5.90
BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene (2006) 3.91
Regulation of corepressor function by nuclear NADH. Science (2002) 3.83
The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J Biol Chem (1998) 3.67
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell (2009) 3.45
BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res (2006) 3.29
Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet (1999) 2.83
Continuous protein synthesis is required to maintain the probability of entry into S phase. Cell (1977) 2.63
Minireview: Obesity and breast cancer: the estrogen connection. Endocrinology (2009) 2.57
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell (2003) 2.42
Transcription factor binding and modified histones in human bidirectional promoters. Genome Res (2007) 2.40
Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev (2004) 2.35
The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc Natl Acad Sci U S A (1998) 2.10
The role of BRCA1 in transcriptional regulation and cell cycle control. Oncogene (2006) 2.09
Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor. Proc Natl Acad Sci U S A (2003) 2.03
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res (2005) 2.02
The transcriptional corepressor CtBP: a foe of multiple tumor suppressors. Cancer Res (2009) 2.02
Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. Proc Natl Acad Sci U S A (2008) 1.93
Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells. Oncogene (1998) 1.74
Eloquent silence: developmental functions of Class I histone deacetylases. Curr Opin Genet Dev (2008) 1.74
Complex regulation of the BRCA1 gene. J Biol Chem (1997) 1.68
Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev (1995) 1.61
Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP. Proc Natl Acad Sci U S A (2000) 1.58
Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling. Trends Endocrinol Metab (2002) 1.47
BRCA1-associated growth arrest is RB-dependent. Proc Natl Acad Sci U S A (1999) 1.47
p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res (2002) 1.36
Regulation of BRCA1 expression and its relationship to sporadic breast cancer. Breast Cancer Res (2002) 1.35
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes. Proc Natl Acad Sci U S A (2009) 1.31
BRCA1 methylation: a significant role in tumour development? Semin Cancer Biol (2002) 1.26
BRCA1 expression is not directly responsive to estrogen. Oncogene (1997) 1.24
Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1. Mol Cell Biol (2009) 1.22
Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiother Oncol (2005) 1.22
BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen. Oncogene (1996) 1.19
Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Oncogene (1998) 1.17
Regulation of BRCA1 expression by the Rb-E2F pathway. J Biol Chem (2000) 1.17
BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer. Breast Cancer Res Treat (2009) 1.16
Distinct transcription start sites generate two forms of BRCA1 mRNA. Hum Mol Genet (1995) 1.08
Transcriptional autoregulation by BRCA1. Cancer Res (2010) 1.05
Regulation of BRCA1 and BRCA2 expression in human breast cancer cells by DNA-damaging agents. Oncogene (1998) 1.04
Control of cellular proliferation by modulation of oxidative phosphorylation in human and rodent fast-growing tumor cells. Toxicol Appl Pharmacol (2006) 1.02
Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding. Oncogene (2001) 0.98
An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription. Neoplasia (2005) 0.97
The complex relationship between BRCA1 and ERalpha in hereditary breast cancer. Clin Cancer Res (2009) 0.95
Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts. Exp Gerontol (2006) 0.93
Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene. Breast Cancer Res (2008) 0.84
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med (2002) 24.07
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
Data Sharing. N Engl J Med (2016) 5.12
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
The origins of age-related proinflammatory state. Blood (2004) 4.15
Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA (2011) 4.09
Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med (2009) 3.71
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell (2008) 3.32
Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci (2006) 2.85
Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science (2005) 2.72
Precision medicine--personalized, problematic, and promising. N Engl J Med (2015) 2.67
Tumor heterogeneity and personalized medicine. N Engl J Med (2012) 2.63
Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum Mol Genet (2011) 2.62
Drug-Induced Megaloblastic Anemia. N Engl J Med (2015) 2.62
Insights into thymic aging and regeneration. Immunol Rev (2005) 2.55
Cyclin T1 overexpression induces malignant transformation and tumor growth. Cell Cycle (2010) 2.38
New therapies for castration-resistant prostate cancer. N Engl J Med (2010) 2.37
Talking with patients about dying. N Engl J Med (2012) 2.34
Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci (2009) 2.32
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32
qPrimerDepot: a primer database for quantitative real time PCR. Nucleic Acids Res (2006) 2.31
Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway. J Biol Chem (2005) 2.30
Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy. Blood (2002) 2.28
Linking beta-catenin to androgen-signaling pathway. J Biol Chem (2002) 2.27
IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med (2007) 2.23
Proinflammatory state, hepcidin, and anemia in older persons. Blood (2010) 2.19
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity (2004) 2.18
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med (2013) 2.18
The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network. Cell Stem Cell (2012) 2.17
A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr (2007) 2.16
Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res (2006) 1.97
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol (2003) 1.75
Proinflammatory state and circulating erythropoietin in persons with and without anemia. Am J Med (2005) 1.72
Multiple loci are associated with white blood cell phenotypes. PLoS Genet (2011) 1.65
Low testosterone levels and the risk of anemia in older men and women. Arch Intern Med (2006) 1.61
Treatment of advanced Hodgkin lymphoma: the more things change, the more they stay the same. J Clin Oncol (2012) 1.61
Serum testosterone is associated with aggressive prostate cancer in older men: results from the Baltimore Longitudinal Study of Aging. BJU Int (2009) 1.59
The frailty syndrome: a critical issue in geriatric oncology. Crit Rev Oncol Hematol (2003) 1.58
A genome-wide association analysis of serum iron concentrations. Blood (2009) 1.55
High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci (2008) 1.52
Late effects from radiation therapy: the hits just keep on coming. J Natl Cancer Inst (2009) 1.47
Serum erythropoietin and aging: a longitudinal analysis. J Am Geriatr Soc (2005) 1.45
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. PLoS Genet (2011) 1.45
Radiation therapy in the treatment of Hodgkin's disease--do you see what I see? J Natl Cancer Inst (2003) 1.42
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res (2008) 1.41
Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. Genome Biol (2007) 1.35
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes. Proc Natl Acad Sci U S A (2009) 1.31
Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma. Clin Cancer Res (2005) 1.31
Changes in weight at the end of life: characterizing weight loss by time to death in a cohort study of older men. Am J Epidemiol (2010) 1.29
Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J Immunol (2003) 1.29
In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma. Int J Oncol (2007) 1.26
Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy. Blood (2012) 1.25
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet (2012) 1.23
Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. Br J Haematol (2007) 1.22
Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension. J Hypertens (2008) 1.19
Pneumococcal vaccination and revaccination of older adults. Clin Microbiol Rev (2003) 1.15
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up. Br J Haematol (2009) 1.15
Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways. Curr Opin Pharmacol (2010) 1.14
Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus. Cell Immunol (2007) 1.14
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab (2013) 1.14
Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun (2013) 1.13
Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism (2007) 1.13
Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B. Blood (2005) 1.13
Gender specificity of altered human immune cytokine profiles in aging. FASEB J (2010) 1.12
Immunity from smallpox vaccine persists for decades: a longitudinal study. Am J Med (2008) 1.11
Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop. Cancer Res (2004) 1.11
Generation of mouse ES cell lines engineered for the forced induction of transcription factors. Sci Rep (2011) 1.11
In support of the BMRB. Nat Struct Mol Biol (2012) 1.09
Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells. Sci Rep (2013) 1.08
Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol Cell Biol (2003) 1.07
ELL facilitates RNA polymerase II pause site entry and release. Nat Commun (2012) 1.07
Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev (2006) 1.06
Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood (2006) 1.06
Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells. Mol Cancer Res (2009) 1.06
Transcriptional autoregulation by BRCA1. Cancer Res (2010) 1.05
Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet (2013) 1.05
Mapping proteoglycan-bound water in cartilage: Improved specificity of matrix assessment using multiexponential transverse relaxation analysis. Magn Reson Med (2010) 1.04
Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives. Am J Physiol Regul Integr Comp Physiol (2008) 1.04
Role of mitofusin 2 (Mfn2) in controlling cellular proliferation. FASEB J (2013) 1.03
Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum Mol Genet (2010) 1.03
Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J (2008) 1.01
Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing. Blood (2011) 1.01
Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment. Proc Natl Acad Sci U S A (2004) 1.00
Increased bone marrow allograft rejection by depletion of NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens. Blood (2002) 1.00
Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial. Am Heart J (2010) 1.00
Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary. BMC Biol (2008) 1.00
Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Mol Carcinog (2003) 1.00
The dual lives of bidirectional promoters. Biochim Biophys Acta (2012) 0.99
Comparison of the effect of mutant and wild-type p53 on global gene expression. Cancer Res (2004) 0.99
Definition and management of anemia in patients infected with hepatitis C virus. Liver Int (2006) 0.98
Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax. Blood (2002) 0.97
Wounds that will not heal: pervasive cellular reprogramming in cancer. Am J Pathol (2013) 0.96
Traf1 induction and protection from tumor necrosis factor by nuclear factor-kappaB p65 is independent of serine 536 phosphorylation. Cancer Res (2007) 0.95