Published in Cancer Res on March 17, 2009
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The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res (2005) 5.93
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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33
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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 6.84
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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell (2007) 6.16
Hypoxia-inducible factors, stem cells, and cancer. Cell (2007) 5.96
The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res (2005) 5.93
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24
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HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell (2008) 4.84
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Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev (2007) 4.13
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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab (2005) 3.94
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Stromal biology and therapy in pancreatic cancer. Gut (2010) 3.80
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest (2007) 3.61
Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51
Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol (2003) 3.24
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature (2006) 3.01
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Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest (2010) 2.48
HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest (2009) 2.47
O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45
Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest (2003) 2.37
An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature (2002) 2.33
Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol (2006) 2.27
Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev (2010) 2.26
Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth. Cancer Res (2005) 2.07
Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr Top Dev Biol (2006) 1.87
HIF-2alpha deletion promotes Kras-driven lung tumor development. Proc Natl Acad Sci U S A (2010) 1.86
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell (2003) 1.85
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res (2010) 1.82
Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood (2009) 1.81
K-Ras-driven pancreatic cancer mouse model for anticancer inhibitor analyses. Methods Enzymol (2008) 1.78
Regulation of transcription and translation by hypoxia. Cancer Biol Ther (2004) 1.74
ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell (2012) 1.71
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood (2009) 1.70
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem (2002) 1.70
Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol (2005) 1.67
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J Clin Invest (2011) 1.67
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene (2008) 1.61
HIFs, hypoxia, and vascular development. Curr Top Dev Biol (2004) 1.60
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A (2009) 1.59
Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes. Curr Opin Genet Dev (2009) 1.57
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res (2010) 1.57
von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J Clin Invest (2007) 1.56
An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth. Cancer Biol Ther (2003) 1.52
Hypoxia-induced angiogenesis: good and evil. Genes Cancer (2011) 1.52
Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism. J Biol Chem (2008) 1.51
Hypoxia-inducible factors as essential regulators of inflammation. Curr Top Microbiol Immunol (2010) 1.51
Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer. Cancer Cell (2010) 1.51
Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J Biol Chem (2008) 1.51
Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J Clin Invest (2012) 1.50
Reactive oxygen species and cellular oxygen sensing. Free Radic Biol Med (2007) 1.49
Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway. Blood (2002) 1.48
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48
Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol (2005) 1.47
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest (2010) 1.46
Quantification of murine pancreatic tumors by high-resolution ultrasound. Methods Mol Biol (2013) 1.45
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis. Cancer Discov (2013) 1.44
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development (2005) 1.44
Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol (2003) 1.44
Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development (2004) 1.41
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev (2013) 1.40
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest (2009) 1.40
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol Ther (2005) 1.38
The importance of PU.1 concentration in hematopoietic lineage commitment and maturation. Blood Cells Mol Dis (2003) 1.34
HIF1α and HIF2α independently activate SRC to promote melanoma metastases. J Clin Invest (2013) 1.32
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat Med (2011) 1.31
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia (2010) 1.31
Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer Res (2004) 1.30
Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem (2006) 1.29
Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. PLoS Pathog (2013) 1.28
Hypoxia-inducible factors in stem cells and cancer. J Cell Mol Med (2009) 1.27
Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell (2005) 1.26
Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development. Cancer Res (2005) 1.26
C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc Natl Acad Sci U S A (2002) 1.26
Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease. J Am Vet Med Assoc (2003) 1.24
HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev Cell (2006) 1.23
The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction. J Biol Chem (2006) 1.22
Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell Melanoma Res (2013) 1.20
In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res (2004) 1.20
Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia. Biomed Opt Express (2010) 1.18
pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol (2006) 1.18
BNip3 regulates mitochondrial function and lipid metabolism in the liver. Mol Cell Biol (2012) 1.17