Published in J Chem Inf Comput Sci on September 27, 2004
Coexistence of passive and carrier-mediated processes in drug transport. Nat Rev Drug Discov (2010) 1.73
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorg Med Chem (2009) 1.04
CheS-Mapper - Chemical Space Mapping and Visualization in 3D. J Cheminform (2012) 0.92
Drug-likeness analysis of traditional Chinese medicines: 1. property distributions of drug-like compounds, non-drug-like compounds and natural compounds from traditional Chinese medicines. J Cheminform (2012) 0.87
Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly. Trends Pharmacol Sci (2015) 0.86
Recent progress in the computational prediction of aqueous solubility and absorption. AAPS J (2006) 0.84
The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities. PeerJ (2015) 0.84
MolClass: a web portal to interrogate diverse small molecule screen datasets with different computational models. Bioinformatics (2012) 0.83
A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes. BMC Syst Biol (2011) 0.82
Artificial neural network models for prediction of intestinal permeability of oligopeptides. BMC Bioinformatics (2007) 0.81
Systems biological approach of molecular descriptors connectivity: optimal descriptors for oral bioavailability prediction. PLoS One (2012) 0.80
Prediction of the permeability of neutral drugs inferred from their solvation properties. Bioinformatics (2015) 0.75
Prediction of In-silico ADME Properties of 1,2-O-Isopropylidene Aldohexose Derivatives. Iran J Pharm Res (2014) 0.75
Effect of drug lipophilicity and ionization on permeability across the buccal mucosa: a technical note. AAPS PharmSciTech (2008) 0.75
Eucalyptol, sabinene and cinnamaldehyde: potent inhibitors of salmonella target protein L-asparaginase. 3 Biotech (2017) 0.75
The sequence of the human genome. Science (2001) 101.55
Evolution and phylogeny of Wolbachia: reproductive parasites of arthropods. Proc Biol Sci (1995) 5.70
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol (2001) 5.36
American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) (2012) 4.82
Microarrays: handling the deluge of data and extracting reliable information. Trends Biotechnol (2001) 4.38
Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A (1994) 4.07
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68
Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60
Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee--the MOVE consensus. Rheumatology (Oxford) (2004) 3.38
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity (1998) 3.36
Analysis of effects of salts and uncharged solutes on protein and nucleic acid equilibria and processes: a practical guide to recognizing and interpreting polyelectrolyte effects, Hofmeister effects, and osmotic effects of salts. Adv Protein Chem (1998) 3.30
Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity (2001) 3.29
Mutations in the gene encoding gap junction protein beta-3 associated with autosomal dominant hearing impairment. Nat Genet (1998) 3.24
Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00
Rickettsial relative associated with male killing in the ladybird beetle (Adalia bipunctata). J Bacteriol (1994) 2.97
Isolation of an efficient actin promoter for use in rice transformation. Plant Cell (1990) 2.94
Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. Proc Natl Acad Sci U S A (1999) 2.88
Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Ann Rheum Dis (2005) 2.88
Visualizing the kinetics of tumor-cell clearance in living animals. Proc Natl Acad Sci U S A (1999) 2.76
Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science (1994) 2.74
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A (2001) 2.73
Site-directed alkylation and the alternating access model for LacY. Proc Natl Acad Sci U S A (2006) 2.65
The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell (2001) 2.64
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol (1995) 2.62
Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br J Cancer (2009) 2.58
Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem (1997) 2.52
LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity (2000) 2.48
The PIE-1 protein and germline specification in C. elegans embryos. Nature (1996) 2.46
The optimal measure of allelic association. Proc Natl Acad Sci U S A (2001) 2.41
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. Immunol Lett (2000) 2.33
Genome comparisons reveal a dominant mechanism of chromosome number reduction in grasses and accelerated genome evolution in Triticeae. Proc Natl Acad Sci U S A (2009) 2.32
Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration. Cancer Res (2001) 2.11
A fern that hyperaccumulates arsenic. Nature (2001) 2.08
The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept (2001) 2.07
A novel augmentation strategy for treating resistant major depression. Am J Psychiatry (2001) 2.05
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol (1998) 2.01
A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer (2004) 2.01
CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am J Pathol (1997) 2.00
Air quality improvement estimation and assessment using contingent valuation method, a case study in Beijing. Environ Monit Assess (2006) 1.96
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene (2011) 1.94
Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. J Neurophysiol (2007) 1.93
The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. Cell (1994) 1.90
Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling. Cancer Res (1999) 1.88
Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.87
Mechanism of topology simplification by type II DNA topoisomerases. Proc Natl Acad Sci U S A (2001) 1.87
A genomic island, termed high-pathogenicity island, is present in certain non-O157 Shiga toxin-producing Escherichia coli clonal lineages. Infect Immun (1999) 1.86
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol (2000) 1.85
MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin Exp Pharmacol Physiol (2008) 1.84
The Hound of the Baskervilles effect: natural experiment on the influence of psychological stress on timing of death. BMJ (2001) 1.83
Tissue specific perfusion imaging using arterial spin labeling. NMR Biomed (1994) 1.82
Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF. Pain (1991) 1.79
Obesity and overweight in Canada: an updated cost-of-illness study. Obes Rev (2009) 1.78
A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J Biol Chem (2001) 1.77
Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS). Neurology (2007) 1.77
Intracellular labeling of T-cells with superparamagnetic contrast agents. Magn Reson Med (1993) 1.76
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage (2012) 1.74
Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer. Cancer Res (1999) 1.74
Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J Exp Med (1998) 1.73
Systematic review of the concurrent and predictive validity of MRI biomarkers in OA. Osteoarthritis Cartilage (2011) 1.73
A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer. Cancer Res (2001) 1.72
Sources of nonlinearity in cDNA microarray expression measurements. Genome Biol (2001) 1.70
Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells. Proc Natl Acad Sci U S A (1994) 1.67
Social consensus through the influence of committed minorities. Phys Rev E Stat Nonlin Soft Matter Phys (2011) 1.67
Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines. Pharmacogenomics J (2010) 1.66
Is the dementia rate increasing in Beijing? Prevalence and incidence of dementia 10 years later in an urban elderly population. Acta Psychiatr Scand (2007) 1.65
A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals. J Med Chem (2000) 1.62
Identifying differentially expressed genes in cDNA microarray experiments. J Comput Biol (2001) 1.61
Meat consumption and risk of lung cancer: evidence from observational studies. Ann Oncol (2012) 1.57
PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res (2000) 1.57
Is gout associated with reduced quality of life? A case-control study. Rheumatology (Oxford) (2007) 1.55
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia (2012) 1.55
Molecular characteristics of non-small cell lung cancer. Proc Natl Acad Sci U S A (2001) 1.53
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood. Am J Hum Genet (1993) 1.52
An interesting case of rifampicin-dependent/-enhanced multidrug-resistant tuberculosis. Int J Tuberc Lung Dis (2010) 1.52
Experience in the surgical management of 82 symptomatic herniated thoracic discs and review of the literature. J Neurosurg (1998) 1.50
Immediate post-abortal insertion of the frameless GyneFix IUD: initial experience in China. Br J Fam Plann (2000) 1.50
Increased mechanical strain imposed on murine lungs during ventilation in vivo depresses airway responsiveness and activation of protein kinase Akt. J Appl Physiol (1985) (2013) 1.50
Fluorine-19 nuclear magnetic resonance imaging and spectroscopy of sevoflurane uptake, distribution, and elimination in rat brain. Anesthesiology (1995) 1.48
Multi-slice MRI of rat brain perfusion during amphetamine stimulation using arterial spin labeling. Magn Reson Med (1995) 1.48
Variable protection of beta 3-integrin--deficient mice from thrombosis initiated by different mechanisms. Blood (2001) 1.47
A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. Proc Natl Acad Sci U S A (1999) 1.47
Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: immunohistochemical and double-fluorescence immunostaining evidence. Histopathology (2008) 1.46
Impaired modulation of sympathetic vasoconstriction in contracting skeletal muscle of rats with chronic myocardial infarctions: role of oxidative stress. Circ Res (2001) 1.46
The nonlinear Fano effect. Nature (2008) 1.46
Responsiveness and reliability of MRI in knee osteoarthritis: a meta-analysis of published evidence. Osteoarthritis Cartilage (2011) 1.46
Sequence verification as quality-control step for production of cDNA microarrays. Biotechniques (2001) 1.45
In vivo dynamic MRI tracking of rat T-cells labeled with superparamagnetic iron-oxide particles. Magn Reson Med (1995) 1.44
Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat Biotechnol (1998) 1.44
Hierarchically biomimetic bone scaffold materials: nano-HA/collagen/PLA composite. J Biomed Mater Res B Appl Biomater (2004) 1.42
Rapidly switchable matrix-assisted laser desorption/ionization and electrospray quadrupole-time-of-flight mass spectrometry for protein identification. J Am Soc Mass Spectrom (2000) 1.42
Functional protease-activated receptors in the dorsal motor nucleus of the vagus. Neurogastroenterol Motil (2009) 1.42
Downregulation of the transforming growth factor-β/connective tissue growth factor 2 signalling pathway in venous malformations: its target potential for sclerotherapy. Br J Dermatol (2014) 1.41
Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. AJNR Am J Neuroradiol (2007) 1.40
Definition of osteoarthritis on MRI: results of a Delphi exercise. Osteoarthritis Cartilage (2011) 1.40
Impact of exercise type and dose on pain and disability in knee osteoarthritis: a systematic review and meta-regression analysis of randomized controlled trials. Arthritis Rheumatol (2014) 1.40
Feeding-based RNA interference of a trehalose phosphate synthase gene in the brown planthopper, Nilaparvata lugens. Insect Mol Biol (2010) 1.40
Influence of family history on frequency of glucagon receptor Gly40Ser mutation in hypertensive subjects. Hypertension (1997) 1.39
Pressure-induced superconductivity in topological parent compound Bi2Te3. Proc Natl Acad Sci U S A (2010) 1.39