Published in J Biol Chem on January 09, 2001
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73
The role of the purinergic P2X7 receptor in inflammation. J Inflamm (Lond) (2007) 1.50
Molecular properties of P2X receptors. Pflugers Arch (2006) 1.47
The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes. Glia (2005) 1.42
Molecular and functional properties of P2X receptors--recent progress and persisting challenges. Purinergic Signal (2012) 1.31
A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization. J Biol Chem (2006) 1.30
Extracellular NAD and ATP: Partners in immune cell modulation. Purinergic Signal (2007) 1.26
BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds. Exp Eye Res (2008) 1.23
Genetics of the P2X7 receptor and human disease. Purinergic Signal (2009) 1.19
The role of the P2X₇ receptor in infectious diseases. PLoS Pathog (2011) 1.15
Expression, signaling, and function of P2X7 receptors in bone. Purinergic Signal (2009) 1.13
P2X(7) receptor: Death or life? Purinergic Signal (2005) 1.13
P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican mestizo patients with pulmonary tuberculosis. Clin Exp Immunol (2007) 1.11
Control of P2X(2) channel permeability by the cytosolic domain. J Gen Physiol (2002) 1.08
Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women. Eur J Hum Genet (2012) 1.02
Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions. Immunol Res (2011) 0.99
A comparative study of interleukin-1beta production and p2x7 expression after ATP stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls. Inflammation (2007) 0.98
Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures. Eur J Hum Genet (2012) 0.98
Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms. Front Pharmacol (2013) 0.97
Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms. J Biol Chem (2011) 0.95
Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue. Br J Pharmacol (2007) 0.95
Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts. Br J Pharmacol (2012) 0.94
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. Nat Commun (2016) 0.93
The P2X(7) receptor and intracellular pathogens: a continuing struggle. Purinergic Signal (2009) 0.93
The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system. J Biol Chem (2012) 0.91
Cell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking. Purinergic Signal (2009) 0.91
Heteromeric assembly of P2X subunits. Front Cell Neurosci (2013) 0.90
A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events. PLoS One (2012) 0.90
Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients. Osteoporos Int (2012) 0.90
Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function. Purinergic Signal (2009) 0.90
C terminus of the P2X7 receptor: treasure hunting. Purinergic Signal (2011) 0.89
Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule. Br J Pharmacol (2007) 0.87
Association between P2X7 Receptor Polymorphisms and Bone Status in Mice. J Osteoporos (2012) 0.86
Cloning and pharmacological characterization of the dog P2X7 receptor. Br J Pharmacol (2009) 0.85
Functional polymorphisms in the P2X7 receptor gene are associated with osteoporosis. Osteoporos Int (2012) 0.85
Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects. Br J Clin Pharmacol (2013) 0.85
ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions. Front Immunol (2015) 0.84
Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines. BMC Immunol (2006) 0.84
The P2X(7) loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels. BMC Immunol (2012) 0.83
The second transmembrane domain of P2X7 contributes to dilated pore formation. PLoS One (2013) 0.83
Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia. PLoS One (2013) 0.81
Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach. Br J Clin Pharmacol (2012) 0.81
P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med (2012) 0.81
Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore. J Neuroinflammation (2016) 0.80
The hyposensitive N187D P2X7 mutant promotes malignant progression in nude mice. J Biol Chem (2010) 0.80
Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers. Int J Mol Sci (2014) 0.80
Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain. Mol Pain (2014) 0.79
Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7. Purinergic Signal (2009) 0.79
P2X(7) receptor at the heart of disease. Hippokratia (2010) 0.79
Correlation between P2X7 receptor gene polymorphisms and gout. Rheumatol Int (2015) 0.78
The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types. Purinergic Signal (2009) 0.77
Expression and function of P2 receptors in hematopoietic stem and progenitor cells. Stem Cell Investig (2015) 0.77
P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance. J Immunol (2015) 0.77
Possible protective role of the 489C>T P2X7R polymorphism in Alzheimer's disease. Exp Gerontol (2014) 0.76
Genetic Association for P2X7R rs3751142 and CARD8 rs2043211 Polymorphisms for Susceptibility of Gout in Korean Men: Multi-Center Study. J Korean Med Sci (2016) 0.76
Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7. Mucosal Immunol (2016) 0.75
Invited Lectures : Overviews Purinergic signalling: past, present and future. Purinergic Signal (2006) 0.75
Functional variant of the P2X7 receptor gene is associated with human papillomavirus-16 positive cervical squamous cell carcinoma. Oncotarget (2016) 0.75
Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function. PLoS One (2016) 0.75
P2X71513 A>C Polymorphism Confers Increased Risk of Extrapulmonary Tuberculosis: A Meta-analysis of Case-Control Studies. Curr Genomics (2015) 0.75
P2X7R Gene Polymorphisms are Associated with Increased Risk of Pulmonary Tuberculosis in the Tibetan Chinese Population. Am J Trop Med Hyg (2016) 0.75
Investigation into the association between P2RX7 gene polymorphisms and susceptibility to primary gout and hyperuricemia in a Chinese Han male population. Rheumatol Int (2017) 0.75
The sequence of the human genome. Science (2001) 101.55
Evolution and phylogeny of Wolbachia: reproductive parasites of arthropods. Proc Biol Sci (1995) 5.70
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol (2001) 5.36
American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) (2012) 4.82
Microarrays: handling the deluge of data and extracting reliable information. Trends Biotechnol (2001) 4.38
Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A (1994) 4.07
Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet (2001) 3.83
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68
Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60
Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee--the MOVE consensus. Rheumatology (Oxford) (2004) 3.38
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity (1998) 3.36
Analysis of effects of salts and uncharged solutes on protein and nucleic acid equilibria and processes: a practical guide to recognizing and interpreting polyelectrolyte effects, Hofmeister effects, and osmotic effects of salts. Adv Protein Chem (1998) 3.30
Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity (2001) 3.29
Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00
Rickettsial relative associated with male killing in the ladybird beetle (Adalia bipunctata). J Bacteriol (1994) 2.97
Isolation of an efficient actin promoter for use in rice transformation. Plant Cell (1990) 2.94
Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. Proc Natl Acad Sci U S A (1999) 2.88
Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Ann Rheum Dis (2005) 2.88
Visualizing the kinetics of tumor-cell clearance in living animals. Proc Natl Acad Sci U S A (1999) 2.76
Site-directed alkylation and the alternating access model for LacY. Proc Natl Acad Sci U S A (2006) 2.65
The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell (2001) 2.64
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol (1995) 2.62
Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br J Cancer (2009) 2.58
Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem (1997) 2.52
LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity (2000) 2.48
The PIE-1 protein and germline specification in C. elegans embryos. Nature (1996) 2.46
The optimal measure of allelic association. Proc Natl Acad Sci U S A (2001) 2.41
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. Immunol Lett (2000) 2.33
Genome comparisons reveal a dominant mechanism of chromosome number reduction in grasses and accelerated genome evolution in Triticeae. Proc Natl Acad Sci U S A (2009) 2.32
Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration. Cancer Res (2001) 2.11
A fern that hyperaccumulates arsenic. Nature (2001) 2.08
The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept (2001) 2.07
A novel augmentation strategy for treating resistant major depression. Am J Psychiatry (2001) 2.05
Modification of red cell membrane structure by cholesterol-rich lipid dispersions. A model for the primary spur cell defect. J Clin Invest (1975) 2.04
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol (1998) 2.01
A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer (2004) 2.01
CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am J Pathol (1997) 2.00
Air quality improvement estimation and assessment using contingent valuation method, a case study in Beijing. Environ Monit Assess (2006) 1.96
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene (2011) 1.94
Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. J Neurophysiol (2007) 1.93
A furosemide-sensitive cotransport of sodium plus potassium in the human red cell. J Clin Invest (1974) 1.91
The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. Cell (1994) 1.90
Experimental arthritis in mice with Mycoplasma pulmonis. J Bacteriol (1969) 1.90
Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling. Cancer Res (1999) 1.88
Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.87
Mechanism of topology simplification by type II DNA topoisomerases. Proc Natl Acad Sci U S A (2001) 1.87
A genomic island, termed high-pathogenicity island, is present in certain non-O157 Shiga toxin-producing Escherichia coli clonal lineages. Infect Immun (1999) 1.86
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol (2000) 1.85
MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin Exp Pharmacol Physiol (2008) 1.84
The Hound of the Baskervilles effect: natural experiment on the influence of psychological stress on timing of death. BMJ (2001) 1.83
Tissue specific perfusion imaging using arterial spin labeling. NMR Biomed (1994) 1.82
Obesity and overweight in Canada: an updated cost-of-illness study. Obes Rev (2009) 1.78
Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS). Neurology (2007) 1.77
Intracellular labeling of T-cells with superparamagnetic contrast agents. Magn Reson Med (1993) 1.76
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage (2012) 1.74
Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer. Cancer Res (1999) 1.74
Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J Exp Med (1998) 1.73
Systematic review of the concurrent and predictive validity of MRI biomarkers in OA. Osteoarthritis Cartilage (2011) 1.73
A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer. Cancer Res (2001) 1.72
Sources of nonlinearity in cDNA microarray expression measurements. Genome Biol (2001) 1.70
Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells. Proc Natl Acad Sci U S A (1994) 1.67
Social consensus through the influence of committed minorities. Phys Rev E Stat Nonlin Soft Matter Phys (2011) 1.67
Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men. J Urol (1999) 1.67
X-linked pyridoxine-responsive sideroblastic anemia due to a Thr388-to-Ser substitution in erythroid 5-aminolevulinate synthase. N Engl J Med (1994) 1.66
Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines. Pharmacogenomics J (2010) 1.66
Is the dementia rate increasing in Beijing? Prevalence and incidence of dementia 10 years later in an urban elderly population. Acta Psychiatr Scand (2007) 1.65
A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals. J Med Chem (2000) 1.62
Identifying differentially expressed genes in cDNA microarray experiments. J Comput Biol (2001) 1.61
Meat consumption and risk of lung cancer: evidence from observational studies. Ann Oncol (2012) 1.57
PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res (2000) 1.57
Is gout associated with reduced quality of life? A case-control study. Rheumatology (Oxford) (2007) 1.55
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia (2012) 1.55
Differentiating keratoacanthoma from squamous cell carcinoma by the use of apoptotic and cell adhesion markers. Histopathology (2005) 1.54
Molecular characteristics of non-small cell lung cancer. Proc Natl Acad Sci U S A (2001) 1.53
An interesting case of rifampicin-dependent/-enhanced multidrug-resistant tuberculosis. Int J Tuberc Lung Dis (2010) 1.52
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood. Am J Hum Genet (1993) 1.52
MAGNEsium Trial In Children (MAGNETIC): a randomised, placebo-controlled trial and economic evaluation of nebulised magnesium sulphate in acute severe asthma in children. Health Technol Assess (2013) 1.52
Experience in the surgical management of 82 symptomatic herniated thoracic discs and review of the literature. J Neurosurg (1998) 1.50
Increased mechanical strain imposed on murine lungs during ventilation in vivo depresses airway responsiveness and activation of protein kinase Akt. J Appl Physiol (1985) (2013) 1.50
Immediate post-abortal insertion of the frameless GyneFix IUD: initial experience in China. Br J Fam Plann (2000) 1.50
Mycoplasma hyorhinis swine arthritis. I. Clinical and microbiologic features. Arthritis Rheum (1971) 1.50
Multi-slice MRI of rat brain perfusion during amphetamine stimulation using arterial spin labeling. Magn Reson Med (1995) 1.48
Fluorine-19 nuclear magnetic resonance imaging and spectroscopy of sevoflurane uptake, distribution, and elimination in rat brain. Anesthesiology (1995) 1.48
Variable protection of beta 3-integrin--deficient mice from thrombosis initiated by different mechanisms. Blood (2001) 1.47
A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. Proc Natl Acad Sci U S A (1999) 1.47
Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: immunohistochemical and double-fluorescence immunostaining evidence. Histopathology (2008) 1.46
Impaired modulation of sympathetic vasoconstriction in contracting skeletal muscle of rats with chronic myocardial infarctions: role of oxidative stress. Circ Res (2001) 1.46
The nonlinear Fano effect. Nature (2008) 1.46
Responsiveness and reliability of MRI in knee osteoarthritis: a meta-analysis of published evidence. Osteoarthritis Cartilage (2011) 1.46
Systematic review of economic aspects of alternative modes of delivery. BJOG (2001) 1.45
Sequence verification as quality-control step for production of cDNA microarrays. Biotechniques (2001) 1.45
Mycoplasma hyorhinis swine arthritis. II. Morphologic features. Arthritis Rheum (1971) 1.44
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br J Pharmacol (1997) 1.44
In vivo dynamic MRI tracking of rat T-cells labeled with superparamagnetic iron-oxide particles. Magn Reson Med (1995) 1.44
Hierarchically biomimetic bone scaffold materials: nano-HA/collagen/PLA composite. J Biomed Mater Res B Appl Biomater (2004) 1.42
Rapidly switchable matrix-assisted laser desorption/ionization and electrospray quadrupole-time-of-flight mass spectrometry for protein identification. J Am Soc Mass Spectrom (2000) 1.42
Functional protease-activated receptors in the dorsal motor nucleus of the vagus. Neurogastroenterol Motil (2009) 1.42
Potassium transport and nucleoside metabolism in human red cells. J Physiol (1967) 1.41