Published in Proc Natl Acad Sci U S A on April 17, 2001
A fine-scale linkage-disequilibrium measure based on length of haplotype sharing. Am J Hum Genet (2006) 6.02
The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis. Proc Natl Acad Sci U S A (2002) 2.80
Biases and reconciliation in estimates of linkage disequilibrium in the human genome. Am J Hum Genet (2006) 2.26
Extent of genome-wide linkage disequilibrium in Australian Holstein-Friesian cattle based on a high-density SNP panel. BMC Genomics (2008) 2.16
Patterns of linkage disequilibrium in the MHC region on human chromosome 6p. Hum Genet (2004) 1.73
Bayesian association-based fine mapping in small chromosomal segments. Genetics (2004) 1.72
A map of the human genome in linkage disequilibrium units. Proc Natl Acad Sci U S A (2005) 1.54
Mathematical properties of the r2 measure of linkage disequilibrium. Theor Popul Biol (2008) 1.51
Linkage disequilibrium in the domesticated pig. Genetics (2004) 1.50
The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern. Genome Res (2005) 1.40
Entropy-based SNP selection for genetic association studies. Hum Genet (2003) 1.36
Multilocus LD measure and tagging SNP selection with generalized mutual information. Genet Epidemiol (2005) 1.33
Genome scanning by composite likelihood. Am J Hum Genet (2006) 1.28
Optimal haplotype block-free selection of tagging SNPs for genome-wide association studies. Genome Res (2004) 1.28
A first-generation metric linkage disequilibrium map of bovine chromosome 6. Genetics (2006) 1.27
Linkage disequilibrium in human populations. Proc Natl Acad Sci U S A (2003) 1.25
Kernel-based association test. Genetics (2008) 1.17
Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps. Proc Natl Acad Sci U S A (2004) 1.16
Properties of linkage disequilibrium (LD) maps. Proc Natl Acad Sci U S A (2002) 1.14
Positional cloning by linkage disequilibrium. Am J Hum Genet (2004) 1.13
Does haplotype diversity predict power for association mapping of disease susceptibility? Hum Genet (2004) 1.07
The impact of interleukin-6 promoter -597/-572/-174genotype on interleukin-6 production after lipopolysaccharide stimulation. Clin Exp Immunol (2007) 0.92
Linkage disequilibrium maps and association mapping. J Clin Invest (2005) 0.92
The utility of low-density genotyping for imputation in the Thoroughbred horse. Genet Sel Evol (2014) 0.90
Efficacy assessment of SNP sets for genome-wide disease association studies. Nucleic Acids Res (2007) 0.90
Dissecting the genetics of complex inheritance: linkage disequilibrium mapping provides insight into Crohn disease. Am J Hum Genet (2011) 0.90
Pronounced inter- and intrachromosomal variation in linkage disequilibrium across the zebra finch genome. Genome Res (2010) 0.88
Mapping a gene for rheumatoid arthritis on chromosome 18q21. BMC Proc (2007) 0.86
Haplotype block partitioning as a tool for dimensionality reduction in SNP association studies. BMC Genomics (2008) 0.85
Cosmopolitan linkage disequilibrium maps. Hum Genomics (2005) 0.81
Comparison of measures for haplotype similarity. BMC Proc (2007) 0.80
An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population. Eur J Hum Genet (2009) 0.80
On measures of association among genetic variables. Anim Genet (2012) 0.80
Whole genome sequences are required to fully resolve the linkage disequilibrium structure of human populations. BMC Genomics (2015) 0.79
Enhancing the power to detect low-frequency variants in genome-wide screens. Genetics (2014) 0.77
Bayesian estimates of linkage disequilibrium. BMC Genet (2007) 0.77
A Scale-Corrected Comparison of Linkage Disequilibrium Levels between Genic and Non-Genic Regions. PLoS One (2015) 0.75
Commercial chicken breeds exhibit highly divergent patterns of linkage disequilibrium. Heredity (Edinb) (2016) 0.75
Genetic epidemiology, genetic maps and positional cloning. Philos Trans R Soc Lond B Biol Sci (2003) 0.75
The future of genetic studies of complex human diseases. Science (1996) 64.76
The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. Genetics (1964) 35.22
Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet (1999) 25.93
The effect of linkage on limits to artificial selection. Genet Res (1966) 16.21
Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland. Nat Genet (1992) 15.62
Linkage disequilibrium and homozygosity of chromosome segments in finite populations. Theor Popul Biol (1971) 13.68
Linkage disequilibrium in finite populations. Theor Appl Genet (1968) 12.55
A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics (1995) 11.58
Gametic disequilibrium measures: proceed with caution. Genetics (1987) 10.30
Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nat Genet (2000) 5.65
The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell (1994) 5.21
Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping. Am J Hum Genet (1999) 4.79
The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes. Nat Genet (2000) 3.92
Genetic epidemiology of single-nucleotide polymorphisms. Proc Natl Acad Sci U S A (1999) 2.81
A scan for linkage disequilibrium across the human genome. Genetics (1999) 2.79
Tests and estimates of allelic association in complex inheritance. Proc Natl Acad Sci U S A (1998) 2.78
Bayesian fine-scale mapping of disease loci, by hidden Markov models. Am J Hum Genet (2000) 2.72
Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region. Am J Hum Genet (1994) 2.65
Mapping a disease locus by allelic association. Proc Natl Acad Sci U S A (1998) 2.51
Alternative bioassays of kinship between loci. Am J Hum Genet (1988) 1.66
Genetic structure of Switzerland. Am J Hum Genet (1973) 1.42
Fieller's theorem and linkage disequilibrium mapping. Genet Epidemiol (1999) 1.41
Allelic association under map error and recombinational heterogeneity: a tale of two sites. Proc Natl Acad Sci U S A (1998) 1.13
Allelic association in the FRAX region. Ann Hum Genet (2000) 0.83
The sequence of the human genome. Science (2001) 101.55
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
A general approach to single-nucleotide polymorphism discovery. Nat Genet (1999) 13.39
Evolution and phylogeny of Wolbachia: reproductive parasites of arthropods. Proc Biol Sci (1995) 5.70
Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nat Genet (2000) 5.65
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol (2001) 5.36
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl) (1997) 5.03
American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) (2012) 4.82
Fluorescence polarization in homogeneous nucleic acid analysis. Genome Res (1999) 4.59
Microarrays: handling the deluge of data and extracting reliable information. Trends Biotechnol (2001) 4.38
Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A (1994) 4.07
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68
Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60
A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules. Nature (1991) 3.59
Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee--the MOVE consensus. Rheumatology (Oxford) (2004) 3.38
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity (1998) 3.36
Reproductive cessation in female mammals. Nature (1998) 3.31
Analysis of effects of salts and uncharged solutes on protein and nucleic acid equilibria and processes: a practical guide to recognizing and interpreting polyelectrolyte effects, Hofmeister effects, and osmotic effects of salts. Adv Protein Chem (1998) 3.30
Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity (2001) 3.29
Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. Eur J Clin Microbiol Infect Dis (2009) 3.11
Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00
Delta-aminolevulinic acid synthetase. II. Induction in rat liver. J Biol Chem (1966) 2.98
Rickettsial relative associated with male killing in the ladybird beetle (Adalia bipunctata). J Bacteriol (1994) 2.97
Isolation of an efficient actin promoter for use in rice transformation. Plant Cell (1990) 2.94
Role of ER export signals in controlling surface potassium channel numbers. Science (2001) 2.93
Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. Proc Natl Acad Sci U S A (1999) 2.88
Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Ann Rheum Dis (2005) 2.88
The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis. Proc Natl Acad Sci U S A (2002) 2.80
Tests and estimates of allelic association in complex inheritance. Proc Natl Acad Sci U S A (1998) 2.78
Visualizing the kinetics of tumor-cell clearance in living animals. Proc Natl Acad Sci U S A (1999) 2.76
The problem of chronic refractory angina; report from the ESC Joint Study Group on the Treatment of Refractory Angina. Eur Heart J (2002) 2.68
Site-directed alkylation and the alternating access model for LacY. Proc Natl Acad Sci U S A (2006) 2.65
The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell (2001) 2.64
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol (1995) 2.62
Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br J Cancer (2009) 2.58
Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem (1997) 2.52
LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity (2000) 2.48
The PIE-1 protein and germline specification in C. elegans embryos. Nature (1996) 2.46
Delta-aminolevulinic acid synthetase. I. Studies in liver homogenates. J Biol Chem (1966) 2.45
Reading bits of genetic information: methods for single-nucleotide polymorphism analysis. Genome Res (1998) 2.38
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. Immunol Lett (2000) 2.33
Genome comparisons reveal a dominant mechanism of chromosome number reduction in grasses and accelerated genome evolution in Triticeae. Proc Natl Acad Sci U S A (2009) 2.32
Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome. Proc Natl Acad Sci U S A (1990) 2.29
Recommendations for conducting the in vivo alkaline Comet assay. 4th International Comet Assay Workshop. Mutagenesis (2003) 2.29
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP. J Gen Physiol (1992) 2.25
Overlapping genomic sequences: a treasure trove of single-nucleotide polymorphisms. Genome Res (1998) 2.24
Single-nucleotide polymorphisms in the public domain: how useful are they? Nat Genet (2001) 2.24
Hardy-Weinberg quality control. Ann Hum Genet (1999) 2.22
Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration. Cancer Res (2001) 2.11
A fern that hyperaccumulates arsenic. Nature (2001) 2.08
The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept (2001) 2.07
A novel augmentation strategy for treating resistant major depression. Am J Psychiatry (2001) 2.05
Multicentre survey of radiologically inserted gastrostomy feeding tube (RIG) in the UK. Clin Radiol (2012) 2.04
AmpliTaq DNA polymerase, FS dye-terminator sequencing: analysis of peak height patterns. Biotechniques (1996) 2.02
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol (1998) 2.01
A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer (2004) 2.01
CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am J Pathol (1997) 2.00
The single cell gel electrophoresis assay (comet assay): a European review. Mutat Res (1993) 1.98
Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration. Br J Ophthalmol (2008) 1.97
Air quality improvement estimation and assessment using contingent valuation method, a case study in Beijing. Environ Monit Assess (2006) 1.96
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene (2011) 1.94
Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. J Neurophysiol (2007) 1.93
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation. J Gen Physiol (1992) 1.92
Error filtration, interference, and the human linkage map. Proc Natl Acad Sci U S A (1991) 1.91
The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. Cell (1994) 1.90
Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling. Cancer Res (1999) 1.88
Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.87
Mechanism of topology simplification by type II DNA topoisomerases. Proc Natl Acad Sci U S A (2001) 1.87
Template-directed dye-terminator incorporation (TDI) assay: a homogeneous DNA diagnostic method based on fluorescence resonance energy transfer. Nucleic Acids Res (1997) 1.86
A genomic island, termed high-pathogenicity island, is present in certain non-O157 Shiga toxin-producing Escherichia coli clonal lineages. Infect Immun (1999) 1.86
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol (2000) 1.85
A medium-density genetic linkage map of the bovine genome. Mamm Genome (1997) 1.85
MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin Exp Pharmacol Physiol (2008) 1.84
The Hound of the Baskervilles effect: natural experiment on the influence of psychological stress on timing of death. BMJ (2001) 1.83
Tissue specific perfusion imaging using arterial spin labeling. NMR Biomed (1994) 1.82
Obesity and overweight in Canada: an updated cost-of-illness study. Obes Rev (2009) 1.78
Injuries caused by pigs in Papua New Guinea. Med J Aust (1989) 1.78
Standard maps of chromosome 10. Ann Hum Genet (1990) 1.77
A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J Biol Chem (2001) 1.77
Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS). Neurology (2007) 1.77
Intracellular labeling of T-cells with superparamagnetic contrast agents. Magn Reson Med (1993) 1.76
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage (2012) 1.74
Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer. Cancer Res (1999) 1.74
Prevalence and transmission of honeybee viruses. Appl Environ Microbiol (2006) 1.74
Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J Exp Med (1998) 1.73
Systematic review of the concurrent and predictive validity of MRI biomarkers in OA. Osteoarthritis Cartilage (2011) 1.73
A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer. Cancer Res (2001) 1.72
Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. J Biol Chem (1991) 1.72
Fluorescence energy transfer detection as a homogeneous DNA diagnostic method. Proc Natl Acad Sci U S A (1997) 1.71
Sources of nonlinearity in cDNA microarray expression measurements. Genome Biol (2001) 1.70
Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells. Proc Natl Acad Sci U S A (1994) 1.67
Social consensus through the influence of committed minorities. Phys Rev E Stat Nonlin Soft Matter Phys (2011) 1.67
Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines. Pharmacogenomics J (2010) 1.66
Is the dementia rate increasing in Beijing? Prevalence and incidence of dementia 10 years later in an urban elderly population. Acta Psychiatr Scand (2007) 1.65
A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals. J Med Chem (2000) 1.62
Non-disjunction of chromosome 18. Hum Mol Genet (1998) 1.62
Universal SNP genotyping assay with fluorescence polarization detection. Biotechniques (2001) 1.62
Identifying differentially expressed genes in cDNA microarray experiments. J Comput Biol (2001) 1.61