Published in J Biol Chem on September 24, 2004
Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet (2010) 15.70
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature (2010) 8.84
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Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice. Nucleic Acids Res (2012) 1.13
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AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity. Nucleic Acids Res (2009) 1.09
AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner. Mol Cell Biol (2006) 1.09
Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients. Transl Psychiatry (2012) 1.08
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Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancer. Cancer Immunol Immunother (2012) 1.05
Injury-dependent Müller glia and ganglion cell reprogramming during tissue regeneration requires Apobec2a and Apobec2b. J Neurosci (2012) 1.04
Rocking the foundations of molecular genetics. Proc Natl Acad Sci U S A (2012) 1.04
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Epigenetic regulation of neurogenesis in the adult mammalian brain. Eur J Neurosci (2011) 0.99
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Mechanisms of base substitution mutagenesis in cancer genomes. Genes (Basel) (2014) 0.98
AID enzymatic activity is inversely proportional to the size of cytosine C5 orbital cloud. PLoS One (2012) 0.98
A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells. Nat Immunol (2013) 0.97
Base excision repair, aging and health span. Mech Ageing Dev (2008) 0.97
GADD45A protein plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells. J Biol Chem (2011) 0.96
Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. Lancet Neurol (2013) 0.96
Active DNA demethylation in post-mitotic neurons: a reason for optimism. Neuropharmacology (2013) 0.94
The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions. Wiley Interdiscip Rev RNA (2014) 0.94
Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis. Br J Cancer (2013) 0.93
Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G. J Biol Chem (2009) 0.93
AID and Apobec3G haphazard deamination and mutational diversity. Cell Mol Life Sci (2012) 0.93
Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability. Proc Natl Acad Sci U S A (2012) 0.93
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun (2016) 0.92
Differential programming of B cells in AID deficient mice. PLoS One (2013) 0.91
Toward the identification of peripheral epigenetic biomarkers of schizophrenia. J Neurogenet (2014) 0.91
The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas. Genome Biol (2014) 0.91
Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc Natl Acad Sci U S A (2013) 0.90
Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse. Dev Dyn (2008) 0.90
Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins. PLoS One (2012) 0.90
Endocrine disruption of the epigenome: a breast cancer link. Endocr Relat Cancer (2014) 0.90
Genome-wide DNA demethylation in mammals. Genome Biol (2010) 0.89
Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age. PLoS One (2011) 0.89
Alternative induction of meiotic recombination from single-base lesions of DNA deaminases. Genetics (2009) 0.89
Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications. Semin Immunol (2012) 0.89
Insights into the role of DNA methylation in disease through the use of mouse models. Dis Model Mech (2010) 0.89
Evolution and functions of long noncoding RNAs. Cell (2009) 17.54
DNA deamination mediates innate immunity to retroviral infection. Cell (2003) 12.10
Active genes dynamically colocalize to shared sites of ongoing transcription. Nat Genet (2004) 9.57
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature (2011) 9.33
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature (2010) 8.84
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Epigenetic reprogramming in mouse primordial germ cells. Mech Dev (2002) 6.67
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol (2002) 5.86
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun (2011) 5.66
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat Genet (2004) 5.47
Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis (2003) 5.19
Epigenetic reprogramming in plant and animal development. Science (2010) 5.18
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science (2012) 5.17
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol Cell (2002) 5.14
Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature (2002) 5.10
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells. Mol Cell (2012) 4.32
Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet (2011) 4.25
Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet (2003) 4.25
Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS Genet (2008) 3.89
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. J Mol Biol (2004) 3.59
Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. Mol Biol Evol (2004) 3.57
DNA demethylation by DNA repair. Trends Genet (2009) 3.49
Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet (2004) 3.47
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS Genet (2009) 3.25
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nat Rev Mol Cell Biol (2009) 3.12
The biology of IGE and the basis of allergic disease. Annu Rev Immunol (2001) 2.80
FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell (2013) 2.79
Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5. Nat Cell Biol (2008) 2.77
Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev (2009) 2.76
The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nat Cell Biol (2012) 2.73
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature (2013) 2.63
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Dynamic chromatin modifications characterise the first cell cycle in mouse embryos. Dev Biol (2005) 2.51
Immunity through DNA deamination. Trends Biochem Sci (2003) 2.39
Estrogen directly activates AID transcription and function. J Exp Med (2009) 2.37
Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nat Genet (2008) 2.20
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol (2003) 2.14
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Mol Cell (2011) 2.13
The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding. Nat Genet (2004) 2.13
Resourceful imprinting. Nature (2004) 2.10
Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. J Physiol (2003) 2.01
AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Curr Biol (2002) 1.98
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Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Proc Natl Acad Sci U S A (2005) 1.90
The nuclear DNA deaminase AID functions distributively whereas cytoplasmic APOBEC3G has a processive mode of action. DNA Repair (Amst) (2006) 1.85
An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype. Hum Mol Genet (2003) 1.85
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The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development (2009) 1.69
Placental overgrowth in mice lacking the imprinted gene Ipl. Proc Natl Acad Sci U S A (2002) 1.67
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Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline. Development (2012) 1.55
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Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine. Nat Protoc (2013) 1.54
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Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus. Mol Cell Biol (2003) 1.47
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