Published in Chest on April 01, 2006
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2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
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Hydrocortisone therapy for patients with septic shock. N Engl J Med (2008) 15.85
Overcoming health-systems constraints to achieve the Millennium Development Goals. Lancet (2004) 15.43
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2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med (2011) 9.96
A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med (2013) 8.94
Protecting households from catastrophic health spending. Health Aff (Millwood) (2007) 8.44
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
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Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14
Responding to the global human resources crisis. Lancet (2004) 7.04
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med (2005) 6.86
Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69
Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet (2005) 6.33
Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17
Aspirin in patients undergoing noncardiac surgery. N Engl J Med (2014) 6.10
Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery--a prospective sequential analysis*. Crit Care Med (2013) 5.88
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med (2008) 5.30
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23
Public use of automated external defibrillators. N Engl J Med (2002) 5.07
Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study. Lancet (2005) 5.01
Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med (2011) 4.59
Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet (2002) 4.42
Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2009) 4.41
Toothbrushing for critically ill mechanically ventilated patients: a systematic review and meta-analysis of randomized trials evaluating ventilator-associated pneumonia. Crit Care Med (2013) 4.29
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA (2002) 4.09
An official American Thoracic Society clinical policy statement: palliative care for patients with respiratory diseases and critical illnesses. Am J Respir Crit Care Med (2008) 3.98
The Global Campaign for the Health MDGs: challenges, opportunities, and the imperative of shared learning. Lancet (2007) 3.86
A trial of an impedance threshold device in out-of-hospital cardiac arrest. N Engl J Med (2011) 3.76
Passive leg raising predicts fluid responsiveness in the critically ill. Crit Care Med (2006) 3.71
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A (2002) 3.68
Publication bias in editorial decision making. JAMA (2002) 3.52
Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. Eur Heart J (2005) 3.50
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med (2014) 3.37
Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med (2004) 3.36
The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med (2009) 3.30
The way forward. Lancet (2007) 3.28
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Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes. Kidney Int (2002) 3.07
Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. Am J Respir Crit Care Med (2008) 2.99
HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology (2002) 2.95
Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit. Crit Care Med (2002) 2.91
Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med (2007) 2.79
The Very Elderly Admitted to ICU: A Quality Finish? Crit Care Med (2015) 2.77
Chest compression rates and survival following out-of-hospital cardiac arrest. Crit Care Med (2015) 2.77
Defining the incidence of cardiorespiratory instability in patients in step-down units using an electronic integrated monitoring system. Arch Intern Med (2008) 2.73
Facilitating clinician adherence to guidelines in the intensive care unit: A multicenter, qualitative study. Crit Care Med (2007) 2.72
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
Clinician predictions of intensive care unit mortality. Crit Care Med (2004) 2.65
Statin use and mortality in the bacteremic critically ill patient. Crit Care Med (2006) 2.57
Projected incidence of mechanical ventilation in Ontario to 2026: Preparing for the aging baby boomers. Crit Care Med (2005) 2.52
Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med (2010) 2.48
Esophageal Doppler monitoring predicts fluid responsiveness in critically ill ventilated patients. Intensive Care Med (2005) 2.48
The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis. Crit Care Med (2007) 2.45
Multicentre, cluster-randomized clinical trial of algorithms for critical-care enteral and parenteral therapy (ACCEPT). CMAJ (2004) 2.45
Evidence based medicine has come a long way. BMJ (2004) 2.42
Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O(2) saturation response. Intensive Care Med (2008) 2.42
Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med (2006) 2.39
Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections. Crit Care Med (2015) 2.37
Probiotics in the critically ill: a systematic review of the randomized trial evidence. Crit Care Med (2012) 2.35
Mechanical ventilation in Ontario, 1992-2000: incidence, survival, and hospital bed utilization of noncardiac surgery adult patients. Crit Care Med (2004) 2.34
Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients. Intensive Care Med (2012) 2.33
Socioeconomic status and incidence of sudden cardiac arrest. CMAJ (2011) 2.31
Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30
Mechanisms of sepsis-induced organ dysfunction. Crit Care Med (2007) 2.30
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med (2006) 2.27
Ventilator-associated lung injury. Lancet (2003) 2.26
Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med (2015) 2.25
Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest (2013) 2.24
The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals. Crit Care Med (2011) 2.23
Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: prevention. J Crit Care (2008) 2.23
Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol (2007) 2.12
Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med (2005) 2.11
Randomized, controlled clinical trials in sepsis: has methodological quality improved over time? Crit Care Med (2002) 2.10
A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med (2012) 2.07
Clonidine in patients undergoing noncardiac surgery. N Engl J Med (2014) 2.07
Medical registrars in 2010: experience and expectations of the future consultant physicians of the UK. Clin Med (2011) 2.04
Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit. Crit Care (2005) 2.03
Targeting mitochondria. Acc Chem Res (2008) 2.03
Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000. Crit Care Med (2003) 2.01
The pulmonary artery catheter: in medio virtus. Crit Care Med (2008) 2.01
Understanding the benefits and harms of oxygen therapy. Intensive Care Med (2015) 2.00
Terlipressin for norepinephrine-resistant septic shock. Lancet (2002) 1.99
Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting? Crit Care Med (2009) 1.99
Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med (2004) 1.97
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol Regul Integr Comp Physiol (2003) 1.95