Published in Crit Care Med on December 01, 2007
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis (2013) 5.00
Mitochondrial dysfunction in peripheral blood mononuclear cells in pediatric septic shock. Pediatr Crit Care Med (2015) 1.59
Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function. PLoS One (2014) 1.42
Understanding urine output in critically ill patients. Ann Intensive Care (2011) 1.18
Effect of fluid resuscitation on mortality and organ function in experimental sepsis models. Crit Care (2009) 1.16
Bench-to-bedside review: Glucose and stress conditions in the intensive care unit. Crit Care (2010) 1.16
Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care (2010) 1.09
Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus. Vasc Med (2014) 1.00
Autophagy: a core cellular process with emerging links to pulmonary disease. Am J Respir Crit Care Med (2011) 1.00
Hemorrhagic shock and resuscitation are associated with peripheral blood mononuclear cell mitochondrial dysfunction and immunosuppression. J Trauma Acute Care Surg (2013) 0.98
Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol (2016) 0.95
Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling. J Biol Chem (2014) 0.93
Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock. Crit Care (2014) 0.91
Sepsis: links between pathogen sensing and organ damage. Curr Pharm Des (2008) 0.90
Immunotherapy - a potential new way forward in the treatment of sepsis. Crit Care (2013) 0.89
Can peripheral blood mononuclear cells be used as a proxy for mitochondrial dysfunction in vital organs during hemorrhagic shock and resuscitation? Shock (2013) 0.89
Patients with sepsis exhibit increased mitochondrial respiratory capacity in peripheral blood immune cells. Crit Care (2013) 0.89
A Review of GM-CSF Therapy in Sepsis. Medicine (Baltimore) (2015) 0.84
Mitochondrial dysfunction during sepsis: still more questions than answers. Crit Care Med (2011) 0.84
Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock. Ann Am Thorac Soc (2015) 0.83
Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions. Proc Natl Acad Sci U S A (2013) 0.83
The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytes. Redox Biol (2015) 0.80
Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis (2015) 0.79
Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome. Pediatr Crit Care Med (2017) 0.78
Oxidants in Acute and Chronic Lung Disease. J Blood Lymph (2015) 0.78
Mitochondrial changes in platelets are not related to those in skeletal muscle during human septic shock. PLoS One (2014) 0.78
Pharmacological optimization of tissue perfusion. Br J Anaesth (2009) 0.78
Prevailing vitamin D status influences mitochondrial and glycolytic bioenergetics in peripheral blood mononuclear cells obtained from adults. Redox Biol (2016) 0.77
Is nosocomial infection really the major cause of death in sepsis? Crit Care (2014) 0.77
α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice. Free Radic Biol Med (2014) 0.76
Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock. J Crit Care (2015) 0.75
Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells. PLoS One (2016) 0.75
Fluorescence imaging of ATP in neutrophils from patients with sepsis using organelle-localizable fluorescent chemosensors. Ann Intensive Care (2016) 0.75
Purification methods: a way to treat severe acute inflammation related to sepsis? Crit Care (2013) 0.75
Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers. Urology (2016) 0.75
The effect of plasma from septic ICU patients on healthy rat muscle mitochondria. Intensive Care Med Exp (2016) 0.75
Serum Procalcitonin and Peripheral Venous Lactate for Predicting Dengue Shock and/or Organ Failure: A Prospective Observational Study. PLoS Negl Trop Dis (2016) 0.75
Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. PLoS One (2017) 0.75
Platelet mitochondrial dysfunction in critically ill patients: comparison between sepsis and cardiogenic shock. Crit Care (2015) 0.75
Suppression of monocyte metabolism by septic plasma: revisiting the concept of "blood poisoning". Crit Care Med (2007) 2.06
Hydrocortisone therapy for patients with septic shock. N Engl J Med (2008) 15.85
Sepsis in European intensive care units: results of the SOAP study. Crit Care Med (2006) 11.78
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
Trial of early, goal-directed resuscitation for septic shock. N Engl J Med (2015) 8.24
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA (2013) 7.23
Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet (2005) 6.33
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med (2008) 5.30
Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study. Lancet (2005) 5.01
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis (2013) 5.00
Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet (2002) 4.42
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol (2013) 4.38
Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Crit Care Med (2014) 4.11
Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial. Intensive Care Med (2015) 3.92
Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. Eur Heart J (2005) 3.50
The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med (2009) 3.30
Decompressive craniectomy and early cranioplasty for the management of severe head injury: a prospective multicenter study on 147 patients. World Neurosurg (2011) 2.89
Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med (2007) 2.79
Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial). Stroke (2007) 2.62
Statin use and mortality in the bacteremic critically ill patient. Crit Care Med (2006) 2.57
Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med (2010) 2.48
Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med (2006) 2.47
The Eldicus prospective, observational study of triage decision making in European intensive care units. Part II: intensive care benefit for the elderly. Crit Care Med (2012) 2.46
The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis. Crit Care Med (2007) 2.45
The use of dabigatran in elderly patients. Arch Intern Med (2011) 2.43
Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction. Crit Care Med (2009) 2.39
Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections. Crit Care Med (2015) 2.37
Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients. Intensive Care Med (2012) 2.33
Mechanisms of sepsis-induced organ dysfunction. Crit Care Med (2007) 2.30
The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals. Crit Care Med (2011) 2.23
High incidence of myocardial ischemia during postpartum hemorrhage. Anesthesiology (2004) 2.16
Influence of arterial dissolved oxygen level on venous oxygen saturation: don't forget the PaO2! Shock (2014) 2.14
A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. Shock (2014) 2.11
Cytokine cascade in sepsis. Scand J Infect Dis (2003) 2.09
Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit. Crit Care (2005) 2.03
The pulmonary artery catheter: in medio virtus. Crit Care Med (2008) 2.01
Case scenario: Hemodynamic management of postoperative acute kidney injury. Anesthesiology (2013) 2.01
An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study. Intensive Care Med (2006) 2.00
Understanding the benefits and harms of oxygen therapy. Intensive Care Med (2015) 2.00
Terlipressin for norepinephrine-resistant septic shock. Lancet (2002) 1.99
Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting? Crit Care Med (2009) 1.99
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol Regul Integr Comp Physiol (2003) 1.95
Functional hemodynamic monitoring. Crit Care (2005) 1.90
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med (2005) 1.83
Microvascular effects of heart rate control with esmolol in patients with septic shock: a pilot study. Crit Care Med (2013) 1.81
Variability in management of early severe sepsis. Emerg Med J (2010) 1.76
Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices. Intensive Care Med (2009) 1.76
Adrenal function in sepsis: the retrospective Corticus cohort study. Crit Care Med (2007) 1.74
Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages. Am J Physiol Regul Integr Comp Physiol (2004) 1.74
Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study. Crit Care (2013) 1.74
H1N1 pneumonitis treated with intravenous zanamivir. Lancet (2009) 1.73
Systemic and renal macro- and microcirculatory responses to arginine vasopressin in endotoxic rabbits. Crit Care Med (2004) 1.73
The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats. Intensive Care Med (2011) 1.72
Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Mol Med (2008) 1.72
International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med (2015) 1.64
Potential metabolic consequences of statins in sepsis. Crit Care Med (2011) 1.64
Clinical review: Update on hemodynamic monitoring--a consensus of 16. Crit Care (2011) 1.62
Impaired plasma B-type natriuretic peptide clearance in human septic shock. Crit Care Med (2008) 1.59
The Eldicus prospective, observational study of triage decision making in European intensive care units: part I--European Intensive Care Admission Triage Scores. Crit Care Med (2012) 1.59
Real-time magnetic resonance-guided laser thermal therapy for focal metastatic brain tumors. Neurosurgery (2008) 1.57
Inhaled nitric oxide therapy in adults: European expert recommendations. Intensive Care Med (2005) 1.56
Temporal changes in tissue cardiorespiratory function during faecal peritonitis. Intensive Care Med (2011) 1.54
Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. Shock (2011) 1.52
Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis. Crit Care Med (2007) 1.50
Factors associated with the mediastinal spread of cervical necrotizing fasciitis. Ann Thorac Surg (2011) 1.48
Post hoc insights from PAC-Man--the U.K. pulmonary artery catheter trial. Crit Care Med (2008) 1.48
The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage. Intensive Care Med (2009) 1.48
Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Intensive Care Med (2014) 1.48
Prehospital noninvasive ventilation for acute respiratory failure: systematic review, network meta-analysis, and individual patient data meta-analysis. Acad Emerg Med (2014) 1.45
Low-molecular-weight polyethylene glycol improves survival in experimental sepsis. Crit Care Med (2010) 1.45
Lack of alteration of endogenous nitric oxide pathway during prolonged nitric oxide inhalation in intensive care unit patients. Crit Care Med (2005) 1.44
Critical care: advances and future perspectives. Lancet (2010) 1.44
Intensive care and emergency medicine: progress over the past 25 years. Chest (2006) 1.43
Effects of sepiapterin infusion on renal oxygenation and early acute renal injury after suprarenal aortic clamping in rats. J Cardiovasc Pharmacol (2011) 1.43
The FTc is not an accurate marker of left ventricular preload. Intensive Care Med (2006) 1.42
Diagnostic accuracy of insulin-like growth factor binding protein-1 for amniotic fluid embolism*. Crit Care Med (2012) 1.41
Multicenter, randomized, placebo-controlled phase III study of pyridoxalated hemoglobin polyoxyethylene in distributive shock (PHOENIX). Crit Care Med (2015) 1.40
In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent. BMC Microbiol (2009) 1.40
Arterial catheter-related bloodstream infections: results of an 8-year survey in a surgical intensive care unit. Crit Care Med (2011) 1.39
Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis. Crit Care Med (2012) 1.38
The validity of trans-esophageal Doppler ultrasonography as a measure of cardiac output in critically ill adults. Intensive Care Med (2004) 1.37
Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability. Circulation (2005) 1.33
The role of the microcirculation in acute kidney injury. Curr Opin Crit Care (2009) 1.30
Mitochondrial Dysfunction in Sepsis. Curr Infect Dis Rep (2003) 1.30
Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure. Crit Care (2006) 1.30
Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats. Crit Care Med (2010) 1.30
Is thenar tissue hemoglobin oxygen saturation in septic shock related to macrohemodynamic variables and outcome? Crit Care (2009) 1.30
Cellular energetic metabolism in sepsis: the need for a systems approach. Biochim Biophys Acta (2008) 1.28
Vasopressin: mechanisms of action on the vasculature in health and in septic shock. Crit Care Med (2007) 1.28
Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med (2012) 1.27
TREM-1 promotes survival during septic shock in mice. Eur J Immunol (2007) 1.27
Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication. Crit Care (2010) 1.22
Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone. Crit Care Med (2007) 1.20
Understanding urine output in critically ill patients. Ann Intensive Care (2011) 1.18
British HIV Association and British Infection Association guidelines for the treatment of opportunistic infection in HIV-seropositive individuals 2011. HIV Med (2011) 1.17