Published in Nat Genet on November 01, 2004
Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine. BMJ (2006) 3.02
Public willingness to participate in and public opinions about genetic variation research: a review of the literature. Am J Public Health (2006) 2.28
Geography is a better determinant of human genetic differentiation than ethnicity. Hum Genet (2005) 2.20
The use of racial, ethnic, and ancestral categories in human genetics research. Am J Hum Genet (2005) 1.73
Can ethical reasoning contribute to better epidemiology? A case study in research on racial health disparities. Eur J Epidemiol (2007) 1.38
The structure of common genetic variation in United States populations. Am J Hum Genet (2007) 1.35
From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions. Drug Metab Rev (2008) 1.35
Heroin addiction in African Americans: a hypothesis-driven association study. Genes Brain Behav (2009) 1.32
A critical analysis of barriers to the clinical implementation of pharmacogenomics. Ther Clin Risk Manag (2007) 1.18
The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin Exp Res (2011) 1.18
Genomic medicine: genetic variation and its impact on the future of health care. Philos Trans R Soc Lond B Biol Sci (2005) 1.16
Self-assessment of cultural attitudes and competence of clinical investigators to enhance recruitment and participation of minority populations in research. J Natl Med Assoc (2006) 1.13
Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing. Pharmacogenomics (2007) 1.12
Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study. Neuropsychopharmacology (2011) 1.05
Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers. BMC Med Genet (2011) 1.04
Racial medicine: here to stay? The success of the International HapMap Project and other initiatives may help to overcome racial profiling in medicine, but old habits die hard. EMBO Rep (2006) 1.01
Asking the right questions: views on genetic variation research among black and white research participants. J Gen Intern Med (2008) 0.97
Ashkenazi Jews and breast cancer: the consequences of linking ethnic identity to genetic disease. Am J Public Health (2006) 0.87
Why personalized medicine will fail if we stay the course. Per Med (2012) 0.86
Naltrexone for the treatment of alcohol dependence among African Americans: results from the COMBINE Study. Drug Alcohol Depend (2009) 0.85
Pharmacogenetics, pharmacogenomics and ecogenetics. J Zhejiang Univ Sci B (2006) 0.82
Perceptions of genetic testing and genomic medicine among drug users. Int J Drug Policy (2014) 0.80
Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity. Am J Addict (2016) 0.79
Grassroots marketing in a global era: more lessons from BiDil. J Law Med Ethics (2011) 0.79
Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. Pharmacol Biochem Behav (2012) 0.78
Genomes, populations and diseases: ethnic genomics and personalized medicine. Acta Naturae (2010) 0.77
Pharmacogenetics in primary care: the promise of personalized medicine and the reality of racial profiling. Cult Med Psychiatry (2013) 0.76
BiDil in the Clinic: An Interdisciplinary Investigation of Physicians' Prescription Patterns of a Race-Based Therapy. AJOB Empir Bioeth (2014) 0.75
Scientometric analyses of studies on the role of innate variation in athletic performance. Springerplus (2014) 0.75
Refining the ideas of "ethnic" skin. An Bras Dermatol (2017) 0.75
Multidrug intolerance in the treatment of hypertension: result from an audit of a specialized hypertension service. Ther Adv Drug Saf (2017) 0.75
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature (2009) 26.47
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
A whole-genome association study of major determinants for host control of HIV-1. Science (2007) 15.19
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature (2009) 13.99
Common variants conferring risk of schizophrenia. Nature (2009) 10.37
Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet (2010) 9.53
Discerning the ancestry of European Americans in genetic association studies. PLoS Genet (2007) 7.81
De novo mutations in epileptic encephalopathies. Nature (2013) 7.42
WGAViewer: software for genomic annotation of whole genome association studies. Genome Res (2008) 7.15
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology (2010) 6.14
Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol (2002) 5.58
Genic intolerance to functional variation and the interpretation of personal genomes. PLoS Genet (2013) 5.58
Tissue-specific genetic control of splicing: implications for the study of complex traits. PLoS Biol (2008) 5.08
A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet (2009) 5.01
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature (2010) 4.64
Selection and evaluation of tagging SNPs in the neuronal-sodium-channel gene SCN1A: implications for linkage-disequilibrium gene mapping. Am J Hum Genet (2003) 4.58
Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene. PLoS Genet (2010) 4.29
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet (2009) 4.11
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med (2011) 3.93
The characterization of twenty sequenced human genomes. PLoS Genet (2010) 3.72
Common genetic variation and the control of HIV-1 in humans. PLoS Genet (2009) 3.68
IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology (2010) 3.57
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med (2003) 3.37
Clinical application of exome sequencing in undiagnosed genetic conditions. J Med Genet (2012) 3.33
Long-range LD can confound genome scans in admixed populations. Am J Hum Genet (2008) 3.06
Hepatitis C pharmacogenetics: state of the art in 2010. Hepatology (2011) 2.99
Host determinants of HIV-1 control in African Americans. J Infect Dis (2010) 2.90
Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Lancet Neurol (2007) 2.88
An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response. Gastroenterology (2010) 2.87
A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology (2010) 2.78
Priorities and standards in pharmacogenetic research. Nat Genet (2005) 2.65
Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Am J Hum Genet (2010) 2.61
Positive selection on a human-specific transcription factor binding site regulating IL4 expression. Curr Biol (2003) 2.59
Next generation disparities in human genomics: concerns and remedies. Trends Genet (2009) 2.53
Which evolutionary processes influence natural genetic variation for phenotypic traits? Nat Rev Genet (2007) 2.45
A single-nucleotide polymorphism tagging set for human drug metabolism and transport. Nat Genet (2004) 2.44
Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A (2005) 2.39
Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nat Genet (2009) 2.38
Ancient and recent positive selection transformed opioid cis-regulation in humans. PLoS Biol (2005) 2.37
De novo mutations in ATP1A3 cause alternating hemiplegia of childhood. Nat Genet (2012) 2.34
Genomics meets HIV-1. Nat Rev Microbiol (2006) 2.34
Pharmacogenetics in the laboratory and the clinic. N Engl J Med (2003) 2.12
SVA: software for annotating and visualizing sequenced human genomes. Bioinformatics (2011) 2.11
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med (2012) 2.08
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature (2012) 2.08
Interpretation of association signals and identification of causal variants from genome-wide association studies. Am J Hum Genet (2010) 2.06
Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A. Am J Hum Genet (2007) 2.04
Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. Gastroenterology (2011) 2.01
Screening the human exome: a comparison of whole genome and whole transcriptome sequencing. Genome Biol (2010) 2.00
Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals. PLoS Pathog (2010) 1.90
Founding mothers of Jewish communities: geographically separated Jewish groups were independently founded by very few female ancestors. Am J Hum Genet (2002) 1.89
A Y chromosome census of the British Isles. Curr Biol (2003) 1.84
Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Curr Biol (2005) 1.79
Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction. Gastroenterology (2010) 1.74
CCL3L1 and HIV/AIDS susceptibility. Nat Med (2009) 1.73
Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy. Am J Hum Genet (2012) 1.72
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Hum Mol Genet (2009) 1.71
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain (2010) 1.67
The utility of the traditional medical genetics diagnostic evaluation in the context of next-generation sequencing for undiagnosed genetic disorders. Genet Med (2013) 1.65
Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene. Genome Res (2004) 1.65
In vitro assays fail to predict in vivo effects of regulatory polymorphisms. Hum Mol Genet (2007) 1.62
Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. J Hepatol (2011) 1.59
A genome-wide comparison of the functional properties of rare and common genetic variants in humans. Am J Hum Genet (2011) 1.56
Drug resistance in epilepsy: more twists in the tale. Epilepsia (2007) 1.55
Quantitation of pretreatment serum interferon-γ-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response. Hepatology (2011) 1.53
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function. Gastroenterology (2011) 1.52
Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1. J Hepatol (2011) 1.47
Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia. Am J Hum Genet (2012) 1.47
Copy number variation of KIR genes influences HIV-1 control. PLoS Biol (2011) 1.44
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy. Epilepsia (2007) 1.43
Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs). Evid Rep Technol Assess (Full Rep) (2007) 1.42
Demography, recombination hotspot intensity, and the block structure of linkage disequilibrium. Curr Biol (2003) 1.41
A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans. Genome Biol (2009) 1.41
Positive selection on MMP3 regulation has shaped heart disease risk. Curr Biol (2004) 1.39
Human genetics: the hidden text of genome-wide associations. Curr Biol (2007) 1.39
Genome-wide tagging for everyone. Nat Genet (2006) 1.38
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Eur J Hum Genet (2009) 1.38
Inferring genetic ancestry: opportunities, challenges, and implications. Am J Hum Genet (2010) 1.36
Genome-wide scan of copy number variation in late-onset Alzheimer's disease. J Alzheimers Dis (2010) 1.35
Common genetic variation and performance on standardized cognitive tests. Eur J Hum Genet (2010) 1.34
Africans and Asians abroad: genetic diversity in Europe. Annu Rev Genomics Hum Genet (2004) 1.33
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls. PLoS Pathog (2013) 1.33
Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. AIDS (2011) 1.33
Genomics: understanding human diversity. Nature (2005) 1.29
Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. PLoS Genet (2010) 1.28
Ethical challenges in genotype-driven research recruitment. Genome Res (2010) 1.26
The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir. J Infect Dis (2008) 1.25
Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humans. Genetics (2004) 1.25
In genetic control of disease, does 'race' matter? Nat Genet (2004) 1.24
A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose. Pharmacogenet Genomics (2006) 1.22
Using ERDS to infer copy-number variants in high-coverage genomes. Am J Hum Genet (2012) 1.22
Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. Pharmacogenet Genomics (2012) 1.21
Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial. J Infect Dis (2011) 1.20
Review of evidence for genetic testing for CYP450 polymorphisms in management of patients with nonpsychotic depression with selective serotonin reuptake inhibitors. Genet Med (2007) 1.17
KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine. Ann Neurol (2014) 1.15
Determinants of protection among HIV‐exposed seronegative persons: an overview. J Infect Dis (2010) 1.13