Published in J Nutr on November 01, 2004
Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development. Cell (2013) 1.42
Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol (2009) 1.29
Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes. J Inherit Metab Dis (2010) 0.94
Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias. Clin Chem Lab Med (2007) 0.91
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency. J Cell Biochem (2008) 0.85
The many flavors of hyperhomocyst(e)inemia: insights from transgenic and inhibitor-based mouse models of disrupted one-carbon metabolism. Antioxid Redox Signal (2007) 0.82
Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women. Int J Health Sci (Qassim) (2008) 0.82
Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors. Int J Cancer (2010) 0.80
Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Front Aging Neurosci (2014) 0.77
Genomic DNA hypomethylation is associated with neural tube defects induced by methotrexate inhibition of folate metabolism. PLoS One (2015) 0.77
Endoplasmic Reticulum Stress and Autophagy in Homocystinuria Patients with Remethylation Defects. PLoS One (2016) 0.77
Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies. PLoS One (2016) 0.76
Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue. Mol Genet Metab Rep (2015) 0.75
Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure. PLoS One (2016) 0.75
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
Paired-end mapping reveals extensive structural variation in the human genome. Science (2007) 30.46
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med (2002) 11.20
The genome of the domesticated apple (Malus × domestica Borkh.). Nat Genet (2010) 8.07
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr (2007) 4.37
Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med (2004) 4.34
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A (2002) 4.22
Autoantibodies to folate receptors in the cerebral folate deficiency syndrome. N Engl J Med (2005) 3.17
Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J Natl Cancer Inst (2003) 2.92
A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev (2007) 2.91
Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study. Am J Obstet Gynecol (2008) 2.82
Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. Circulation (2011) 2.62
C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study. Circ Cardiovasc Qual Outcomes (2008) 2.50
Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community. Circulation (2010) 2.32
Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med (2005) 2.29
Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr (2006) 2.25
Common variants of FUT2 are associated with plasma vitamin B12 levels. Nat Genet (2008) 2.07
Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease. Circ Res (2006) 1.99
A multi-marker approach to predict incident CKD and microalbuminuria. J Am Soc Nephrol (2010) 1.95
Folic acid intake from fortification in United States exceeds predictions. J Nutr (2002) 1.94
A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Anal Chem (2002) 1.81
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71
Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Am J Clin Nutr (2004) 1.70
Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone (2005) 1.69
High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke (2008) 1.67
Total homocysteine lowering treatment among coronary artery disease patients in the era of folic acid-fortified cereal grain flour. Arterioscler Thromb Vasc Biol (2002) 1.66
Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation (2007) 1.65
Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging. Am J Med (2002) 1.63
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J (2003) 1.59
Relationship between homocysteine and mortality in chronic kidney disease. Circulation (2006) 1.58
The Nutrition, Aging, and Memory in Elders (NAME) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population. Int J Geriatr Psychiatry (2006) 1.50
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Biomarkers of folate status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci U S A (2008) 1.37
Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr (2008) 1.37
Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study. Eur Heart J (2004) 1.37
Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women. J Natl Cancer Inst (2005) 1.36
Circulating folic acid in plasma: relation to folic acid fortification. Am J Clin Nutr (2008) 1.35
The atherogenic effect of excess methionine intake. Proc Natl Acad Sci U S A (2003) 1.35
Multiple biomarkers and the risk of incident hypertension. Hypertension (2007) 1.34
Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. Age (Dordr) (2006) 1.33
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet (2009) 1.33
Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. Am J Clin Nutr (2010) 1.32
Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. Clin Cancer Res (2003) 1.31
Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors. Atherosclerosis (2004) 1.30
Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction. JAMA (2003) 1.30
A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr (2009) 1.28
Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr (2008) 1.26
Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study. Circulation (2008) 1.26
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab (2007) 1.24
A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr (2008) 1.22
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. J Nutr (2005) 1.17
Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis (2003) 1.17
Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr (2002) 1.17
Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides. J Nutr (2005) 1.17
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. Hum Mutat (2009) 1.16
Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. Br J Nutr (2008) 1.15
Multimarker approach for the prediction of heart failure incidence in the community. Circulation (2010) 1.15
Enhancement of folates in plants through metabolic engineering. Proc Natl Acad Sci U S A (2004) 1.15
Prediagnostic plasma folate and the risk of death in patients with colorectal cancer. J Clin Oncol (2008) 1.14
One-carbon metabolism biomarkers and risk of colon and rectal cancers. Cancer Epidemiol Biomarkers Prev (2008) 1.14
Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model. Teratology (2002) 1.13
Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J Biol Chem (2006) 1.13
Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study. J Bone Miner Res (2004) 1.13
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice. Am J Clin Nutr (2005) 1.11
Homocysteine and cognitive performance in the Framingham offspring study: age is important. Am J Epidemiol (2005) 1.10
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood (2003) 1.09
Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr (2009) 1.09
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr (2013) 1.08
Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. J Nutr (2004) 1.07
Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer (2004) 1.07
Depression and folate status in the US Population. Psychother Psychosom (2003) 1.07
Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A (2003) 1.06
Preconception homocysteine and B vitamin status and birth outcomes in Chinese women. Am J Clin Nutr (2002) 1.05
Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrinol Metab (2008) 1.05
Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. J Biol Chem (2003) 1.04
Spina bifida, folate metabolism, and dietary folate intake in a Northern Canadian aboriginal population. Int J Circumpolar Health (2002) 1.04
Baseline characteristics of participants in the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial. Am J Kidney Dis (2008) 1.03
Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. Pharmacogenetics (2002) 1.03
Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism. J Nutr (2010) 1.01
Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med (2003) 1.01
A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment. Mol Genet Metab (2010) 1.00
Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults. J Nutr (2012) 0.99
Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther (2005) 0.99
Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice. Toxicol Lett (2003) 0.98
Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis (2003) 0.98
ApcMin/+ mouse model of colon cancer: gene expression profiling in tumors. J Cell Biochem (2004) 0.98
Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arterioscler Thromb Vasc Biol (2003) 0.98
High intake of folic acid disrupts embryonic development in mice. Birth Defects Res A Clin Mol Teratol (2010) 0.97
Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer. Cancer Epidemiol Biomarkers Prev (2003) 0.96
Vitamin B-12 and folate status in relation to decline in scores on the mini-mental state examination in the framingham heart study. J Am Geriatr Soc (2012) 0.96