Published in Teratology on May 01, 2002
Neural tube defects: recent advances, unsolved questions, and controversies. Lancet Neurol (2013) 1.68
Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border. Environ Health Perspect (2006) 1.47
Folic acid and orofacial clefts: a review of the evidence. Oral Dis (2010) 1.33
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. Hum Mol Genet (2008) 1.33
Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol (2009) 1.29
Gene-environment interactions, folate metabolism and the embryonic nervous system. Wiley Interdiscip Rev Syst Biol Med (2010) 1.14
Mechanistic insights into folate supplementation from Crooked tail and other NTD-prone mutant mice. Birth Defects Res A Clin Mol Teratol (2009) 1.14
The emerging role of epigenetic mechanisms in the etiology of neural tube defects. Epigenetics (2011) 1.08
Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy. J Neurol (2008) 0.99
Current concepts in genetics of nonsyndromic clefts. Indian J Plast Surg (2009) 0.98
Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice. Mol Genet Metab (2008) 0.94
The genetic background of the curly tail strain confers susceptibility to folate-deficiency-induced exencephaly. Birth Defects Res A Clin Mol Teratol (2010) 0.93
Oral cleft prevention program (OCPP). BMC Pediatr (2012) 0.89
Folic acid supplementation in pregnancy and implications in health and disease. J Biomed Sci (2014) 0.84
Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation. Birth Defects Res A Clin Mol Teratol (2010) 0.84
C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. J Immunol (2013) 0.82
Modeling anterior development in mice: diet as modulator of risk for neural tube defects. Am J Med Genet C Semin Med Genet (2013) 0.81
Gene expression profiling in the fetal cardiac tissue after folate and low-dose trichloroethylene exposure. Birth Defects Res A Clin Mol Teratol (2010) 0.81
The role of folate metabolism in orofacial development and clefting. Dev Biol (2015) 0.80
Pregnancy outcome in ethanol-treated mice with folic acid supplementation in saccharose. Childs Nerv Syst (2007) 0.79
Using frogs faces to dissect the mechanisms underlying human orofacial defects. Semin Cell Dev Biol (2016) 0.78
Maternal diet supplementation with methyl donors and increased parity affect the incidence of craniofacial defects in the offspring of twisted gastrulation mutant mice. J Nutr (2013) 0.78
Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects. Biochimie (2016) 0.77
High levels of iron supplementation prevents neural tube defects in the Fpn1(ffe) mouse model. Birth Defects Res (2017) 0.77
NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice. Free Radic Biol Med (2015) 0.76
Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Res A Clin Mol Teratol (2016) 0.76
Organ-Specific Gene Expression Changes in the Fetal Liver and Placenta in Response to Maternal Folate Depletion. Nutrients (2016) 0.75
Gene promoter DNA methylation patterns have a limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy. Mol Nutr Food Res (2016) 0.75
Lack of association between folate receptor autoantibodies and conotruncal congenital heart defects. Pediatr Cardiol (2012) 0.75
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med (2002) 11.20
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr (2007) 4.37
Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med (2004) 4.34
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A (2002) 4.22
Autoantibodies to folate receptors in the cerebral folate deficiency syndrome. N Engl J Med (2005) 3.17
Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J Natl Cancer Inst (2003) 2.92
A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev (2007) 2.91
Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. Circulation (2011) 2.62
C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study. Circ Cardiovasc Qual Outcomes (2008) 2.50
Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community. Circulation (2010) 2.32
Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med (2005) 2.29
Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr (2006) 2.25
Common variants of FUT2 are associated with plasma vitamin B12 levels. Nat Genet (2008) 2.07
A multi-marker approach to predict incident CKD and microalbuminuria. J Am Soc Nephrol (2010) 1.95
Folic acid intake from fortification in United States exceeds predictions. J Nutr (2002) 1.94
Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. Am J Clin Nutr (2006) 1.89
A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Anal Chem (2002) 1.81
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71
Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Am J Clin Nutr (2004) 1.70
Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone (2005) 1.69
High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke (2008) 1.67
Total homocysteine lowering treatment among coronary artery disease patients in the era of folic acid-fortified cereal grain flour. Arterioscler Thromb Vasc Biol (2002) 1.66
Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation (2007) 1.65
Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging. Am J Med (2002) 1.63
Relationship between homocysteine and mortality in chronic kidney disease. Circulation (2006) 1.58
The Nutrition, Aging, and Memory in Elders (NAME) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population. Int J Geriatr Psychiatry (2006) 1.50
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Biomarkers of folate status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Mouse embryonic cardiac metabolism under euglycemic and hypoglycemic conditions. Teratology (1996) 1.39
A teratologist to extinction? Teratology (1995) 1.38
B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci U S A (2008) 1.37
Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr (2008) 1.37
Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study. Eur Heart J (2004) 1.37
Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women. J Natl Cancer Inst (2005) 1.36
Circulating folic acid in plasma: relation to folic acid fortification. Am J Clin Nutr (2008) 1.35
The atherogenic effect of excess methionine intake. Proc Natl Acad Sci U S A (2003) 1.35
Multiple biomarkers and the risk of incident hypertension. Hypertension (2007) 1.34
Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. Age (Dordr) (2006) 1.33
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet (2009) 1.33
Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. Am J Clin Nutr (2010) 1.32
Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors. Atherosclerosis (2004) 1.30
Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction. JAMA (2003) 1.30
A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr (2009) 1.28
Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr (2008) 1.26
Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study. Circulation (2008) 1.26
A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr (2008) 1.22
Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology (2001) 1.21
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. J Nutr (2005) 1.17
Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr (2002) 1.17
Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides. J Nutr (2005) 1.17
Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. Br J Nutr (2008) 1.15
Multimarker approach for the prediction of heart failure incidence in the community. Circulation (2010) 1.15
Enhancement of folates in plants through metabolic engineering. Proc Natl Acad Sci U S A (2004) 1.15
Prediagnostic plasma folate and the risk of death in patients with colorectal cancer. J Clin Oncol (2008) 1.14
One-carbon metabolism biomarkers and risk of colon and rectal cancers. Cancer Epidemiol Biomarkers Prev (2008) 1.14
Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J Biol Chem (2006) 1.13
Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study. J Bone Miner Res (2004) 1.13
Serotonin and cardiac morphogenesis in the mouse embryo. Teratology (1993) 1.12
Homocysteine and cognitive performance in the Framingham offspring study: age is important. Am J Epidemiol (2005) 1.10
Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr (2009) 1.09
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr (2013) 1.08
Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. J Nutr (2004) 1.07
Depression and folate status in the US Population. Psychother Psychosom (2003) 1.07
Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer (2004) 1.07
Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrinol Metab (2008) 1.05
Preconception homocysteine and B vitamin status and birth outcomes in Chinese women. Am J Clin Nutr (2002) 1.05
Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. J Biol Chem (2003) 1.04
Baseline characteristics of participants in the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial. Am J Kidney Dis (2008) 1.03
Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. Pharmacogenetics (2002) 1.03
Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med (2003) 1.01
Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults. J Nutr (2012) 0.99
Serotonin uptake in the ectoplacental cone and placenta of the mouse. Placenta (1993) 0.99
Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther (2005) 0.99
Serotonin as a regulator of craniofacial morphogenesis: site specific malformations following exposure to serotonin uptake inhibitors. Teratology (1992) 0.99
Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice. Toxicol Lett (2003) 0.98
Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis (2003) 0.98
Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates. J Nutr (2004) 0.98
High intake of folic acid disrupts embryonic development in mice. Birth Defects Res A Clin Mol Teratol (2010) 0.97
Activity profiles of developmental toxicity: design considerations and pilot implementation. Teratology (1991) 0.97
Serotonin and morphogenesis. I. Sites of serotonin uptake and -binding protein immunoreactivity in the midgestation mouse embryo. Development (1988) 0.96
Vitamin B-12 and folate status in relation to decline in scores on the mini-mental state examination in the framingham heart study. J Am Geriatr Soc (2012) 0.96
Phenylalanine and its metabolites induce embryopathies in mouse embryos in culture. Teratology (1990) 0.96
Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer. Cancer Epidemiol Biomarkers Prev (2003) 0.96
A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma. Cancer Causes Control (2010) 0.96
Actin distribution patterns in the mouse neural tube during neurulation. Science (1982) 0.96
Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status. J Nutr (2003) 0.94
Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation. Nutr Rev (2013) 0.94
Telomere length in peripheral blood mononuclear cells is associated with folate status in men. J Nutr (2009) 0.94
Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Circulation (2012) 0.93
Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart Study. Circulation (2007) 0.93
Plasma homocysteine and cysteine and risk of breast cancer in women. Cancer Res (2010) 0.93