Published in Stem Cells on May 08, 2008
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Control of the embryonic stem cell state. Cell (2011) 6.89
Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state. Genes Dev (2009) 4.09
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell (2011) 4.04
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol (2011) 3.25
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Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64
Trithorax group proteins: switching genes on and keeping them active. Nat Rev Mol Cell Biol (2011) 2.56
Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature (2010) 2.46
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol (2011) 2.13
β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell (2011) 2.07
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Maintaining embryonic stem cell pluripotency with Wnt signaling. Development (2011) 1.57
Canonical Wnt/β-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expression. Stem Cells (2010) 1.43
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A PiggyBac-based recessive screening method to identify pluripotency regulators. PLoS One (2011) 1.30
Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. Dev Cell (2010) 1.29
A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells. Development (2013) 1.26
The transcriptional regulation of pluripotency. Cell Res (2012) 1.15
Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells (2013) 1.14
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Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling. EMBO J (2010) 1.05
Identification of pluripotency genes in the fish medaka. Int J Biol Sci (2011) 1.04
Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J (2014) 1.02
Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells. Proc Natl Acad Sci U S A (2011) 1.02
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Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation. PLoS Genet (2013) 0.97
Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells. PLoS One (2012) 0.95
T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications. Proc Natl Acad Sci U S A (2011) 0.94
TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. Cell Death Dis (2013) 0.93
Systems biology provides new insights into the molecular mechanisms that control the fate of embryonic stem cells. J Cell Physiol (2012) 0.93
Mapping key features of transcriptional regulatory circuitry in embryonic stem cells. Cold Spring Harb Symp Quant Biol (2008) 0.93
Wnt: what's needed to maintain pluripotency? Nat Cell Biol (2011) 0.92
Identification of Wnt-responsive cells in the zebrafish hypothalamus. Zebrafish (2009) 0.92
Embryonic stem cells shed new light on the developmental roles of p53. Cell Biosci (2013) 0.88
Temporal perturbation of the Wnt signaling pathway in the control of cell reprogramming is modulated by TCF1. Stem Cell Reports (2014) 0.88
Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification. Development (2013) 0.88
Wnt signaling through T-cell factor phosphorylation. Cell Res (2011) 0.87
Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells. Stem Cells (2011) 0.85
The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia. Haematologica (2014) 0.85
Noncanonical function of DGCR8 controls mESC exit from pluripotency. J Cell Biol (2017) 0.84
Integrative genome-wide approaches in embryonic stem cell research. Integr Biol (Camb) (2010) 0.84
NonO binds to the CpG island of oct4 promoter and functions as a transcriptional activator of oct4 gene expression. Mol Cells (2012) 0.82
Dynamic changes in Wnt signaling are required for neuronal differentiation of mouse embryonic stem cells. Mol Cell Neurosci (2011) 0.82
Evolution of gene regulation of pluripotency--the case for wiki tracks at genome browsers. Biol Direct (2010) 0.81
Alternative splicing: An important mechanism in stem cell biology. World J Stem Cells (2015) 0.81
ILK induces cardiomyogenesis in the human heart. PLoS One (2012) 0.81
Retracted Nuclear Ago2/HSP60 contributes to broad spectrum of hATSCs function via Oct4 regulation. Antioxid Redox Signal (2011) 0.80
Preimplantation development regulatory pathway construction through a text-mining approach. BMC Genomics (2011) 0.79
Retinoic acid suppresses the canonical Wnt signaling pathway in embryonic stem cells and activates the noncanonical Wnt signaling pathway. Stem Cells (2014) 0.79
Geminin promotes an epithelial-to-mesenchymal transition in an embryonic stem cell model of gastrulation. Stem Cells Dev (2013) 0.78
C-terminal binding proteins (CtBPs) attenuate KLF4-mediated transcriptional activation. FEBS Lett (2009) 0.78
Regulators of pluripotency and their implications in regenerative medicine. Stem Cells Cloning (2015) 0.78
Alternative splicing in self-renewal of embryonic stem cells. Stem Cells Int (2011) 0.78
Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3. Exp Cell Res (2009) 0.77
Deciphering the stem cell machinery as a basis for understanding the molecular mechanism underlying reprogramming. Cell Mol Life Sci (2009) 0.76
Looking into the black box: insights into the mechanisms of somatic cell reprogramming. Genes (Basel) (2011) 0.76
JmjC Domain-containing Protein 6 (Jmjd6) Derepresses the Transcriptional Repressor Transcription Factor 7-like 1 (Tcf7l1) and Is Required for Body Axis Patterning during Xenopus Embryogenesis. J Biol Chem (2015) 0.76
Binding site discovery from nucleic acid sequences by discriminative learning of hidden Markov models. Nucleic Acids Res (2014) 0.76
SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation. Epigenetics Chromatin (2017) 0.75
G protein-coupled receptors in stem cell maintenance and somatic reprogramming to pluripotent or cancer stem cells. BMB Rep (2015) 0.75
Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality. Development (2016) 0.75
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Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell (1998) 19.05
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell (2003) 17.72
Rational siRNA design for RNA interference. Nat Biotechnol (2004) 14.16
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med (2003) 12.94
A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81
Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
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Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84
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beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell (2001) 8.41
Wnt signalling regulates adult hippocampal neurogenesis. Nature (2005) 6.66
Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (2005) 6.14
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol (2004) 5.82
New type of POU domain in germ line-specific protein Oct-4. Nature (1990) 5.65
Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol (2001) 5.42
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature (1998) 5.16
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol (2006) 4.81
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Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol (2005) 3.97
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Tcf3 governs stem cell features and represses cell fate determination in skin. Cell (2006) 3.88
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Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol (2005) 3.41
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Groucho/TLE family proteins and transcriptional repression. Gene (2000) 3.31
All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res (2001) 2.98
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beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol (2003) 2.85
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol (2002) 2.64
Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol Cell Biol (2006) 2.63
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Tcf3: a transcriptional regulator of axis induction in the early embryo. Development (2003) 2.26
Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation. Mol Cell Biol (2005) 2.07
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Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. Dev Dyn (2005) 1.60
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Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development (2004) 1.50
T-box genes and heart development: putting the "T" in heart. Dev Dyn (2005) 1.49
Back to basics: Sox genes. Dev Dyn (2007) 1.43
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GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos. Development (2005) 1.40
Wnt7b regulates placental development in mice. Dev Biol (2001) 1.37
Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression. Mol Cell Neurosci (2003) 1.32
Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling. Dev Dyn (2007) 1.12
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell (2006) 14.70
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature (2008) 9.83
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Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med (2013) 7.48
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell (2007) 7.05
A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol (2008) 6.90
Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem (2005) 6.05
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev (2007) 5.79
Transposable elements have rewired the core regulatory network of human embryonic stem cells. Nat Genet (2010) 5.26
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol (2006) 4.81
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol (2005) 4.54
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature (2010) 4.38
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell (2012) 3.92
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
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Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol (2008) 3.37
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem (2006) 3.24
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Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell (2009) 3.02
MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes (2009) 3.02
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell (2011) 3.00
miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One (2009) 2.97
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell (2010) 2.89
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Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation (2010) 2.39
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
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Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes Dev (2009) 2.18
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MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
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Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet (2009) 1.76
Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells (2009) 1.72
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p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J Biol Chem (2004) 1.70
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Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells (2011) 1.51
Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells (2010) 1.44
Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state. Stem Cells (2010) 1.44
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Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Cell Stem Cell (2013) 1.42
KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells. Stem Cells (2009) 1.39
C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence. Nat Cell Biol (2013) 1.36
Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev (2012) 1.34
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