Telomeres-structure, function, and regulation.

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Published in Exp Cell Res on September 21, 2012

Authors

Weisi Lu1, Yi Zhang, Dan Liu, Zhou Songyang, Ma Wan

Author Affiliations

1: State Key Laboratory for Biocontrol, SYSU, Guangzhou, PR China.

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A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J Mol Biol (1978) 6.45

Cloning yeast telomeres on linear plasmid vectors. Cell (1982) 6.39

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