Published in Diabetes on December 01, 2004
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest (2012) 4.01
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci U S A (2007) 3.40
Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth. PLoS Comput Biol (2009) 2.81
Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet (2006) 2.80
Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol (2008) 2.45
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo. Cell (2015) 2.31
The use of animal models in diabetes research. Br J Pharmacol (2012) 2.15
Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome. Cell Metab (2015) 1.81
The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. J Lipid Res (2012) 1.74
Reduced body weight is a common effect of gene knockout in mice. BMC Genet (2008) 1.72
Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice. Diabetologia (2014) 1.49
Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria. Diabetes (2015) 1.45
A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease. Diabetes (2010) 1.41
Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ. J Anat (2008) 1.36
Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. PLoS One (2012) 1.17
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest (2011) 1.15
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J Clin Invest (2005) 1.14
Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects. PLoS One (2012) 1.13
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS One (2012) 1.12
Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiol Rev (2015) 1.10
Metabolic and cardiovascular implications of a metabolically healthy obesity phenotype. Endocrinol Metab (Seoul) (2014) 1.09
A decade of progress in adipose tissue macrophage biology. Immunol Rev (2014) 1.07
The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage. Cell Metab (2015) 1.05
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Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice. Mamm Genome (2006) 1.05
Metabolically healthy and unhealthy obese--the 2013 Stock Conference report. Obes Rev (2014) 1.04
Waves of adipose tissue growth in the genetically obese Zucker fatty rat. PLoS One (2010) 1.03
Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med (2013) 1.02
Candidate genes for obesity revealed from a C57BL/6J x 129S1/SvImJ intercross. Int J Obes (Lond) (2008) 1.02
Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo. Mol Cell Biol (2014) 1.02
Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning. J Clin Invest (2016) 0.97
Effects of murine norovirus infection on a mouse model of diet-induced obesity and insulin resistance. Comp Med (2010) 0.95
Activation of hindbrain neurons in response to gastrointestinal lipid is attenuated by high fat, high energy diets in mice prone to diet-induced obesity. Brain Res (2008) 0.93
Genome-wide profiling of microRNAs in adipose mesenchymal stem cell differentiation and mouse models of obesity. PLoS One (2011) 0.92
Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice. Diabetologia (2013) 0.91
Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol (2010) 0.91
Nutrigenomics of high fat diet induced obesity in mice suggests relationships between susceptibility to fatty liver disease and the proteasome. PLoS One (2013) 0.91
Differential effects of sucrose and fructose on dietary obesity in four mouse strains. Physiol Behav (2010) 0.90
Exercise and diet affect quantitative trait loci for body weight and composition traits in an advanced intercross population of mice. Physiol Genomics (2012) 0.86
QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects. PLoS One (2013) 0.86
Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a Western diet. J Biol Chem (2013) 0.85
Wheel access does not attenuate weight gain in mice fed high-fat or high-CHO diets. Med Sci Sports Exerc (2010) 0.85
Targeted proteomics reveals strain-specific changes in the mouse insulin and central metabolic pathways after a sustained high-fat diet. Mol Syst Biol (2013) 0.85
Susceptibility of Different Mouse Wild Type Strains to Develop Diet-Induced NAFLD/AFLD-Associated Liver Disease. PLoS One (2016) 0.84
Knockout mouse models of insulin signaling: Relevance past and future. World J Diabetes (2014) 0.83
Strategies for assessment of botanical action on metabolic syndrome in the mouse and evidence for a genotype-specific effect of Russian tarragon in the regulation of insulin sensitivity. Metabolism (2008) 0.83
Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome. Mol Metab (2016) 0.82
Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling. Toxicol Appl Pharmacol (2015) 0.82
Cidea improves the metabolic profile through expansion of adipose tissue. Nat Commun (2015) 0.82
SOCS-1 deficiency does not prevent diet-induced insulin resistance. Biochem Biophys Res Commun (2008) 0.82
FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemia. FASEB J (2009) 0.82
Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox. Appetite (2006) 0.81
Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism. Diabetes (2015) 0.80
Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD. Am J Physiol Endocrinol Metab (2015) 0.80
Genetic variance contributes to dopamine and opioid receptor antagonist-induced inhibition of intralipid (fat) intake in inbred and outbred mouse strains. Brain Res (2009) 0.80
World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease: part 2. Diabetes Care (2011) 0.80
Mouse models and type 2 diabetes: translational opportunities. Mamm Genome (2011) 0.79
Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance- obesity is no road to late-onset diabetes in mice. PLoS One (2013) 0.78
Hürthle cells predict hypothyroidism in interferon-γ transgenic mice of different genetic backgrounds. Endocrinology (2012) 0.78
Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice. Biochem Pharmacol (2014) 0.78
Diet-induced obesity modulates epigenetic responses to ionizing radiation in mice. PLoS One (2014) 0.78
Low level of trans-10, cis-12 conjugated linoleic acid decreases adiposity and increases browning independent of inflammatory signaling in overweight Sv129 mice. J Nutr Biochem (2015) 0.78
C57BL/6J mice as a polygenic developmental model of diet-induced obesity. Physiol Rep (2017) 0.78
Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans. J Clin Endocrinol Metab (2015) 0.77
Effect of Hypericum perforatum L. extract on insulin resistance and lipid metabolic disorder in high-fat-diet induced obese mice. Phytother Res (2014) 0.76
Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. Behav Brain Res (2015) 0.76
Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice. Mamm Genome (2014) 0.76
High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population. BMC Genet (2016) 0.76
Genetic dissection of susceptibility genes for diabetes and related phenotypes on mouse chromosome 14 by means of congenic strains. BMC Genet (2014) 0.75
Coordinate control of adipose 'browning' and energy expenditure by β-adrenergic and natriuretic peptide signalling. Int J Obes Suppl (2014) 0.75
Effects of G6pc2 deletion on body weight and cholesterol in mice. J Mol Endocrinol (2017) 0.75
Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals. Sci Rep (2016) 0.75
SNP-SNP interactions between WNT4 and WNT5A were associated with obesity related traits in Han Chinese Population. Sci Rep (2017) 0.75
WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice. EBioMedicine (2017) 0.75
Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. Front Physiol (2016) 0.75
Lean Body Weight and Metformin Are Insufficient to Prevent Endometrial Hyperplasia in Mice Harboring Inactivating Mutations in PTEN. Oncology (2016) 0.75
Retinol as a cofactor for PKCδ-mediated impairment of insulin sensitivity in a mouse model of diet-induced obesity. FASEB J (2015) 0.75
Genetic backgrounds determine brown remodeling of white fat in rodents. Mol Metab (2016) 0.75
Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. J Clin Invest (2017) 0.75
Prolactin activation of the long form of its cognate receptor causes increased visceral fat and obesity in males as shown in transgenic mice expressing only this receptor subtype. Horm Metab Res (2011) 0.75
Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 20.57
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol (2006) 10.67
Developmental origin of fat: tracking obesity to its source. Cell (2007) 8.80
Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab (2008) 7.97
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature (2008) 6.82
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A (2009) 5.19
Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab (2008) 5.07
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell (2002) 5.01
Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci U S A (2006) 4.81
From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol (2006) 4.58
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov (2010) 4.23
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol (2004) 3.79
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69
Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med (2008) 3.66
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell (2005) 3.52
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci U S A (2007) 3.40
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab (2006) 3.34
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Endocrine regulation of ageing. Nat Rev Mol Cell Biol (2007) 3.28
Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci U S A (2010) 3.16
Retracted Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J Biol Chem (2003) 3.06
Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab (2010) 3.05
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest (2003) 2.87
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med (2012) 2.86
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab (2006) 2.82
The emerging genetic architecture of type 2 diabetes. Cell Metab (2008) 2.77
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes (2005) 2.72
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol (2005) 2.68
Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics (2012) 2.66
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest (2002) 2.65
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest (2004) 2.56
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A (2004) 2.54
Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A (2004) 2.54
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest (2002) 2.53
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2001) 2.49
Phlorizin: a review. Diabetes Metab Res Rev (2005) 2.48
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol (2002) 2.42
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab (2007) 2.42
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A (2011) 2.41
Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates. Proc Natl Acad Sci U S A (2006) 2.32
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (2002) 2.28
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet (2006) 2.21
Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol (2011) 2.20
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest (2007) 2.17
Mouse models of insulin resistance. Physiol Rev (2004) 2.16
Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol (2004) 2.14
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest (2003) 2.11
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J (2003) 2.11
Dissection of the insulin signaling pathway via quantitative phosphoproteomics. Proc Natl Acad Sci U S A (2008) 2.11
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab (2010) 2.09
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol (2006) 2.09
Lessons on conditional gene targeting in mouse adipose tissue. Diabetes (2013) 2.04
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest (2005) 2.01
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A (2013) 2.01
Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest (2008) 2.00
The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev (2004) 1.98
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochem J (2011) 1.96
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med (2010) 1.93
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
Brown fat as a therapy for obesity and diabetes. Curr Opin Endocrinol Diabetes Obes (2010) 1.93
Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes (2012) 1.91
Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Proc Natl Acad Sci U S A (2002) 1.86
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem (2002) 1.86
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A (2004) 1.80
Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proc Natl Acad Sci U S A (2006) 1.79
Glypican-4 enhances insulin signaling via interaction with the insulin receptor and serves as a novel adipokine. Diabetes (2012) 1.76
Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes (2009) 1.76
Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One (2011) 1.74
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes (2003) 1.73
Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. J Clin Invest (2003) 1.73
Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. J Biol Chem (2003) 1.72
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J Clin Invest (2004) 1.71
Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest (2010) 1.70
Insulin receptor knockout mice. Annu Rev Physiol (2002) 1.70
Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology (2004) 1.69
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab (2003) 1.68
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. Cancer Res (2003) 1.66
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. Metabolism (2012) 1.63
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol (2003) 1.60
Role of Foxa-2 in adipocyte metabolism and differentiation. J Clin Invest (2003) 1.60
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat Med (2012) 1.57
Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol (2010) 1.56
Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci U S A (2012) 1.56
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. J Clin Invest (2013) 1.55
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev (2002) 1.52
Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab (2012) 1.52
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell (2007) 1.52
Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem (2008) 1.52
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab (2006) 1.50
Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun (2012) 1.43
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest (2003) 1.43
TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity. Mol Cell Biol (2007) 1.43