Mechanism and function of deubiquitinating enzymes.

One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol (2008) 8.68

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem (2009) 6.23

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23

Origin and function of ubiquitin-like proteins. Nature (2009) 4.22

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J Virol (2005) 2.49

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35

Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell (2005) 2.31

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Mol Biol Cell (2007) 2.28

The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme. J Virol (2005) 2.27

Targeting proteins for degradation. Nat Chem Biol (2009) 2.22

Protein partners of deubiquitinating enzymes. Biochem J (2008) 2.15

Interferon-stimulated gene 15 and the protein ISGylation system. J Interferon Cytokine Res (2010) 2.14

A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol (2008) 2.12

The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem (2008) 2.09

Insights into the evolution of Archaea and eukaryotic protein modifier systems revealed by the genome of a novel archaeal group. Nucleic Acids Res (2010) 2.00

SseL, a Salmonella deubiquitinase required for macrophage killing and virulence. Proc Natl Acad Sci U S A (2007) 1.99

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol (2014) 1.86

A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. J Virol (2005) 1.85

Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20. J Mol Biol (2007) 1.82

Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol (2009) 1.82

Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding. Wiley Interdiscip Rev Syst Biol Med (2012) 1.81

Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways. Curr Opin Struct Biol (2007) 1.76

The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme. EMBO J (2005) 1.76

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Mol Cell Biol (2007) 1.76

Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. J Biol Chem (2008) 1.75

Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1. Proc Natl Acad Sci U S A (2006) 1.74

Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins. Genes Dev (2007) 1.57

Screen for ISG15-crossreactive deubiquitinases. PLoS One (2007) 1.57

Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane. Mol Biol Cell (2008) 1.48

Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodies. EMBO J (2007) 1.48

A novel type of E3 ligase for the Ufm1 conjugation system. J Biol Chem (2009) 1.47

Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain. Proc Natl Acad Sci U S A (2005) 1.46

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3. EMBO J (2009) 1.46

Deubiquitinating enzymes as novel anticancer targets. Future Oncol (2007) 1.43

Regulation of catalytic activities of HECT ubiquitin ligases. Biochem Biophys Res Commun (2007) 1.42

Ligation independent cloning vectors for expression of SUMO fusions. Protein Expr Purif (2006) 1.42

Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42

Regulation of the epithelial sodium channel by membrane trafficking. Am J Physiol Renal Physiol (2008) 1.41

Plasticity of polyubiquitin recognition as lysosomal targeting signals by the endosomal sorting machinery. Mol Biol Cell (2007) 1.37

Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev (2009) 1.36

Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Biol (2011) 1.35

Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat Genet (2009) 1.33

Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer. Clin Proteomics (2011) 1.32

Dissecting the ubiquitin pathway by mass spectrometry. Biochim Biophys Acta (2006) 1.32

An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem Biophys (2011) 1.30

Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies. J Clin Oncol (2013) 1.30

Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome. Nat Struct Mol Biol (2009) 1.30

Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci (2008) 1.26

DUBs at a glance. J Cell Sci (2009) 1.26

Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes. J Cell Biol (2006) 1.22

Thioesterases: a new perspective based on their primary and tertiary structures. Protein Sci (2010) 1.22

Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids. Mol Cell (2010) 1.21

Ubiquitin in NF-kappaB signaling. Chem Rev (2009) 1.20

Proteomic snapshot of the EGF-induced ubiquitin network. Mol Syst Biol (2011) 1.19

The discovery of ubiquitin-dependent proteolysis. Proc Natl Acad Sci U S A (2005) 1.18

Deubiquitylating enzymes and disease. BMC Biochem (2008) 1.17

Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. Cell Signal (2012) 1.16

Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery. ACS Chem Biol (2009) 1.16

c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells. J Biol Chem (2010) 1.15

A conditional yeast E1 mutant blocks the ubiquitin-proteasome pathway and reveals a role for ubiquitin conjugates in targeting Rad23 to the proteasome. Mol Biol Cell (2007) 1.14

Cleavage specificity of the UL48 deubiquitinating protease activity of human cytomegalovirus and the growth of an active-site mutant virus in cultured cells. J Virol (2009) 1.13

Characterization of polyubiquitin chain structure by middle-down mass spectrometry. Anal Chem (2008) 1.13

Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. J Biol Chem (2010) 1.12

ElaD, a Deubiquitinating protease expressed by E. coli. PLoS One (2007) 1.11

Dynamic regulation of PCNA ubiquitylation/deubiquitylation. FEBS Lett (2011) 1.10

Ubiquitination is required for effective replication of coxsackievirus B3. PLoS One (2008) 1.09

Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer. J Cancer Res Clin Oncol (2011) 1.08

Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes). Biochem J (2008) 1.08

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates. J Cell Biol (2009) 1.07

TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Oncogene (2010) 1.06

A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function. J Cell Biol (2006) 1.04

Hepatitis E virus inhibits type I interferon induction by ORF1 products. J Virol (2014) 1.03

Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration. Proc Natl Acad Sci U S A (2009) 1.03

Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages. Infect Immun (2009) 1.03

Deubiquitinases and the new therapeutic opportunities offered to cancer. Endocr Relat Cancer (2015) 1.02

OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity. J Biol Chem (2009) 1.02

Properties of the ubiquitin-pex5p thiol ester conjugate. J Biol Chem (2009) 1.02

Ubiquitylation of proteins in livers of hibernating golden-mantled ground squirrels, Spermophilus lateralis. Cryobiology (2007) 1.01

Epstein-barr virus encodes three bona fide ubiquitin-specific proteases. J Virol (2008) 1.01

The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessays (2008) 1.01

Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format. Assay Drug Dev Technol (2010) 1.00

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res (2014) 1.00

The ubiquitin-proteasome pathway in Huntington's disease. ScientificWorldJournal (2008) 0.99

Regulation of the epithelial sodium channel (ENaC) by membrane trafficking. Biochim Biophys Acta (2010) 0.99

Prokaryotic ubiquitin-like protein modification. Annu Rev Microbiol (2014) 0.99

Ubiquitin-specific protease16 modulates salt tolerance in Arabidopsis by regulating Na(+)/H(+) antiport activity and serine hydroxymethyltransferase stability. Plant Cell (2012) 0.98

Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity. J Biol Chem (2010) 0.98

Chronic ethanol feeding affects proteasome-interacting proteins. Proteomics (2009) 0.98

Archaeal JAB1/MPN/MOV34 metalloenzyme (HvJAMM1) cleaves ubiquitin-like small archaeal modifier proteins (SAMPs) from protein-conjugates. Mol Microbiol (2012) 0.98

Kaposi's sarcoma-associated herpesvirus encodes a viral deubiquitinase. J Virol (2009) 0.97

Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics (2009) 0.97

A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection. J Virol (2007) 0.97

The pupylation pathway and its role in mycobacteria. BMC Biol (2012) 0.97

An atomic structure of the human 26S proteasome. Nat Struct Mol Biol (2016) 0.96

The ubiquitin-specific protease subfamily UBP3/UBP4 is essential for pollen development and transmission in Arabidopsis. Plant Physiol (2007) 0.96

The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP. Genes Dev (2013) 0.96

Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress. EMBO J (2011) 0.95

Essential role of nuclear localization for yeast Ulp2 SUMO protease function. Mol Biol Cell (2009) 0.95

The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation. Toxicol Appl Pharmacol (2008) 0.95

Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol (2006) 10.74

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16

Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol (2008) 4.42

Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53

A superfamily of protein tags: ubiquitin, SUMO and related modifiers. Trends Biochem Sci (2003) 3.19

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J (2006) 2.58

Function and regulation of SUMO proteases. Nat Rev Mol Cell Biol (2012) 2.55

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. J Biol Chem (2004) 2.41

Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Mol Cell (2010) 2.35

Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat Cell Biol (2007) 2.32

A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol (2008) 2.20

The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. J Biol Chem (2007) 2.14

Molecular architecture and assembly of the eukaryotic proteasome. Annu Rev Biochem (2013) 2.04

The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. J Cell Biol (2003) 1.97

Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell (2009) 1.85

Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature (2006) 1.78

Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state. Genes Dev (2003) 1.76

Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). J Biol Chem (2005) 1.68

Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing. Proc Natl Acad Sci U S A (2005) 1.55

beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J (2007) 1.52

Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability. J Cell Sci (2004) 1.42

An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci U S A (2006) 1.35

Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast. EMBO J (2004) 1.34

A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance. J Cell Biol (2007) 1.29

SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor. Genes Dev (2010) 1.28

Small epitope-linker modules for PCR-based C-terminal tagging in Saccharomyces cerevisiae. Yeast (2009) 1.20

Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis. Biol Chem (2008) 1.16

The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint. Mol Cell Biol (2007) 1.13

A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel. Structure (2009) 1.11

Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Hepatology (2008) 1.07

A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding. Nat Struct Mol Biol (2011) 1.05

A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function. J Cell Biol (2006) 1.04

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Biol (2012) 1.03

Order of the proteasomal ATPases and eukaryotic proteasome assembly. Cell Biochem Biophys (2011) 1.03

An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme. J Biol Chem (2011) 1.02

Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining. Mol Cell (2011) 0.98

The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. Cell Cycle (2009) 0.97

Essential role of nuclear localization for yeast Ulp2 SUMO protease function. Mol Biol Cell (2009) 0.95

Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol (2014) 0.92

Ubiquitin signalling: what's in a chain? Nat Cell Biol (2004) 0.92

Designed proteins to modulate cellular networks. ACS Chem Biol (2010) 0.89

The short-lived Matalpha2 transcriptional repressor is protected from degradation in vivo by interactions with its corepressors Tup1 and Ssn6. Mol Cell Biol (2006) 0.89

Assembly of the 20S proteasome. Biochim Biophys Acta (2013) 0.88

Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor. Cell Cycle (2010) 0.88

Analysis of protein ubiquitination. Curr Protoc Protein Sci (2011) 0.88

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Mol Biol Cell (2013) 0.88

Introduction to intracellular protein degradation. Chem Rev (2009) 0.87

A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. J Biol Chem (2013) 0.86

Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Mol Cell Biol (2011) 0.85

Ulp2 and the DNA damage response: desumoylation enables safe passage through mitosis. Cell Cycle (2007) 0.83

Assaying protein ubiquitination in Saccharomyces cerevisiae. Methods Enzymol (2002) 0.82

Identification of SUMO-interacting proteins by yeast two-hybrid analysis. Methods Mol Biol (2009) 0.82

Analysis of protein ubiquitination. Curr Protoc Protein Sci (2002) 0.82

A WLM protein with SUMO-directed protease activity. Mol Cell Biol (2010) 0.79

NF-kappaB signaling: flipping the switch with polyubiquitin chains. Curr Biol (2004) 0.78

Preparation and characterization of yeast and human desumoylating enzymes. Methods Enzymol (2005) 0.78

Ubiquitin-dependent control of development in Saccharomyces cerevisiae. Curr Opin Microbiol (2004) 0.77

A new class of SUMO proteases. EMBO Rep (2012) 0.76

Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene. PLoS One (2012) 0.76

Varshavsky's contributions. Science (2004) 0.75