Published in J Cell Biol on December 04, 2006
ESCRT complexes and the biogenesis of multivesicular bodies. Curr Opin Cell Biol (2008) 3.90
The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73
How ubiquitin functions with ESCRTs. Traffic (2011) 1.51
Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodies. EMBO J (2007) 1.48
Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev (2009) 1.36
MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between. Curr Opin Cell Biol (2011) 1.33
Reverse the curse--the role of deubiquitination in cell cycle control. Curr Opin Cell Biol (2008) 1.31
Molecular mechanisms of ubiquitin-dependent membrane traffic. Annu Rev Biophys (2011) 1.19
Ubiquitin-dependent sorting in endocytosis. Cold Spring Harb Perspect Biol (2014) 1.10
A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol (2010) 1.08
DOA1/UFD3 plays a role in sorting ubiquitinated membrane proteins into multivesicular bodies. J Biol Chem (2008) 1.08
The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes. Dev Cell (2013) 1.05
Split-ubiquitin two-hybrid assay to analyze protein-protein interactions at the endosome: application to Saccharomyces cerevisiae Bro1 interacting with ESCRT complexes, the Doa4 ubiquitin hydrolase, and the Rsp5 ubiquitin ligase. Eukaryot Cell (2007) 1.02
Structural basis for ESCRT-III CHMP3 recruitment of AMSH. Structure (2011) 1.00
Environmental stresses disrupt telomere length homeostasis. PLoS Genet (2013) 1.00
Intersection of the multivesicular body pathway and lipid homeostasis in RNA replication by a positive-strand RNA virus. J Virol (2011) 0.91
Multiplexed, Proteome-Wide Protein Expression Profiling: Yeast Deubiquitylating Enzyme Knockout Strains. J Proteome Res (2015) 0.84
Intervention of Bro1 in pH-responsive Rim20 localization in Saccharomyces cerevisiae. Eukaryot Cell (2010) 0.82
Doa4 function in ILV budding is restricted through its interaction with the Vps20 subunit of ESCRT-III. J Cell Sci (2013) 0.80
The ESCRT-III adaptor protein Bro1 controls functions of regulator for free ubiquitin chains 1 (Rfu1) in ubiquitin homeostasis. J Biol Chem (2014) 0.77
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast (1998) 48.29
The ubiquitin system. Annu Rev Biochem (1998) 43.36
A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A (2001) 33.71
Ubiquitin-dependent protein degradation. Annu Rev Genet (1996) 10.97
Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol (2002) 10.12
A genomic and functional inventory of deubiquitinating enzymes. Cell (2005) 9.36
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell (2001) 9.08
Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol (2001) 8.68
Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu Rev Cell Dev Biol (2003) 8.13
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J (1998) 7.68
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science (2002) 7.49
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell (2002) 7.32
A cryptic protease couples deubiquitination and degradation by the proteasome. Nature (2002) 6.21
Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor. Cell (1993) 5.05
Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97
Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant. Mol Biol Cell (1996) 4.71
Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta (2004) 4.54
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor. Cell (1990) 3.50
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell (2006) 3.46
The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature (1993) 3.33
Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J (1997) 3.24
Endocytosis and degradation of the yeast uracil permease under adverse conditions. J Biol Chem (1994) 3.09
The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways. Mol Biol Cell (2000) 2.94
The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast. Mol Biol Cell (1999) 2.73
Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. J Cell Sci (2003) 2.57
Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome. Mol Biol Cell (1999) 2.57
Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T. Biochemistry (1995) 2.31
Structural basis for endosomal targeting by the Bro1 domain. Dev Cell (2005) 2.28
Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae. Traffic (2004) 2.24
Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae. Biol Chem (2001) 2.10
Membrane transport: ubiquitylation in endosomal sorting. Curr Biol (2001) 2.07
In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome. EMBO J (1997) 2.03
Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes. J Cell Biol (2004) 1.93
Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol (2006) 1.76
Split decisions: coordinating cytokinesis in yeast. Trends Cell Biol (2005) 1.63
Permease recycling and ubiquitination status reveal a particular role for Bro1 in the multivesicular body pathway. J Biol Chem (2003) 1.48
Degradation of Hof1 by SCF(Grr1) is important for actomyosin contraction during cytokinesis in yeast. EMBO J (2005) 1.44
A family of yeast proteins mediating bidirectional vacuolar amino acid transport. J Biol Chem (2001) 1.40
Control of Bro1-domain protein Rim20 localization by external pH, ESCRT machinery, and the Saccharomyces cerevisiae Rim101 pathway. Mol Biol Cell (2006) 1.39
Biogenesis of the yeast vacuole (lysosome). The precursor forms of the soluble hydrolase carboxypeptidase yscS are associated with the vacuolar membrane. J Biol Chem (1992) 1.23
The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin. Mol Biol Cell (2004) 1.22
Divergent N-terminal sequences target an inducible testis deubiquitinating enzyme to distinct subcellular structures. Mol Cell Biol (2000) 1.08
The yeast deubiquitinating enzyme Ubp16 is anchored to the outer mitochondrial membrane. FEBS Lett (2003) 1.07
Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme. J Biol Chem (2004) 0.88
Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol (2006) 10.74
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16
Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta (2004) 4.54
Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol (2008) 4.42
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53
A superfamily of protein tags: ubiquitin, SUMO and related modifiers. Trends Biochem Sci (2003) 3.19
Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J (2006) 2.58
Function and regulation of SUMO proteases. Nat Rev Mol Cell Biol (2012) 2.55
Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. J Biol Chem (2004) 2.41
Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Mol Cell (2010) 2.35
Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat Cell Biol (2007) 2.32
A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol (2008) 2.20
The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. J Biol Chem (2007) 2.14
Molecular architecture and assembly of the eukaryotic proteasome. Annu Rev Biochem (2013) 2.04
The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. J Cell Biol (2003) 1.97
Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell (2009) 1.85
Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature (2006) 1.78
Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state. Genes Dev (2003) 1.76
Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). J Biol Chem (2005) 1.68
Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing. Proc Natl Acad Sci U S A (2005) 1.55
beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J (2007) 1.52
Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability. J Cell Sci (2004) 1.42
An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci U S A (2006) 1.35
Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast. EMBO J (2004) 1.34
A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance. J Cell Biol (2007) 1.29
SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor. Genes Dev (2010) 1.28
Small epitope-linker modules for PCR-based C-terminal tagging in Saccharomyces cerevisiae. Yeast (2009) 1.20
Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis. Biol Chem (2008) 1.16
The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint. Mol Cell Biol (2007) 1.13
A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel. Structure (2009) 1.11
Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Hepatology (2008) 1.07
A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding. Nat Struct Mol Biol (2011) 1.05
Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Biol (2012) 1.03
Order of the proteasomal ATPases and eukaryotic proteasome assembly. Cell Biochem Biophys (2011) 1.03
An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme. J Biol Chem (2011) 1.02
Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining. Mol Cell (2011) 0.98
De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane. Mol Cell Biochem (2006) 0.97
The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. Cell Cycle (2009) 0.97
Essential role of nuclear localization for yeast Ulp2 SUMO protease function. Mol Biol Cell (2009) 0.95
Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol (2014) 0.92
Ubiquitin signalling: what's in a chain? Nat Cell Biol (2004) 0.92
Designed proteins to modulate cellular networks. ACS Chem Biol (2010) 0.89
The short-lived Matalpha2 transcriptional repressor is protected from degradation in vivo by interactions with its corepressors Tup1 and Ssn6. Mol Cell Biol (2006) 0.89
Assembly of the 20S proteasome. Biochim Biophys Acta (2013) 0.88
Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor. Cell Cycle (2010) 0.88
N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Mol Biol Cell (2013) 0.88
Analysis of protein ubiquitination. Curr Protoc Protein Sci (2011) 0.88
Introduction to intracellular protein degradation. Chem Rev (2009) 0.87
A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. J Biol Chem (2013) 0.86
Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Mol Cell Biol (2011) 0.85
Ulp2 and the DNA damage response: desumoylation enables safe passage through mitosis. Cell Cycle (2007) 0.83
Identification of SUMO-interacting proteins by yeast two-hybrid analysis. Methods Mol Biol (2009) 0.82
Assaying protein ubiquitination in Saccharomyces cerevisiae. Methods Enzymol (2002) 0.82
Analysis of protein ubiquitination. Curr Protoc Protein Sci (2002) 0.82
A WLM protein with SUMO-directed protease activity. Mol Cell Biol (2010) 0.79
Preparation and characterization of yeast and human desumoylating enzymes. Methods Enzymol (2005) 0.78
NF-kappaB signaling: flipping the switch with polyubiquitin chains. Curr Biol (2004) 0.78
Ubiquitin-dependent control of development in Saccharomyces cerevisiae. Curr Opin Microbiol (2004) 0.77
A new class of SUMO proteases. EMBO Rep (2012) 0.76
Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene. PLoS One (2012) 0.76
Varshavsky's contributions. Science (2004) 0.75