Published in Trends Genet on February 01, 2005
Genomewide comparative analysis of alternative splicing in plants. Proc Natl Acad Sci U S A (2006) 4.51
Alternative splicing and evolution: diversification, exon definition and function. Nat Rev Genet (2010) 4.30
Sex-specific and lineage-specific alternative splicing in primates. Genome Res (2009) 3.61
Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev (2006) 3.18
Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dog and human. PLoS Comput Biol (2006) 3.07
Protein modularity of alternatively spliced exons is associated with tissue-specific regulation of alternative splicing. PLoS Genet (2005) 2.63
Complexity of the alternative splicing landscape in plants. Plant Cell (2013) 2.62
Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol (2008) 2.25
Global analysis of alternative splicing during T-cell activation. RNA (2007) 2.11
Stochastic noise in splicing machinery. Nucleic Acids Res (2009) 2.06
Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks. Mol Cell (2012) 2.02
Function of alternative splicing. Gene (2012) 2.00
Global analysis of alternative splicing differences between humans and chimpanzees. Genes Dev (2007) 2.00
Splice site strength-dependent activity and genetic buffering by poly-G runs. Nat Struct Mol Biol (2009) 1.99
Functional coordination of alternative splicing in the mammalian central nervous system. Genome Biol (2007) 1.80
Regulation of alternative splicing by the core spliceosomal machinery. Genes Dev (2011) 1.60
Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A (2010) 1.59
Characterization of intron loss events in mammals. Genome Res (2006) 1.56
Alternative splicing regulation at tandem 3' splice sites. Nucleic Acids Res (2006) 1.53
Transcriptome analyses of the human retina identify unprecedented transcript diversity and 3.5 Mb of novel transcribed sequence via significant alternative splicing and novel genes. BMC Genomics (2013) 1.46
Genome-wide analysis of alternative splicing in Caenorhabditis elegans. Genome Res (2010) 1.46
A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. Genome Res (2008) 1.44
RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell (2016) 1.42
Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. Genome Res (2011) 1.38
Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Genome Res (2007) 1.37
Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles. Nucleic Acids Res (2005) 1.34
Genetic resources, genome mapping and evolutionary genomics of the pig (Sus scrofa). Int J Biol Sci (2007) 1.29
The "alternative" choice of constitutive exons throughout evolution. PLoS Genet (2007) 1.27
Evolution of Nova-dependent splicing regulation in the brain. PLoS Genet (2007) 1.23
Positive selection acting on splicing motifs reflects compensatory evolution. Genome Res (2008) 1.18
Ab initio prediction of mutation-induced cryptic splice-site activation and exon skipping. Eur J Hum Genet (2009) 1.18
Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay. BMC Biol (2009) 1.11
Dual-specificity splice sites function alternatively as 5' and 3' splice sites. Proc Natl Acad Sci U S A (2007) 1.10
When orthologs diverge between human and mouse. Brief Bioinform (2011) 1.07
SERpredict: detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements. BMC Genet (2007) 1.05
Alternative splicing networks regulated by signaling in human T cells. RNA (2012) 1.03
Identification and evolutionary analysis of novel exons and alternative splicing events using cross-species EST-to-genome comparisons in human, mouse and rat. BMC Bioinformatics (2006) 1.02
Structural implication of splicing stochastics. Nucleic Acids Res (2009) 1.01
Alternative splicing: a potential source of functional innovation in the eukaryotic genome. Int J Evol Biol (2012) 1.00
Evolution of alternative splicing in primate brain transcriptomes. Hum Mol Genet (2010) 0.99
Genomic fossils as a snapshot of the human transcriptome. Proc Natl Acad Sci U S A (2006) 0.99
Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder. Nucleic Acids Res (2010) 0.98
Epigenetic mechanisms for breakdown of self-incompatibility in interspecific hybrids. Genetics (2007) 0.96
Limitations of animal models of Parkinson's disease. Parkinsons Dis (2010) 0.96
The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms. BMC Genomics (2007) 0.95
Assessment of orthologous splicing isoforms in human and mouse orthologous genes. BMC Genomics (2010) 0.95
Assessing the fraction of short-distance tandem splice sites under purifying selection. RNA (2008) 0.95
Review: Alternative Splicing (AS) of Genes As An Approach for Generating Protein Complexity. Curr Genomics (2013) 0.91
Assessing the number of ancestral alternatively spliced exons in the human genome. BMC Genomics (2006) 0.87
Using several pair-wise informant sequences for de novo prediction of alternatively spliced transcripts. Genome Biol (2006) 0.85
Width of gene expression profile drives alternative splicing. PLoS One (2008) 0.85
Divergence of exonic splicing elements after gene duplication and the impact on gene structures. Genome Biol (2009) 0.85
Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing. Proc Natl Acad Sci U S A (2016) 0.84
A network of conserved co-occurring motifs for the regulation of alternative splicing. Nucleic Acids Res (2010) 0.83
Complex tissue-specific patterns and distribution of multiple RAGE splice variants in different mammals. Genome Biol Evol (2013) 0.82
A procedure for identifying homologous alternative splicing events. BMC Bioinformatics (2007) 0.81
The evolutionary fate of alternatively spliced homologous exons after gene duplication. Genome Biol Evol (2015) 0.81
Computational prediction of splicing regulatory elements shared by Tetrapoda organisms. BMC Genomics (2009) 0.81
Functional implications of the emergence of alternative splicing in hnRNP A/B transcripts. RNA (2010) 0.81
Evolutionary conservation of alternative splicing in chicken. Cytogenet Genome Res (2007) 0.79
Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques. Physiol Genomics (2011) 0.77
Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex. PLoS Genet (2015) 0.77
Improved identification of conserved cassette exons using Bayesian networks. BMC Bioinformatics (2008) 0.76
Correspondence of D. melanogaster and C. elegans developmental stages revealed by alternative splicing characteristics of conserved exons. BMC Genomics (2017) 0.75
The Mouse-Specific Splice Variant mRAGE_v4 Encodes a Membrane-Bound RAGE That Is Resistant to Shedding and Does Not Contribute to the Production of Soluble RAGE. PLoS One (2016) 0.75
RNA editing-dependent epitranscriptome diversity in cancer stem cells. Nat Rev Cancer (2017) 0.75
The relationship between gene isoform multiplicity, number of exons and protein divergence. PLoS One (2013) 0.75
Estimating the prevalence of functional exonic splice regulatory information. Hum Genet (2017) 0.75
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet (2008) 24.51
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Structures of the bacterial ribosome at 3.5 A resolution. Science (2005) 12.63
A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet (2007) 12.21
The DNA-encoded nucleosome organization of a eukaryotic genome. Nature (2008) 11.41
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res (2010) 10.97
Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature (2011) 10.16
Cytoscape Web: an interactive web-based network browser. Bioinformatics (2010) 10.03
Diversity and complexity in DNA recognition by transcription factors. Science (2009) 9.07
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
The first metal-organic framework (MOF) of Imazethapyr and its SHG, piezoelectric and ferroelectric properties. Dalton Trans (2008) 8.86
The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell (2010) 8.66
Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. Cell (2007) 8.43
FunSpec: a web-based cluster interpreter for yeast. BMC Bioinformatics (2002) 8.01
Regulation of alternative splicing by histone modifications. Science (2010) 7.98
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell (2008) 7.93
An RNA map predicting Nova-dependent splicing regulation. Nature (2006) 7.63
Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Mol Cell (2004) 7.32
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
Hydrogen-bonded ferroelectrics based on metal-organic coordination. J Am Chem Soc (2009) 6.69
Most "dark matter" transcripts are associated with known genes. PLoS Biol (2010) 6.60
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
Deciphering the splicing code. Nature (2010) 6.27
GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function. Genome Biol (2008) 5.94
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell (2003) 5.57
Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J Biol Chem (2006) 5.50
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol (2009) 5.41
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
DNA-binding specificities of human transcription factors. Cell (2013) 5.14
A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91
Probing microRNAs with microarrays: tissue specificity and functional inference. RNA (2004) 4.91
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78
A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78
The evolutionary landscape of alternative splicing in vertebrate species. Science (2012) 4.78
Supramolecular bola-like ferroelectric: 4-methoxyanilinium tetrafluoroborate-18-crown-6. J Am Chem Soc (2011) 4.73
Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet (2002) 4.68
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell (2008) 4.49
Diisopropylammonium chloride: a ferroelectric organic salt with a high phase transition temperature and practical utilization level of spontaneous polarization. Adv Mater (2011) 4.30
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
Rapid tRNA decay can result from lack of nonessential modifications. Mol Cell (2006) 3.86
Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors. Mol Cell Biol (2004) 3.72
Identification of a bacterial type III effector family with G protein mimicry functions. Cell (2006) 3.47
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. Genome Res (2010) 3.46
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat Biotechnol (2009) 3.44
Using expression profiling data to identify human microRNA targets. Nat Methods (2007) 3.37
Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev (2006) 3.18
Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection. Clin Infect Dis (2010) 3.12
A panoramic view of yeast noncoding RNA processing. Cell (2003) 3.11
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
G+C content dominates intrinsic nucleosome occupancy. BMC Bioinformatics (2009) 3.05
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
A multiferroic perdeutero metal-organic framework. Angew Chem Int Ed Engl (2011) 2.88
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell (2010) 2.87
Conservation of core gene expression in vertebrate tissues. J Biol (2009) 2.84
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A (2004) 2.80
GeneMANIA prediction server 2013 update. Nucleic Acids Res (2013) 2.74
Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome. PLoS Biol (2008) 2.73
SRm160 splicing coactivator promotes transcript 3'-end cleavage. Mol Cell Biol (2002) 2.73
Why are there still over 1000 uncharacterized yeast genes? Genetics (2007) 2.71
SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase. Dev Cell (2007) 2.64
Net primary production of Chinese croplands from 1950 to 1999. Ecol Appl (2007) 2.61
Structural basis for mRNA and tRNA positioning on the ribosome. Proc Natl Acad Sci U S A (2006) 2.55
Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol (2007) 2.54
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
High nucleosome occupancy is encoded at human regulatory sequences. PLoS One (2010) 2.43
RBPDB: a database of RNA-binding specificities. Nucleic Acids Res (2010) 2.42