Published in Cell on July 09, 2004
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell (2008) 7.63
Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics (2005) 5.08
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58
Tuning genetic control through promoter engineering. Proc Natl Acad Sci U S A (2005) 4.07
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Res (2005) 4.00
A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods (2008) 3.79
The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell (2008) 3.51
Mitochondrial protein import: from proteomics to functional mechanisms. Nat Rev Mol Cell Biol (2010) 2.87
Trait variation in yeast is defined by population history. PLoS Genet (2011) 2.50
Efflux-mediated antifungal drug resistance. Clin Microbiol Rev (2009) 2.44
Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A (2006) 2.39
Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell (2008) 2.39
Progress in metabolic engineering of Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2008) 2.27
Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol (2011) 2.26
A general lack of compensation for gene dosage in yeast. Mol Syst Biol (2010) 1.96
RSC mobilizes nucleosomes to improve accessibility of repair machinery to the damaged chromatin. Mol Cell Biol (2006) 1.94
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J Cell Biol (2008) 1.92
Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol (2009) 1.81
Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes. Genome Biol (2007) 1.73
A role for phosphatidic acid in the formation of "supersized" lipid droplets. PLoS Genet (2011) 1.69
The dependence of viral RNA replication on co-opted host factors. Nat Rev Microbiol (2011) 1.66
Global identification of noncoding RNAs in Saccharomyces cerevisiae by modulating an essential RNA processing pathway. Proc Natl Acad Sci U S A (2006) 1.64
Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. Nat Cell Biol (2014) 1.62
Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.61
A map of human protein interactions derived from co-expression of human mRNAs and their orthologs. Mol Syst Biol (2008) 1.53
Confirmation of organized modularity in the yeast interactome. PLoS Biol (2007) 1.52
Tunable and reversible drug control of protein production via a self-excising degron. Nat Chem Biol (2015) 1.52
Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity. Mol Syst Biol (2010) 1.50
In vivo robustness analysis of cell division cycle genes in Saccharomyces cerevisiae. PLoS Genet (2006) 1.49
Mutations in the Saccharomyces cerevisiae RPB1 gene conferring hypersensitivity to 6-azauracil. Genetics (2006) 1.47
Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1. PLoS Genet (2011) 1.47
Analysis of transcriptional activation at a distance in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.46
Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1. J Cell Biol (2006) 1.44
The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet (2011) 1.41
The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease. Genome Res (2016) 1.40
Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L. EMBO J (2011) 1.40
GeneWeaver: a web-based system for integrative functional genomics. Nucleic Acids Res (2011) 1.39
Cdc34p ubiquitin-conjugating enzyme is a component of the tombusvirus replicase complex and ubiquitinates p33 replication protein. J Virol (2008) 1.38
Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nat Struct Mol Biol (2009) 1.36
Identification of essential host factors affecting tombusvirus RNA replication based on the yeast Tet promoters Hughes Collection. J Virol (2006) 1.36
Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. J Cell Biol (2008) 1.33
Evolution. Systematic humanization of yeast genes reveals conserved functions and genetic modularity. Science (2015) 1.32
The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae. J Cell Biol (2008) 1.31
A fast and efficient translational control system for conditional expression of yeast genes. Nucleic Acids Res (2009) 1.26
The small subunit processome is required for cell cycle progression at G1. Mol Biol Cell (2004) 1.26
Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae. Proc Natl Acad Sci U S A (2007) 1.25
Rpb9 subunit controls transcription fidelity by delaying NTP sequestration in RNA polymerase II. J Biol Chem (2009) 1.25
The cotranscriptional assembly of snoRNPs controls the biosynthesis of H/ACA snoRNAs in Saccharomyces cerevisiae. Mol Cell Biol (2005) 1.24
Screening of the yeast yTHC collection identifies essential host factors affecting tombusvirus RNA recombination. J Virol (2006) 1.23
A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell (2006) 1.23
Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast. Mol Biol Cell (2005) 1.23
Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet (2012) 1.20
Systems-level antimicrobial drug and drug synergy discovery. Nat Chem Biol (2013) 1.19
A prototrophic deletion mutant collection for yeast metabolomics and systems biology. Nat Biotechnol (2012) 1.19
Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast. Mol Biol Cell (2006) 1.19
Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription. Mol Cell Biol (2007) 1.18
Predicting gene targets of perturbations via network-based filtering of mRNA expression compendia. Bioinformatics (2008) 1.18
Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. Microb Cell Fact (2006) 1.17
The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast. J Cell Biol (2011) 1.16
The mRNA encoding the yeast ARE-binding protein Cth2 is generated by a novel 3' processing pathway. Nucleic Acids Res (2008) 1.15
Incorporating functional inter-relationships into protein function prediction algorithms. BMC Bioinformatics (2009) 1.14
Inferring condition-specific transcription factor function from DNA binding and gene expression data. Mol Syst Biol (2007) 1.13
Efficient protein depletion by genetically controlled deprotection of a dormant N-degron. Mol Syst Biol (2009) 1.12
High confidence prediction of essential genes in Burkholderia cenocepacia. PLoS One (2012) 1.12
An integrative multi-network and multi-classifier approach to predict genetic interactions. PLoS Comput Biol (2010) 1.11
An integrated approach to functional genomics: construction of a novel reporter gene fusion library for Sinorhizobium meliloti. Appl Environ Microbiol (2006) 1.10
Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing. Mol Biol Cell (2006) 1.08
Data-driven assessment of eQTL mapping methods. BMC Genomics (2010) 1.08
The mechanism of pentabromopseudilin inhibition of myosin motor activity. Nat Struct Mol Biol (2009) 1.08
The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro. Nucleic Acids Res (2013) 1.08
Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. Mol Biol Cell (2007) 1.06
Inferring condition-specific modulation of transcription factor activity in yeast through regulon-based analysis of genomewide expression. PLoS One (2008) 1.05
Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55. J Biol Chem (2009) 1.05
Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol Cell Biol (2005) 1.04
A compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription. PLoS Genet (2013) 1.04
Common gene expression strategies revealed by genome-wide analysis in yeast. Genome Biol (2007) 1.04
Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III. Mol Cell Biol (2009) 1.03
Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport. Mol Biol Cell (2009) 1.03
LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. Mol Biol Cell (2011) 1.03
Elucidating regulatory mechanisms downstream of a signaling pathway using informative experiments. Mol Syst Biol (2009) 1.03
The roles of 3'-exoribonucleases and the exosome in trypanosome mRNA degradation. RNA (2013) 1.02
Chemical-genetic profile analysis of five inhibitory compounds in yeast. BMC Chem Biol (2010) 1.02
Genome-wide screen for inner nuclear membrane protein targeting in Saccharomyces cerevisiae: roles for N-acetylation and an integral membrane protein. Genetics (2005) 1.02
Detection and discovery of RNA modifications using microarrays. Nucleic Acids Res (2005) 1.02
Mim1, a protein required for the assembly of the TOM complex of mitochondria. EMBO Rep (2005) 1.01
Inferring activity changes of transcription factors by binding association with sorted expression profiles. BMC Bioinformatics (2007) 1.01
Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis. Mol Cell Biol (2006) 1.01
YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation. J Cell Biol (2007) 1.00
Novel cargo-binding site in the beta and delta subunits of coatomer. J Cell Biol (2007) 1.00
Inhibition of sterol biosynthesis reduces tombusvirus replication in yeast and plants. J Virol (2009) 1.00
High-resolution network biology: connecting sequence with function. Nat Rev Genet (2013) 0.99
S. cerevisiae Vts1p induces deadenylation-dependent transcript degradation and interacts with the Ccr4p-Pop2p-Not deadenylase complex. RNA (2008) 0.99
Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria. Cell Metab (2013) 0.98
A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis. Genes Dev (2009) 0.98
Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis. Eukaryot Cell (2009) 0.98
Dynamic modular architecture of protein-protein interaction networks beyond the dichotomy of 'date' and 'party' hubs. Sci Rep (2013) 0.98
Combining classifiers to predict gene function in Arabidopsis thaliana using large-scale gene expression measurements. BMC Bioinformatics (2007) 0.97
Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance. Mol Cell Biol (2008) 0.96
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol (2006) 32.51
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
The genetic landscape of a cell. Science (2010) 16.52
Structures of the bacterial ribosome at 3.5 A resolution. Science (2005) 12.63
A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet (2007) 12.21
A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science (2003) 12.07
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell (2006) 11.48
The DNA-encoded nucleosome organization of a eukaryotic genome. Nature (2008) 11.41
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res (2010) 10.97
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell (2005) 10.41
Cytoscape Web: an interactive web-based network browser. Bioinformatics (2010) 10.03
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Diversity and complexity in DNA recognition by transcription factors. Science (2009) 9.07
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
The first metal-organic framework (MOF) of Imazethapyr and its SHG, piezoelectric and ferroelectric properties. Dalton Trans (2008) 8.86
Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. Cell (2007) 8.43
FunSpec: a web-based cluster interpreter for yeast. BMC Bioinformatics (2002) 8.01
Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Mol Cell Proteomics (2007) 7.93
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell (2008) 7.93
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47
Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Mol Cell (2004) 7.32
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Science (2001) 7.08
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Hydrogen-bonded ferroelectrics based on metal-organic coordination. J Am Chem Soc (2009) 6.69
Most "dark matter" transcripts are associated with known genes. PLoS Biol (2010) 6.60
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function. Genome Biol (2008) 5.94
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
Exploring genetic interactions and networks with yeast. Nat Rev Genet (2007) 5.67
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell (2003) 5.57
Role of formins in actin assembly: nucleation and barbed-end association. Science (2002) 5.47
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol (2009) 5.41
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci U S A (2009) 5.15
DNA-binding specificities of human transcription factors. Cell (2013) 5.14
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell (2004) 4.91
A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91
Probing microRNAs with microarrays: tissue specificity and functional inference. RNA (2004) 4.91
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78
A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78
Supramolecular bola-like ferroelectric: 4-methoxyanilinium tetrafluoroborate-18-crown-6. J Am Chem Soc (2011) 4.73
Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet (2002) 4.68
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature (2004) 4.65
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49
A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol (2006) 4.49
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell (2008) 4.49
Synthetic genetic array analysis in Saccharomyces cerevisiae. Methods Mol Biol (2006) 4.45
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science (2008) 4.36
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
Diisopropylammonium chloride: a ferroelectric organic salt with a high phase transition temperature and practical utilization level of spontaneous polarization. Adv Mater (2011) 4.30
Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog (2009) 4.24
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell (2004) 4.20
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05