Published in Cell on August 11, 2006
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Chemical-genetic profile analysis of five inhibitory compounds in yeast. BMC Chem Biol (2010) 1.02
Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees. PLoS One (2011) 1.00
Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae. Eukaryot Cell (2007) 0.98
Chemogenetic fingerprinting by analysis of cellular growth dynamics. BMC Chem Biol (2008) 0.98
Expression of Magnaporthe grisea avirulence gene ACE1 is connected to the initiation of appressorium-mediated penetration. Eukaryot Cell (2006) 0.98
Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases. Proc Natl Acad Sci U S A (2013) 0.97
In vivo veritas: using yeast to probe the biological functions of G-quadruplexes. Biochimie (2008) 0.97
Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering. Genome Biol (2010) 0.97
Mining for genotype-phenotype relations in Saccharomyces using partial least squares. BMC Bioinformatics (2011) 0.96
Energetics-based discovery of protein-ligand interactions on a proteomic scale. J Mol Biol (2011) 0.96
Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment. Org Lett (2011) 0.96
Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells. PLoS Genet (2008) 0.94
Unraveling the biology of a fungal meningitis pathogen using chemical genetics. Cell (2014) 0.93
Saccharomyces cerevisiae: a versatile eukaryotic system in virology. Microb Cell Fact (2007) 0.93
A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells. Mol Syst Biol (2015) 0.93
Small molecule probes of cellular pathways and networks. ACS Chem Biol (2010) 0.92
High-content, image-based screening for drug targets in yeast. PLoS One (2010) 0.92
Composite synthetic lethal identification of membrane traffic inhibitors. Proc Natl Acad Sci U S A (2007) 0.92
Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan. Eukaryot Cell (2007) 0.92
Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology. Chem Biol (2012) 0.92
Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p. Proc Natl Acad Sci U S A (2013) 0.92
Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance. BMC Syst Biol (2011) 0.91
Identifying druggable disease-modifying gene products. Curr Opin Chem Biol (2009) 0.91
Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex. Mol Biol Cell (2008) 0.90
Death by a thousand cuts: the challenges and diverse landscape of lignocellulosic hydrolysate inhibitors. Front Microbiol (2014) 0.90
Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. BMC Biol (2011) 0.90
Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation. Eukaryot Cell (2011) 0.90
Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae. Curr Genet (2009) 0.90
Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis. BMC Genomics (2008) 0.90
Plant-derived antifungal agent poacic acid targets β-1,3-glucan. Proc Natl Acad Sci U S A (2015) 0.90
Characterizing the anti-HIV activity of papuamide A. Mar Drugs (2008) 0.89
Identification and validation of protein targets of bioactive small molecules. Bioorg Med Chem (2011) 0.89
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A chemogenomic screening of sulfanilamide-hypersensitive Saccharomyces cerevisiae mutants uncovers ABZ2, the gene encoding a fungal aminodeoxychorismate lyase. Eukaryot Cell (2007) 0.88
Exploring genetic suppression interactions on a global scale. Science (2016) 0.87
High-confidence mapping of chemical compounds and protein complexes reveals novel aspects of chemical stress response in yeast. Mol Biosyst (2009) 0.87
Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis. ACS Chem Biol (2013) 0.87
Collateral Lethality: A new therapeutic strategy in oncology. Trends Cancer (2015) 0.87
Discovering the targets of drugs via computational systems biology. J Biol Chem (2011) 0.86
Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. G3 (Bethesda) (2013) 0.86
Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion. PLoS One (2010) 0.85
Role of phosphatidylserine in phospholipid flippase-mediated vesicle transport in Saccharomyces cerevisiae. Eukaryot Cell (2014) 0.85
Functional expression of parasite drug targets and their human orthologs in yeast. PLoS Negl Trop Dis (2011) 0.85
Phospholipid flippases Lem3p-Dnf1p and Lem3p-Dnf2p are involved in the sorting of the tryptophan permease Tat2p in yeast. J Biol Chem (2012) 0.85
A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. PLoS Genet (2011) 0.84
Robustness and evolvability in natural chemical resistance: identification of novel systems properties, biochemical mechanisms and regulatory interactions. Mol Biosyst (2010) 0.84
Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism. Molecules (2012) 0.84
Genome-Wide Fitness and Genetic Interactions Determined by Tn-seq, a High-Throughput Massively Parallel Sequencing Method for Microorganisms. Curr Protoc Microbiol (2015) 0.83
Comparative interaction networks: bridging genotype to phenotype. Adv Exp Med Biol (2012) 0.83
Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. Mol Cell Proteomics (2012) 0.83
Genome stability control by checkpoint regulation of tRNA gene transcription. Transcription (2010) 0.83
Chemical genomic profiling via barcode sequencing to predict compound mode of action. Methods Mol Biol (2015) 0.83
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet (2008) 24.51
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
The genetic landscape of a cell. Science (2010) 16.52
A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet (2007) 12.21
The DNA-encoded nucleosome organization of a eukaryotic genome. Nature (2008) 11.41
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell (2005) 10.41
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Diversity and complexity in DNA recognition by transcription factors. Science (2009) 9.07
Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. Cell (2007) 8.43
FunSpec: a web-based cluster interpreter for yeast. BMC Bioinformatics (2002) 8.01
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell (2008) 7.93
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Mol Cell (2004) 7.32
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Science (2001) 7.08
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol (2007) 6.94
p53 activation by knockdown technologies. PLoS Genet (2007) 6.85
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Most "dark matter" transcripts are associated with known genes. PLoS Biol (2010) 6.60
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
Deciphering the splicing code. Nature (2010) 6.27
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell (2003) 5.57
Role of formins in actin assembly: nucleation and barbed-end association. Science (2002) 5.47
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
DNA-binding specificities of human transcription factors. Cell (2013) 5.14
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95
Probing microRNAs with microarrays: tissue specificity and functional inference. RNA (2004) 4.91
A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78
A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78
The evolutionary landscape of alternative splicing in vertebrate species. Science (2012) 4.78
Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet (2002) 4.68
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell (2008) 4.49
Synthetic genetic array analysis in Saccharomyces cerevisiae. Methods Mol Biol (2006) 4.45
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell (2010) 4.16
CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast. Cell (2004) 4.04
A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell (2003) 4.04
Rapid tRNA decay can result from lack of nonessential modifications. Mol Cell (2006) 3.86
Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors. Mol Cell Biol (2004) 3.72
Identification of a bacterial type III effector family with G protein mimicry functions. Cell (2006) 3.47
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. Genome Res (2010) 3.46
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46
NAD+ metabolism in health and disease. Trends Biochem Sci (2006) 3.45
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat Biotechnol (2009) 3.44
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res (2007) 3.43
Using expression profiling data to identify human microRNA targets. Nat Methods (2007) 3.37
Preceramic adoption of peanut, squash, and cotton in northern Peru. Science (2007) 3.23
Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A (2004) 3.18
Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev (2006) 3.18
A specificity map for the PDZ domain family. PLoS Biol (2008) 3.16
A panoramic view of yeast noncoding RNA processing. Cell (2003) 3.11
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
G+C content dominates intrinsic nucleosome occupancy. BMC Bioinformatics (2009) 3.05
eSGA: E. coli synthetic genetic array analysis. Nat Methods (2008) 3.01
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nat Cell Biol (2002) 2.95
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal (2010) 2.95
Genotype to phenotype: a complex problem. Science (2010) 2.92
High-dimensional and large-scale phenotyping of yeast mutants. Proc Natl Acad Sci U S A (2005) 2.90
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol (2003) 2.84
Conservation of core gene expression in vertebrate tissues. J Biol (2009) 2.84
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell (2007) 2.83
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A (2004) 2.80
Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study. Chem Res Toxicol (2009) 2.80
Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome. PLoS Biol (2008) 2.73