PubRank

Edwin Cuppen

Author PubWeight™ 212.86‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Phylogenetic shadowing and computational identification of human microRNA genes. Cell 2005 13.24
2 Diversity of microRNAs in human and chimpanzee brain. Nat Genet 2006 6.57
3 Progress and prospects in rat genetics: a community view. Nat Genet 2008 6.01
4 Mammalian mirtron genes. Mol Cell 2007 5.75
5 Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. Genome Res 2006 5.23
6 The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet 2003 4.97
7 Limitations and possibilities of small RNA digital gene expression profiling. Nat Methods 2009 4.34
8 Approaches to microRNA discovery. Nat Genet 2006 4.32
9 Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 2013 3.97
10 Disclosure of individual genetic data to research participants: the debate reconsidered. Trends Genet 2010 3.83
11 Efficient target-selected mutagenesis in zebrafish. Genome Res 2003 3.61
12 A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature 2013 3.52
13 Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries. Nucleic Acids Res 2010 3.23
14 Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol 2008 3.02
15 SNP and haplotype mapping for genetic analysis in the rat. Nat Genet 2008 2.96
16 The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature 2003 2.89
17 Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms. Cell Rep 2012 2.67
18 Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res 2006 2.58
19 Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell 2012 2.45
20 Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline. Hum Mol Genet 2011 2.43
21 Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology. J Clin Oncol 2013 2.36
22 Genetic variation in the zebrafish. Genome Res 2006 2.22
23 Distribution and functional impact of DNA copy number variation in the rat. Nat Genet 2008 2.20
24 Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biol 2011 2.11
25 Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res 2006 1.94
26 Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans. Curr Biol 2008 1.80
27 Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples. Nat Methods 2010 1.77
28 Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes. Genome Biol 2014 1.66
29 Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. Clin Cancer Res 2011 1.64
30 Repertoire and evolution of miRNA genes in four divergent nematode species. Genome Res 2009 1.64
31 Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet Genomics 2006 1.60
32 CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting. Genome Res 2003 1.57
33 Zebrafish as a cancer model. Mol Cancer Res 2008 1.55
34 Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell 2013 1.53
35 Dominant missense mutations in ABCC9 cause Cantú syndrome. Nat Genet 2012 1.50
36 Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Obesity (Silver Spring) 2011 1.50
37 Zebrafish development and regeneration: new tools for biomedical research. Int J Dev Biol 2009 1.46
38 The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance. Genome Res 2010 1.45
39 Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis. Ann Neurol 2011 1.45
40 Single nucleotide polymorphisms associated with rat expressed sequences. Genome Res 2004 1.43
41 Systematic biases in DNA copy number originate from isolation procedures. Genome Biol 2013 1.39
42 Multiplexed array-based and in-solution genomic enrichment for flexible and cost-effective targeted next-generation sequencing. Nat Protoc 2011 1.36
43 Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet 2013 1.30
44 Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol 2006 1.30
45 Target-selected mutagenesis of the rat. Genomics 2004 1.26
46 E2F7 represses a network of oscillating cell cycle genes to control S-phase progression. Nucleic Acids Res 2011 1.26
47 GENOTRACE: cDNA-based local GENOme assembly from TRACE archives. Bioinformatics 2002 1.25
48 CONREAL web server: identification and visualization of conserved transcription factor binding sites. Nucleic Acids Res 2005 1.25
49 Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol 2013 1.24
50 Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development 2010 1.23
51 Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq. Bioinformatics 2010 1.18
52 Small RNA expression and strain specificity in the rat. BMC Genomics 2010 1.16
53 Genomic and transcriptomic plasticity in treatment-naive ovarian cancer. Genome Res 2013 1.15
54 High-throughput target-selected gene inactivation in zebrafish. Methods Cell Biol 2011 1.15
55 Expanding the spectrum of phenotypes associated with germline PIGA mutations: a child with developmental delay, accelerated linear growth, facial dysmorphisms, elevated alkaline phosphatase, and progressive CNS abnormalities. Am J Med Genet A 2013 1.14
56 Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals. BMC Genomics 2008 1.14
57 Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 2009 1.14
58 Haplotype block structure is conserved across mammals. PLoS Genet 2006 1.13
59 Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles. PLoS One 2010 1.12
60 High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors. Genome Res 2011 1.12
61 Identification of factors required for meristem function in Arabidopsis using a novel next generation sequencing fast forward genetics approach. BMC Genomics 2011 1.10
62 Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility. Eur J Neurosci 2007 1.08
63 FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands. Arch Neurol 2010 1.08
64 Tracing the history of goat pastoralism: new clues from mitochondrial and Y chromosome DNA in North Africa. Mol Biol Evol 2009 1.07
65 Serotonin transporter dosage modulates long-term decision-making in rat and human. Neuropharmacology 2008 1.06
66 Chromothripsis in congenital disorders and cancer: similarities and differences. Curr Opin Cell Biol 2013 1.05
67 Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain. Epigenetics Chromatin 2013 1.05
68 Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. EMBO J 2014 1.05
69 RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. EMBO J 2007 1.04
70 A deep sequencing approach to uncover the miRNOME in the human heart. PLoS One 2013 1.04
71 Genomic DNA pooling strategy for next-generation sequencing-based rare variant discovery in abdominal aortic aneurysm regions of interest-challenges and limitations. J Cardiovasc Transl Res 2011 1.04
72 CASCAD: a database of annotated candidate single nucleotide polymorphisms associated with expressed sequences. BMC Genomics 2005 1.03
73 Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats. Psychopharmacology (Berl) 2007 1.03
74 Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes. Nucleic Acids Res 2011 1.02
75 Discovery of variants unmasked by hemizygous deletions. Eur J Hum Genet 2012 1.02
76 Genetic variation in coding regions between and within commonly used inbred rat strains. Genome Res 2004 1.01
77 A functional screen identifies specific microRNAs capable of inhibiting human melanoma cell viability. PLoS One 2012 1.00
78 A genome-wide SNP panel for mapping and association studies in the rat. BMC Genomics 2008 1.00
79 miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. PLoS One 2012 1.00
80 ENU mutagenesis to generate genetically modified rat models. Methods Mol Biol 2010 1.00
81 The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females. Neuropharmacology 2008 0.99
82 Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates. BMC Genomics 2005 0.98
83 X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face. J Med Genet 2012 0.97
84 NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis. Hum Mol Genet 2012 0.97
85 Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats. Am J Physiol Endocrinol Metab 2012 0.95
86 Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus. Eur J Hum Genet 2012 0.95
87 Next-generation sequencing-based genome diagnostics across clinical genetics centers: implementation choices and their effects. Eur J Hum Genet 2015 0.94
88 Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis. Carcinogenesis 2008 0.94
89 Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency. Am J Pathol 2011 0.93
90 Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors. Cancer Res 2008 0.93
91 Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology (Berl) 2008 0.93
92 Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics. Genetics 2005 0.92
93 Mlh1 deficiency in zebrafish results in male sterility and aneuploid as well as triploid progeny in females. Genetics 2007 0.92
94 Pmch expression during early development is critical for normal energy homeostasis. Am J Physiol Endocrinol Metab 2009 0.92
95 Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation. FEBS Lett 2009 0.91
96 The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders. PLoS One 2012 0.90
97 Improving mammalian genome scaffolding using large insert mate-pair next-generation sequencing. BMC Genomics 2013 0.90
98 Resolving the breakpoints of the 17q21.31 microdeletion syndrome with next-generation sequencing. Am J Hum Genet 2012 0.90
99 Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol Cell Biol 2012 0.90
100 Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C. Curr Biol 2003 0.89
101 A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat. J Biol Chem 2011 0.89
102 Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridization. Cancer Res 2009 0.89
103 Blood pressure in mutant rats lacking the 5-hydroxytryptamine transporter. Hypertension 2006 0.88
104 An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions. PLoS One 2011 0.88
105 Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel. Genome Biol 2012 0.88
106 Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration. Am J Physiol Gastrointest Liver Physiol 2009 0.88
107 Highly Efficient ENU Mutagenesis in Zebrafish. Methods Mol Biol 2009 0.87
108 Effector identification in the lettuce downy mildew Bremia lactucae by massively parallel transcriptome sequencing. Mol Plant Pathol 2012 0.87
109 A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds. Hum Mol Genet 2010 0.86
110 Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos. Nucleic Acids Res 2008 0.86
111 ALK2 mutation in a patient with Down's syndrome and a congenital heart defect. Eur J Hum Genet 2011 0.86
112 Rat genetics: the next episode. Trends Genet 2006 0.86
113 MEFV mutations affecting pyrin amino acid 577 cause autosomal dominant autoinflammatory disease. Ann Rheum Dis 2013 0.86
114 Rat traps: filling the toolbox for manipulating the rat genome. Genome Biol 2010 0.86
115 Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat. PLoS One 2011 0.85
116 The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1. Mamm Genome 2008 0.84
117 Functional microRNA screening using a comprehensive lentiviral human microRNA expression library. BMC Genomics 2011 0.84
118 Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib. Pigment Cell Melanoma Res 2015 0.83
119 Mismatch repair deficiency does not enhance ENU mutagenesis in the zebrafish germ line. Mutagenesis 2008 0.83
120 A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction. Int J Dev Biol 2010 0.83
121 Serotonin transporter deficiency increases abdominal fat in female, but not male rats. Obesity (Silver Spring) 2009 0.83
122 Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. Eur J Pharmacol 2008 0.82
123 The Atp1a1 gene from inbred Dahl salt sensitive rats does not contain the A1079T missense transversion. Hypertension 2008 0.81
124 Generation of genetically modified rodents using random ENU mutagenesis. Methods Mol Biol 2011 0.81
125 Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats. Physiol Genomics 2010 0.80
126 Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish. Methods Cell Biol 2011 0.80
127 Prioritization and burden analysis of rare variants in 208 candidate genes suggest they do not play a major role in CAKUT. Kidney Int 2016 0.79
128 Genome-wide survey indicates involvement of loci on canine chromosomes 7 and 31 in patellar luxation in Flat-Coated Retrievers. BMC Genet 2014 0.79
129 miRNAs: small changes, widespread effects. Cell Res 2008 0.79
130 Application of exome sequencing in the search for genetic causes of rare disorders of copper metabolism. Metallomics 2012 0.79
131 The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats. J Sex Med 2011 0.79
132 Exploring conservation of transcription factor binding sites with CONREAL. Methods Mol Biol 2007 0.79
133 Methods for small RNA preparation for digital gene expression profiling by next-generation sequencing. Methods Mol Biol 2012 0.78
134 Completion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1. Cell Tissue Res 2008 0.78
135 A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats. PLoS One 2011 0.77
136 Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive. PLoS One 2013 0.77
137 Serotonin transporter null mutation and sexual behavior in female rats: 5-HT1A receptor desensitization. J Sex Med 2010 0.76
138 Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats. BMC Genet 2010 0.76
139 No link of serotonin 2C receptor editing to serotonin transporter genotype. Neuroreport 2010 0.75
140 Pluripotency in the light of the developmental hourglass. Biol Rev Camb Philos Soc 2014 0.75
141 Rats go genomic. Genome Biol 2006 0.75
142 DNA isolation from rat tail or ear. Cold Spring Harb Protoc 2010 0.75