Published in Trends Biochem Sci on February 01, 2005
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. Genome Res (2011) 4.09
Kinetoplastids: related protozoan pathogens, different diseases. J Clin Invest (2008) 3.59
Dead-box proteins: a family affair--active and passive players in RNP-remodeling. Nucleic Acids Res (2006) 3.26
Biochemistry and evolution of anaerobic energy metabolism in eukaryotes. Microbiol Mol Biol Rev (2012) 2.65
RNA-specific ribonucleotidyl transferases. RNA (2007) 2.15
TAC102 Is a Novel Component of the Mitochondrial Genome Segregation Machinery in Trypanosomes. PLoS Pathog (2016) 2.05
Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates. Curr Genet (2005) 2.01
An essential RNase III insertion editing endonuclease in Trypanosoma brucei. Proc Natl Acad Sci U S A (2005) 1.96
A comprehensive analysis of Trypanosoma brucei mitochondrial proteome. Proteomics (2009) 1.94
RNA editing in Trypanosoma brucei requires three different editosomes. Mol Cell Biol (2007) 1.87
Compositionally and functionally distinct editosomes in Trypanosoma brucei. RNA (2006) 1.86
The F1-ATP synthase complex in bloodstream stage trypanosomes has an unusual and essential function. EMBO J (2005) 1.75
Guide RNA-binding complex from mitochondria of trypanosomatids. Mol Cell (2008) 1.75
Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei. Proc Natl Acad Sci U S A (2008) 1.73
The expanding transcriptome: the genome as the 'Book of Sand'. EMBO J (2006) 1.73
Trypanosomes have six mitochondrial DNA helicases with one controlling kinetoplast maxicircle replication. Mol Cell (2009) 1.64
3' adenylation determines mRNA abundance and monitors completion of RNA editing in T. brucei mitochondria. EMBO J (2008) 1.63
Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei. Proc Natl Acad Sci U S A (2008) 1.51
TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex. RNA (2008) 1.47
Trypanosoma brucei mitochondrial ribosomes: affinity purification and component identification by mass spectrometry. Mol Cell Proteomics (2008) 1.44
Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasit Vectors (2015) 1.39
Structure of a mitochondrial ribosome with minimal RNA. Proc Natl Acad Sci U S A (2009) 1.38
Kinetoplastid guide RNA biogenesis is dependent on subunits of the mitochondrial RNA binding complex 1 and mitochondrial RNA polymerase. RNA (2009) 1.37
UTP-bound and Apo structures of a minimal RNA uridylyltransferase. J Mol Biol (2006) 1.36
Direct comparison of nick-joining activity of the nucleic acid ligases from bacteriophage T4. Biochem J (2006) 1.30
Uridine insertion/deletion editing in trypanosomes: a playground for RNA-guided information transfer. Wiley Interdiscip Rev RNA (2011) 1.29
The MRB1 complex functions in kinetoplastid RNA processing. RNA (2008) 1.24
p166, a link between the trypanosome mitochondrial DNA and flagellum, mediates genome segregation. EMBO J (2007) 1.23
Alternative editing of cytochrome c oxidase III mRNA in trypanosome mitochondria generates protein diversity. EMBO Rep (2006) 1.22
Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1. PLoS Negl Trop Dis (2010) 1.20
KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2006) 1.19
RNA editing: a driving force for adaptive evolution? Bioessays (2009) 1.19
Diversity and roles of (t)RNA ligases. Cell Mol Life Sci (2012) 1.18
Gene expression in trypanosomatid parasites. J Biomed Biotechnol (2010) 1.18
Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. Nucleic Acids Res (2006) 1.17
Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex. Trends Parasitol (2013) 1.17
KISS: the kinetoplastid RNA editing sequence search tool. RNA (2006) 1.16
A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway. Genes Dev (2010) 1.16
Role of p38 in replication of Trypanosoma brucei kinetoplast DNA. Mol Cell Biol (2006) 1.15
KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2007) 1.14
Persistent ER stress induces the spliced leader RNA silencing pathway (SLS), leading to programmed cell death in Trypanosoma brucei. PLoS Pathog (2010) 1.13
Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei. Int J Parasitol (2008) 1.13
Darned in 2013: inclusion of model organisms and linking with Wikipedia. Nucleic Acids Res (2012) 1.12
The killing of African trypanosomes by ethidium bromide. PLoS Pathog (2010) 1.12
TbRGG2 facilitates kinetoplastid RNA editing initiation and progression past intrinsic pause sites. RNA (2010) 1.11
Reconstitution of full-round uridine-deletion RNA editing with three recombinant proteins. Proc Natl Acad Sci U S A (2006) 1.11
Architecture of the trypanosome RNA editing accessory complex, MRB1. Nucleic Acids Res (2012) 1.10
A pilot study of bacterial genes with disrupted ORFs reveals a surprising profusion of protein sequence recoding mediated by ribosomal frameshifting and transcriptional realignment. Mol Biol Evol (2011) 1.08
Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci U S A (2007) 1.08
A protein-protein interaction map of trypanosome ~20S editosomes. J Biol Chem (2009) 1.08
An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei. RNA (2007) 1.08
Trypanosome REH1 is an RNA helicase involved with the 3'-5' polarity of multiple gRNA-guided uridine insertion/deletion RNA editing. Proc Natl Acad Sci U S A (2011) 1.07
Mitochondrial RNA editing in trypanosomes: small RNAs in control. Biochimie (2014) 1.07
Endonuclease associations with three distinct editosomes in Trypanosoma brucei. J Biol Chem (2011) 1.07
Differential functions of two editosome exoUases in Trypanosoma brucei. RNA (2009) 1.06
RBP16 stimulates trypanosome RNA editing in vitro at an early step in the editing reaction. RNA (2006) 1.06
Arginine methylation regulates mitochondrial gene expression in Trypanosoma brucei through multiple effector proteins. RNA (2006) 1.05
Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes. Proc Natl Acad Sci U S A (2009) 1.04
Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo. EMBO J (2009) 1.04
Distinct and overlapping functions of MRP1/2 and RBP16 in mitochondrial RNA metabolism. Mol Cell Biol (2009) 1.04
Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology. Mol Cell Proteomics (2012) 1.03
Guide to the nomenclature of kinetoplastid RNA editing: a proposal. Protist (2009) 1.03
Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. PLoS Negl Trop Dis (2015) 1.03
Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria. Proc Natl Acad Sci U S A (2009) 1.02
Uridine insertion/deletion RNA editing in trypanosomatid mitochondria: In search of the editosome. RNA (2009) 1.02
MRB3010 is a core component of the MRB1 complex that facilitates an early step of the kinetoplastid RNA editing process. RNA (2011) 1.01
Systematically fragmented genes in a multipartite mitochondrial genome. Nucleic Acids Res (2010) 1.01
Alternative RNA editing produces a novel protein involved in mitochondrial DNA maintenance in trypanosomes. Mol Cell Biol (2008) 1.01
Alternative mRNA editing in trypanosomes is extensive and may contribute to mitochondrial protein diversity. PLoS One (2008) 1.00
What happens when Trypanosoma brucei leaves Africa. Trends Parasitol (2008) 0.99
Novel TUTase associates with an editosome-like complex in mitochondria of Trypanosoma brucei. RNA (2009) 0.99
The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei. Mol Cell Biol (2008) 0.99
Functional and structural insights revealed by molecular dynamics simulations of an essential RNA editing ligase in Trypanosoma brucei. PLoS Negl Trop Dis (2007) 0.99
Terminal RNA uridylyltransferases of trypanosomes. Biochim Biophys Acta (2007) 0.98
Proteomic analysis reveals diverse classes of arginine methylproteins in mitochondria of trypanosomes. Mol Cell Proteomics (2012) 0.98
Structural asymmetry and discrete nucleic acid subdomains in the Trypanosoma brucei kinetoplast. Mol Microbiol (2007) 0.98
Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody. Nucleic Acids Res (2011) 0.97
Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei. RNA (2012) 0.97
Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei. RNA (2011) 0.96
Trypanosomes and the solution to a 50-year mitochondrial calcium mystery. Trends Parasitol (2011) 0.96
Trypanosome RNA editing: the complexity of getting U in and taking U out. Wiley Interdiscip Rev RNA (2015) 0.96
Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. J Struct Biol (2010) 0.95
Downregulation of mitochondrial porin inhibits cell growth and alters respiratory phenotype in Trypanosoma brucei. Eukaryot Cell (2009) 0.95
The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. PLoS Genet (2014) 0.95
RNA-level unscrambling of fragmented genes in Diplonema mitochondria. RNA Biol (2013) 0.95
Immunobiology of African trypanosomes: need of alternative interventions. J Biomed Biotechnol (2010) 0.94
Pentatricopeptide repeat proteins involved in plant organellar RNA editing. RNA Biol (2013) 0.93
TbPIF1, a Trypanosoma brucei mitochondrial DNA helicase, is essential for kinetoplast minicircle replication. J Biol Chem (2009) 0.93
In Trypanosoma brucei RNA editing, TbMP18 (band VII) is critical for editosome integrity and for both insertional and deletional cleavages. Mol Cell Biol (2006) 0.92
SUMOylation pathway in Trypanosoma cruzi: functional characterization and proteomic analysis of target proteins. Mol Cell Proteomics (2011) 0.92
RNA editing complex interactions with a site for full-round U deletion in Trypanosoma brucei. RNA (2006) 0.92
A mitochondrial DNA primase is essential for cell growth and kinetoplast DNA replication in Trypanosoma brucei. Mol Cell Biol (2010) 0.92
Complete characterization of the edited transcriptome of the mitochondrion of Physarum polycephalum using deep sequencing of RNA. Nucleic Acids Res (2011) 0.92
Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei. Eukaryot Cell (2007) 0.92
A new function of Trypanosoma brucei mitochondrial topoisomerase II is to maintain kinetoplast DNA network topology. Mol Microbiol (2008) 0.91
Mutational analysis of Trypanosoma brucei editosome proteins KREPB4 and KREPB5 reveals domains critical for function. RNA (2012) 0.90
Targeted depletion of a mitochondrial nucleotidyltransferase suggests the presence of multiple enzymes that polymerize mRNA 3' tails in Trypanosoma brucei mitochondria. Mol Biochem Parasitol (2007) 0.90
TbPIF5 is a Trypanosoma brucei mitochondrial DNA helicase involved in processing of minicircle Okazaki fragments. PLoS Pathog (2009) 0.90
The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei. PLoS One (2010) 0.89
Identification of novel components of Trypanosoma brucei editosomes. RNA (2003) 2.30
An essential RNase III insertion editing endonuclease in Trypanosoma brucei. Proc Natl Acad Sci U S A (2005) 1.96
Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex. Mol Cell (2003) 1.94
TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosome. Mol Cell (2003) 1.88
Compositionally and functionally distinct editosomes in Trypanosoma brucei. RNA (2006) 1.86
Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei. Proc Natl Acad Sci U S A (2008) 1.73
High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1. J Mol Biol (2004) 1.67
Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma brucei. EMBO J (2005) 1.61
RNA interference analyses suggest a transcript-specific regulatory role for mitochondrial RNA-binding proteins MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma brucei. J Biol Chem (2004) 1.58
A deletion site editing endonuclease in Trypanosoma brucei. Mol Cell (2005) 1.57
Role of uridylate-specific exoribonuclease activity in Trypanosoma brucei RNA editing. Eukaryot Cell (2002) 1.55
Comparative analysis of editosome proteins in trypanosomatids. Nucleic Acids Res (2003) 1.52
TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex. RNA (2008) 1.47
Trypanosoma brucei mitochondrial ribosomes: affinity purification and component identification by mass spectrometry. Mol Cell Proteomics (2008) 1.44
TbMP44 is essential for RNA editing and structural integrity of the editosome in Trypanosoma brucei. Eukaryot Cell (2003) 1.39
RNA editing: complexity and complications. Mol Microbiol (2002) 1.36
Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene. Nucleic Acids Res (2003) 1.29
Glucose is toxic to glycosome-deficient trypanosomes. Proc Natl Acad Sci U S A (2002) 1.25
The MRB1 complex functions in kinetoplastid RNA processing. RNA (2008) 1.24
Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1. PLoS Negl Trop Dis (2010) 1.20
KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2006) 1.19
The F(0)F(1)-ATP synthase complex contains novel subunits and is essential for procyclic Trypanosoma brucei. PLoS Pathog (2009) 1.14
KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2007) 1.14
The 14-3-3 proteins of Trypanosoma brucei function in motility, cytokinesis, and cell cycle. J Biol Chem (2005) 1.13
Spliceosomal proteomics in Trypanosoma brucei reveal new RNA splicing factors. Eukaryot Cell (2009) 1.11
An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei. RNA (2007) 1.08
Kinetoplastid RNA editing ligases: complex association, characterization, and substrate requirements. Mol Biochem Parasitol (2003) 1.05
Isolation and compositional analysis of trypanosomatid editosomes. Methods Enzymol (2007) 1.03
Identification and characterization of trypanosome RNA-editing complex components. Methods Mol Biol (2004) 1.02
Endoribonuclease activities of Trypanosoma brucei mitochondria. Mol Biochem Parasitol (2002) 1.00
The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei. Mol Cell Biol (2008) 0.99
Trypanosoma brucei mitochondrial respiratome: composition and organization in procyclic form. Mol Cell Proteomics (2011) 0.96
A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes. Mol Cell Biol (2010) 0.95
A low-background inducible promoter system in Leishmania donovani. Mol Biochem Parasitol (2002) 0.91
Mutational analysis of Trypanosoma brucei editosome proteins KREPB4 and KREPB5 reveals domains critical for function. RNA (2012) 0.90
Protein composition of Trypanosoma brucei mitochondrial membranes. Proteomics (2009) 0.89
The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei. PLoS One (2010) 0.89
Enigmatic presence of mitochondrial complex I in Trypanosoma brucei bloodstream forms. Eukaryot Cell (2011) 0.88
Evolution of dyskinetoplastic trypanosomes: how, and how often? Trends Parasitol (2010) 0.87
Characterization of a novel class I transcription factor A (CITFA) subunit that is indispensable for transcription by the multifunctional RNA polymerase I of Trypanosoma brucei. Eukaryot Cell (2012) 0.87
KREPB6, KREPB7, and KREPB8 are important for editing endonuclease function in Trypanosoma brucei. RNA (2011) 0.87
Structural and functional association of Trypanosoma brucei MIX protein with cytochrome c oxidase complex. Eukaryot Cell (2008) 0.87
Editosome accessory factors KREPB9 and KREPB10 in Trypanosoma brucei. Eukaryot Cell (2012) 0.85
Independence from Kinetoplast DNA maintenance and expression is associated with multidrug resistance in Trypanosoma brucei in vitro. Antimicrob Agents Chemother (2014) 0.80
Trypanosoma brucei Tb927.2.6100 is an essential protein associated with kinetoplast DNA. Eukaryot Cell (2013) 0.80
Proteome analysis of functionally differentiated bovine (Bos indicus) mammary epithelial cells isolated from milk. Proteomics (2013) 0.78
Correction: TAC102 Is a Novel Component of the Mitochondrial Genome Segregation Machinery in Trypanosomes. PLoS Pathog (2016) 0.75
Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo. J Biochem (2013) 0.75