Published in Nature on February 07, 2010
The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24
Control of the embryonic stem cell state. Cell (2011) 6.89
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell (2011) 3.53
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells (2010) 3.24
Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature (2015) 2.77
Induced pluripotent stem cells: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci (2011) 2.09
Mechanisms and models of somatic cell reprogramming. Nat Rev Genet (2013) 2.09
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol (2014) 2.01
Molecular analyses of human induced pluripotent stem cells and embryonic stem cells. Cell Stem Cell (2010) 1.81
Pioneer transcription factors in cell reprogramming. Genes Dev (2014) 1.71
Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis (2011) 1.70
Maintaining embryonic stem cell pluripotency with Wnt signaling. Development (2011) 1.57
Induction of pluripotent stem cells from human third molar mesenchymal stromal cells. J Biol Chem (2010) 1.50
MicroRNA-302 increases reprogramming efficiency via repression of NR2F2. Stem Cells (2013) 1.41
Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape. Cell Res (2011) 1.41
Induced pluripotent stem cells and senescence: learning the biology to improve the technology. EMBO Rep (2010) 1.38
Large-scale quality analysis of published ChIP-seq data. G3 (Bethesda) (2014) 1.23
Diverse functional networks of Tbx3 in development and disease. Wiley Interdiscip Rev Syst Biol Med (2012) 1.21
Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. Cell Res (2011) 1.19
A decade of transcription factor-mediated reprogramming to pluripotency. Nat Rev Mol Cell Biol (2016) 1.16
Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells (2013) 1.14
Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins. Cell Rep (2013) 1.11
Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells. J Biol Chem (2010) 1.08
Dual functions of T-box 3 (Tbx3) in the control of self-renewal and extraembryonic endoderm differentiation in mouse embryonic stem cells. J Biol Chem (2010) 1.04
Chromatin landscapes of retroviral and transposon integration profiles. PLoS Genet (2014) 1.02
Purified mesenchymal stem cells are an efficient source for iPS cell induction. PLoS One (2011) 1.02
An Oct4-Sall4-Nanog network controls developmental progression in the pre-implantation mouse embryo. Mol Syst Biol (2013) 1.01
TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model. BMC Dev Biol (2011) 1.00
MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs. PLoS One (2012) 0.99
TBX3 Directs Cell-Fate Decision toward Mesendoderm. Stem Cell Reports (2013) 0.98
The T-box gene family: emerging roles in development, stem cells and cancer. Development (2014) 0.96
A cell surfaceome map for immunophenotyping and sorting pluripotent stem cells. Mol Cell Proteomics (2012) 0.94
Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife (2014) 0.93
Mechanistic insights into reprogramming to induced pluripotency. J Cell Physiol (2011) 0.92
TBX3 promotes human embryonic stem cell proliferation and neuroepithelial differentiation in a differentiation stage-dependent manner. Stem Cells (2012) 0.92
microRNAs as novel regulators of stem cell pluripotency and somatic cell reprogramming. Bioessays (2012) 0.89
Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary. Hum Mol Genet (2011) 0.89
The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells. PLoS One (2012) 0.88
Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells. Sci Rep (2013) 0.88
The functions of microRNAs and long non-coding RNAs in embryonic and induced pluripotent stem cells. Genomics Proteomics Bioinformatics (2013) 0.87
The different shades of mammalian pluripotent stem cells. Hum Reprod Update (2010) 0.86
Zic3 enhances the generation of mouse induced pluripotent stem cells. Stem Cells Dev (2013) 0.85
Changes in the inflammatory response to injury and its resolution during the loss of regenerative capacity in developing Xenopus limbs. PLoS One (2013) 0.85
Methods of induced pluripotent stem cells for clinical application. World J Stem Cells (2015) 0.85
Induction of pluripotency by defined factors. Proc Jpn Acad Ser B Phys Biol Sci (2014) 0.84
Nucleic acid and non-nucleic acid-based reprogramming of adult limbal progenitors to pluripotency. PLoS One (2012) 0.83
Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion. Curr Biol (2015) 0.82
From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis. Philos Trans R Soc Lond B Biol Sci (2014) 0.81
Toward pluripotency by reprogramming: mechanisms and application. Protein Cell (2013) 0.81
Decoding the genome with an integrative analysis tool: combinatorial CRM Decoder. Nucleic Acids Res (2011) 0.81
Tbx3: another important piece fitted into the pluripotent stem cell puzzle. Stem Cell Res Ther (2010) 0.80
Using potential master regulator sites and paralogous expansion to construct tissue-specific transcriptional networks. BMC Syst Biol (2012) 0.80
TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome. PLoS Genet (2014) 0.80
The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development. Mol Biol Cell (2012) 0.80
Genomic characterization of the mouse ribosomal DNA locus. G3 (Bethesda) (2014) 0.80
Generation of mice derived from induced pluripotent stem cells. J Vis Exp (2012) 0.80
Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43. Cell Mol Life Sci (2011) 0.80
Network-based comparison of temporal gene expression patterns. Bioinformatics (2010) 0.79
Synergetic cooperation of microRNAs with transcription factors in iPS cell generation. PLoS One (2012) 0.79
Overcoming barriers to the clinical utilization of iPSCs: reprogramming efficiency, safety and quality. Protein Cell (2012) 0.79
Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency. Stem Cell Reports (2014) 0.79
Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells (2015) 0.79
Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm. Stem Cell Reports (2015) 0.79
Induced Pluripotent Stem Cells-A New Foundation in Medicine. J Exp Clin Med (2010) 0.79
Molecular mechanisms of pluripotency and reprogramming. Stem Cell Res Ther (2010) 0.79
Non integrative strategy decreases chromosome instability and improves endogenous pluripotency genes reactivation in porcine induced pluripotent-like stem cells. Sci Rep (2016) 0.78
Dynamic expression of Tbx2 and Tbx3 in developing mouse pancreas. Gene Expr Patterns (2011) 0.78
RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements. Nucleic Acids Res (2015) 0.77
Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells. Apoptosis (2013) 0.77
Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming. Stem Cells Int (2011) 0.77
Reprogramming cells with synthetic proteins. Asian J Androl (2015) 0.76
T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. Elife (2016) 0.76
Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction. Sci Rep (2016) 0.76
Time to reconsider stem cell induction strategies. Cells (2012) 0.76
Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium. PLoS One (2014) 0.76
Looking into the black box: insights into the mechanisms of somatic cell reprogramming. Genes (Basel) (2011) 0.76
Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions. Cell Transplant (2013) 0.76
Improvement in Mouse iPSC Induction by Rab32 Reveals the Importance of Lipid Metabolism during Reprogramming. Sci Rep (2015) 0.76
Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos. Genome Res (2017) 0.75
Delineating nuclear reprogramming. Protein Cell (2012) 0.75
Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation. Cell Rep (2016) 0.75
Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival. Stem Cell Res (2017) 0.75
Differential gene expression in mouse spermatogonial stem cells and embryonic stem cells. Int J Mol Med (2016) 0.75
A Dynamic Role of TBX3 in the Pluripotency Circuitry. Stem Cell Reports (2015) 0.75
Review of literature: genes related to postaxial polydactyly. Front Pediatr (2015) 0.75
Pluripotency Factors on Their Lineage Move. Stem Cells Int (2015) 0.75
Techniques of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell Derivation. Arch Immunol Ther Exp (Warsz) (2016) 0.75
Gene Signature of Human Oral Mucosa Fibroblasts: Comparison with Dermal Fibroblasts and Induced Pluripotent Stem Cells. Biomed Res Int (2015) 0.75
TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Stem Cells Int (2015) 0.75
Tbx3 represses bmp4 expression and, with Pax6, is required and sufficient for retina formation. Development (2016) 0.75
Cellular reprogramming for clinical cartilage repair. Cell Biol Toxicol (2017) 0.75
Embryo development after mitochondrial supplementation from induced pluripotent stem cells. J Assist Reprod Genet (2017) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell (2003) 17.72
Generation of mouse induced pluripotent stem cells without viral vectors. Science (2008) 15.25
Rational siRNA design for RNA interference. Nat Biotechnol (2004) 14.16
Dissecting self-renewal in stem cells with RNA interference. Nature (2006) 11.66
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell (2008) 7.79
A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol (2008) 6.90
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol (2006) 4.81
Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43
Nanog promotes transfer of pluripotency after cell fusion. Nature (2006) 4.38
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell (2009) 3.03
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells (2008) 2.43
Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states. J Cell Biochem (2008) 1.71
Production of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos. Nat Protoc (2006) 1.39
A novel normalization method for effective removal of systematic variation in microarray data. Nucleic Acids Res (2006) 1.38
Increasing the cell number of host tetraploid embryos can improve the production of mice derived from embryonic stem cells. Biol Reprod (2008) 0.90
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell (2006) 14.70
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature (2008) 9.83
Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science (2003) 8.79
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41
Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med (2013) 7.48
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell (2007) 7.05
A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol (2008) 6.90
Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem (2005) 6.05
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev (2007) 5.79
Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A (2006) 5.27
Transposable elements have rewired the core regulatory network of human embryonic stem cells. Nat Genet (2010) 5.26
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol (2006) 4.81
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol (2005) 4.54
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell (2012) 3.92
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J Clin Invest (2010) 3.41
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol (2008) 3.37
Specification of jaw subdivisions by Dlx genes. Science (2002) 3.33
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem (2006) 3.24
Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state. Stem Cells (2005) 3.16
MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes (2009) 3.02
Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell (2009) 3.02
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell (2011) 3.00
miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One (2009) 2.97
Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell (2005) 2.95
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell (2010) 2.89
Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor. J Infect Dis (2011) 2.69
The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev (2002) 2.48
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells (2008) 2.43
MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells (2007) 2.40
Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation (2010) 2.39
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genet (2005) 2.32
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages. Cell Stem Cell (2008) 2.28
Linking beta-catenin to androgen-signaling pathway. J Biol Chem (2002) 2.27
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes Dev (2009) 2.18
Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells (2006) 2.11
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension. Cardiovasc Res (2013) 2.08
A precarious balance: pluripotency factors as lineage specifiers. Cell Stem Cell (2011) 2.07
Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast. Cell Stem Cell (2013) 2.06
Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Mol Cell (2007) 2.05
Integrative model of genomic factors for determining binding site selection by estrogen receptor-α. Mol Syst Biol (2010) 2.04
Tackling the epigenome: challenges and opportunities for collaboration. Nat Biotechnol (2010) 2.04
Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells (2006) 1.93
Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia. Cancer Cell (2013) 1.89
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol (2005) 1.86
Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells. RNA (2009) 1.78
Zic3 is required for maintenance of pluripotency in embryonic stem cells. Mol Biol Cell (2007) 1.77
Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem (2012) 1.76