Published in J Biol Chem on April 29, 2011
Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev (2014) 1.59
Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet (2012) 1.20
Regulation of pol III transcription by nutrient and stress signaling pathways. Biochim Biophys Acta (2012) 1.04
The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Mol Biol Cell (2013) 0.97
Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. PLoS Genet (2014) 0.88
Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes. Eukaryot Cell (2012) 0.86
Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase. Biochim Biophys Acta (2012) 0.78
Target of rapamycin signaling regulates high mobility group protein association to chromatin, which functions to suppress necrotic cell death. Epigenetics Chromatin (2013) 0.78
Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Mol Microbiol (2013) 0.77
Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis. Respir Res (2015) 0.76
Lipid Signaling via Pkh1/2 Regulates Fungal CO2 Sensing through the Kinase Sch9. MBio (2017) 0.76
Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response. BMC Genomics (2015) 0.75
Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD(+) homeostasis and contributes to longevity. Front Biol (Beijing) (2015) 0.75
The Aspergillus fumigatus SchA(SCH9) kinase modulates SakA(HOG1) MAP kinase activity and it is essential for virulence. Mol Microbiol (2016) 0.75
Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells. Microb Cell (2014) 0.75
The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1. Biochim Biophys Acta (2017) 0.75
CO2 sensing in fungi: at the heart of metabolic signaling. Curr Genet (2017) 0.75
The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae. Biomolecules (2017) 0.75
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol (1997) 15.32
In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell (1985) 11.63
Active and inactive protein kinases: structural basis for regulation. Cell (1996) 7.98
Role of translocation in the activation and function of protein kinase B. J Biol Chem (1997) 7.29
Systematic identification of pathways that couple cell growth and division in yeast. Science (2002) 6.95
The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol (2010) 6.91
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79
Regulation of longevity and stress resistance by Sch9 in yeast. Science (2001) 5.93
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell (2007) 5.67
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev (2004) 5.08
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol (1998) 5.04
Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci (1997) 4.52
cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell (1988) 3.72
A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1. EMBO J (2000) 3.70
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J (2001) 3.58
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev (2009) 3.31
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science (2005) 3.28
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem J (1999) 3.03
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. EMBO J (2002) 2.72
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J (2000) 2.67
SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev (1988) 2.57
Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol (1999) 2.56
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. Biochem J (2003) 2.15
TOR regulation of AGC kinases in yeast and mammals. Biochem J (2008) 2.13
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc Natl Acad Sci U S A (1998) 2.09
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. EMBO J (2002) 1.93
PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol (1999) 1.83
Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell (2002) 1.77
Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol Cell Biol (2000) 1.72
Caffeine extends yeast lifespan by targeting TORC1. Mol Microbiol (2008) 1.68
Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1979) 1.66
A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A (2009) 1.50
The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae. Mol Microbiol (2003) 1.44
The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9. J Biol Chem (2005) 1.44
The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J Cell Biol (2002) 1.41
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation. Trends Biochem Sci (2004) 1.41
Using substrate-binding variants of the cAMP-dependent protein kinase to identify novel targets and a kinase domain important for substrate interactions in Saccharomyces cerevisiae. Genetics (2006) 1.35
Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast. Mol Microbiol (2006) 1.33
The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiology (1997) 1.32
Association of catalytic and regulatory subunits of cyclic AMP-dependent protein kinase requires a negatively charged side group at a conserved threonine. Mol Cell Biol (1990) 1.31
Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. J Biol Chem (2002) 1.30
Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase. J Biol Chem (1993) 1.26
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nat Chem Biol (2008) 1.16
The molecular chaperone Sse1 and the growth control protein kinase Sch9 collaborate to regulate protein kinase A activity in Saccharomyces cerevisiae. Genetics (2005) 1.15
A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation. Science (1988) 1.15
Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J Exp Med (2006) 1.13
Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A (2006) 1.11
Nutrient-induced activation of trehalase in nutrient-starved cells of the yeast Saccharomyces cerevisiae: cAMP is not involved as second messenger. J Gen Microbiol (1992) 1.04
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem (1992) 1.01
In vivo activation of protein kinase A in Schizosaccharomyces pombe requires threonine phosphorylation at its activation loop and is dependent on PDK1. Genetics (2004) 0.95
Glucose-dependent activation of protein kinase A activity in Saccharomyces cerevisiae and phosphorylation of its TPK1 catalytic subunit. Cell Signal (2005) 0.88
A central integrator of transcription networks in plant stress and energy signalling. Nature (2007) 5.05
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. N Engl J Med (2014) 4.98
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet (2006) 3.04
Glucose-sensing and -signalling mechanisms in yeast. FEMS Yeast Res (2002) 2.50
The Arabidopsis trehalose-6-P synthase AtTPS1 gene is a regulator of glucose, abscisic acid, and stress signaling. Plant Physiol (2004) 1.71
Inorganic phosphate is sensed by specific phosphate carriers and acts in concert with glucose as a nutrient signal for activation of the protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol (2003) 1.69
PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability. Mol Microbiol (2005) 1.69
The eukaryotic plasma membrane as a nutrient-sensing device. Trends Biochem Sci (2004) 1.63
Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev (2014) 1.59
Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae. Mol Cell (2004) 1.58
Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters. Appl Environ Microbiol (2003) 1.56
Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis. Genome Res (2012) 1.46
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. Proc Natl Acad Sci U S A (2010) 1.45
The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae. Mol Microbiol (2003) 1.44
Aquaporin expression correlates with freeze tolerance in baker's yeast, and overexpression improves freeze tolerance in industrial strains. Appl Environ Microbiol (2002) 1.42
Flavor-active esters: adding fruitiness to beer. J Biosci Bioeng (2003) 1.39
The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans. Mol Biol Cell (2005) 1.38
The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. J Biol Chem (2005) 1.34
Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast. Mol Microbiol (2006) 1.33
Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation. Infect Immun (2002) 1.33
Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae. J Biol Chem (2004) 1.22
A short regulatory domain restricts glycerol transport through yeast Fps1p. J Biol Chem (2002) 1.17
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nat Chem Biol (2008) 1.16
Why do microorganisms have aquaporins? Trends Microbiol (2006) 1.15
Production and biological function of volatile esters in Saccharomyces cerevisiae. Microb Biotechnol (2009) 1.15
Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor. Proc Natl Acad Sci U S A (2010) 1.14
Molecular mechanisms controlling the localisation of protein kinase A. Curr Genet (2002) 1.14
Multi-level response of the yeast genome to glucose. Genome Biol (2003) 1.12
Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco. Proc Natl Acad Sci U S A (2011) 1.12
Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A (2006) 1.11
Truncation of Arabidopsis thaliana and Selaginella lepidophylla trehalose-6-phosphate synthase unlocks high catalytic activity and supports high trehalose levels on expression in yeast. Biochem J (2002) 1.08
QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing. PLoS Genet (2013) 1.08
ABI4 mediates the effects of exogenous trehalose on Arabidopsis growth and starch breakdown. Plant Mol Biol (2006) 1.05
Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Mol Microbiol (2002) 1.05
Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Cell Res (2012) 1.04
Extensive expression regulation and lack of heterologous enzymatic activity of the Class II trehalose metabolism proteins from Arabidopsis thaliana. Plant Cell Environ (2009) 1.04
Genetic mapping of quantitative phenotypic traits in Saccharomyces cerevisiae. FEMS Yeast Res (2012) 1.03
Uncoupling of the glucose growth defect and the deregulation of glycolysis in Saccharomyces cerevisiae Tps1 mutants expressing trehalose-6-phosphate-insensitive hexokinase from Schizosaccharomyces pombe. Biochim Biophys Acta (2003) 1.03
Isolation and characterization of a freeze-tolerant diploid derivative of an industrial baker's yeast strain and its use in frozen doughs. Appl Environ Microbiol (2002) 1.03
Comparative polygenic analysis of maximal ethanol accumulation capacity and tolerance to high ethanol levels of cell proliferation in yeast. PLoS Genet (2013) 1.01
Saccharomyces cerevisiae plasma membrane nutrient sensors and their role in PKA signaling. FEMS Yeast Res (2009) 1.00
Feedback inhibition on cell wall integrity signaling by Zds1 involves Gsk3 phosphorylation of a cAMP-dependent protein kinase regulatory subunit. J Biol Chem (2003) 1.00
The protein quality control system manages plant defence compound synthesis. Nature (2013) 0.99
Isolation and characterization of brewer's yeast variants with improved fermentation performance under high-gravity conditions. Appl Environ Microbiol (2006) 0.99
Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum. Proc Natl Acad Sci U S A (2014) 0.96
A bifunctional TPS-TPP enzyme from yeast confers tolerance to multiple and extreme abiotic-stress conditions in transgenic Arabidopsis. Planta (2007) 0.96
Molecular mechanisms of feedback inhibition of protein kinase A on intracellular cAMP accumulation. Cell Signal (2012) 0.96
Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro. New Phytol (2013) 0.95
The Saccharomyces cerevisiae alcohol acetyl transferase Atf1p is localized in lipid particles. Yeast (2004) 0.95
Combining inhibitor tolerance and D-xylose fermentation in industrial Saccharomyces cerevisiae for efficient lignocellulose-based bioethanol production. Biotechnol Biofuels (2013) 0.95
An integrated framework for discovery and genotyping of genomic variants from high-throughput sequencing experiments. Nucleic Acids Res (2014) 0.94
Molecular mechanisms controlling phosphate-induced downregulation of the yeast Pho84 phosphate transporter. Biochemistry (2009) 0.94
Yeast nutrient transceptors provide novel insight in the functionality of membrane transporters. Curr Genet (2013) 0.93
A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys (2009) 0.92
Cyclic AMP-protein kinase A and Snf1 signaling mechanisms underlie the superior potency of sucrose for induction of filamentation in Saccharomyces cerevisiae. Eukaryot Cell (2007) 0.92
Determinants of freeze tolerance in microorganisms, physiological importance, and biotechnological applications. Adv Appl Microbiol (2003) 0.91
Glucose and sucrose: hazardous fast-food for industrial yeast? Trends Biotechnol (2004) 0.91
Mutational analysis of putative phosphate- and proton-binding sites in the Saccharomyces cerevisiae Pho84 phosphate:H(+) transceptor and its effect on signalling to the PKA and PHO pathways. Biochem J (2012) 0.90
Phenotypic evaluation of natural and industrial Saccharomyces yeasts for different traits desirable in industrial bioethanol production. Appl Microbiol Biotechnol (2014) 0.89
Peptides induce persistent signaling from endosomes by a nutrient transceptor. Nat Chem Biol (2012) 0.89
The Saccharomyces cerevisiae alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathways. FEMS Yeast Res (2003) 0.88
Aquaporin-mediated improvement of freeze tolerance of Saccharomyces cerevisiae is restricted to rapid freezing conditions. Appl Environ Microbiol (2004) 0.87
The trehalose pathway regulates mitochondrial respiratory chain content through hexokinase 2 and cAMP in Saccharomyces cerevisiae. J Biol Chem (2009) 0.85
Characterization of the Pho89 phosphate transporter by functional hyperexpression in Saccharomyces cerevisiae. FEMS Yeast Res (2008) 0.85
A split-ubiquitin two-hybrid screen for proteins physically interacting with the yeast amino acid transceptor Gap1 and ammonium transceptor Mep2. PLoS One (2011) 0.85
Directly from Galpha to protein kinase A: the kelch repeat protein bypass of adenylate cyclase. Trends Biochem Sci (2007) 0.85
Evidence for inositol triphosphate as a second messenger for glucose-induced calcium signalling in budding yeast. Curr Genet (2003) 0.85
Novel mechanisms in nutrient activation of the yeast protein kinase A pathway. Acta Microbiol Immunol Hung (2008) 0.85
Identification of hexose transporter-like sensor HXS1 and functional hexose transporter HXT1 in the methylotrophic yeast Hansenula polymorpha. Eukaryot Cell (2008) 0.85
In vivo phosphorylation of Ser21 and Ser83 during nutrient-induced activation of the yeast protein kinase A (PKA) target trehalase. J Biol Chem (2012) 0.85
Quantitative trait analysis of yeast biodiversity yields novel gene tools for metabolic engineering. Metab Eng (2013) 0.84
Specific analogues uncouple transport, signalling, oligo-ubiquitination and endocytosis in the yeast Gap1 amino acid transceptor. Mol Microbiol (2014) 0.84
Identification of multiple interacting alleles conferring low glycerol and high ethanol yield in Saccharomyces cerevisiae ethanolic fermentation. Biotechnol Biofuels (2013) 0.83
Agp2, a member of the yeast amino acid permease family, positively regulates polyamine transport at the transcriptional level. PLoS One (2013) 0.83
G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae. Cell Biol Int (2007) 0.82
Combined inactivation of the Candida albicans GPR1 and TPS2 genes results in avirulence in a mouse model for systemic infection. Infect Immun (2008) 0.82
Correlation between glucose/fructose discrepancy and hexokinase kinetic properties in different Saccharomyces cerevisiae wine yeast strains. Appl Microbiol Biotechnol (2007) 0.81
Controlled expression of homologous genes by genomic promoter replacement in the yeast Saccharomyces cerevisiae. Methods Mol Biol (2004) 0.81
Aquaporin expression and freeze tolerance in Candida albicans. Appl Environ Microbiol (2005) 0.81
Trehalose-6-phosphate synthase as an intrinsic selection marker for plant transformation. J Biotechnol (2005) 0.81
Evidence for rapid uptake of D-galacturonic acid in the yeast Saccharomyces cerevisiae by a channel-type transport system. FEBS Lett (2012) 0.81
Flavour formation in fungi: characterisation of KlAtf, the Kluyveromyces lactis orthologue of the Saccharomyces cerevisiae alcohol acetyltransferases Atf1 and Atf2. Appl Microbiol Biotechnol (2008) 0.81
Natural and modified promoters for tailored metabolic engineering of the yeast Saccharomyces cerevisiae. Methods Mol Biol (2014) 0.81
Activation state of protein kinase A as measured in permeabilised Saccharomyces cerevisiae cells correlates with PKA-controlled phenotypes in vivo. FEMS Yeast Res (2003) 0.79
Assessing the potential of wild yeasts for bioethanol production. J Ind Microbiol Biotechnol (2014) 0.79
The use of semiparametric mixed models to analyze PamChip(R) peptide array data: an application to an oncology experiment. Bioinformatics (2011) 0.78
Heterologous aquaporin (AQY2-1) expression strongly enhances freeze tolerance of Schizosaccharomyces pombe. J Mol Microbiol Biotechnol (2005) 0.78