Biosynthesis and mode of action of lantibiotics.

PubWeight™: 4.59‹?› | Rank: Top 1%

🔗 View Article (PMID 15700960)

Published in Chem Rev on February 01, 2005

Authors

Champak Chatterjee1, Moushumi Paul, Lili Xie, Wilfred A van der Donk

Author Affiliations

1: Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois, USA.

Articles citing this

(truncated to the top 100)

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci U S A (2005) 5.02

Interspecies interactions within oral microbial communities. Microbiol Mol Biol Rev (2007) 3.16

Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds. Nat Prod Rep (2009) 2.32

Biosynthesis of phosphonic and phosphinic acid natural products. Annu Rev Biochem (2009) 2.19

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18

Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. Antimicrob Agents Chemother (2007) 2.14

Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95

Common mechanisms of target cell recognition and immunity for class II bacteriocins. Proc Natl Acad Sci U S A (2007) 1.81

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74

Lipid intermediates in the biosynthesis of bacterial peptidoglycan. Microbiol Mol Biol Rev (2007) 1.69

Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins. Appl Environ Microbiol (2009) 1.68

Bacteriocin diversity in Streptococcus and Enterococcus. J Bacteriol (2006) 1.57

Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes. Proc Natl Acad Sci U S A (2010) 1.57

Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants. Chem Biol (2012) 1.55

Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin. Appl Environ Microbiol (2006) 1.54

Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides. Proc Natl Acad Sci U S A (2010) 1.52

Substrate control in stereoselective lanthionine biosynthesis. Nat Chem (2014) 1.51

The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities. Anal Bioanal Chem (2006) 1.49

Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis. Cell Chem Biol (2016) 1.48

Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation. Appl Environ Microbiol (2007) 1.46

The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry (2008) 1.46

Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins. J Biol Chem (2010) 1.41

Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiol Mol Biol Rev (2006) 1.41

The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A. Nat Chem Biol (2012) 1.39

Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain Streptococcus salivarius K12. Appl Environ Microbiol (2006) 1.36

Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry (2007) 1.36

Production of dehydroamino acid-containing peptides by Lactococcus lactis. Appl Environ Microbiol (2007) 1.36

Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis. Appl Environ Microbiol (2006) 1.35

Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol (2009) 1.32

The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc (2007) 1.31

Linking chemistry and genetics in the growing cyanobactin natural products family. Chem Biol (2011) 1.29

Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry (2007) 1.22

Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus. Proc Natl Acad Sci U S A (2010) 1.22

Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin. J Biol Chem (2009) 1.21

Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry (2012) 1.18

Novel mechanism for nisin resistance via proteolytic degradation of nisin by the nisin resistance protein NSR. Antimicrob Agents Chemother (2009) 1.17

Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc (2009) 1.16

In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry (2008) 1.16

On the substrate specificity of dehydration by lacticin 481 synthetase. J Am Chem Soc (2007) 1.16

Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc (2011) 1.15

Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry (2013) 1.15

How nature morphs peptide scaffolds into antibiotics. Chembiochem (2009) 1.14

Studies with bioengineered Nisin peptides highlight the broad-spectrum potency of Nisin V. Microb Biotechnol (2010) 1.14

Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage. Appl Environ Microbiol (2010) 1.11

Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks. ACS Chem Biol (2012) 1.11

Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol (2011) 1.10

The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat Chem Biol (2013) 1.09

Immunity to the bacteriocin sublancin 168 Is determined by the SunI (YolF) protein of Bacillus subtilis. Antimicrob Agents Chemother (2008) 1.09

Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrob Agents Chemother (2010) 1.08

The dehydratase activity of lacticin 481 synthetase is highly processive. J Am Chem Soc (2006) 1.08

Inhibition of Bacillus anthracis spore outgrowth by nisin. Antimicrob Agents Chemother (2008) 1.08

The GCR2 gene family is not required for ABA control of seed germination and early seedling development in Arabidopsis. PLoS One (2008) 1.07

Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin. ACS Chem Biol (2011) 1.06

Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome. BMC Genomics (2011) 1.05

Bacterial interactions in dental biofilm. Virulence (2011) 1.04

Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. Chembiochem (2009) 1.02

Cloning and analysis of the planosporicin lantibiotic biosynthetic gene cluster of Planomonospora alba. J Bacteriol (2013) 0.99

Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures. J Neurosci (2010) 0.98

Entianin, a novel subtilin-like lantibiotic from Bacillus subtilis subsp. spizizenii DSM 15029T with high antimicrobial activity. Appl Environ Microbiol (2011) 0.98

Rings, radicals, and regeneration: the early years of a bioorganic laboratory. J Org Chem (2006) 0.98

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett (2008) 0.98

On the regioselectivity of thioether formation by lacticin 481 synthetase. Org Lett (2007) 0.98

An association mapping approach to identify favourable alleles for tomato fruit quality breeding. BMC Plant Biol (2014) 0.96

Substrate recognition and specificity of the NisB protein, the lantibiotic dehydratase involved in nisin biosynthesis. J Biol Chem (2011) 0.96

A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2. J Am Chem Soc (2014) 0.96

The two peptide lantibiotic lacticin 3147 acts synergistically with polymyxin to inhibit Gram negative bacteria. BMC Microbiol (2013) 0.96

Therapeutic potential of type A (I) lantibiotics, a group of cationic peptide antibiotics. Curr Opin Microbiol (2008) 0.95

Bioengineering of a Nisin A-producing Lactococcus lactis to create isogenic strains producing the natural variants Nisin F, Q and Z. Microb Biotechnol (2010) 0.95

Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2. PLoS One (2012) 0.95

Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense. J Biol Chem (2012) 0.95

Cerecidins, novel lantibiotics from Bacillus cereus with potent antimicrobial activity. Appl Environ Microbiol (2014) 0.95

Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry. J Am Chem Soc (2011) 0.94

Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Genes Dev (2009) 0.94

Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria. BMC Genomics (2014) 0.93

Insights into the evolution of lanthipeptide biosynthesis. Protein Sci (2013) 0.93

Stereoselective additions of thiyl radicals to terminal ynamides. Org Lett (2010) 0.93

Mechanistic dissection of the enzyme complexes involved in biosynthesis of lacticin 3147 and nisin. Appl Environ Microbiol (2008) 0.93

The large mechanosensitive channel MscL determines bacterial susceptibility to the bacteriocin sublancin 168. Antimicrob Agents Chemother (2009) 0.93

The inhibitory spectrum of thermophilin 9 from Streptococcus thermophilus LMD-9 depends on the production of multiple peptides and the activity of BlpG(St), a thiol-disulfide oxidase. Appl Environ Microbiol (2007) 0.92

Site-directed mutations in the lanthipeptide mutacin 1140. Appl Environ Microbiol (2013) 0.92

Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcM. J Am Chem Soc (2014) 0.92

The Clostridium difficile cpr locus is regulated by a noncontiguous two-component system in response to type A and B lantibiotics. J Bacteriol (2013) 0.91

Lacticin 481 synthetase as a general serine/threonine kinase. ACS Chem Biol (2009) 0.91

Feed-forward regulation of microbisporicin biosynthesis in Microbispora corallina. J Bacteriol (2011) 0.91

Effects of bacteriocins on methicillin-resistant Staphylococcus aureus biofilm. Antimicrob Agents Chemother (2013) 0.90

Restoration of bioactive lantibiotic suicin from a remnant lan locus of pathogenic Streptococcus suis serotype 2. Appl Environ Microbiol (2013) 0.90

High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis. ACS Chem Biol (2014) 0.90

Ribosomal synthesis of dehydroalanine-containing peptides. J Am Chem Soc (2006) 0.90

Lantibiotic resistance. Microbiol Mol Biol Rev (2015) 0.89

Cooperative transport between NukFEG and NukH in immunity against the lantibiotic nukacin ISK-1 produced by Staphylococcus warneri ISK-1. J Bacteriol (2007) 0.89

Quorum sensing in group A Streptococcus. Front Cell Infect Microbiol (2014) 0.89

The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions. J Biol Chem (2014) 0.89

Mutacins from Streptococcus mutans UA159 are active against multiple streptococcal species. Appl Environ Microbiol (2011) 0.88

Distinct contributions of the nisin biosynthesis enzymes NisB and NisC and transporter NisT to prenisin production by Lactococcus lactis. Appl Environ Microbiol (2008) 0.88

GCR2 is a new member of the eukaryotic lanthionine synthetase component C-like protein family. Plant Signal Behav (2008) 0.87

Purification, characterization, and gene sequence of michiganin A, an actagardine-like lantibiotic produced by the tomato pathogen Clavibacter michiganensis subsp. michiganensis. Appl Environ Microbiol (2006) 0.87

Overproduction of wild-type and bioengineered derivatives of the lantibiotic lacticin 3147. Appl Environ Microbiol (2006) 0.87

Articles by these authors

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science (2006) 3.29

Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16

Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83

Biosynthesis of phosphonic and phosphinic acid natural products. Annu Rev Biochem (2009) 2.19

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18

Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem (2012) 2.01

Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95

Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74

Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72

Genome mining for ribosomally synthesized natural products. Curr Opin Chem Biol (2010) 1.58

Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56

Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem Biol (2006) 1.56

Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (2012) 1.53

New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb) (2006) 1.53

Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A (2012) 1.53

An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis. Nature (2009) 1.51

Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47

The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry (2008) 1.46

Sublancin is not a lantibiotic but an S-linked glycopeptide. Nat Chem Biol (2011) 1.44

Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44

In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc (2009) 1.37

Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry (2007) 1.36

Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33

Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol (2009) 1.32

The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc (2007) 1.31

Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. Chem Biol (2010) 1.30

Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J Biol Chem (2007) 1.25

Post-translational modifications during lantibiotic biosynthesis. Curr Opin Chem Biol (2004) 1.24

Biomimetic stereoselective formation of methyllanthionine. Org Lett (2002) 1.23

SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry (2003) 1.23

Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry (2007) 1.22

Hydroperoxylation by hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2009) 1.22

Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis. Proc Natl Acad Sci U S A (2010) 1.20

Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry (2012) 1.18

Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster. Chem Biol (2010) 1.17

Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. J Biol Chem (2008) 1.17

Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc (2009) 1.16

In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry (2008) 1.16

On the substrate specificity of dehydration by lacticin 481 synthetase. J Am Chem Soc (2007) 1.16

Biomimetic studies on the mechanism of stereoselective lanthionine formation. Org Biomol Chem (2003) 1.15

Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc (2011) 1.15

Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry (2013) 1.15

Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods Enzymol (2009) 1.13

Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design. Biochemistry (2003) 1.13

Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol (2011) 1.10

In vitro activity of the nisin dehydratase NisB. Proc Natl Acad Sci U S A (2013) 1.10

Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase. J Am Chem Soc (2002) 1.09

The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat Chem Biol (2013) 1.09

An engineered lantibiotic synthetase that does not require a leader peptide on its substrate. J Am Chem Soc (2012) 1.09

The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. J Am Chem Soc (2004) 1.09

The dehydratase activity of lacticin 481 synthetase is highly processive. J Am Chem Soc (2006) 1.08

Inhibition of Bacillus anthracis spore outgrowth by nisin. Antimicrob Agents Chemother (2008) 1.08

Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin. ACS Chem Biol (2011) 1.06

Regeneration of cofactors for use in biocatalysis. Curr Opin Biotechnol (2003) 1.04

Synthesis of site-specifically labeled arachidonic acids as mechanistic probes for prostaglandin H synthase. Org Lett (2004) 1.04

Heterologous expression and purification of SpaB involved in subtilin biosynthesis. Biochem Biophys Res Commun (2002) 1.03

Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. Chembiochem (2009) 1.02

Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme. Angew Chem Int Ed Engl (2002) 1.02

Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa. Appl Environ Microbiol (2005) 1.02

Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angew Chem Int Ed Engl (2007) 1.02

Agreement between prospective interactive voice response telephone reporting and structured recall reports of risk behaviors in rural substance users living with HIV/AIDS. Psychol Addict Behav (2011) 1.00

On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2011) 1.00

Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids. Chem Commun (Camb) (2003) 0.98

Interactive voice response self-monitoring to assess risk behaviors in rural substance users living with HIV/AIDS. AIDS Behav (2012) 0.98

Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species. Antimicrob Agents Chemother (2012) 0.98

On the regioselectivity of thioether formation by lacticin 481 synthetase. Org Lett (2007) 0.98

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett (2008) 0.98

Biosynthesis of the class III lantipeptide catenulipeptin. ACS Chem Biol (2012) 0.97

Mechanisms decreasing in vitro susceptibility to the LpxC inhibitor CHIR-090 in the gram-negative pathogen Pseudomonas aeruginosa. Antimicrob Agents Chemother (2011) 0.96

A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2. J Am Chem Soc (2014) 0.96

Accurate projector calibration method by using an optical coaxial camera. Appl Opt (2015) 0.96

Comparison of the properties of prostaglandin H synthase-1 and -2. Prog Lipid Res (2003) 0.96

Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. Chem Biol (2011) 0.95

A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization. J Am Chem Soc (2013) 0.95

Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry. J Am Chem Soc (2011) 0.94

Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family. Biochemistry (2011) 0.94

Site-directed mutagenesis of active site residues of phosphite dehydrogenase. Biochemistry (2005) 0.94

Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry (2008) 0.94

Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin. ACS Chem Biol (2011) 0.94

Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway. Proc Natl Acad Sci U S A (2013) 0.93

Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. Biochemistry (2009) 0.93

Insights into the evolution of lanthipeptide biosynthesis. Protein Sci (2013) 0.93

Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2. J Biol Chem (2002) 0.93

Model studies of the histidine-tyrosine cross-link in cytochrome C oxidase reveal the flexible substituent effect of the imidazole moiety. Org Lett (2005) 0.92

Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angew Chem Int Ed Engl (2013) 0.92

Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcM. J Am Chem Soc (2014) 0.92

Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin. Arch Biochem Biophys (2010) 0.92

Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology. Curr Opin Chem Biol (2013) 0.92

Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021. J Biol Chem (2011) 0.91

Transforming a blue copper into a red copper protein: engineering cysteine and homocysteine into the axial position of azurin using site-directed mutagenesis and expressed protein ligation. J Am Chem Soc (2010) 0.91

Lacticin 481 synthetase as a general serine/threonine kinase. ACS Chem Biol (2009) 0.91

Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification. J Am Chem Soc (2005) 0.91