Published in Science on March 10, 2006
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16
Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds. Nat Prod Rep (2009) 2.32
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19
Unearthing the roots of the terpenome. Curr Opin Chem Biol (2008) 2.00
Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95
Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74
Calling International Rescue: knowledge lost in literature and data landslide! Biochem J (2009) 1.71
Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56
Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB. Nature (2014) 1.53
Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants. J Am Chem Soc (2010) 1.51
Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. J Biol Chem (2009) 1.50
Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family. BMC Biol (2010) 1.49
The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry (2008) 1.46
Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44
Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins. J Biol Chem (2010) 1.41
Production of dehydroamino acid-containing peptides by Lactococcus lactis. Appl Environ Microbiol (2007) 1.36
Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry (2007) 1.36
The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc (2007) 1.31
Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry (2007) 1.22
Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin. J Biol Chem (2009) 1.21
Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry (2012) 1.18
Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc (2009) 1.16
In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry (2008) 1.16
On the substrate specificity of dehydration by lacticin 481 synthetase. J Am Chem Soc (2007) 1.16
Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc (2011) 1.15
Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry (2013) 1.15
How nature morphs peptide scaffolds into antibiotics. Chembiochem (2009) 1.14
Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks. ACS Chem Biol (2012) 1.11
Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage. Appl Environ Microbiol (2010) 1.11
Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol (2011) 1.10
In vitro activity of the nisin dehydratase NisB. Proc Natl Acad Sci U S A (2013) 1.10
An engineered lantibiotic synthetase that does not require a leader peptide on its substrate. J Am Chem Soc (2012) 1.09
Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. Chembiochem (2009) 1.02
Sec-mediated transport of posttranslationally dehydrated peptides in Lactococcus lactis. Appl Environ Microbiol (2006) 1.01
Cloning and analysis of the planosporicin lantibiotic biosynthetic gene cluster of Planomonospora alba. J Bacteriol (2013) 0.99
Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett (2008) 0.98
Rings, radicals, and regeneration: the early years of a bioorganic laboratory. J Org Chem (2006) 0.98
On the regioselectivity of thioether formation by lacticin 481 synthetase. Org Lett (2007) 0.98
New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products. Cell Chem Biol (2016) 0.98
Biosynthesis of the class III lantipeptide catenulipeptin. ACS Chem Biol (2012) 0.97
Substrate recognition and specificity of the NisB protein, the lantibiotic dehydratase involved in nisin biosynthesis. J Biol Chem (2011) 0.96
Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink. Nat Chem (2015) 0.95
Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc Natl Acad Sci U S A (2008) 0.94
Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family. Biochemistry (2011) 0.94
Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Genes Dev (2009) 0.94
Insights into the evolution of lanthipeptide biosynthesis. Protein Sci (2013) 0.93
Mechanistic dissection of the enzyme complexes involved in biosynthesis of lacticin 3147 and nisin. Appl Environ Microbiol (2008) 0.93
Influence of shifting positions of Ser, Thr, and Cys residues in prenisin on the efficiency of modification reactions and on the antimicrobial activities of the modified prepeptides. Appl Environ Microbiol (2008) 0.91
High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis. ACS Chem Biol (2014) 0.90
GCR2 is a new member of the eukaryotic lanthionine synthetase component C-like protein family. Plant Signal Behav (2008) 0.87
Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt. Mol Biol Cell (2014) 0.86
Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in actinobacteria. Appl Environ Microbiol (2015) 0.86
The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold. Elife (2015) 0.86
Novel LanT associated lantibiotic clusters identified by genome database mining. PLoS One (2014) 0.85
Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC. FEBS Open Bio (2013) 0.84
Product Formation by the Promiscuous Lanthipeptide Synthetase ProcM is under Kinetic Control. J Am Chem Soc (2015) 0.84
Derivatisable Cyanobactin Analogues: A Semisynthetic Approach. Chembiochem (2015) 0.83
Efficient synthesis of suitably protected beta-difluoroalanine and gamma-difluorothreonine from L-ascorbic acid. Org Lett (2007) 0.82
Zirex: a novel zinc-regulated expression system for Lactococcus lactis. Appl Environ Microbiol (2013) 0.82
Michael-type cyclizations in lantibiotic biosynthesis are reversible. ACS Chem Biol (2015) 0.81
Structure and mechanism of lanthipeptide biosynthetic enzymes. Curr Opin Struct Biol (2014) 0.79
Optimization of the Production of the Lantibiotic Mutacin 1140 in Minimal Media. Process Biochem (2010) 0.79
Biochemistry. Five golden rings. Science (2006) 0.78
Value addition in the efficacy of conventional antibiotics by Nisin against Salmonella. PLoS One (2013) 0.78
Heterotrimeric G-protein signaling in Arabidopsis: Puzzling G-protein-coupled receptor. Plant Signal Behav (2008) 0.78
Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides. Beilstein J Org Chem (2016) 0.77
Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO. ACS Chem Biol (2014) 0.77
Activation of Histidine Kinase SpaK Is Mediated by the N-Terminal Portion of Subtilin-Like Lantibiotics and Is Independent of Lipid II. Appl Environ Microbiol (2015) 0.77
Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis. J Am Chem Soc (2016) 0.77
The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin. J Biol Chem (2015) 0.76
Discovery and biosynthesis of mathermycin from marine-derived Marinactinospora thermotolerans SCSIO 00652. Appl Environ Microbiol (2017) 0.76
Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes. Chem Rev (2017) 0.75
Prospects of In vivo Incorporation of Non-canonical Amino Acids for the Chemical Diversification of Antimicrobial Peptides. Front Microbiol (2017) 0.75
Autoinduction Specificities of the Lantibiotics Subtilin and Nisin. Appl Environ Microbiol (2015) 0.75
Characterization of a Multipeptide Lantibiotic Locus in Streptococcus pneumoniae. MBio (2016) 0.75
Stoichiometry and structure of a lantibiotic maturation complex. Sci Rep (2017) 0.75
Genome Analysis of Two Pseudonocardia Phylotypes Associated with Acromyrmex Leafcutter Ants Reveals Their Biosynthetic Potential. Front Microbiol (2016) 0.75
LanCL proteins are not Involved in Lanthionine Synthesis in Mammals. Sci Rep (2017) 0.75
Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM. Biopolymers (2016) 0.75
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Biosynthesis and mode of action of lantibiotics. Chem Rev (2005) 4.59
A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome. Nature (2005) 4.03
Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat Struct Mol Biol (2007) 3.77
Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83
Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev (2005) 2.56
Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (2011) 2.52
High resolution structure of Deinococcus bacteriophytochrome yields new insights into phytochrome architecture and evolution. J Biol Chem (2007) 2.33
Biosynthesis of phosphonic and phosphinic acid natural products. Annu Rev Biochem (2009) 2.19
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19
Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18
Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem (2012) 2.01
Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95
Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem Biol (2009) 1.88
Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes. Biochemistry (2005) 1.84
Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76
Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J (2007) 1.74
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72
Structural origins for the product specificity of SET domain protein methyltransferases. Proc Natl Acad Sci U S A (2008) 1.72
Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin. Biochemistry (2005) 1.68
Structural basis for molecular recognition of folic acid by folate receptors. Nature (2013) 1.62
Genome mining for ribosomally synthesized natural products. Curr Opin Chem Biol (2010) 1.58
Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56
Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem Biol (2006) 1.56
Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (2012) 1.53
New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb) (2006) 1.53
Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A (2012) 1.53
An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis. Nature (2009) 1.51
Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains. J Biol Chem (2009) 1.50
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47
NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides. J Biol Chem (2004) 1.47
Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation. Appl Environ Microbiol (2007) 1.46
The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry (2008) 1.46
Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling. J Immunol (2005) 1.45
Sublancin is not a lantibiotic but an S-linked glycopeptide. Nat Chem Biol (2011) 1.44
Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44
In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis. Proc Natl Acad Sci U S A (2008) 1.39
Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proc Natl Acad Sci U S A (2012) 1.38
Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst. J Am Chem Soc (2010) 1.38
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc (2009) 1.37
Production of dehydroamino acid-containing peptides by Lactococcus lactis. Appl Environ Microbiol (2007) 1.36
Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry (2007) 1.36
Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33
Characterization of the deoxynucleotide triphosphate triphosphohydrolase (dNTPase) activity of the EF1143 protein from Enterococcus faecalis and crystal structure of the activator-substrate complex. J Biol Chem (2011) 1.33
Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol (2009) 1.32
The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc (2007) 1.31
Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. Chem Biol (2010) 1.30
Structure and regulon of Campylobacter jejuni ferric uptake regulator Fur define apo-Fur regulation. Proc Natl Acad Sci U S A (2012) 1.27
Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog. J Pharmacol Exp Ther (2008) 1.26
Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J Biol Chem (2007) 1.25
Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters. Structure (2007) 1.25
Enzymatic basis of ribosomal peptide prenylation in cyanobacteria. J Am Chem Soc (2011) 1.25
Post-translational modifications during lantibiotic biosynthesis. Curr Opin Chem Biol (2004) 1.24
Biomimetic stereoselective formation of methyllanthionine. Org Lett (2002) 1.23
SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry (2003) 1.23
Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry (2007) 1.22
Hydroperoxylation by hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2009) 1.22
NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides. Biochemistry (2007) 1.21
Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis. Proc Natl Acad Sci U S A (2010) 1.20
Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry (2012) 1.18
Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proc Natl Acad Sci U S A (2012) 1.17
Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster. Chem Biol (2010) 1.17
Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. J Biol Chem (2008) 1.17
On the substrate specificity of dehydration by lacticin 481 synthetase. J Am Chem Soc (2007) 1.16
In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry (2008) 1.16
Structural analysis of a viral ovarian tumor domain protease from the Crimean-Congo hemorrhagic fever virus in complex with covalently bonded ubiquitin. J Virol (2011) 1.16
Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc (2009) 1.16
Biomimetic studies on the mechanism of stereoselective lanthionine formation. Org Biomol Chem (2003) 1.15
Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc (2011) 1.15
Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry (2013) 1.15
The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res (2012) 1.15
Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods Enzymol (2009) 1.13
Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design. Biochemistry (2003) 1.13
Insights into the architecture of the replicative helicase from the structure of an archaeal MCM homolog. Structure (2009) 1.12
Structural basis for RNA recognition by a dimeric PPR-protein complex. Nat Struct Mol Biol (2013) 1.12
Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism. Mol Cell (2004) 1.11
Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage. Appl Environ Microbiol (2010) 1.11
Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol (2011) 1.10
In vitro activity of the nisin dehydratase NisB. Proc Natl Acad Sci U S A (2013) 1.10
Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase. J Am Chem Soc (2002) 1.09
An engineered lantibiotic synthetase that does not require a leader peptide on its substrate. J Am Chem Soc (2012) 1.09
The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat Chem Biol (2013) 1.09
The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. J Am Chem Soc (2004) 1.09
Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrob Agents Chemother (2010) 1.08
The dehydratase activity of lacticin 481 synthetase is highly processive. J Am Chem Soc (2006) 1.08
Inhibition of Bacillus anthracis spore outgrowth by nisin. Antimicrob Agents Chemother (2008) 1.08
Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin. ACS Chem Biol (2011) 1.06
Structures of cyanobactin maturation enzymes define a family of transamidating proteases. Chem Biol (2012) 1.06
Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1. Proc Natl Acad Sci U S A (2009) 1.05