Lantibiotics from Geobacillus thermodenitrificans.

PubWeight™: 1.53‹?› | Rank: Top 4%

🔗 View Article (PMC 3325677)

Published in Proc Natl Acad Sci U S A on March 19, 2012

Authors

Neha Garg1, Weixin Tang, Yuki Goto, Satish K Nair, Wilfred A van der Donk

Author Affiliations

1: Department of Biochemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA.

Articles citing this

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Bacteriocins - a viable alternative to antibiotics? Nat Rev Microbiol (2012) 2.76

Substrate control in stereoselective lanthionine biosynthesis. Nat Chem (2014) 1.51

Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis. Cell Chem Biol (2016) 1.48

Structural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium. Cell Chem Biol (2016) 1.45

Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44

Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry (2012) 1.18

The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat Chem Biol (2013) 1.09

Biosynthesis of the class III lantipeptide catenulipeptin. ACS Chem Biol (2012) 0.97

A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization. J Am Chem Soc (2013) 0.95

Cerecidins, novel lantibiotics from Bacillus cereus with potent antimicrobial activity. Appl Environ Microbiol (2014) 0.95

Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli. Chem Commun (Camb) (2012) 0.88

Characteristics of thermostable endoxylanase and β-xylosidase of the extremely thermophilic bacterium Geobacillus thermodenitrificans TSAA1 and its applicability in generating xylooligosaccharides and xylose from agro-residues. Extremophiles (2013) 0.86

Lessons learned from the transformation of natural product discovery to a genome-driven endeavor. J Ind Microbiol Biotechnol (2013) 0.83

Improved lanthipeptide detection and prediction for antiSMASH. PLoS One (2014) 0.83

Bioengineering of the model lantibiotic nisin. Bioengineered (2015) 0.82

In silico identification of bacteriocin gene clusters in the gastrointestinal tract, based on the Human Microbiome Project's reference genome database. BMC Microbiol (2015) 0.82

Michael-type cyclizations in lantibiotic biosynthesis are reversible. ACS Chem Biol (2015) 0.81

Some (bacilli) like it hot: genomics of Geobacillus species. Microb Biotechnol (2014) 0.81

The Bacillus cereus group is an excellent reservoir of novel lanthipeptides. Appl Environ Microbiol (2014) 0.81

Nucleophilic 1,4-additions for natural product discovery. ACS Chem Biol (2014) 0.80

Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry. J Am Chem Soc (2013) 0.80

Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid. J Am Chem Soc (2015) 0.79

Mode of action and structure-activity relationship studies of geobacillin I. J Antibiot (Tokyo) (2013) 0.79

Insights into the biosynthesis of duramycin. Appl Environ Microbiol (2016) 0.78

Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis. J Am Chem Soc (2016) 0.77

Three Novel Lantibiotics, Ticins A1, A3, and A4, Have Extremely Stable Properties and Are Promising Food Biopreservatives. Appl Environ Microbiol (2015) 0.76

Genome Sequence of Geobacillus sp. Strain ZGt-1, an Antibacterial Peptide-Producing Bacterium from Hot Springs in Jordan. Genome Announc (2015) 0.76

Antimicrobial Protein Candidates from the Thermophilic Geobacillus sp. Strain ZGt-1: Production, Proteomics, and Bioinformatics Analysis. Int J Mol Sci (2016) 0.75

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes. Chem Rev (2017) 0.75

Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species. BMC Genomics (2016) 0.75

One-pot synthesis of class II lanthipeptide bovicin HJ50 via an engineered lanthipeptide synthetase. Sci Rep (2016) 0.75

Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM. Biopolymers (2016) 0.75

Draft Genome Sequences of Two Geobacillus Species Strains, Isolated from Oil Wells and Surface Soil above Oil Pools. Genome Announc (2016) 0.75

Articles cited by this

Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science (1999) 5.30

A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export. Mol Microbiol (1995) 4.07

Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00

Applications of the bacteriocin, nisin. Antonie Van Leeuwenhoek (1996) 3.16

Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16

An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II. Science (2006) 3.05

Lipid II as a target for antibiotics. Nat Rev Drug Discov (2006) 3.01

Characterization of the Lactococcus lactis nisin A operon genes nisP, encoding a subtilisin-like serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis. J Bacteriol (1993) 2.84

Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics. Mol Microbiol (1998) 2.69

Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes. J Biol Chem (2003) 2.26

Genome mining for novel natural product discovery. J Med Chem (2008) 2.22

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18

Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein. Appl Environ Microbiol (1992) 2.18

Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir. Proc Natl Acad Sci U S A (2007) 2.06

A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol (2011) 2.05

The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor. Proc Natl Acad Sci U S A (2004) 2.04

Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74

Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins. Appl Environ Microbiol (2009) 1.68

Genome mining for ribosomally synthesized natural products. Curr Opin Chem Biol (2010) 1.58

Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56

Enterococcal cytolysin: a novel two component peptide system that serves as a bacterial defense against eukaryotic and prokaryotic cells. Curr Protein Pept Sci (2005) 1.54

Improvement of solubility and stability of the antimicrobial peptide nisin by protein engineering. Appl Environ Microbiol (1995) 1.45

Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics. Microbiology (2001) 1.34

Identification of a novel two-peptide lantibiotic, haloduracin, produced by the alkaliphile Bacillus halodurans C-125. FEMS Microbiol Lett (2007) 1.21

Heterologous expression, biosynthesis, and mutagenesis of type II lantibiotics from Bacillus licheniformis in Escherichia coli. Chem Biol (2011) 1.20

Lipid II-mediated pore formation by the peptide antibiotic nisin: a black lipid membrane study. J Bacteriol (2004) 1.17

Solution structures of nisin A and its two major degradation products determined by n.m.r. Biochem J (1992) 1.16

Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13. PLoS One (2009) 1.14

Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods Enzymol (2009) 1.13

SapT, a lanthionine-containing peptide involved in aerial hyphae formation in the streptomycetes. Mol Microbiol (2005) 1.13

Novel lantibiotics and their pre-peptides. Antonie Van Leeuwenhoek (1996) 1.12

Genome mining demonstrates the widespread occurrence of gene clusters encoding bacteriocins in cyanobacteria. PLoS One (2011) 1.11

Application of a recN sequence similarity analysis to the identification of species within the bacterial genus Geobacillus. Int J Syst Evol Microbiol (2005) 1.11

Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol (2011) 1.10

Lipid II: a central component in bacterial cell wall synthesis and a target for antibiotics. Prostaglandins Leukot Essent Fatty Acids (2008) 1.10

Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrob Agents Chemother (2010) 1.08

Isolation, structure elucidation, and synergistic antibacterial activity of a novel two-component lantibiotic lichenicidin from Bacillus licheniformis VK21. Biochemistry (2010) 1.07

In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria. BMC Genomics (2010) 1.04

Lipid II and other bactoprenol-bound cell wall precursors as drug targets. Curr Opin Investig Drugs (2010) 1.04

Structure and biological activity of chemically modified nisin A species. Eur J Biochem (1996) 1.00

The effect of season on somatic cell count and the incidence of clinical mastitis. J Dairy Sci (2007) 0.99

Whole-cell matrix-assisted laser desorption/ionization mass spectrometry for rapid identification of bacteriocin/lantibiotic-producing bacteria. Rapid Commun Mass Spectrom (2008) 0.96

A unique lantibiotic, thermophilin 1277, containing a disulfide bridge and two thioether bridges. J Appl Microbiol (2009) 0.84

Studies of the degradation products of nisin, a peptide antibiotic, using capillary electrophoresis with off-line mass spectrometry. J Chromatogr A (1996) 0.78

Articles by these authors

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38

Biosynthesis and mode of action of lantibiotics. Chem Rev (2005) 4.59

Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science (2006) 3.29

Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16

Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83

Biosynthesis of phosphonic and phosphinic acid natural products. Annu Rev Biochem (2009) 2.19

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18

Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem (2012) 2.01

Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95

Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem Biol (2009) 1.88

Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74

Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72

Genome mining for ribosomally synthesized natural products. Curr Opin Chem Biol (2010) 1.58

Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56

Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem Biol (2006) 1.56

Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (2012) 1.53

New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb) (2006) 1.53

An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis. Nature (2009) 1.51

Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47

The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry (2008) 1.46

Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling. J Immunol (2005) 1.45

Sublancin is not a lantibiotic but an S-linked glycopeptide. Nat Chem Biol (2011) 1.44

Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44

In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis. Proc Natl Acad Sci U S A (2008) 1.39

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proc Natl Acad Sci U S A (2012) 1.38

Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst. J Am Chem Soc (2010) 1.38

In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc (2009) 1.37

Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry (2007) 1.36

Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33

Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol (2009) 1.32

The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc (2007) 1.31

Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. Chem Biol (2010) 1.30

Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J Biol Chem (2007) 1.25

Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters. Structure (2007) 1.25

Enzymatic basis of ribosomal peptide prenylation in cyanobacteria. J Am Chem Soc (2011) 1.25

Post-translational modifications during lantibiotic biosynthesis. Curr Opin Chem Biol (2004) 1.24

Biomimetic stereoselective formation of methyllanthionine. Org Lett (2002) 1.23

SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry (2003) 1.23

Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry (2007) 1.22

Hydroperoxylation by hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2009) 1.22

Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis. Proc Natl Acad Sci U S A (2010) 1.20

Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry (2012) 1.18

Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proc Natl Acad Sci U S A (2012) 1.17

Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster. Chem Biol (2010) 1.17

Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. J Biol Chem (2008) 1.17

In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry (2008) 1.16

Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc (2009) 1.16

On the substrate specificity of dehydration by lacticin 481 synthetase. J Am Chem Soc (2007) 1.16

Biomimetic studies on the mechanism of stereoselective lanthionine formation. Org Biomol Chem (2003) 1.15

Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc (2011) 1.15

Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry (2013) 1.15

Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods Enzymol (2009) 1.13

Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design. Biochemistry (2003) 1.13

Insights into the architecture of the replicative helicase from the structure of an archaeal MCM homolog. Structure (2009) 1.12

Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library. Chem Biol (2011) 1.11

In vitro activity of the nisin dehydratase NisB. Proc Natl Acad Sci U S A (2013) 1.10

Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol (2011) 1.10

Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase. J Am Chem Soc (2002) 1.09

An engineered lantibiotic synthetase that does not require a leader peptide on its substrate. J Am Chem Soc (2012) 1.09

The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat Chem Biol (2013) 1.09

The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. J Am Chem Soc (2004) 1.09

The dehydratase activity of lacticin 481 synthetase is highly processive. J Am Chem Soc (2006) 1.08

Inhibition of Bacillus anthracis spore outgrowth by nisin. Antimicrob Agents Chemother (2008) 1.08

Structures of cyanobactin maturation enzymes define a family of transamidating proteases. Chem Biol (2012) 1.06

Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin. ACS Chem Biol (2011) 1.06

Regeneration of cofactors for use in biocatalysis. Curr Opin Biotechnol (2003) 1.04

Synthesis of site-specifically labeled arachidonic acids as mechanistic probes for prostaglandin H synthase. Org Lett (2004) 1.04

Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis. Proc Natl Acad Sci U S A (2012) 1.03

HNF1B alterations associated with congenital anomalies of the kidney and urinary tract. Pediatr Nephrol (2010) 1.03

Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis. Proc Natl Acad Sci U S A (2013) 1.03

Heterologous expression and purification of SpaB involved in subtilin biosynthesis. Biochem Biophys Res Commun (2002) 1.03

Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase. EMBO J (2008) 1.03

Molecular basis for the selectivity and specificity of ligand recognition by the family 16 carbohydrate-binding modules from Thermoanaerobacterium polysaccharolyticum ManA. J Biol Chem (2007) 1.02

Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. Chembiochem (2009) 1.02

Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angew Chem Int Ed Engl (2007) 1.02

Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme. Angew Chem Int Ed Engl (2002) 1.02

Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa. Appl Environ Microbiol (2005) 1.02

Distinct structural elements dictate the specificity of the type III pentaketide synthase from Neurospora crassa. Chem Biol (2008) 1.01

Identification of hydrogen bonds to the Rieske cluster through the weakly coupled nitrogens detected by electron spin echo envelope modulation spectroscopy. J Biol Chem (2006) 1.00

On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2011) 1.00

On the regioselectivity of thioether formation by lacticin 481 synthetase. Org Lett (2007) 0.98

Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species. Antimicrob Agents Chemother (2012) 0.98

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett (2008) 0.98

Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids. Chem Commun (Camb) (2003) 0.98

The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket. J Immunol (2012) 0.97

Biosynthesis of the class III lantipeptide catenulipeptin. ACS Chem Biol (2012) 0.97

A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2. J Am Chem Soc (2014) 0.96

Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography. Proc Natl Acad Sci U S A (2013) 0.96

Comparison of the properties of prostaglandin H synthase-1 and -2. Prog Lipid Res (2003) 0.96

Biochemical and structural insights into xylan utilization by the thermophilic bacterium Caldanaerobius polysaccharolyticus. J Biol Chem (2012) 0.95

Roles of small laccases from Streptomyces in lignin degradation. Biochemistry (2014) 0.95

Modifications of protein environment of the [2Fe-2S] cluster of the bc1 complex: effects on the biophysical properties of the rieske iron-sulfur protein and on the kinetics of the complex. J Biol Chem (2009) 0.95

Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. Chem Biol (2011) 0.95