Published in Annu Rev Biochem on January 01, 2009
Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (2012) 1.53
Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33
Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis. Chem Rev (2011) 1.32
Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. Chem Biol (2010) 1.30
The genes and enzymes of phosphonate metabolism by bacteria, and their distribution in the marine environment. Front Microbiol (2012) 1.27
Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes. BMC Genomics (2013) 1.27
Hydroperoxylation by hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2009) 1.22
Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis. Proc Natl Acad Sci U S A (2010) 1.20
Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster. Chem Biol (2010) 1.17
Organophosphonates revealed: new insights into the microbial metabolism of ancient molecules. Nat Rev Microbiol (2013) 1.13
Diversity and abundance of phosphonate biosynthetic genes in nature. Proc Natl Acad Sci U S A (2013) 1.08
In vitro phosphinate methylation by PhpK from Kitasatospora phosalacinea. Biochemistry (2011) 1.06
Divergence of chemical function in the alkaline phosphatase superfamily: structure and mechanism of the P-C bond cleaving enzyme phosphonoacetate hydrolase. Biochemistry (2011) 1.03
Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proc Natl Acad Sci U S A (2015) 1.03
Squaramide-catalyzed enantioselective Michael addition of diphenyl phosphite to nitroalkenes. Angew Chem Int Ed Engl (2010) 1.00
On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2011) 1.00
Prodrugs of phosphonates and phosphates: crossing the membrane barrier. Top Curr Chem (2015) 1.00
Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species. Antimicrob Agents Chemother (2012) 0.98
Structure of the Escherichia coli phosphonate binding protein PhnD and rationally optimized phosphonate biosensors. J Mol Biol (2011) 0.96
Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. Chem Biol (2011) 0.95
Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway. Proc Natl Acad Sci U S A (2013) 0.93
Crystal structure of PhnZ in complex with substrate reveals a di-iron oxygenase mechanism for catabolism of organophosphonates. Proc Natl Acad Sci U S A (2014) 0.93
Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angew Chem Int Ed Engl (2013) 0.92
Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin. Arch Biochem Biophys (2010) 0.92
Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology. Curr Opin Chem Biol (2013) 0.92
Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis. Arch Biochem Biophys (2013) 0.92
Constructing de novo biosynthetic pathways for chemical synthesis inside living cells. Biochemistry (2011) 0.91
Structure-activity relationships of the phosphonate antibiotic dehydrophos. Chem Commun (Camb) (2010) 0.89
Alternative pathways for phosphonate metabolism in thermophilic cyanobacteria from microbial mats. ISME J (2010) 0.88
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases. Proc Natl Acad Sci U S A (2013) 0.86
Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. ACS Chem Biol (2013) 0.84
Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase. J Am Chem Soc (2012) 0.83
Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways. J Ind Microbiol Biotechnol (2013) 0.82
Unusual outer membrane lipid composition of the gram-negative, lipopolysaccharide-lacking myxobacterium Sorangium cellulosum So ce56. J Biol Chem (2011) 0.82
Answers to the carbon-phosphorus lyase conundrum. Chembiochem (2012) 0.82
Phosphatase-inert glucosamine 6-phosphate mimics serve as actuators of the glmS riboswitch. ACS Chem Biol (2014) 0.81
Utilization of glyphosate as phosphate source: biochemistry and genetics of bacterial carbon-phosphorus lyase. Microbiol Mol Biol Rev (2014) 0.81
Cyanohydrin phosphonate natural product from Streptomyces regensis. J Nat Prod (2014) 0.81
Spectroscopic characterization and mechanistic investigation of P-methyl transfer by a radical SAM enzyme from the marine bacterium Shewanella denitrificans OS217. Biochim Biophys Acta (2014) 0.81
Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation. Chem Biol (2013) 0.80
Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate Biosynthesis. Medchemcomm (2012) 0.80
Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase. Biochemistry (2011) 0.80
Purification and characterization of phosphonoglycans from Glycomyces sp. strain NRRL B-16210 and Stackebrandtia nassauensis NRRL B-16338. J Bacteriol (2014) 0.80
A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase. J Am Chem Soc (2015) 0.79
Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases. J Med Chem (2012) 0.78
The Pseudomonas aeruginosa antimetabolite L -2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor. Front Microbiol (2015) 0.78
Phylogenomic Analysis of Natural Products Biosynthetic Gene Clusters Allows Discovery of Arseno-Organic Metabolites in Model Streptomycetes. Genome Biol Evol (2016) 0.78
Biosynthesis of fosfazinomycin is a convergent process. Chem Sci (2015) 0.78
Identification of the biosynthetic gene cluster for the herbicide phosphonothrixin in Saccharothrix sp. ST-888. J Antibiot (Tokyo) (2014) 0.77
Reaction of HppE with substrate analogues: evidence for carbon-phosphorus bond cleavage by a carbocation rearrangement. J Am Chem Soc (2013) 0.77
Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products. J Antibiot (Tokyo) (2015) 0.76
Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols. Chemistry (2016) 0.76
Probing a coral genome for components of the photoprotective scytonemin biosynthetic pathway and the 2-aminoethylphosphonate pathway. Mar Drugs (2013) 0.76
Room-temperature alternative to the Arbuzov reaction: the reductive deoxygenation of acyl phosphonates. Org Lett (2010) 0.75
In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors. Biochem Pharmacol (2015) 0.75
Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads. ACS Chem Biol (2016) 0.75
Investigation of enzymatic C-P bond formation using multiple quantum HCP nuclear magnetic resonance spectroscopy. Magn Reson Chem (2015) 0.75
P-C bond formation via P-H addition of a fluoroaryl phosphinic acid to ketones. J Fluor Chem (2010) 0.75
A Salmonella Regulator Modulates Intestinal Colonization and Use of Phosphonoacetic Acid. Front Cell Infect Microbiol (2017) 0.75
Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes. J Biol Inorg Chem (2016) 0.75
Evaporative light scattering quantification of natural products possessing a carbon-phosphorus bond. J Antibiot (Tokyo) (2015) 0.75
O-H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase. J Am Chem Soc (2017) 0.75
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science (1999) 7.54
Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods. Nucleic Acids Res (2001) 6.49
Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates. Chem Rev (2004) 6.11
Biosynthesis and mode of action of lantibiotics. Chem Rev (2005) 4.59
Phosphonomycin, a new antibiotic produced by strains of streptomyces. Science (1969) 3.89
Phosphonopeptides, a new class of synthetic antibacterial agents. Nature (1978) 3.35
Characterization of the herbicide-resistance gene bar from Streptomyces hygroscopicus. EMBO J (1987) 3.33
Cupins: the most functionally diverse protein superfamily? Phytochemistry (2004) 3.05
[Metabolic products of microorganisms. 98. Phosphinothricin and phosphinothricyl-alanyl-analine]. Helv Chim Acta (1972) 2.99
Evolutionary relationships among pyridoxal-5'-phosphate-dependent enzymes. Regio-specific alpha, beta and gamma families. Eur J Biochem (1994) 2.33
Phosphonopeptides as antibacterial agents: mechanism of action of alaphosphin. Antimicrob Agents Chemother (1979) 2.26
The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids. Biochemistry (1996) 2.15
Fosfomycin: use beyond urinary tract and gastrointestinal infections. Clin Infect Dis (2008) 2.08
Isolation of 2-aminoethane phosphonic acid from rumen protozoa. Nature (1959) 2.05
Fosmidomycin for malaria. Lancet (2002) 2.03
Structural elucidation of two capsular polysaccharides from one strain of Bacteroides fragilis using high-resolution NMR spectroscopy. Biochemistry (1992) 1.98
S-Adenosylmethionine: a wolf in sheep's clothing, or a rich man's adenosylcobalamin? Chem Rev (2003) 1.98
Nucleotide sequence of the phosphinothricin N-acetyltransferase gene from Streptomyces viridochromogenes Tü494 and its expression in Nicotiana tabacum. Gene (1988) 1.92
Bioactive natural products with carbon-phosphorus bonds and their biosynthesis. Nat Prod Rep (1999) 1.89
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72
Aminophosphonic acids of potential medical importance. Curr Med Chem Anticancer Agents (2001) 1.66
Evidence for C-H cleavage by an iron-superoxide complex in the glycol cleavage reaction catalyzed by myo-inositol oxygenase. Proc Natl Acad Sci U S A (2006) 1.65
Radical mechanisms of enzymatic catalysis. Annu Rev Biochem (2001) 1.64
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin. Biochemistry (1996) 1.63
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycin. Biochemistry (1994) 1.62
Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme. Nature (2005) 1.59
Protein purification and function assignment of the epoxidase catalyzing the formation of fosfomycin. J Am Chem Soc (2001) 1.54
New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb) (2006) 1.53
Studies on the conformational changes in the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyltransferase (MurA). Eur J Biochem (1998) 1.52
Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736. Antimicrob Agents Chemother (2005) 1.50
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47
Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci. Infect Immun (2000) 1.44
Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon-phosphorus bond. Nature (1988) 1.42
Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. Chem Biol (2008) 1.41
Fosmidomycin for the treatment of malaria. Parasitol Res (2002) 1.40
The reaction cycle of isopenicillin N synthase observed by X-ray diffraction. Nature (1999) 1.39
Phosphonolipids: localization in surface membranes of Tetrahymena. Science (1970) 1.34
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosis. Microbiology (1999) 1.33
Mechanistic studies of HPP epoxidase: configuration of the substrate governs its enzymatic fate. Angew Chem Int Ed Engl (2002) 1.28
Biosynthetic gene cluster of the herbicide phosphinothricin tripeptide from Streptomyces viridochromogenes Tü494. Appl Environ Microbiol (2004) 1.25
The structure of thiostrepton. Nature (1970) 1.24
Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis. Mol Gen Genet (1995) 1.23
Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: a novel mononuclear non-heme iron enzyme. Biochemistry (2003) 1.20
Studies on new phosphonic acid antibiotics. I. FR-900098, isolation and characterization. J Antibiot (Tokyo) (1980) 1.20
Studies on the biosynthesis of bialaphos (SF-1293). 6. Production of N-acetyl-demethylphosphinothricin and N-acetylbialaphos by blocked mutants of Streptomyces hygroscopicus SF-1293 and their roles in the biosynthesis of bialaphos. J Antibiot (Tokyo) (1985) 1.19
Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. J Biol Chem (2008) 1.17
Production of fosfomycin (phosphonomycin) by Pseudomonas syringae. J Antibiot (Tokyo) (1986) 1.16
Structure and function of radical SAM enzymes. Curr Opin Chem Biol (2004) 1.16
Studies on the biosynthesis of bialaphos (SF-1293) 12. C-P bond formation mechanism of bialaphos: discovery of a P-methylation enzyme. J Antibiot (Tokyo) (1992) 1.11
Degradation pathway of the phosphonate ciliatine: crystal structure of 2-aminoethylphosphonate transaminase. Biochemistry (2002) 1.11
Biosynthesis of phosphonic acids in Tetrahymena. Biochim Biophys Acta (1968) 1.10
Studies on the biosynthesis of bialaphos (SF-1293). 2. Isolation of the first natural products with a C-P-H bond and their involvement in the C-P-C bond formation. J Antibiot (Tokyo) (1983) 1.09
Purification and properties of 2-aminoethylphosphonate:pyruvate aminotransferase from Pseudomonas aeruginosa. Eur J Biochem (1983) 1.08
Genetic analysis of the phosphinothricin-tripeptide biosynthetic pathway of Streptomyces viridochromogenes Tü494. Appl Microbiol Biotechnol (1991) 1.07
Crystal structure of an iron-dependent group III dehydrogenase that interconverts L-lactaldehyde and L-1,2-propanediol in Escherichia coli. J Bacteriol (2005) 1.07
Single-dose treatment of acute cystitis with fosfomycin tromethamine. Ann Pharmacother (1998) 1.07
Studies on new phosphonic acid antibiotics. III. Isolation and characterization of FR-31564, FR-32863 and FR-33289. J Antibiot (Tokyo) (1980) 1.07
Elucidation of the 2-aminoethylphosphonate biosynthetic pathway in Tetrahymena pyriformis. Biochem Biophys Res Commun (1988) 1.06
Enhancement of antimicrobial effects of various antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) by combination with fosfomycin. J Infect Chemother (2003) 1.06
Inhibition of bacterial isoprenoid synthesis by fosmidomycin, a phosphonic acid-containing antibiotic. J Antimicrob Chemother (1989) 1.06
The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway. J Bacteriol (2002) 1.02
Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angew Chem Int Ed Engl (2007) 1.02
Identification of a variant "Rome clone" of methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin, responsible for an outbreak in an intensive care unit. Microb Drug Resist (2004) 1.02
Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues. Biochemistry (2007) 1.01
Management of lower urinary tract infections. Drugs (1993) 1.01
In-vitro activity of fosfomycin against vancomycin-resistant enterococci. J Antimicrob Chemother (1999) 1.01
The peptide synthetase gene phsA from Streptomyces viridochromogenes is not juxtaposed with other genes involved in nonribosomal biosynthesis of peptides. Appl Environ Microbiol (1996) 1.01
Fosfadecin and fosfocytocin, new nucleotide antibiotics produced by bacteria. J Antibiot (Tokyo) (1990) 0.99
Studies on the biosynthesis of fosfomycin. 4. The biosynthetic origin of the methyl group of fosfomycin. J Antibiot (Tokyo) (1992) 0.99
Helix swapping between two alpha/beta barrels: crystal structure of phosphoenolpyruvate mutase with bound Mg(2+)-oxalate. Structure (1999) 0.98
Studies on the biosynthesis of bialaphos (SF-1293). 9. Biochemical mechanism of C-P bond formation in bialaphos: discovery of phosphoenolpyruvate phosphomutase which catalyzes the formation of phosphonopyruvate from phosphoenolpyruvate. J Antibiot (Tokyo) (1989) 0.98
Rings, radicals, and regeneration: the early years of a bioorganic laboratory. J Org Chem (2006) 0.98
Emergent mechanistic diversity of enzyme-catalysed beta-diketone cleavage. Biochem J (2005) 0.98
Biosynthetic origins of C-P bond containing tripeptide K-26. Org Lett (2005) 0.97
Phosphinothricin-tripeptide synthetases from Streptomyces viridochromogenes. Biochemistry (1998) 0.97
Brief overview of single-dose therapy for uncomplicated urinary tract infections. Chemotherapy (1990) 0.96
Pharmacokinetics of fosmidomycin, a new phosphonic acid antibiotic. Antimicrob Agents Chemother (1982) 0.96
Methylcorrinoids Methylate Radicals-Their Second Biological Mode of Action? Angew Chem Int Ed Engl (2000) 0.95
The phosphonopyruvate decarboxylase from Bacteroides fragilis. J Biol Chem (2003) 0.94
K-26, a novel inhibitor of angiotensin I converting enzyme produced by an actinomycete K-26. J Antibiot (Tokyo) (1986) 0.94
Bialaphos. Biotechnology (1995) 0.93
Carboxyphosphonoenolpyruvate phosphonomutase, a novel enzyme catalyzing C-P bond formation. J Bacteriol (1990) 0.93
Pharmacokinetics and metabolism of fosmidomycin, a new phosphonic acid, in rats and dogs. Eur J Drug Metab Pharmacokinet (1982) 0.92
Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase. Arch Biochem Biophys (2005) 0.92
Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus. Eur J Biochem (1992) 0.92
Phosphoprotein with phosphoglycerate mutase activity from the archaeon Sulfolobus solfataricus. J Bacteriol (2003) 0.91
Pharmacokinetic evaluation of fosmidomycin, a new phosphonic acid antibiotic. Chemioterapia (1987) 0.91
Evidence that the reaction of the UDP-N-acetylglucosamine 1-carboxyvinyltransferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzyme. Eur J Biochem (1993) 0.91
Stereochemistry of the reaction catalysed by 2-aminoethylphosphonate aminotransferase. A 1H-NMR study. Eur J Biochem (1993) 0.90
Phosphinothricin tripeptide synthetases in Streptomyces viridochromogenes Tü494. Antimicrob Agents Chemother (2005) 0.90
Fosfomycin trometamol. J Antimicrob Chemother (1994) 0.90
Studies on the biosynthesis of bialaphos (SF-1293). 18. 2-phosphinomethylmalic acid synthase: a descendant of (R)-citrate synthase? J Antibiot (Tokyo) (1999) 0.89
Insight into the mechanism of phosphoenolpyruvate mutase catalysis derived from site-directed mutagenesis studies of active site residues. Biochemistry (1999) 0.89
Biosynthesis of 2-aminoethylphosphonic acid in cell-free preparations from Tetrahymena. Biochim Biophys Acta (1972) 0.89
Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action. J Antibiot (Tokyo) (1984) 0.89
Treatment of bacteriuria in pregnancy with single dose fosfomycin trometamol: a review. Infection (1992) 0.88
K-4, a novel inhibitor of angiotensin I converting enzyme produced by Actinomadura spiculosospora. J Antibiot (Tokyo) (1986) 0.88
Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis. Chem Commun (Camb) (2006) 0.87
Dissociative phosphoryl transfer in PEP mutase catalysis: structure of the enzyme/sulfopyruvate complex and kinetic properties of mutants. Biochemistry (2002) 0.87
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Biosynthesis and mode of action of lantibiotics. Chem Rev (2005) 4.59
Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol (2007) 4.00
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science (2006) 3.29
Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol (2010) 3.16
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19
Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18
Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem (2012) 2.01
Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol (2008) 1.95
Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76
Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol (2010) 1.74
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72
Genome mining for ribosomally synthesized natural products. Curr Opin Chem Biol (2010) 1.58
Production of lantipeptides in Escherichia coli. J Am Chem Soc (2010) 1.56
Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem Biol (2006) 1.56
Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (2012) 1.53
Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A (2012) 1.53
New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb) (2006) 1.53
An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis. Nature (2009) 1.51
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47
The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry (2008) 1.46
Sublancin is not a lantibiotic but an S-linked glycopeptide. Nat Chem Biol (2011) 1.44
Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A (2012) 1.44
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc (2009) 1.37
Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry (2007) 1.36
Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33
Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol (2009) 1.32
The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc (2007) 1.31
Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. Chem Biol (2010) 1.30
Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J Biol Chem (2007) 1.25
Post-translational modifications during lantibiotic biosynthesis. Curr Opin Chem Biol (2004) 1.24
Biomimetic stereoselective formation of methyllanthionine. Org Lett (2002) 1.23
SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry (2003) 1.23
Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry (2007) 1.22
Hydroperoxylation by hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2009) 1.22
Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis. Proc Natl Acad Sci U S A (2010) 1.20
Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry (2012) 1.18
Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster. Chem Biol (2010) 1.17
Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. J Biol Chem (2008) 1.17
In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry (2008) 1.16
Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc (2009) 1.16
On the substrate specificity of dehydration by lacticin 481 synthetase. J Am Chem Soc (2007) 1.16
Biomimetic studies on the mechanism of stereoselective lanthionine formation. Org Biomol Chem (2003) 1.15
Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc (2011) 1.15
Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry (2013) 1.15
Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods Enzymol (2009) 1.13
Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design. Biochemistry (2003) 1.13
In vitro activity of the nisin dehydratase NisB. Proc Natl Acad Sci U S A (2013) 1.10
Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol (2011) 1.10
Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase. J Am Chem Soc (2002) 1.09
An engineered lantibiotic synthetase that does not require a leader peptide on its substrate. J Am Chem Soc (2012) 1.09
The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat Chem Biol (2013) 1.09
The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. J Am Chem Soc (2004) 1.09
The dehydratase activity of lacticin 481 synthetase is highly processive. J Am Chem Soc (2006) 1.08
Inhibition of Bacillus anthracis spore outgrowth by nisin. Antimicrob Agents Chemother (2008) 1.08
Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin. ACS Chem Biol (2011) 1.06
Regeneration of cofactors for use in biocatalysis. Curr Opin Biotechnol (2003) 1.04
Synthesis of site-specifically labeled arachidonic acids as mechanistic probes for prostaglandin H synthase. Org Lett (2004) 1.04
Heterologous expression and purification of SpaB involved in subtilin biosynthesis. Biochem Biophys Res Commun (2002) 1.03
Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. Chembiochem (2009) 1.02
Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa. Appl Environ Microbiol (2005) 1.02
Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angew Chem Int Ed Engl (2007) 1.02
Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme. Angew Chem Int Ed Engl (2002) 1.02
On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase. J Am Chem Soc (2011) 1.00
Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids. Chem Commun (Camb) (2003) 0.98
Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett (2008) 0.98
Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species. Antimicrob Agents Chemother (2012) 0.98
On the regioselectivity of thioether formation by lacticin 481 synthetase. Org Lett (2007) 0.98
Biosynthesis of the class III lantipeptide catenulipeptin. ACS Chem Biol (2012) 0.97
Comparison of the properties of prostaglandin H synthase-1 and -2. Prog Lipid Res (2003) 0.96
A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2. J Am Chem Soc (2014) 0.96
Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. Chem Biol (2011) 0.95
A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization. J Am Chem Soc (2013) 0.95
Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry. J Am Chem Soc (2011) 0.94
Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin. ACS Chem Biol (2011) 0.94
Site-directed mutagenesis of active site residues of phosphite dehydrogenase. Biochemistry (2005) 0.94
Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family. Biochemistry (2011) 0.94
Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry (2008) 0.94
Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway. Proc Natl Acad Sci U S A (2013) 0.93
Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2. J Biol Chem (2002) 0.93
Insights into the evolution of lanthipeptide biosynthesis. Protein Sci (2013) 0.93
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. Biochemistry (2009) 0.93
Model studies of the histidine-tyrosine cross-link in cytochrome C oxidase reveal the flexible substituent effect of the imidazole moiety. Org Lett (2005) 0.92
Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcM. J Am Chem Soc (2014) 0.92
Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angew Chem Int Ed Engl (2013) 0.92
Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin. Arch Biochem Biophys (2010) 0.92
Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology. Curr Opin Chem Biol (2013) 0.92
Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021. J Biol Chem (2011) 0.91
Lacticin 481 synthetase as a general serine/threonine kinase. ACS Chem Biol (2009) 0.91
Transforming a blue copper into a red copper protein: engineering cysteine and homocysteine into the axial position of azurin using site-directed mutagenesis and expressed protein ligation. J Am Chem Soc (2010) 0.91
Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification. J Am Chem Soc (2005) 0.91
High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis. ACS Chem Biol (2014) 0.90
Catalytic promiscuity of a bacterial α-N-methyltransferase. FEBS Lett (2012) 0.90
Site-selective conjugation of thiols with aziridine-2-carboxylic acid-containing peptides. J Am Chem Soc (2004) 0.90
New developments in lantibiotic biosynthesis and mode of action. Curr Opin Microbiol (2005) 0.90
Structure-activity relationships of the phosphonate antibiotic dehydrophos. Chem Commun (Camb) (2010) 0.89
In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis. Biochemistry (2009) 0.88
Bacillus anthracis spore interactions with mammalian cells: relationship between germination state and the outcome of in vitro. BMC Microbiol (2011) 0.88
Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli. Chem Commun (Camb) (2012) 0.88