Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury.

PubWeight™: 1.20‹?› | Rank: Top 10%

🔗 View Article (PMC 3948131)

Published in J Cereb Blood Flow Metab on January 08, 2014

Authors

Juan Pablo de Rivero Vaccari1, W Dalton Dietrich1, Robert W Keane2

Author Affiliations

1: Department of Neurological Surgery, The Miami Project to Cure Paralysis, Lois Pope LIFE Center, Miami, Florida, USA.
2: Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida, USA.

Articles citing this

Microglial M1/M2 polarization and metabolic states. Br J Pharmacol (2015) 1.14

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proc Natl Acad Sci U S A (2016) 0.91

Contributions of the immune system to the pathophysiology of traumatic brain injury - evidence by intravital microscopy. Front Cell Neurosci (2014) 0.91

Long-Term Consequences of Traumatic Brain Injury: Current Status of Potential Mechanisms of Injury and Neurological Outcomes. J Neurotrauma (2014) 0.91

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes. PLoS One (2015) 0.90

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease. Glia (2015) 0.83

Emerging Roles for the Immune System in Traumatic Brain Injury. Front Immunol (2016) 0.80

DAMP-Mediated Activation of NLRP3-Inflammasome in Brain Sterile Inflammation: The Fine Line between Healing and Neurodegeneration. Front Immunol (2014) 0.80

Chaperone-Mediated Autophagy after Traumatic Brain Injury. J Neurotrauma (2015) 0.79

Relationship of endothelin-1 and NLRP3 inflammasome activation in HT22 hippocampal cells in diabetes. Life Sci (2016) 0.79

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate. Front Neurol (2015) 0.79

Guanosine inhibits LPS-induced pro-inflammatory response and oxidative stress in hippocampal astrocytes through the heme oxygenase-1 pathway. Purinergic Signal (2015) 0.78

Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain. Mol Neurobiol (2016) 0.78

Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders. Neuropsychopharmacology (2016) 0.78

RIG-I contributes to the innate immune response after cerebral ischemia. J Inflamm (Lond) (2015) 0.78

Identification of novel gene and pathway targets for human epilepsy treatment. Biol Res (2016) 0.77

Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats. Brain Behav Immun (2015) 0.77

Identification of Glial Activation Markers by Comparison of Transcriptome Changes between Astrocytes and Microglia following Innate Immune Stimulation. PLoS One (2015) 0.76

The inflammasome as a target for pain therapy. Br J Anaesth (2016) 0.76

Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia. Oncotarget (2015) 0.76

The Role of Microglia in the Etiology and Evolution of Chronic Traumatic Encephalopathy. Shock (2017) 0.75

Neuroprotective effects of HTR1A antagonist WAY-100635 on scopolamine-induced delirium in rats and underlying molecular mechanisms. BMC Neurosci (2016) 0.75

Sterile Neuroinflammation and Strategies for Therapeutic Intervention. Int J Inflam (2017) 0.75

Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology. Toxicol Sci (2015) 0.75

Glucose and oxygen metabolism after penetrating ballistic-like brain injury. J Cereb Blood Flow Metab (2015) 0.75

Pain Input Impairs Recovery After Spinal Cord Injury: Treatment With Lidocaine. J Neurotrauma (2016) 0.75

D-β-hydroxybutyrate promotes functional recovery and relieves pain hypersensitivity in mice with spinal cord injury. Br J Pharmacol (2017) 0.75

NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol. Oxid Med Cell Longev (2016) 0.75

Acidification changes affect the inflammasome in human nucleus pulposus cells. J Inflamm (Lond) (2016) 0.75

Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis. Hum Mutat (2017) 0.75

Effects of Tobacco Smoking on the Degeneration of the Intervertebral Disc: A Finite Element Study. PLoS One (2015) 0.75

Anti-inflammatory interventions-what has worked, not worked, and what may work in the future. Transl Res (2015) 0.75

Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle. Front Cell Neurosci (2017) 0.75

Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice. Mol Neurobiol (2016) 0.75

NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury. Oxid Med Cell Longev (2017) 0.75

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children. Neurocrit Care (2017) 0.75

Articles cited by this

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11

The inflammasomes. Cell (2010) 19.37

Cryopyrin activates the inflammasome in response to toxins and ATP. Nature (2006) 18.74

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature (2009) 13.23

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature (2009) 10.83

DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol (2006) 10.73

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol (2008) 10.39

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ (2007) 8.85

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol (2009) 8.40

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol (2009) 7.93

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol (2010) 7.47

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet (2006) 6.89

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell (2004) 6.06

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol (2010) 6.05

Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol (2004) 4.89

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell (2007) 4.33

Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem (2007) 4.27

Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett (2005) 3.89

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol (2009) 3.85

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J (1999) 3.51

Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab (2011) 3.49

Caspase-1-induced pyroptotic cell death. Immunol Rev (2011) 3.47

Pharmacology of cloned P2X receptors. Annu Rev Pharmacol Toxicol (2000) 3.44

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol (2009) 3.32

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A (2008) 3.27

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem (2006) 3.20

Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett (2007) 3.19

Novel role of PKR in inflammasome activation and HMGB1 release. Nature (2012) 3.13

Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol Sci (2007) 3.01

The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem (2009) 2.90

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell (2007) 2.79

Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2. J Immunol (2008) 2.65

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut (2010) 2.42

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. Oncogene (1997) 2.35

PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev (2012) 2.24

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity (2012) 2.14

Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. J Cereb Blood Flow Metab (2008) 1.99

XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci U S A (2009) 1.95

A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci (2008) 1.93

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. PLoS Pathog (2012) 1.90

PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. J Biol Chem (2004) 1.89

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol (2008) 1.86

Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med (2010) 1.84

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc Natl Acad Sci U S A (2011) 1.83

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci Transl Med (2011) 1.74

Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. J Cereb Blood Flow Metab (2009) 1.69

Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta. J Biol Chem (2009) 1.67

Pannexins in ischemia-induced neurodegeneration. Proc Natl Acad Sci U S A (2011) 1.55

Human keratinocytes express AIM2 and respond to dsDNA with IL-1β secretion. Exp Dermatol (2011) 1.53

Targeting pannexin1 improves seizure outcome. PLoS One (2011) 1.43

Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis. Cell Microbiol (2011) 1.41

CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J Biol Chem (2005) 1.35

Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. J Immunol (2013) 1.32

Activation of the NLRP3 inflammasome by group B streptococci. J Immunol (2012) 1.25

Pannexin: from discovery to bedside in 11±4 years? Brain Res (2012) 1.24

ATP-stimulated release of ATP by human endothelial cells. J Cardiovasc Pharmacol (1996) 1.23

Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. Eur J Immunol (2011) 1.18

Alarmins, inflammasomes and immunity. Biomed J (2013) 1.13

Inflammasomes and host defenses against bacterial infections. Curr Opin Microbiol (2013) 1.11

Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia. J Neurochem (2011) 1.10

The NLRP3 inflammasome in Alzheimer's disease. Mol Neurobiol (2013) 1.07

Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity. J Biol Chem (2012) 1.07

P2X4 receptors influence inflammasome activation after spinal cord injury. J Neurosci (2012) 1.05

Human astrocytes express a novel NLRP2 inflammasome. Glia (2013) 1.05

Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions. Microbes Infect (2007) 1.01

Effects of therapeutic hypothermia on inflammasome signaling after traumatic brain injury. J Cereb Blood Flow Metab (2012) 0.99

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats. BMC Neurosci (2011) 0.98

Promises and pitfalls of a Pannexin1 transgenic mouse line. Front Pharmacol (2013) 0.97

Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome: clinical article. J Neurosurg (2012) 0.95

NLRP2, an inhibitor of the NF-kappaB pathway, is transcriptionally activated by NF-kappaB and exhibits a nonfunctional allelic variant. J Immunol (2007) 0.93

Caspase-11: the driving factor for noncanonical inflammasomes. Eur J Immunol (2013) 0.91

Inflammasome and cytokine blocking strategies in autoinflammatory disorders. Clin Immunol (2013) 0.90

Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses. J Immunol (2013) 0.89

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells. PLoS One (2012) 0.86

NLRP1, a regulator of innate immunity associated with vitiligo. Pigment Cell Melanoma Res (2012) 0.83

Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia. J Neuroimmunol (2013) 0.82

Purinergic regulation of inflammasome activation after central nervous system injury. J Gen Physiol (2012) 0.80