Published in Mol Biol Cell on February 23, 2005
A SNARE complex unique to seed plants is required for protein storage vacuole biogenesis and seed development of Arabidopsis thaliana. Plant Cell (2008) 1.38
Binding interactions control SNARE specificity in vivo. J Cell Biol (2008) 0.89
Distinct subcellular localization of a group of synaptobrevin-like SNAREs in Paramecium tetraurelia and effects of silencing SNARE-specific chaperone NSF. Eukaryot Cell (2009) 0.77
Multiple ER-Golgi SNARE transmembrane domains are dispensable for trafficking but required for SNARE recycling. Mol Biol Cell (2016) 0.76
Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy. Am J Physiol Heart Circ Physiol (2014) 0.75
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30
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Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res (1992) 34.33
Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell (1980) 23.17
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature (1998) 15.80
Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole. Cell (1982) 10.55
The mechanisms of vesicle budding and fusion. Cell (2004) 7.96
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Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell (1997) 5.72
Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles. Cell (1996) 5.18
Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs. Proc Natl Acad Sci U S A (1998) 4.99
A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell (1994) 4.47
Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stack. Cell (1988) 4.37
Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily. Mol Cell Biol (1991) 3.68
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BET1, BOS1, and SEC22 are members of a group of interacting yeast genes required for transport from the endoplasmic reticulum to the Golgi complex. Mol Cell Biol (1990) 3.05
Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J Cell Biol (2000) 2.91
The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin. Mol Biol Cell (1998) 2.70
SNARE interactions are not selective. Implications for membrane fusion specificity. J Biol Chem (1999) 2.60
Topological restriction of SNARE-dependent membrane fusion. Nature (2000) 2.58
Ypt1p implicated in v-SNARE activation. Nature (1994) 2.29
Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Nat Struct Biol (2002) 2.21
Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem (1997) 2.17
A SNARE-like protein required for traffic through the Golgi complex. Nature (1995) 2.15
The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole. Mol Biol Cell (1999) 2.13
Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc Natl Acad Sci U S A (2002) 2.07
Asymmetric requirements for a Rab GTPase and SNARE proteins in fusion of COPII vesicles with acceptor membranes. J Cell Biol (2000) 1.97
Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly. Neuron (1998) 1.96
A novel SNARE complex implicated in vesicle fusion with the endoplasmic reticulum. EMBO J (1997) 1.88
Analysis of Sec22p in endoplasmic reticulum/Golgi transport reveals cellular redundancy in SNARE protein function. Mol Biol Cell (2002) 1.69
Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion. J Cell Biol (2000) 1.66
Use1p is a yeast SNARE protein required for retrograde traffic to the ER. EMBO J (2003) 1.40
Bet1p activates the v-SNARE Bos1p. Mol Biol Cell (1997) 1.39
Subunit structure of a mammalian ER/Golgi SNARE complex. J Biol Chem (2000) 1.39
GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. Mol Biol Cell (2002) 1.36
The synaptobrevin-related domains of Bos1p and Sec22p bind to the syntaxin-like region of Sed5p. J Biol Chem (1997) 1.34
A SNARE required for retrograde transport to the endoplasmic reticulum. Proc Natl Acad Sci U S A (2003) 1.31
Selective formation of Sed5p-containing SNARE complexes is mediated by combinatorial binding interactions. Mol Biol Cell (2001) 1.28
Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25. EMBO J (2000) 1.26
Structural insights into the SNARE mechanism. Biochim Biophys Acta (2003) 1.23
Defining the SNARE complex binding surface of alpha-SNAP: implications for SNARE complex disassembly. J Biol Chem (2003) 1.20
Genetic interactions with the yeast Q-SNARE VTI1 reveal novel functions for the R-SNARE YKT6. J Biol Chem (2001) 1.16
Sec22p export from the endoplasmic reticulum is independent of SNARE pairing. J Biol Chem (2004) 1.14
Yeast exocytic v-SNAREs confer endocytosis. Mol Biol Cell (2000) 1.12
Functional analysis of conserved structural elements in yeast syntaxin Vam3p. J Biol Chem (2001) 1.08
The transmembrane domain of Vam3 affects the composition of cis- and trans-SNARE complexes to promote homotypic vacuole fusion. J Biol Chem (2002) 1.03
SNARE proteins mediate lipid bilayer fusion. Proc Natl Acad Sci U S A (1999) 1.02
Testing the 3Q:1R "rule": mutational analysis of the ionic "zero" layer in the yeast exocytic SNARE complex reveals no requirement for arginine. Mol Biol Cell (2000) 0.98
Exocytosis requires asymmetry in the central layer of the SNARE complex. EMBO J (2000) 0.98
Ykt6p is a multifunctional yeast R-SNARE that is required for multiple membrane transport pathways to the vacuole. Mol Biol Cell (2003) 0.94
Mechanics of membrane fusion. Nat Struct Biol (1998) 0.93
Predicting the distribution, conservation, and functions of SNAREs and related proteins in fungi. Fungal Genet Biol (2002) 0.91
The ionic layer is required for efficient dissociation of the SNARE complex by alpha-SNAP and NSF. Proc Natl Acad Sci U S A (2001) 0.91
SNAP-25 with mutations in the zero layer supports normal membrane fusion kinetics. J Cell Sci (2001) 0.82
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis. Nature (2006) 6.54
Video-rate far-field optical nanoscopy dissects synaptic vesicle movement. Science (2008) 5.87
The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell (2008) 3.51
Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR. Proc Natl Acad Sci U S A (2005) 3.37
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Macromolecular-scale resolution in biological fluorescence microscopy. Proc Natl Acad Sci U S A (2006) 3.04
Helical extension of the neuronal SNARE complex into the membrane. Nature (2009) 2.92
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids. Nat Struct Mol Biol (2007) 2.63
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
Two-color far-field fluorescence nanoscopy. Biophys J (2007) 2.44
SNARE assembly and disassembly exhibit a pronounced hysteresis. Nat Struct Biol (2002) 2.40
Membrane protein sequestering by ionic protein-lipid interactions. Nature (2011) 2.40
Tuning of synapse number, structure and function in the cochlea. Nat Neurosci (2009) 2.29
Determinants of liposome fusion mediated by synaptic SNARE proteins. Proc Natl Acad Sci U S A (2004) 2.28
Characterization of the Drosophila lipid droplet subproteome. Mol Cell Proteomics (2006) 2.23
A complete genetic analysis of neuronal Rab3 function. J Neurosci (2004) 2.21
Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Nat Struct Biol (2002) 2.21
Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes. PLoS Biol (2006) 2.17
One SNARE complex is sufficient for membrane fusion. Nat Struct Mol Biol (2010) 2.14
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Mol Cell (2005) 2.09
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J (2009) 2.09
Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell (2009) 2.06
Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells. Proc Natl Acad Sci U S A (2002) 2.03
Atomic model of the type III secretion system needle. Nature (2012) 2.02
Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling. Neuron (2010) 1.95
Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci (2013) 1.82
Membrane fusion intermediates via directional and full assembly of the SNARE complex. Science (2012) 1.71
Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells. J Neurosci (2005) 1.71
SNAREs prefer liquid-disordered over "raft" (liquid-ordered) domains when reconstituted into giant unilamellar vesicles. J Biol Chem (2004) 1.65
The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila. Dev Cell (2003) 1.64
Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis. J Biol Chem (2001) 1.63
Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity. Proc Natl Acad Sci U S A (2006) 1.59
Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation. Proc Natl Acad Sci U S A (2009) 1.57
Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. J Biol Chem (2002) 1.56
Dissociation of amyloid fibrils of alpha-synuclein in supercooled water. Angew Chem Int Ed Engl (2008) 1.51
The riddle of the Sec1/Munc-18 proteins - new twists added to their interactions with SNAREs. Trends Biochem Sci (2003) 1.50
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. Nat Neurosci (2010) 1.48
SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs. J Cell Biol (2002) 1.45
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor. J Neurochem (2009) 1.44
Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation. Nat Struct Mol Biol (2011) 1.41
Use1p is a yeast SNARE protein required for retrograde traffic to the ER. EMBO J (2003) 1.40
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nat Struct Mol Biol (2013) 1.38
The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis. J Biol Chem (2003) 1.38
The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2009) 1.38
MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Mol Biol Cell (2011) 1.37
Discrimination between docking and fusion of liposomes reconstituted with neuronal SNARE-proteins using FCS. Proc Natl Acad Sci U S A (2009) 1.36
Molecular cloning and functional characterization of human vesicular glutamate transporter 3. EMBO Rep (2002) 1.35
Probing the mechanism of exocytosis at the hair cell ribbon synapse. J Neurosci (2007) 1.33
Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis. J Neurosci (2003) 1.32
Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein. J Neurosci (2010) 1.32
Synaptic vesicles are constitutively active fusion machines that function independently of Ca2+. Curr Biol (2008) 1.31
ARF-GAP-mediated interaction between the ER-Golgi v-SNAREs and the COPI coat. J Cell Biol (2002) 1.30
Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies. EMBO J (2006) 1.30
Distinct kinetic changes in neurotransmitter release after SNARE protein cleavage. Science (2005) 1.29
STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria. Proc Natl Acad Sci U S A (2013) 1.29
Evidence for early endosome-like fusion of recently endocytosed synaptic vesicles. Traffic (2006) 1.27
Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses. Proc Natl Acad Sci U S A (2011) 1.27
Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol (2002) 1.26
Kiss-and-run, collapse and 'readily retrievable' vesicles. Traffic (2007) 1.26
3D reconstruction of high-resolution STED microscope images. Microsc Res Tech (2008) 1.26
Maturation of ribbon synapses in hair cells is driven by thyroid hormone. J Neurosci (2007) 1.25
Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat. J Biol Chem (2003) 1.25
The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly. J Biol Chem (2002) 1.25
Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast. Mol Biol Cell (2005) 1.23
Core proteins of the secretory machinery. Handb Exp Pharmacol (2008) 1.22
Determinants of synaptobrevin regulation in membranes. Mol Biol Cell (2007) 1.20
Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression. J Biol Chem (2006) 1.19
Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein. J Mol Biol (2008) 1.16
Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules. J Neurosci (2006) 1.15
Unique luminal localization of VGAT-C terminus allows for selective labeling of active cortical GABAergic synapses. J Neurosci (2008) 1.14
A link between ER tethering and COP-I vesicle uncoating. Dev Cell (2009) 1.14
The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing. J Neurosci (2009) 1.14
Endosomal fusion upon SNARE knockdown is maintained by residual SNARE activity and enhanced docking. Traffic (2009) 1.11
Structural characterization of polyglutamine fibrils by solid-state NMR spectroscopy. J Mol Biol (2011) 1.11
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. EMBO J (2006) 1.11
Controlling synaptotagmin activity by electrostatic screening. Nat Struct Mol Biol (2012) 1.08
Methods for studying synaptosomal copper release. J Neurosci Methods (2003) 1.08
Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption. Mol Cell Biol (2005) 1.08
Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions. EMBO J (2011) 1.07
Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold. J Biol Chem (2012) 1.06
Amyloid precursor protein is trafficked and secreted via synaptic vesicles. PLoS One (2011) 1.06
Specification of primordial germ cells in medaka (Oryzias latipes). BMC Dev Biol (2007) 1.05
Cis- and trans-membrane interactions of synaptotagmin-1. Proc Natl Acad Sci U S A (2012) 1.04
A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion. Mol Biol Cell (2007) 1.04
Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. J Neurosci (2010) 1.03
The architecture of an excitatory synapse. J Cell Sci (2010) 1.02
Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Neuron (2013) 1.02