The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria.

PubWeight™: 1.44‹?› | Rank: Top 5%

🔗 View Article (PMID 15749903)

Published in J Immunol on March 15, 2005

Authors

Tomonori Hirotani1, Pui Y Lee, Hirotaka Kuwata, Masahiro Yamamoto, Makoto Matsumoto, Ichiro Kawase, Shizuo Akira, Kiyoshi Takeda

Author Affiliations

1: Department of Host Defense, Research Institute for Microbial Diseases, Graduate School of Medicine, Osaka University, Osaka, Japan.

Articles citing this

NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77

Transcriptional control of the inflammatory response. Nat Rev Immunol (2009) 5.20

Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest (2008) 3.00

Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization. J Immunol (2011) 2.34

Beyond pattern recognition: five immune checkpoints for scaling the microbial threat. Nat Rev Immunol (2012) 2.04

Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol (2010) 2.02

Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages. Mucosal Immunol (2008) 1.75

Mucosal macrophages in intestinal homeostasis and inflammation. J Innate Immun (2011) 1.44

The nuclear IκB family protein IκBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model. PLoS One (2014) 1.42

Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT. Proc Natl Acad Sci U S A (2005) 1.39

Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair. Front Cell Neurosci (2013) 1.34

Macrophages in intestinal homeostasis and inflammation. Immunol Rev (2014) 1.32

NOD2 regulation of Toll-like receptor responses and the pathogenesis of Crohn's disease. Gut (2005) 1.17

ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions. Mol Cell Biol (2007) 1.12

Role of Toll-like receptors in health and diseases of gastrointestinal tract. World J Gastroenterol (2006) 1.06

Peptidoglycan from lactobacilli inhibits interleukin-12 production by macrophages induced by Lactobacillus casei through Toll-like receptor 2-dependent and independent mechanisms. Immunology (2009) 1.05

Innate sensors of microbial infection. J Clin Immunol (2005) 1.05

A component of polysaccharide peptidoglycan complex on Lactobacillus induced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer. Immunology (2008) 1.01

IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IκBζ mRNA. J Biol Chem (2010) 1.00

A structural guide to proteins of the NF-kappaB signaling module. Cold Spring Harb Perspect Biol (2009) 0.99

The monocyte-macrophage axis in the intestine. Cell Immunol (2014) 0.97

Structure-function relationship of cytoplasmic and nuclear IκB proteins: an in silico analysis. PLoS One (2010) 0.94

Microbes, the gut and ankylosing spondylitis. Arthritis Res Ther (2013) 0.93

NF-κB signaling. Wiley Interdiscip Rev Syst Biol Med (2010) 0.92

Intestinal antigen-presenting cells in mucosal immune homeostasis: crosstalk between dendritic cells, macrophages and B-cells. World J Gastroenterol (2014) 0.90

Atypical IκB proteins - nuclear modulators of NF-κB signaling. Cell Commun Signal (2013) 0.90

IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50. Proc Natl Acad Sci U S A (2010) 0.89

Alternative nuclear functions for NF-κB family members. Am J Cancer Res (2011) 0.89

Immune responses to gut microbiota-commensals and pathogens. Gut Microbes (2010) 0.89

ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis (2013) 0.87

Impaired B cell development and function in the absence of IkappaBNS. J Immunol (2011) 0.86

IkappaBeta, a nuclear IkappaB protein, positively regulates the NF-kappaB-mediated expression of proinflammatory cytokines. Proc Natl Acad Sci U S A (2010) 0.86

Eradication of the commensal intestinal microflora by oral antimicrobials interferes with the host response to lipopolysaccharide. Eur J Clin Microbiol Infect Dis (2010) 0.85

Prolyl isomerase pin1 protects mice from endotoxin shock. PLoS One (2011) 0.80

The Nuclear Protein IκBζ Forms a Transcriptionally Active Complex with Nuclear Factor-κB (NF-κB) p50 and the Lcn2 Promoter via the N- and C-terminal Ankyrin Repeat Motifs. J Biol Chem (2016) 0.76

Diversity and functions of intestinal mononuclear phagocytes. Mucosal Immunol (2017) 0.75

The Atypical Inhibitor of NF-κB, IκBζ, Controls Macrophage Interleukin-10 Expression. J Biol Chem (2016) 0.75

Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases. Clin Immunol (2016) 0.75

IκBζ: an emerging player in cancer. Oncotarget (2016) 0.75

NF-κB and hypoxia: a double-edged sword in atherosclerosis. Am J Pathol (2012) 0.75

Macrophages in gastrointestinal homeostasis and inflammation. Pflugers Arch (2017) 0.75

Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis. Sci Rep (2017) 0.75

Immune balance: the development of the idea and its applications. J Hist Biol (2014) 0.75

Articles by these authors

Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12

Toll-like receptors. Annu Rev Immunol (2001) 26.06

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65

Pattern recognition receptors and inflammation. Cell (2010) 21.05

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57

Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26

5'-Triphosphate RNA is the ligand for RIG-I. Science (2006) 15.78

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10

Toll-like receptors in innate immunity. Int Immunol (2005) 12.24

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77

Innate immune recognition of viral infection. Nat Immunol (2006) 9.59

Robust single-particle tracking in live-cell time-lapse sequences. Nat Methods (2008) 9.43

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature (2004) 9.40

Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17

TLR signaling pathways. Semin Immunol (2004) 9.08

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87

TLR signaling. Semin Immunol (2007) 8.16

ATP drives lamina propria T(H)17 cell differentiation. Nature (2008) 8.02

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med (2007) 7.25

Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med (2005) 7.18

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07

Innate immunity to virus infection. Immunol Rev (2009) 7.04

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62

Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature (2008) 6.40

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13

Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity (2006) 5.98

Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci (2008) 5.95

Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 5.76

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A (2006) 5.70

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48

Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41

The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem (2006) 5.11

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol (2008) 5.10

Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med (2006) 5.01

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4.94

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med (2005) 4.92

Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol (2005) 4.91

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol (2005) 4.83

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature (2002) 4.81

Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest (2006) 4.72

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol (2010) 4.66

TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity (2004) 4.50

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A (2009) 4.48

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46

Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol (2006) 4.37

Toll-like receptors and innate immunity. Biochem Biophys Res Commun (2009) 4.26

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 4.23

Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18

Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol (2006) 4.15