Desmosomes: new perpetrators in tumour suppression.

Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. J Cell Sci (2013) 1.63

Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. J Cell Sci (2012) 1.32

Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells. J Extracell Vesicles (2012) 1.16

Mechanistic basis of desmosome-targeted diseases. J Mol Biol (2013) 1.16

Plakoglobin: role in tumorigenesis and metastasis. Int J Cell Biol (2012) 1.15

Keratins control intercellular adhesion involving PKC-α-mediated desmoplakin phosphorylation. J Cell Biol (2013) 1.09

Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion. PLoS One (2012) 1.08

Cell adhesion and its endocytic regulation in cell migration during neural development and cancer metastasis. Int J Mol Sci (2012) 1.04

Structure, function, and regulation of desmosomes. Prog Mol Biol Transl Sci (2013) 1.00

Classical and desmosomal cadherins at a glance. J Cell Sci (2012) 0.96

Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast Cancer Res (2012) 0.90

Holding Tight: Cell Junctions and Cancer Spread. Trends Cancer Res (2012) 0.89

Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton. Exp Cell Res (2011) 0.87

Laminin, gamma 2 (LAMC2): a promising new putative pancreatic cancer biomarker identified by proteomic analysis of pancreatic adenocarcinoma tissues. Mol Cell Proteomics (2013) 0.87

Desmoglein 3: a help or a hindrance in cancer progression? Cancers (Basel) (2015) 0.87

Plakophilin-2 promotes tumor development by enhancing ligand-dependent and -independent epidermal growth factor receptor dimerization and activation. Mol Cell Biol (2014) 0.86

Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1. Mol Cancer (2012) 0.86

Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin. PLoS One (2014) 0.85

Desmosomes: regulators of cellular signaling and adhesion in epidermal health and disease. Cold Spring Harb Perspect Med (2014) 0.84

Desmosome regulation and signaling in disease. Cell Tissue Res (2015) 0.84

Desmosomes in acquired disease. Cell Tissue Res (2015) 0.83

killerFLIP: a novel lytic peptide specifically inducing cancer cell death. Cell Death Dis (2013) 0.83

Reelin is involved in the crypt-villus unit homeostasis. Tissue Eng Part A (2012) 0.82

Direct RNA sequencing mediated identification of mRNA localized in protrusions of human MDA-MB-231 metastatic breast cancer cells. J Mol Signal (2013) 0.82

Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis. Biomaterials (2012) 0.82

Regulation of Desmocollin3 Expression by Promoter Hypermethylation is Associated with Advanced Esophageal Adenocarcinomas. J Cancer (2014) 0.82

Expression of DSG1 and DSC1 are prognostic markers in anal carcinoma patients. Br J Cancer (2012) 0.81

Desmoglein-1, differentiation, and disease. J Clin Invest (2013) 0.81

Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion. J Biol Chem (2014) 0.80

Restoration of desmosomal junction protein expression and inhibition of H3K9-specific histone demethylase activity by cytostatic proline-rich polypeptide-1 leads to suppression of tumorigenic potential in human chondrosarcoma cells. Mol Clin Oncol (2014) 0.79

Impairement of HT29 Cancer Cells Cohesion by the Soluble Form of Neurotensin Receptor-3. Genes Cancer (2014) 0.79

Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas. J Cancer (2016) 0.78

Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier. Mol Biol Cell (2015) 0.78

Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma. Hum Mutat (2014) 0.78

Aberrant expression and altered cellular localization of desmosomal and hemidesmosomal proteins are associated with aggressive clinicopathological features of oral squamous cell carcinoma. Virchows Arch (2014) 0.78

Transmembrane protein PERP is a component of tessellate junctions and of other junctional and non-junctional plasma membrane regions in diverse epithelial and epithelium-derived cells. Cell Tissue Res (2013) 0.77

Mechanisms of Autoantibody-Induced Pathology. Front Immunol (2017) 0.76

Desmoglein-2 is overexpressed in non-small cell lung cancer tissues and its knockdown suppresses NSCLC growth by regulation of p27 and CDK2. J Cancer Res Clin Oncol (2016) 0.76

Down-regulated γ-catenin expression is associated with tumor aggressiveness in esophageal cancer. World J Gastroenterol (2014) 0.76

Modulation of cytoskeletal dynamics by mammalian nucleoside diphosphate kinase (NDPK) proteins. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.76

Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq. Oncotarget (2015) 0.75

Implications of PPPDE1 expression in the distribution of plakoglobin and β-catenin in pancreatic ductal adenocarcinoma. Oncol Lett (2014) 0.75

Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation. Int J Mol Sci (2016) 0.75

A functional module-based exploration between inflammation and cancer in esophagus. Sci Rep (2015) 0.75

NetNorM: Capturing cancer-relevant information in somatic exome mutation data with gene networks for cancer stratification and prognosis. PLoS Comput Biol (2017) 0.75

Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (1996) 15.88

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell (1996) 11.70

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A (1999) 10.75

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J (1989) 10.05

A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature (1998) 8.48

Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell (1997) 8.23

Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell (2000) 8.13

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62

A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science (1991) 5.71

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci U S A (1995) 5.54

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol (1994) 4.34

Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol (2002) 4.29

Molecular and functional analysis of cadherin-based adherens junctions. Annu Rev Cell Dev Biol (1997) 4.29

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell (2006) 4.15

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell (2005) 4.14

Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol (1994) 3.66

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells. J Cell Biol (1994) 3.61

Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol (2001) 3.31

Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest (2006) 3.22

A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation. EMBO J (1999) 3.20

Localization of specificity determining sites in cadherin cell adhesion molecules. Cell (1990) 2.99

Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. Nat Rev Mol Cell Biol (2004) 2.79

Desmosomes: new perspectives on a classic. J Invest Dermatol (2007) 2.78

The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J Biol Chem (1995) 2.62

Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58

Plakoglobin and beta-catenin: distinct but closely related. Science (1992) 2.40

Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin. J Cell Biol (1998) 2.38

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev (2000) 2.33

High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol (2002) 2.33

Plakoglobin and beta-catenin: protein interactions, regulation and biological roles. J Cell Sci (2000) 2.32

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol (1996) 2.27

Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol (1997) 2.23

Are desmosomes more than tethers for intermediate filaments? Nat Rev Mol Cell Biol (2000) 2.20

Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol (1998) 2.14

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat Cell Biol (2001) 2.10

Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation. J Cell Biol (2001) 2.01

Embryonic heart and skin defects in mice lacking plakoglobin. Dev Biol (1996) 2.01

Disassembling adherens junctions: breaking up is hard to do. Trends Cell Biol (2005) 2.00

Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol (2002) 2.00

Specificity of cell-cell adhesion by classical cadherins: Critical role for low-affinity dimerization through beta-strand swapping. Proc Natl Acad Sci U S A (2005) 1.99

The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. J Cell Biol (1997) 1.93

Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol Cell Biol (2000) 1.93

Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J Biol Chem (2005) 1.89

gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev (2000) 1.89

Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol (1994) 1.87

Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling. J Biol Chem (2002) 1.84

Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin. Proc Natl Acad Sci U S A (1995) 1.81

Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus. J Cell Biol (1997) 1.81

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque. J Cell Biol (1996) 1.80

Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion. J Cell Biol (1997) 1.80

Defining the interactions between intermediate filaments and desmosomes. J Cell Biol (1998) 1.78

Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. Proc Natl Acad Sci U S A (2006) 1.77

Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland. Dev Cell (2006) 1.77

Cellular and molecular events leading to the development of skin cancer. Mutat Res (2005) 1.69

Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line. Oncogene (2004) 1.63

Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA. J Invest Dermatol (2010) 1.62

Regulation of beta-catenin levels and localization by overexpression of plakoglobin and inhibition of the ubiquitin-proteasome system. J Cell Biol (1997) 1.59

Desmosomal adhesion inhibits invasive behavior. Proc Natl Acad Sci U S A (1998) 1.54

Expression of desmoglein I and plakoglobin in skin carcinomas. J Cutan Pathol (2000) 1.53

Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin. EMBO J (2006) 1.52

Desmosomes: adhesive strength and signalling in health and disease. Biochem J (2010) 1.51

Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev (2002) 1.50

Epigenetic silencing of DSC3 is a common event in human breast cancer. Breast Cancer Res (2005) 1.50

Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction. J Clin Invest (2005) 1.48

Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer. Cell Growth Differ (1999) 1.46

Molecular interactions between desmosomal cadherins. Biochem J (2002) 1.42

Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc Natl Acad Sci U S A (2008) 1.40

Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes. J Cell Sci (2007) 1.39

Desmoglein 2 is expressed abnormally rather than mutated in familial and sporadic gastric cancer. J Pathol (2005) 1.39

Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin. J Biol Chem (1994) 1.37

Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin. J Cell Biol (1996) 1.36

Defining desmosomal plakophilin-3 interactions. J Cell Biol (2003) 1.36

Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage. J Cell Biol (1994) 1.35

Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. Mol Cell Biol (2003) 1.33

Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells. Eur J Cell Biol (2002) 1.33

Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. Cell Tissue Res (1997) 1.33

Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure. J Cell Sci (2005) 1.32

DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. Oncogene (2006) 1.31

Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation. J Clin Oncol (2005) 1.30

Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium. J Invest Dermatol (1994) 1.30

Expression of desmosomal proteins in squamous cell carcinomas of the skin. J Cutan Pathol (2003) 1.30

E-cadherin expression in bladder cancer using formalin-fixed, paraffin-embedded tissues: correlation with histopathological grade, tumour stage and survival. Int J Cancer (1995) 1.25

Desmosomal cadherin binding domains of plakoglobin. J Biol Chem (1996) 1.25

Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. Mol Biol Cell (2006) 1.23

Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2. J Biol Chem (2000) 1.23

Calcium-independent desmosomes of keratinocytes are hyper-adhesive. J Invest Dermatol (2006) 1.20

Downregulation and abnormal expression of E-cadherin and beta-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis. Hum Pathol (1999) 1.20

The function of plakophilin 1 in desmosome assembly and actin filament organization. J Cell Biol (2000) 1.20

gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth. Oncogene (2002) 1.19

Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. Cancer Res (2005) 1.18

Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol (2011) 1.17

Cytoplasmically anchored plakoglobin induces a WNT-like phenotype in Xenopus. Dev Biol (1997) 1.17

E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance. Histopathology (2005) 1.17

Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction. J Immunol (2008) 1.17

Loss of desmocollin 3 in mice leads to epidermal blistering. J Cell Sci (2008) 1.16

Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study. Cell Adh Migr (2009) 1.15

Desmocollin switching in colorectal cancer. Br J Cancer (2006) 1.14

Restoration of plakoglobin expression in bladder carcinoma cell lines suppresses cell migration and tumorigenic potential. Br J Cancer (2005) 1.13

Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling. Mol Biol Cell (1999) 1.13

A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell (2010) 12.27

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell (2011) 4.74

The role of apoptosis in cancer development and treatment response. Nat Rev Cancer (2005) 4.19

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet (2005) 2.66

Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58

Developmental context determines latency of MYC-induced tumorigenesis. PLoS Biol (2004) 2.05

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev (2013) 1.88

p53 at a glance. J Cell Sci (2010) 1.88

The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell (2008) 1.88

Deconstructing p53 transcriptional networks in tumor suppression. Trends Cell Biol (2011) 1.62

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol (2004) 1.44

Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies. J Invest Dermatol (2009) 1.44

Genome-wide analysis of p53 under hypoxic conditions. Mol Cell Biol (2006) 1.37

Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer. Biochem Biophys Res Commun (2005) 1.20

In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis (2010) 1.14

Multiple response elements and differential p53 binding control Perp expression during apoptosis. Mol Cancer Res (2003) 1.11

Perp is a mediator of p53-dependent apoptosis in diverse cell types. Curr Biol (2003) 1.11

Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. Proc Natl Acad Sci U S A (2008) 1.05

Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet (2010) 1.04

Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. Cancer Res (2007) 1.01

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95

International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome. Am J Med Genet A (2009) 0.94

Perp-etrating p53-dependent apoptosis. Cell Cycle (2004) 0.90

Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast Cancer Res (2012) 0.90

Mice lacking the p53/p63 target gene Perp are resistant to papilloma development. Cancer Res (2005) 0.90

A new Perp in the lineup: linking p63 and desmosomal adhesion. Cell Cycle (2005) 0.90

PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci (2011) 0.89

p63, cell adhesion and survival. Cell Cycle (2007) 0.88

Conquering the complexity of p53. Nat Genet (2004) 0.85

Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis. Am J Med Genet A (2009) 0.84

SKP-ing TAp63: stem cell depletion, senescence, and premature aging. Cell Stem Cell (2009) 0.84

Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice. PLoS One (2012) 0.82

TRP53 activates a global autophagy program to promote tumor suppression. Autophagy (2013) 0.80

Tumor suppression: p53 alters immune surveillance to restrain liver cancer. Curr Biol (2013) 0.80

Engaging the p53 metabolic brake drives senescence. Cell Res (2013) 0.80

The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia. J Invest Dermatol (2006) 0.79

Loss of the desmosomal component perp impairs wound healing in vivo. Dermatol Res Pract (2010) 0.78

p53QS: an old mutant teaches us new tricks. Cell Cycle (2005) 0.78

Guilty as CHARGED: p53's expanding role in disease. Cell Cycle (2014) 0.77

Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse. Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 0.76

A healthy tan? N Engl J Med (2007) 0.76