Published in Nat Cell Biol on September 21, 2014
p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling. Proc Natl Acad Sci U S A (2015) 1.20
p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer. Oncogene (2015) 1.02
ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion. Oncotarget (2016) 0.92
p63 controls cell migration and invasion by transcriptional regulation of MTSS1. Oncogene (2015) 0.91
Overexpression and knockout of miR-126 both promote leukemogenesis. Blood (2015) 0.88
ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis. Oncotarget (2016) 0.87
Pathway Regulation of p63, a Director of Epithelial Cell Fate. Front Endocrinol (Lausanne) (2015) 0.85
Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ. Cell Stem Cell (2016) 0.82
The mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapes. Endocr Relat Cancer (2015) 0.81
Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia. J Clin Invest (2016) 0.81
ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program. Cancer Res (2015) 0.80
Deregulation of RGS17 Expression Promotes Breast Cancer Progression. J Cancer (2015) 0.78
Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer. Cancers (Basel) (2016) 0.78
Wnt signaling in triple-negative breast cancer. Oncogenesis (2017) 0.78
p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function. Aging (Albany NY) (2016) 0.78
Mammary Development and Breast Cancer: A Wnt Perspective. Cancers (Basel) (2016) 0.77
Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERα-ΔNp63-Integrin β4 Signaling Pathway. PLoS One (2016) 0.77
FZD7 regulates BMSCs-mediated protection of CML cells. Oncotarget (2016) 0.77
A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues. BMC Genomics (2015) 0.77
Targeting BMI1(+) Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma. Cell Stem Cell (2017) 0.77
FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells. PLoS One (2016) 0.76
Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis. Oncotarget (2016) 0.75
Properties and feasibility of using cancer stem cells in clinical cancer treatment. Cancer Biol Med (2016) 0.75
p63 role in breast cancer. Aging (Albany NY) (2016) 0.75
ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells. BMC Cancer (2016) 0.75
TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway. Oncogene (2016) 0.75
Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol (2017) 0.75
The propensity for epithelial-mesenchymal transitions is dictated by chromatin states in the cancer cell of origin. Stem Cell Investig (2017) 0.75
Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1(-/-) mice, a model of dry eye. Exp Eye Res (2016) 0.75
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A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med (2008) 3.64
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GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell (2008) 3.44
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res (2010) 3.40
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature (2010) 3.37
p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol (2006) 3.37
The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res (2008) 3.23
Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell (2012) 3.17
Dissecting the heterogeneity of triple-negative breast cancer. J Clin Oncol (2012) 2.64
Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol (2012) 2.46
Lentiviral vectors to probe and manipulate the Wnt signaling pathway. PLoS One (2010) 2.28
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development (2006) 2.23
Wnt signaling and breast cancer. Cancer Biol Ther (2004) 2.22
p63 in epithelial survival, germ cell surveillance, and neoplasia. Annu Rev Pathol (2010) 2.21
Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am J Pathol (2010) 2.20
TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol (2009) 2.15
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet (2010) 2.14
p63 and p73 in human cancer: defining the network. Oncogene (2007) 2.13
ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development (2012) 1.97
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell (2011) 1.75
Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res (2002) 1.69
Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia. Development (2004) 1.58
FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene (2011) 1.53
Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ (2010) 1.50
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A (2006) 1.48
Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. Am J Pathol (2011) 1.39
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer. Oncogene (2011) 1.29
Frizzled7 as an emerging target for cancer therapy. Cell Signal (2011) 1.16
Transcription factor Oct1 is a somatic and cancer stem cell determinant. PLoS Genet (2012) 1.15
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells (2008) 1.15
Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation. Cell Death Dis (2010) 1.08
p63 overexpression induces the expression of Sonic Hedgehog. Mol Cancer Res (2006) 1.06
A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression. Methods Enzymol (2008) 1.05
Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling. Cold Spring Harb Perspect Biol (2012) 1.05
Optimization of duplex stability and terminal asymmetry for shRNA design. PLoS One (2010) 1.05
p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network. J Biol Chem (2011) 0.98
ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res (2012) 0.94
The cell of origin of BRCA1 mutation-associated breast cancer: a cautionary tale of gene expression profiling. J Mammary Gland Biol Neoplasia (2011) 0.91
A prophylactic vaccine for breast cancer? Breast Cancer Res (2010) 0.89
Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells. PLoS Biol (2013) 0.89
Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets. Proc Natl Acad Sci U S A (2014) 0.81
Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol (2017) 0.75
Identification of Nidogen 1 as a lung metastasis protein through secretome analysis. Genes Dev (2017) 0.75