Published in Development on April 20, 2005
Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos. Development (2005) 1.38
A clinical and experimental overview of sirenomelia: insight into the mechanisms of congenital limb malformations. Dis Model Mech (2011) 1.03
New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling. Curr Opin Genet Dev (2009) 0.97
Sirenomelia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review. Am J Med Genet C Semin Med Genet (2011) 0.96
Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia. PLoS One (2012) 0.86
Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice. Arch Oral Biol (2005) 0.86
Glycosylation of Twisted Gastrulation is Required for BMP Binding and Activity during Craniofacial Development. Front Physiol (2011) 0.85
SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res (2015) 0.85
BMP signaling controls formation of a primordial germ cell niche within the early genital ridges. Dev Biol (2010) 0.84
Sirenomelia phenotype in bmp7;shh compound mutants: a novel experimental model for studies of caudal body malformations. PLoS One (2012) 0.83
The expression of twisted gastrulation in postnatal mouse brain and functional implications. Neuroscience (2010) 0.82
Control of the bone morphogenetic protein 7 gene in developmental and adult life. Curr Genomics (2009) 0.77
Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos. Dev Biol (2014) 0.76
Minimal evidence for a direct involvement of twisted gastrulation homolog 1 (TWSG1) gene in human holoprosencephaly. Mol Genet Metab (2010) 0.76
Birth defects associated with perturbations in preimplantation, gastrulation, and axis extension: from conjoined twinning to caudal dysgenesis. Wiley Interdiscip Rev Dev Biol (2012) 0.75
Subtilisin-like proprotein convertase activity is necessary for left-right axis determination in Xenopus neurula embryos. Dev Genes Evol (2006) 0.75
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol (2002) 4.14
Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev (2003) 4.08
Dorsal-ventral patterning and neural induction in Xenopus embryos. Annu Rev Cell Dev Biol (2004) 3.96
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell (2007) 3.53
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases. Cell (2006) 2.85
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A (2005) 2.82
Autoregulation of neurogenesis by GDF11. Neuron (2003) 2.40
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
GDF11 controls the timing of progenitor cell competence in developing retina. Science (2005) 2.04
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem (2006) 1.96
BMP signaling is required for septation of the outflow tract of the mammalian heart. Development (2003) 1.95
Multiple functions of BMPs in chondrogenesis. J Cell Biochem (2004) 1.92
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Hum Mol Genet (2006) 1.74
Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos. Dev Cell (2003) 1.68
Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK. EMBO J (2004) 1.67
Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report. Genet Med (2011) 1.62
BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development (2006) 1.59
CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res (2006) 1.57
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem (2008) 1.55
Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation. Genes Dev (2005) 1.52
Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res (2008) 1.51
BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A (2005) 1.44
Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genet (2011) 1.39
Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos. Development (2005) 1.38
Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Proc Natl Acad Sci U S A (2006) 1.34
Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development (2005) 1.33
CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One (2012) 1.33
Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. J Bone Miner Res (2010) 1.29
Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem (2005) 1.28
Tempting fate: BMP signals for cardiac morphogenesis. Cytokine Growth Factor Rev (2003) 1.26
The pro-BMP activity of Twisted gastrulation is independent of BMP binding. Development (2003) 1.25
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol (2009) 1.24
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal (2007) 1.24
Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling. Am J Hum Genet (2010) 1.24
C5orf42 is the major gene responsible for OFD syndrome type VI. Hum Genet (2013) 1.24
BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci (2010) 1.22
A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol (2008) 1.21
CTGF inhibits BMP-7 signaling in diabetic nephropathy. J Am Soc Nephrol (2008) 1.19
Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development (2004) 1.18
Smad signaling in skeletal development and regeneration. Cytokine Growth Factor Rev (2009) 1.17
Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol (2010) 1.17
Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice. J Histochem Cytochem (2007) 1.10
The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. EMBO J (2007) 1.09
Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma. Nat Genet (2012) 1.08
Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Dev Dyn (2004) 1.08
Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol (2011) 1.07
Roles for CCN2 in normal physiological processes. Cell Mol Life Sci (2011) 1.06
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem (2008) 1.04
BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression. J Histochem Cytochem (2009) 1.04
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem Biophys Res Commun (2007) 1.03
Smad6 is essential to limit BMP signaling during cartilage development. J Bone Miner Res (2011) 1.02
Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Am J Hum Genet (2012) 1.02
CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). J Bone Miner Res (2011) 0.96
Connective tissue growth factor is required for normal follicle development and ovulation. Mol Endocrinol (2011) 0.96
Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice. J Histochem Cytochem (2008) 0.95
Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos. Mech Dev (2007) 0.93
Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin. J Biol Chem (2010) 0.93
Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program. Curr Biol (2015) 0.91
Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1. Nat Genet (2012) 0.89
Postoperative cerebral white matter damage associated with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy: a diffusion tensor magnetic resonance imaging study. Cerebrovasc Dis (2012) 0.89
Adverse effects of intravenous acetazolamide administration for evaluation of cerebrovascular reactivity using brain perfusion single-photon emission computed tomography in patients with major cerebral artery steno-occlusive diseases. Neurol Med Chir (Tokyo) (2011) 0.88
Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity. J Biol Chem (2013) 0.87
Tracking expression of virally mediated BMP-2 in gene therapy for bone repair. Clin Orthop Relat Res (2006) 0.86
Fungal laryngitis. Ear Nose Throat J (2009) 0.85
Whole-mount skeletal staining. Methods Mol Biol (2014) 0.85
TGFβ signaling in cartilage development and maintenance. Birth Defects Res C Embryo Today (2014) 0.85
The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity. J Cell Commun Signal (2007) 0.85
Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res (2011) 0.84
The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. J Bone Miner Res (2015) 0.84
Combination of preoperative cerebral blood flow and 123I-iomazenil SPECT imaging predicts postoperative cognitive improvement in patients undergoing uncomplicated endarterectomy for unilateral carotid stenosis. Clin Nucl Med (2012) 0.83
Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization. J Theor Biol (2011) 0.82
ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities. Crit Rev Oral Biol Med (2003) 0.82
Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Mol Biol Cell (2012) 0.82
Sirtuin inhibitor Ex-527 causes neural tube defects, ventral edema formations, and gastrointestinal malformations in Xenopus laevis embryos. Dev Growth Differ (2014) 0.81
Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol (2013) 0.81
Optimal histone H3 to linker histone H1 chromatin ratio is vital for mesodermal competence in Xenopus. Development (2013) 0.81
The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms. Biol Open (2013) 0.79
Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Mol Biol Cell (2013) 0.79
Integrin-alpha3 mediates binding of Chordin to the cell surface and promotes its endocytosis. EMBO Rep (2003) 0.79
Laryngeal thrush from asthma inhalers. Ear Nose Throat J (2012) 0.78
CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress. J Cell Commun Signal (2013) 0.78
Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development. Cells Tissues Organs (2007) 0.78
Preoperative 123I-iomazenil SPECT imaging predicts cerebral hyperperfusion following endarterectomy for unilateral cervical internal carotid artery stenosis. Am J Nucl Med Mol Imaging (2011) 0.78
CCN2 as a novel molecule supporting energy metabolism of chondrocytes. J Cell Biochem (2014) 0.77
KDEL tagging: a method for generating dominant-negative inhibitors of the secretion of TGF-beta superfamily proteins. Int J Dev Biol (2012) 0.77
Comparison of early and late images on 123I-iomazenil SPECT with cerebral blood flow and oxygen extraction fraction images on PET in the cerebral cortex of patients with chronic unilateral major cerebral artery occlusive disease. Nucl Med Commun (2012) 0.77
Intentional hypertension during dissection of carotid arteries in endarterectomy prevents postoperative development of new cerebral ischemic lesions caused by intraoperative microemboli. Neurosurgery (2011) 0.77
Rapamycin treatment causes developmental delay, pigmentation defects, and gastrointestinal malformation on Xenopus embryogenesis. Biochem Biophys Res Commun (2010) 0.75
Eddy M. De Robertis. Curr Biol (2008) 0.75
Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program. Curr Biol (2017) 0.75
Ischemic events due to intraoperative microemboli developing in the cerebral hemisphere contralateral to carotid endarterectomy in a patient with preoperative cerebral hemodynamic impairment. Neurol Med Chir (Tokyo) (2012) 0.75
Rupture of a concomitant unruptured cerebral aneurysm within 2 weeks of surgical repair of a ruptured cerebral aneurysm--case report. Neurol Med Chir (Tokyo) (2008) 0.75