Published in Clin Orthop Relat Res on September 01, 2006
Role of mesenchymal stem cells in bone regeneration and fracture repair: a review. Int Orthop (2013) 1.16
The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions. Clin Orthop Relat Res (2009) 1.01
"Same day" ex-vivo regional gene therapy: a novel strategy to enhance bone repair. Mol Ther (2011) 0.97
Mesenchymal stem cells: mechanisms and role in bone regeneration. Postgrad Med J (2014) 0.85
Biologic adjuvants for fracture healing. Arthritis Res Ther (2012) 0.82
Effect of a novel nonviral gene delivery of BMP-2 on bone healing. ScientificWorldJournal (2012) 0.78
The role of transduced bone marrow cells overexpressing BMP-2 in healing critical-sized defects in a mouse femur. Gene Ther (2015) 0.77
The role of mesenchymal stem cells in bone repair and regeneration. Eur J Orthop Surg Traumatol (2013) 0.76
Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am (2002) 5.95
Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am (2001) 5.13
Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol (1996) 4.97
A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology (1988) 4.72
Iliac crest bone graft harvest donor site morbidity. A statistical evaluation. Spine (Phila Pa 1976) (1995) 4.38
Autogenous iliac crest bone graft. Complications and functional assessment. Clin Orthop Relat Res (1997) 3.29
Comparison of anterior and posterior iliac crest bone grafts in terms of harvest-site morbidity and functional outcomes. J Bone Joint Surg Am (2002) 2.97
The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. Spine (Phila Pa 1976) (2000) 2.87
The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg Am (1999) 2.00
Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology (1992) 1.75
Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol Ther (2001) 1.63
Bone induction by BMP-2 transduced stem cells derived from human fat. J Orthop Res (2003) 1.60
Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF beta family member. Cell (1993) 1.57
Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J Orthop Res (1998) 1.41
Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther (2000) 1.39
Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J Bone Joint Surg Am (1995) 1.36
Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. J Gene Med (2000) 1.32
Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J Gene Med (2001) 1.30
Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone. Bone (1999) 1.16
Effect of bone morphogenetic protein-2-expressing muscle-derived cells on healing of critical-sized bone defects in mice. J Bone Joint Surg Am (2001) 1.15
In vitro and in vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene. Calcif Tissue Int (2001) 1.07
Muscle-derived stem cells for musculoskeletal tissue regeneration and repair. Transpl Immunol (2004) 1.04
Production of first generation adenovirus vectors: a review. Gene Ther (2000) 1.04
Genetic modification of stem cells to enhance bone repair. Ann Biomed Eng (2004) 1.01
Gene transfer approaches to the healing of bone and cartilage. Mol Ther (2002) 1.00
Regional gene therapy to enhance bone repair. Gene Ther (2004) 0.99
In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector. Hum Gene Ther (1999) 0.98
Stem cells as vehicles for orthopedic gene therapy. Gene Ther (2004) 0.94
Osteoinductive molecules in orthopaedics: basic science and preclinical studies. Clin Orthop Relat Res (2002) 0.94
Gene therapy for osteoinduction. Orthop Clin North Am (1999) 0.87
Orthopedic applications of gene therapy. J Orthop Sci (2001) 0.84
Genetically augmented tissue engineering of the musculoskeletal system. Clin Orthop Relat Res (1999) 0.82
Adenoviral gene transfer in a rat fracture model. Lab Anim (2002) 0.77
Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med (2008) 6.32
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31
Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N Engl J Med (2003) 3.96
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A (2005) 2.82
Denosumab induces tumor reduction and bone formation in patients with giant-cell tumor of bone. Clin Cancer Res (2012) 2.46
Autoregulation of neurogenesis by GDF11. Neuron (2003) 2.40
Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty (2008) 2.30
Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions. Bone (2005) 2.26
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
Factors predicting complication rates following total knee replacement. J Bone Joint Surg Am (2006) 2.15
Minimally invasive total hip arthroplasty. Development, early results, and a critical analysis. Presented at the Annual Meeting of the American Orthopaedic Association, Charleston, South Carolina, USA, June 14, 2003. J Bone Joint Surg Am (2003) 2.11
Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res (2005) 2.04
GDF11 controls the timing of progenitor cell competence in developing retina. Science (2005) 2.04
Osteonecrosis of the femoral head: evaluation and treatment. J Am Acad Orthop Surg (2014) 2.04
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem (2006) 1.96
BMP signaling is required for septation of the outflow tract of the mammalian heart. Development (2003) 1.95
Multiple functions of BMPs in chondrogenesis. J Cell Biochem (2004) 1.92
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
Revisiting CT-guided percutaneous core needle biopsy of musculoskeletal lesions: contributors to biopsy success. AJR Am J Roentgenol (2011) 1.80
Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Hum Mol Genet (2006) 1.74
Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Eng (2005) 1.69
High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality. Ann Surg (2003) 1.63
Reduction of glucose metabolic activity is more accurate than change in size at predicting histopathologic response to neoadjuvant therapy in high-grade soft-tissue sarcomas. Clin Cancer Res (2008) 1.62
Bone induction by BMP-2 transduced stem cells derived from human fat. J Orthop Res (2003) 1.60
BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development (2006) 1.59
Oral direct thrombin inhibitor ximelagatran compared with warfarin for the prevention of venous thromboembolism after total knee arthroplasty. J Bone Joint Surg Am (2005) 1.59
Factors that predict short-term complication rates after total hip arthroplasty. Clin Orthop Relat Res (2010) 1.57
CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res (2006) 1.57
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem (2008) 1.55
A mouse model of post-arthroplasty Staphylococcus aureus joint infection to evaluate in vivo the efficacy of antimicrobial implant coatings. PLoS One (2010) 1.52
Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res (2008) 1.51
BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A (2005) 1.44
Characterization of osteolytic, osteoblastic, and mixed lesions in a prostate cancer mouse model using 18F-FDG and 18F-fluoride PET/CT. J Nucl Med (2008) 1.43
Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. J Bone Miner Res (2004) 1.42
Developing a pathway for high-value, patient-centered total joint arthroplasty. Clin Orthop Relat Res (2013) 1.39
The orthopaedic genome: what does the future hold and are we ready? J Bone Joint Surg Am (2002) 1.39
Use of navigation-assisted fluoroscopy to decrease radiation exposure during minimally invasive spine surgery. Spine J (2007) 1.36
American academy of orthopaedic surgeons clinical practice guideline on. Prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty. J Bone Joint Surg Am (2009) 1.34
Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Proc Natl Acad Sci U S A (2006) 1.34
Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development (2005) 1.33
CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One (2012) 1.33
Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. J Bone Miner Res (2010) 1.29
Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem (2005) 1.28
Osteoinductivity of commercially available demineralized bone matrix. Preparations in a spine fusion model. J Bone Joint Surg Am (2004) 1.27
Tempting fate: BMP signals for cardiac morphogenesis. Cytokine Growth Factor Rev (2003) 1.26
Influence of BMPs on the formation of osteoblastic lesions in metastatic prostate cancer. J Bone Miner Res (2005) 1.25
Prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty. J Am Acad Orthop Surg (2009) 1.25
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol (2009) 1.24
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal (2007) 1.24
Primary total knee arthroplasty in California 1991 to 2001: does hospital volume affect outcomes? J Arthroplasty (2006) 1.24
BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci (2010) 1.22
A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol (2008) 1.21
Cost-effectiveness analysis of unicompartmental knee arthroplasty as an alternative to total knee arthroplasty for unicompartmental osteoarthritis. J Bone Joint Surg Am (2006) 1.20
CTGF inhibits BMP-7 signaling in diabetic nephropathy. J Am Soc Nephrol (2008) 1.19
Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J Bone Joint Surg Am (2003) 1.19
Osteonecrosis of the hip: novel approaches to evaluation and treatment. Clin Orthop Relat Res (2007) 1.18
Mixed metastatic lung cancer lesions in bone are inhibited by noggin overexpression and Rank:Fc administration. J Bone Miner Res (2006) 1.18
Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development (2004) 1.18
Influence of simultaneous targeting of the bone morphogenetic protein pathway and RANK/RANKL axis in osteolytic prostate cancer lesion in bone. Bone (2008) 1.18
Whole-body skeletal imaging in mice utilizing microPET: optimization of reproducibility and applications in animal models of bone disease. Eur J Nucl Med Mol Imaging (2002) 1.17
Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol (2010) 1.17
Smad signaling in skeletal development and regeneration. Cytokine Growth Factor Rev (2009) 1.17
Use of zoledronate to treat osteoblastic versus osteolytic lesions in a severe-combined-immunodeficient mouse model. Cancer Res (2002) 1.16
Tissue-engineered bone from BMP-2-transduced stem cells derived from human fat. Plast Reconstr Surg (2005) 1.14
Mesenchymal stem cell concentration and bone repair: potential pitfalls from bench to bedside. J Bone Joint Surg Am (2009) 1.14
A novel dual-targeted lentiviral vector leads to specific transduction of prostate cancer bone metastases in vivo after systemic administration. Mol Ther (2007) 1.13
A comparison of commercially available demineralized bone matrix for spinal fusion. Eur Spine J (2007) 1.10
Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice. J Histochem Cytochem (2007) 1.10
Optimal timeframe for reporting short-term complication rates after total knee arthroplasty. J Arthroplasty (2006) 1.08
Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Dev Dyn (2004) 1.08
A Randomized, Controlled Trial of Total Knee Replacement. N Engl J Med (2016) 1.08
Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol (2011) 1.07
Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo. Mol Ther (2005) 1.07
Roles for CCN2 in normal physiological processes. Cell Mol Life Sci (2011) 1.06
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem (2008) 1.04
The effects of RANK blockade and osteoclast depletion in a model of pure osteoblastic prostate cancer metastasis in bone. J Orthop Res (2005) 1.04
Bone graft for revision hip arthroplasty: biology and future applications. Clin Orthop Relat Res (2003) 1.04
BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression. J Histochem Cytochem (2009) 1.04
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem Biophys Res Commun (2007) 1.03
Diagnostic relevance of overexpressions of PKC-θ and DOG-1 and KIT/PDGFRA gene mutations in extragastrointestinal stromal tumors: a Korean six-centers study of 28 cases. Anticancer Res (2012) 1.02
Smad6 is essential to limit BMP signaling during cartilage development. J Bone Miner Res (2011) 1.02
Stem cells from human fat as cellular delivery vehicles in an athymic rat posterolateral spine fusion model. J Bone Joint Surg Am (2008) 1.02
Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Am J Hum Genet (2012) 1.02
Genetic modification of stem cells to enhance bone repair. Ann Biomed Eng (2004) 1.01
Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trial. Ann Intern Med (2002) 1.00
An evaluation of human demineralized bone matrices in a rat femoral defect model. Clin Orthop Relat Res (2003) 1.00
Comparison of the responsiveness of the SF-36 and WOMAC in patients undergoing total hip arthroplasty. J Arthroplasty (2007) 0.98
Tumor metastasis to bone. Arthritis Res Ther (2007) 0.98
Bone morphogenetic protein-2 (BMP-2) in the treatment of pyogenic vertebral osteomyelitis. Spine (Phila Pa 1976) (2007) 0.97
"Same day" ex-vivo regional gene therapy: a novel strategy to enhance bone repair. Mol Ther (2011) 0.97
Gene therapy approaches to regenerating bone. Adv Drug Deliv Rev (2012) 0.97
CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). J Bone Miner Res (2011) 0.96
Connective tissue growth factor is required for normal follicle development and ovulation. Mol Endocrinol (2011) 0.96
Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development (2005) 0.95
Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice. J Histochem Cytochem (2008) 0.95