MicroRNA biogenesis and cancer.

miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A (2005) 21.51

microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci U S A (2006) 8.24

Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Am J Pathol (2006) 3.30

MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics (2010) 2.80

microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis. Cancer Res (2009) 2.51

LncRNA loc285194 is a p53-regulated tumor suppressor. Nucleic Acids Res (2013) 2.38

Argonaute--a database for gene regulation by mammalian microRNAs. Nucleic Acids Res (2006) 2.26

MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. Br J Cancer (2009) 1.88

Host-virus interaction: a new role for microRNAs. Retrovirology (2006) 1.88

MicroRNA miR-328 regulates zonation morphogenesis by targeting CD44 expression. PLoS One (2008) 1.80

The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One (2008) 1.78

microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res (2010) 1.76

Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. Biochem Pharmacol (2009) 1.75

Aberrant expression of microRNAs in bladder cancer. Nat Rev Urol (2013) 1.74

Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications. J Clin Invest (2007) 1.72

Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA (2009) 1.67

The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One (2010) 1.63

MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop. J Clin Invest (2011) 1.60

miR-182 as a prognostic marker for glioma progression and patient survival. Am J Pathol (2010) 1.56

Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy. Mol Cancer (2010) 1.56

Unregulated miR-96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a. PLoS One (2010) 1.49

Retracted Down-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients. Diagn Pathol (2015) 1.45

Development of the human cancer microRNA network. Silence (2010) 1.43

Prognostic significance of differentially expressed miRNAs in esophageal cancer. Int J Cancer (2011) 1.43

In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5. Nucleic Acids Res (2006) 1.39

Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis. BMC Syst Biol (2012) 1.35

MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells. Carcinogenesis (2011) 1.33

Mature and functional viral miRNAs transcribed from novel RNA polymerase III promoters. RNA (2009) 1.32

Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease. BMC Genomics (2008) 1.32

Systematic validation of predicted microRNAs for cyclin D1. BMC Cancer (2009) 1.32

Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications. Mamm Genome (2008) 1.23

microRNA expression during trophectoderm specification. PLoS One (2009) 1.22

MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4. J Cancer Res Clin Oncol (2012) 1.21

dbDEMC: a database of differentially expressed miRNAs in human cancers. BMC Genomics (2010) 1.20

Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization. Nucleic Acids Res (2010) 1.19

MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary. PLoS One (2009) 1.18

Next-generation sequencing of microRNAs for breast cancer detection. J Biomed Biotechnol (2011) 1.17

MicroRNAs in the pathogenesis of Lung Cancer. J Thorac Oncol (2009) 1.17

Direct detection and quantification of microRNAs. Anal Biochem (2009) 1.16

An integrated analysis of miRNA and mRNA expressions in non-small cell lung cancers. PLoS One (2011) 1.16

MiR-221/222 target the DNA methyltransferase MGMT in glioma cells. PLoS One (2013) 1.16

MicroRNA-107, an oncogene microRNA that regulates tumour invasion and metastasis by targeting DICER1 in gastric cancer. J Cell Mol Med (2011) 1.15

cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a. Proc Natl Acad Sci U S A (2012) 1.15

miR-497 induces apoptosis of breast cancer cells by targeting Bcl-w. Exp Ther Med (2011) 1.15

MiR-378 is an independent prognostic factor and inhibits cell growth and invasion in colorectal cancer. BMC Cancer (2014) 1.14

Elevated expression of prostate cancer-associated genes is linked to down-regulation of microRNAs. BMC Cancer (2014) 1.12

The prognostic value of microRNAs varies with patient race/ethnicity and stage of colorectal cancer. Clin Cancer Res (2013) 1.12

Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis. BMC Evol Biol (2006) 1.12

Comprehensive analysis of the functional microRNA-mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression. Nucleic Acids Res (2013) 1.11

Glycogen synthase kinase 3 beta (GSK3β) phosphorylates the RNAase III enzyme Drosha at S300 and S302. PLoS One (2011) 1.09

MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis. BMC Cancer (2010) 1.09

Genetic polymorphisms in MicroRNA-related genes as predictors of clinical outcomes in colorectal adenocarcinoma patients. Clin Cancer Res (2012) 1.08

MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN. Oncotarget (2015) 1.07

Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the β-Catenin/TCF/LEF-1 pathway in gastric cancer cells. Nucleic Acids Res (2013) 1.06

Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation. Mamm Genome (2009) 1.05

MicroRNA-mediated posttranscriptional regulation is required for maintaining undifferentiated properties of blastoderm and primordial germ cells in chickens. Proc Natl Acad Sci U S A (2011) 1.05

Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas. Virchows Arch (2011) 1.03

Circulating miR-148b and miR-133a as biomarkers for breast cancer detection. Oncotarget (2014) 1.02

MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin D1 and cyclin E1. PLoS One (2013) 1.02

MicroRNA in pancreatic cancer: pathological, diagnostic and therapeutic implications. Cancer Lett (2009) 1.01

Molecular markers for breast cancer: prediction on tumor behavior. Dis Markers (2014) 1.01

Polymorphisms of microRNA sequences or binding sites and lung cancer: a meta-analysis and systematic review. PLoS One (2013) 1.01

MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. Carcinogenesis (2010) 1.01

Genome-wide analysis of mir-548 gene family reveals evolutionary and functional implications. J Biomed Biotechnol (2012) 0.99

Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines. Int J Mol Med (2012) 0.98

MicroRNA-related genetic variants associated with clinical outcomes in early-stage non-small cell lung cancer patients. Cancer Res (2013) 0.98

Retracted Down-regulated microRNA-124 expression as predictive biomarker and its prognostic significance with clinicopathological features in breast cancer patients. Diagn Pathol (2015) 0.98

Design and application of oncolytic HSV vectors for glioblastoma therapy. Expert Rev Neurother (2009) 0.98

Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function. Mamm Genome (2008) 0.97

Functional polymorphisms in two pre-microRNAs and cancer risk: a meta-analysis. Int J Mol Epidemiol Genet (2010) 0.97

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation. Front Cell Neurosci (2015) 0.97

dCLIP: a computational approach for comparative CLIP-seq analyses. Genome Biol (2014) 0.95

HGIMDA: Heterogeneous graph inference for miRNA-disease association prediction. Oncotarget (2016) 0.95

MicroRNA-326 functions as a tumor suppressor in glioma by targeting the Nin one binding protein (NOB1). PLoS One (2013) 0.93

Regulation of cardiac microRNAs by serum response factor. J Biomed Sci (2011) 0.93

Exploration of miRNA families for hypotheses generation. Sci Rep (2013) 0.92

MicroRNA: A matter of life or death. World J Biol Chem (2010) 0.91

The Akt-associated microRNAs. Cell Mol Life Sci (2012) 0.91

HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96. Oncotarget (2014) 0.90

Ovarian cancer: opportunity for targeted therapy. J Oncol (2011) 0.90

Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse. PLoS One (2007) 0.89

miR-181b as a key regulator of the oncogenic process and its clinical implications in cancer (Review). Biomed Rep (2013) 0.89

Non coding RNA and brain. BMC Neurosci (2006) 0.89

MicroRNA-106b promotes colorectal cancer cell migration and invasion by directly targeting DLC1. J Exp Clin Cancer Res (2015) 0.89

Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility. Cancer Biol Med (2012) 0.88

Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors. Med Mol Morphol (2013) 0.88

MicroRNAs as novel regulators of neuroinflammation. Mediators Inflamm (2013) 0.88

Clinical and prognostic significance of miR-155 and miR-146a expression levels in formalin-fixed/paraffin-embedded tissue of patients with diffuse large B-cell lymphoma. Exp Ther Med (2012) 0.88

Heterogeneity of microRNAs expression in cervical cancer cells: over-expression of miR-196a. Int J Clin Exp Pathol (2014) 0.87

microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (review). Mol Med Rep (2012) 0.87

Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. PLoS One (2013) 0.87

Screening biomarkers of prostate cancer by integrating microRNA and mRNA microarrays. Genet Test Mol Biomarkers (2013) 0.86

MiR-92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta-catenin signaling pathway. J Transl Med (2013) 0.86

miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. Cell Cycle (2015) 0.86

Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation. Oncotarget (2015) 0.86

miR-155 is involved in Alzheimer's disease by regulating T lymphocyte function. Front Aging Neurosci (2015) 0.86

Risk factors and biomarkers of age-related macular degeneration. Prog Retin Eye Res (2016) 0.85

microRNA-450a targets DNA methyltransferase 3a in hepatocellular carcinoma. Exp Ther Med (2011) 0.84

miR-27b-3p suppresses cell proliferation through targeting receptor tyrosine kinase like orphan receptor 1 in gastric cancer. J Exp Clin Cancer Res (2015) 0.84

Non-coding RNAs in lung cancer. Oncoscience (2014) 0.83

The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70

The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res (2012) 15.41

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44

Long noncoding RNAs with enhancer-like function in human cells. Cell (2010) 13.00

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell (2005) 9.27

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol (2005) 7.49

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41

An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature (2005) 5.89

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53

MicroRNA silencing through RISC recruitment of eIF6. Nature (2007) 4.37

An operational definition of epigenetics. Genes Dev (2009) 4.26

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature (2013) 3.98

Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66

RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex. EMBO Rep (2007) 3.40

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol (2006) 3.15

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell (2003) 2.90

A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78

A chromatin remodelling complex that loads cohesin onto human chromosomes. Nature (2002) 2.53

Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell (2007) 2.29

Functional interplay between histone demethylase and deacetylase enzymes. Mol Cell Biol (2006) 2.20

The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05

A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. J Biol Chem (2004) 1.98

Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA. J Biol Chem (2003) 1.93

The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. EMBO J (2007) 1.92

Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol (2007) 1.89

Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80

Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. J Biol Chem (2008) 1.75

Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase. Mol Cell Biol (2007) 1.72

MicroRNA biogenesis: isolation and characterization of the microprocessor complex. Methods Mol Biol (2006) 1.69

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67

Long noncoding RNAs usher in a new era in the biology of enhancers. Cell (2013) 1.58

Long non-coding RNAs and enhancers. Curr Opin Genet Dev (2011) 1.52

Functional dissection of the human TNRC6 (GW182-related) family of proteins. Mol Cell Biol (2009) 1.49

Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Proc Natl Acad Sci U S A (2006) 1.44

Regulation of transcription by long noncoding RNAs. Annu Rev Genet (2014) 1.43

Cell cycle regulation of chromatin at an origin of DNA replication. EMBO J (2005) 1.40

CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. Hum Mol Genet (2005) 1.35

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Proc Natl Acad Sci U S A (2008) 1.35

Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.26

PHF8 targets histone methylation and RNA polymerase II to activate transcription. Mol Cell Biol (2010) 1.25

Functional analysis of Hes-1 in preadipocytes. Mol Endocrinol (2005) 1.21

Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation. Nat Cell Biol (2005) 1.15

Jarid2 regulates mouse epidermal stem cell activation and differentiation. EMBO J (2011) 1.14

Noncoding RNAs and enhancers: complications of a long-distance relationship. Trends Genet (2011) 1.13

Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol (2012) 1.10

Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res (2005) 1.09

Human GTPases associate with RNA polymerase II to mediate its nuclear import. Mol Cell Biol (2011) 1.05

Plant homeodomain fingers form a helping hand for transcription. Epigenetics (2011) 0.96

A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling. J Biol Chem (2004) 0.95

Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. Biochemistry (2006) 0.89

Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functions. J Biol Chem (2006) 0.88

Chromatin modifiers and carcinogenesis. Trends Cell Biol (2004) 0.88

The many faces of long noncoding RNAs. FEBS J (2014) 0.87

Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals. Mol Cell Biol (2012) 0.84

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation. EMBO J (2014) 0.83

Isolation and characterization of histone H3 lysine 4 demethylase-containing complexes. Methods (2006) 0.81

The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis. J Biol Chem (2002) 0.81

PINTing for p53. Genome Biol (2013) 0.78

Preparation and assays for mammalian ISWI complexes. Methods Enzymol (2004) 0.78

Thrilling transcription through threonine phosphorylation. Nat Cell Biol (2008) 0.77

Retraction: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2016) 0.75