Published in J Biol Chem on May 16, 2005
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes (2008) 3.05
Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. Dev Cell (2012) 1.72
Glucolipotoxicity of the pancreatic beta cell. Biochim Biophys Acta (2009) 1.69
GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J Biol Chem (2009) 1.36
Regulation of the insulin gene by glucose and fatty acids. J Nutr (2006) 1.34
Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest (2006) 1.33
Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass. Diabetologia (2010) 1.25
Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells. Proc Natl Acad Sci U S A (2008) 1.23
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Diabetes (2009) 1.18
Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets. Diabetes (2007) 1.17
Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF-{alpha} gene expression in pancreatic islet endocrine cells. J Biol Chem (2010) 1.12
Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells. Proc Natl Acad Sci U S A (2007) 1.04
NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proc Natl Acad Sci U S A (2013) 1.02
Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol (2006) 1.02
Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells. Br J Pharmacol (2011) 1.01
The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4. J Biol Chem (2010) 1.00
Signal control through Raf: in sickness and in health. Cell Res (2011) 0.97
Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling. PLoS One (2012) 0.97
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells. J Biol Chem (2008) 0.96
C/EBPbeta regulates body composition, energy balance-related hormones and tumor growth. Carcinogenesis (2008) 0.94
Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation. J Transl Med (2007) 0.94
Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells. J Biol Chem (2010) 0.94
Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB J (2011) 0.94
The role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus. Diabetes Obes Metab (2010) 0.93
Calcineurin activates interleukin-6 transcription in mouse skeletal muscle in vivo and in C2C12 myotubes in vitro. Am J Physiol Regul Integr Comp Physiol (2009) 0.92
A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc Natl Acad Sci U S A (2011) 0.92
Inflammatory response in islet transplantation. Int J Endocrinol (2014) 0.91
Natural history of β-cell adaptation and failure in type 2 diabetes. Mol Aspects Med (2014) 0.91
Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription. Proc Natl Acad Sci U S A (2009) 0.91
Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway. Diabetologia (2011) 0.86
Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster. Mol Cell Biol (2012) 0.85
Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1. PLoS One (2012) 0.85
Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. Proc Natl Acad Sci U S A (2010) 0.84
A molecular rheostat at the interface of cancer and diabetes. Biochim Biophys Acta (2013) 0.84
miR-25 and miR-92a regulate insulin I biosynthesis in rats. RNA Biol (2013) 0.82
ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets. J Lipid Res (2010) 0.81
Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells. Mol Endocrinol (2015) 0.80
A model of insulin resistance in mice, born to diabetic pregnancy, is associated with alterations of transcription-related genes in pancreas and epididymal adipose tissue. J Obes (2010) 0.80
NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition. Oncogenesis (2013) 0.80
Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J Biol Chem (2013) 0.79
NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas. Mol Biol Cell (2014) 0.78
Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance. Mol Cell Biochem (2016) 0.76
NFAT targets signaling molecules to gene promoters in pancreatic β-cells. Mol Endocrinol (2014) 0.76
Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cells. PLoS One (2014) 0.76
Reduction of insulin signalling pathway IRS-1/IRS-2/AKT/mTOR and decrease of epithelial cell proliferation in the prostate of glucocorticoid-treated rats. Int J Exp Pathol (2012) 0.76
Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling. J Biol Chem (2014) 0.76
Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion. Islets (2015) 0.75
Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-Cells. Int J Mol Sci (2016) 0.75
Leptin and insulin up-regulate miR-4443 to suppress NCOA1 and TRAF4, and decrease the invasiveness of human colon cancer cells. BMC Cancer (2016) 0.75
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell (2002) 2.64
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol Cell (2002) 2.51
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem (2002) 2.16
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci U S A (2008) 2.12
Rapid transformation of white adipocytes into fat-oxidizing machines. Proc Natl Acad Sci U S A (2004) 2.03
Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes (2008) 2.00
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proc Natl Acad Sci U S A (2006) 1.90
Properties of WNK1 and implications for other family members. J Biol Chem (2005) 1.89
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res (2009) 1.87
Crystal structure of domain-swapped STE20 OSR1 kinase domain. Protein Sci (2009) 1.87
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure (2004) 1.82
WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem (2003) 1.80
WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A (2005) 1.76
Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma. Hum Pathol (2010) 1.76
The roles of MAPKs in disease. Cell Res (2008) 1.76
Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci (2002) 1.73
TAO kinases mediate activation of p38 in response to DNA damage. EMBO J (2007) 1.59
ERK2 enters the nucleus by a carrier-independent mechanism. Proc Natl Acad Sci U S A (2002) 1.54
Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1. J Biol Chem (2002) 1.49
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. J Biol Chem (2003) 1.46
PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites. Proc Natl Acad Sci U S A (2009) 1.46
Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Mol Cell Biol (2004) 1.45
SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma. Am J Surg Pathol (2008) 1.43
Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. J Biol Chem (2002) 1.39
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J Biol Chem (2005) 1.37
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Mol Cell (2004) 1.35
Chloride sensing by WNK1 involves inhibition of autophosphorylation. Sci Signal (2014) 1.33
Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells. J Biol Chem (2003) 1.33
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours. Pathology (2009) 1.29
The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol Cell (2012) 1.29
Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin. Diabetes (2007) 1.26
Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway. Toxicol Appl Pharmacol (2008) 1.26
Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. J Biol Chem (2004) 1.24
MAP kinase modules: many roads home. Curr Biol (2003) 1.24
Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells. Proc Natl Acad Sci U S A (2008) 1.23
The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. J Biol Chem (2004) 1.23
Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K. Structure (2004) 1.21
Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice. Proc Natl Acad Sci U S A (2004) 1.21
Mutations in ERK2 binding sites affect nuclear entry. J Biol Chem (2007) 1.18
WNKs: protein kinases with a unique kinase domain. Exp Mol Med (2007) 1.15
Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. Biochem Pharmacol (2008) 1.14
Expression of the serum response factor in hepatocellular carcinoma: implications for epithelial-mesenchymal transition. Int J Oncol (2007) 1.13
Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF-{alpha} gene expression in pancreatic islet endocrine cells. J Biol Chem (2010) 1.12
Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochem Pharmacol (2002) 1.11
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatr Nephrol (2006) 1.11
The MAP kinase ERK5 binds to and phosphorylates p90 RSK. Arch Biochem Biophys (2006) 1.11
Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. Pharmacol Res (2009) 1.08
A20 suppresses inflammatory responses and bone destruction in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis. Arthritis Rheum (2010) 1.08
RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. J Biol Chem (2003) 1.08
Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice. Biochem Biophys Res Commun (2006) 1.07
Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells. Proc Natl Acad Sci U S A (2007) 1.04
NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proc Natl Acad Sci U S A (2013) 1.02
Structure of MAPKs. Methods Mol Biol (2004) 1.02
Genistein protects pancreatic beta cells against cytokine-mediated toxicity. Mol Cell Endocrinol (2007) 1.01
Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation. Pancreas (2007) 1.01
FIZZ2/RELM-β induction and role in pulmonary fibrosis. J Immunol (2011) 1.01
Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway. Int J Biochem Cell Biol (2007) 1.00
Guggulsterone, a plant sterol, inhibits NF-kappaB activation and protects pancreatic beta cells from cytokine toxicity. Mol Cell Endocrinol (2008) 0.99
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. J Biol Chem (2010) 0.99
TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J Biol Chem (2003) 0.99
A20 attenuates allergic airway inflammation in mice. J Immunol (2009) 0.98
WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. Cell Res (2005) 0.98
Signal control through Raf: in sickness and in health. Cell Res (2011) 0.97
Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway. J Biol Chem (2007) 0.97
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure (2009) 0.97
Mxi2 promotes stimulus-independent ERK nuclear translocation. EMBO J (2007) 0.97
Cortex cinnamomi extract prevents streptozotocin- and cytokine-induced beta-cell damage by inhibiting NF-kappaB. World J Gastroenterol (2006) 0.96
Characterization of mitogen-activated protein kinase (MAPK) dimers. Biochemistry (2006) 0.96
NF-kappaB-dependent lymphocyte hyperadhesiveness to synovial fibroblasts by hypoxia and reoxygenation: potential role in rheumatoid arthritis. J Leukoc Biol (2003) 0.96
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells. J Biol Chem (2008) 0.96
Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells. Int J Mol Med (2007) 0.96
The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy. J Biol Chem (2006) 0.95
Cell condition-dependent regulation of ERK5 by cAMP. J Biol Chem (2002) 0.94
Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2. J Biol Chem (2009) 0.94
Activation of PPAR gamma induces profound multilocularization of adipocytes in adult mouse white adipose tissues. Exp Mol Med (2009) 0.94
Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells. Leuk Res (2005) 0.94
Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells. J Biol Chem (2010) 0.94
Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis. Arthritis Rheum (2013) 0.93
Off-target effects of MEK inhibitors. Biochemistry (2013) 0.93
Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells. Diabetes (2006) 0.93
Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. J Biol Chem (2002) 0.93
Sulfuretin protects against cytokine-induced beta-cell damage and prevents streptozotocin-induced diabetes. Exp Mol Med (2010) 0.92
A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc Natl Acad Sci U S A (2011) 0.92
Expression of nerve growth factor and heme oxygenase-1 predict poor survival of breast carcinoma patients. BMC Cancer (2013) 0.92
Inhibition of IL-1beta-mediated inflammatory responses by the IkappaB alpha super-repressor in human fibroblast-like synoviocytes. Biochem Biophys Res Commun (2008) 0.92
WNK1 is required for mitosis and abscission. Proc Natl Acad Sci U S A (2011) 0.91
SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death. Neurobiol Aging (2010) 0.91
Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals. Mol Cell Biol (2006) 0.91
Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription. Proc Natl Acad Sci U S A (2009) 0.91
WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis. J Biol Chem (2007) 0.91
Minireview: Nutrient sensing by G protein-coupled receptors. Mol Endocrinol (2013) 0.90