MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals.

PubWeight™: 5.67‹?› | Rank: Top 1%

🔗 View Article (PMC 2072999)

Published in Mol Cell on June 08, 2007

Authors

John Tsang1, Jun Zhu, Alexander van Oudenaarden

Author Affiliations

1: Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Articles citing this

(truncated to the top 100)

Roles for microRNAs in conferring robustness to biological processes. Cell (2012) 6.32

MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74

MicroRNA functions in stress responses. Mol Cell (2010) 4.46

A microRNA imparts robustness against environmental fluctuation during development. Cell (2009) 4.08

Diversity-based, model-guided construction of synthetic gene networks with predicted functions. Nat Biotechnol (2009) 3.86

Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging (2011) 3.83

MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol (2012) 3.78

The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. J Neurosci (2008) 3.62

A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity. Genes Dev (2008) 3.19

Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes. J Neurosci (2008) 2.95

Evolution of microRNA diversity and regulation in animals. Nat Rev Genet (2011) 2.92

Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nat Struct Mol Biol (2011) 2.85

A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell Stem Cell (2013) 2.68

Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J (2009) 2.65

Striatal microRNA controls cocaine intake through CREB signalling. Nature (2010) 2.56

MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis. Genome Res (2008) 2.51

MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev (2010) 2.51

Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol Cell (2009) 2.47

Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell (2010) 2.37

Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS One (2010) 2.26

MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc. Proc Natl Acad Sci U S A (2008) 2.24

The base-pairing RNA spot 42 participates in a multioutput feedforward loop to help enact catabolite repression in Escherichia coli. Mol Cell (2011) 2.23

MicroRNA target prediction by expression analysis of host genes. Genome Res (2008) 2.21

Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures. Mol Cell (2010) 2.12

Nitrate-responsive miR393/AFB3 regulatory module controls root system architecture in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2010) 2.03

Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects. BMC Genomics (2010) 1.99

miR390, Arabidopsis TAS3 tasiRNAs, and their AUXIN RESPONSE FACTOR targets define an autoregulatory network quantitatively regulating lateral root growth. Plant Cell (2010) 1.96

Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation. J Immunol (2009) 1.93

Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition. Gynecol Oncol (2009) 1.84

Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Genes Dev (2009) 1.84

The role of incoherent microRNA-mediated feedforward loops in noise buffering. PLoS Comput Biol (2011) 1.84

miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ (2009) 1.82

Absolute quantification of microRNAs by using a universal reference. RNA (2009) 1.79

Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Genes Dev (2009) 1.77

The role of miRNAs in regulating gene expression networks. J Mol Biol (2013) 1.74

The interplay between transcription factors and microRNAs in genome-scale regulatory networks. Bioessays (2009) 1.72

Evolution under canalization and the dual roles of microRNAs: a hypothesis. Genome Res (2009) 1.72

Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis. Elife (2013) 1.64

MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer. Theranostics (2015) 1.62

Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates. Nucleic Acids Res (2009) 1.60

The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nat Immunol (2013) 1.60

Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet (2011) 1.55

A splicing-independent function of SF2/ASF in microRNA processing. Mol Cell (2010) 1.55

Uncovering MicroRNA and Transcription Factor Mediated Regulatory Networks in Glioblastoma. PLoS Comput Biol (2012) 1.54

Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol (2008) 1.53

Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template. Mol Syst Biol (2011) 1.53

Genome-wide survey of microRNA-transcription factor feed-forward regulatory circuits in human. Mol Biosyst (2009) 1.53

Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. Breast Cancer Res (2011) 1.49

A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi. Mol Microbiol (2008) 1.47

Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks. Genome Res (2012) 1.47

The biological functions of miRNAs: lessons from in vivo studies. Trends Cell Biol (2014) 1.47

Inter- and intra-combinatorial regulation by transcription factors and microRNAs. BMC Genomics (2007) 1.45

"Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron. PLoS Genet (2007) 1.45

Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med (2012) 1.42

miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell Death Dis (2012) 1.40

A novel microRNA and transcription factor mediated regulatory network in schizophrenia. BMC Syst Biol (2010) 1.40

Construction and analysis of an integrated regulatory network derived from high-throughput sequencing data. PLoS Comput Biol (2011) 1.39

Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function. Nucleic Acids Res (2013) 1.38

Analysis of regulatory network topology reveals functionally distinct classes of microRNAs. Nucleic Acids Res (2008) 1.36

Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging. Aging (Albany NY) (2011) 1.35

MicroRNAs as a selective channel of communication between competing RNAs: a steady-state theory. Biophys J (2013) 1.35

Global coordination of transcriptional control and mRNA decay during cellular differentiation. Mol Syst Biol (2010) 1.34

Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proc Natl Acad Sci U S A (2011) 1.33

MIR@NT@N: a framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model. BMC Bioinformatics (2011) 1.33

RNA viruses and the host microRNA machinery. Nat Rev Microbiol (2013) 1.31

Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation. EMBO J (2011) 1.30

Epigenetic Control of MicroRNA Expression and Aging. Curr Genomics (2009) 1.28

Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2. Genes Dev (2012) 1.28

Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis. PLoS Biol (2010) 1.26

CircuitsDB: a database of mixed microRNA/transcription factor feed-forward regulatory circuits in human and mouse. BMC Bioinformatics (2010) 1.26

MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS One (2012) 1.25

The promoter of the pri-miR-375 gene directs expression selectively to the endocrine pancreas. PLoS One (2009) 1.25

Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha. BMC Genomics (2010) 1.25

Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques. Mol Syst Biol (2011) 1.25

MiRNAs confer phenotypic robustness to gene networks by suppressing biological noise. Nat Commun (2013) 1.24

Small RNAs establish delays and temporal thresholds in gene expression. Biophys J (2008) 1.24

MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2. Cell Death Differ (2011) 1.24

The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans. Nucleic Acids Res (2010) 1.22

miRNAs: effectors of environmental influences on gene expression and disease. Toxicol Sci (2008) 1.21

Modelling Competing Endogenous RNA Networks. PLoS One (2013) 1.21

MicroRNA regulatory networks in human adipose tissue and obesity. Nat Rev Endocrinol (2015) 1.20

miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell (2013) 1.19

A microRNA-dependent circuit controlling p63/p73 homeostasis: p53 family cross-talk meets therapeutic opportunity. Oncotarget (2011) 1.19

Dissecting microregulation of a master regulatory network. BMC Genomics (2008) 1.18

Tissue and process specific microRNA-mRNA co-expression in mammalian development and malignancy. PLoS One (2009) 1.17

MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia. Nucleic Acids Res (2012) 1.15

Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis. BMC Neurosci (2009) 1.14

Biological robustness and the role of microRNAs: a network perspective. Curr Top Dev Biol (2012) 1.14

Dampening of expression oscillations by synchronous regulation of a microRNA and its target. Nat Genet (2013) 1.11

Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells. PLoS One (2008) 1.11

MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes. J Neurosci (2011) 1.09

The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem (2013) 1.09

Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate. Aging (Albany NY) (2009) 1.07

Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Res (2012) 1.07

MicroRNAs: new players in IBD. Gut (2014) 1.07

Genome-wide and species-wide in silico screening for intragenic MicroRNAs in human, mouse and chicken. PLoS One (2013) 1.06

miTALOS: analyzing the tissue-specific regulation of signaling pathways by human and mouse microRNAs. RNA (2011) 1.05

Coregulation of transcription factors and microRNAs in human transcriptional regulatory network. BMC Bioinformatics (2011) 1.05

Genome-wide survey of rice microRNAs and microRNA-target pairs in the root of a novel auxin-resistant mutant. Planta (2009) 1.04

Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution. PLoS Genet (2012) 1.03

Articles cited by this

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A (1998) 192.97

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87

Combinatorial microRNA target predictions. Nat Genet (2005) 50.48

Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47

A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81

miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25

Network motifs: simple building blocks of complex networks. Science (2002) 35.80

Identification of tissue-specific microRNAs from mouse. Curr Biol (2002) 34.55

Human MicroRNA targets. PLoS Biol (2004) 34.51

c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60

GenePattern 2.0. Nat Genet (2006) 29.07

Principles of microRNA-target recognition. PLoS Biol (2005) 23.70

MicroRNA targets in Drosophila. Genome Biol (2003) 23.59

Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51

Network motifs in the transcriptional regulation network of Escherichia coli. Nat Genet (2002) 19.57

Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2006) 18.85

siRNAs can function as miRNAs. Genes Dev (2003) 16.08

The diverse functions of microRNAs in animal development and disease. Dev Cell (2006) 15.62

Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Cell (2005) 15.38

Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev (2006) 15.20

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol (2004) 15.15

Identification of mammalian microRNA host genes and transcription units. Genome Res (2004) 14.63

Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet (2005) 14.39

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA (2005) 14.14

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet (2004) 12.97

Engineering stability in gene networks by autoregulation. Nature (2000) 12.88

Stochastic mRNA synthesis in mammalian cells. PLoS Biol (2006) 12.58

Gene regulation at the single-cell level. Science (2005) 11.52

Real-time kinetics of gene activity in individual bacteria. Cell (2005) 11.08

Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev (2006) 11.04

microRNA target predictions in animals. Nat Genet (2006) 10.76

A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell (2005) 9.22

Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol (2002) 9.17

REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell (2005) 8.65

Noise propagation in gene networks. Science (2005) 8.19

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95

Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol (2004) 7.33

Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron (2005) 7.28

Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A (2006) 7.11

Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science (2005) 6.88

Post-transcriptional regulation of microRNA expression. RNA (2006) 6.76

Molecular taxonomy of major neuronal classes in the adult mouse forebrain. Nat Neurosci (2005) 6.71

REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43

Processing of intronic microRNAs. EMBO J (2007) 6.32

Negative autoregulation speeds the response times of transcription networks. J Mol Biol (2002) 6.32

MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev (2006) 6.30

Numerous microRNPs in neuronal cells containing novel microRNAs. RNA (2003) 6.28

Enhancement of cellular memory by reducing stochastic transitions. Nature (2005) 6.01

Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci U S A (2006) 5.78

Canalization of development by microRNAs. Nat Genet (2006) 5.46

An E2F/miR-20a autoregulatory feedback loop. J Biol Chem (2006) 5.20

Phenotypic consequences of promoter-mediated transcriptional noise. Mol Cell (2006) 4.93

A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell (2005) 4.54

Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J (2006) 4.34

LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Science (2005) 4.28

Gene regulation by microRNAs. Curr Opin Genet Dev (2006) 4.01

MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision. Proc Natl Acad Sci U S A (2005) 3.69

Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci (2006) 3.41

Comparative genomics modeling of the NRSF/REST repressor network: from single conserved sites to genome-wide repertoire. Genome Res (2006) 3.23

Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci U S A (2005) 2.62

Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol (2006) 2.49

cis-Regulatory control circuits in development. Dev Biol (2004) 1.54

Building a cellular switch: more lessons from a good egg. Bioessays (1999) 1.10

Articles by these authors

(truncated to the top 100)

Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med (2009) 39.97

Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med (2011) 23.50

Genetics of gene expression and its effect on disease. Nature (2008) 21.35

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A (2009) 20.66

Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44

Regulation of noise in the expression of a single gene. Nat Genet (2002) 14.93

Nature, nurture, or chance: stochastic gene expression and its consequences. Cell (2008) 12.13

Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04

Population genomics of domestic and wild yeasts. Nature (2009) 11.79

An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40

Imaging individual mRNA molecules using multiple singly labeled probes. Nat Methods (2008) 10.40

Apixaban in patients with atrial fibrillation. N Engl J Med (2011) 9.97

Dronedarone in high-risk permanent atrial fibrillation. N Engl J Med (2011) 8.93

Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71

Noise propagation in gene networks. Science (2005) 8.19

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2015) 7.99

Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17

Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA (2005) 6.68

Enhancement of cellular memory by reducing stochastic transitions. Nature (2005) 6.01

Stochastic switching as a survival strategy in fluctuating environments. Nat Genet (2008) 5.87

Variability in gene expression underlies incomplete penetrance. Nature (2010) 5.85

The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae. Science (2008) 4.94

Early versus delayed invasive intervention in acute coronary syndromes. N Engl J Med (2009) 4.83

Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77

Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol (2008) 4.68

A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45

Cellular decision making and biological noise: from microbes to mammals. Cell (2011) 4.44

Stochastic gene expression in fluctuating environments. Genetics (2004) 4.23

Contributions of low molecule number and chromosomal positioning to stochastic gene expression. Nat Genet (2005) 4.07

MicroRNAs can generate thresholds in target gene expression. Nat Genet (2011) 3.90

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70

Snowdrift game dynamics and facultative cheating in yeast. Nature (2009) 3.66

Using gene expression noise to understand gene regulation. Science (2012) 3.49

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol (2012) 3.30

Genetic heterogeneity of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A (2013) 3.25

Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation. JAMA (2005) 3.19

Bortezomib-based therapy for newly diagnosed mantle-cell lymphoma. N Engl J Med (2015) 3.18

Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction. JAMA (2007) 3.09

A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res (2011) 3.00

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97

A systems-level analysis of perfect adaptation in yeast osmoregulation. Cell (2009) 2.91

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat Med (2008) 2.85

Stochastic gene expression: from single molecules to the proteome. Curr Opin Genet Dev (2007) 2.81

RNA sequencing reveals two major classes of gene expression levels in metazoan cells. Mol Syst Biol (2011) 2.77

Single-molecule approaches to stochastic gene expression. Annu Rev Biophys (2009) 2.75

BioMagResBank database with sets of experimental NMR constraints corresponding to the structures of over 1400 biomolecules deposited in the Protein Data Bank. J Biomol NMR (2003) 2.74

Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol (2011) 2.72

The Long-Term Multicenter Observational Study of Dabigatran Treatment in Patients With Atrial Fibrillation (RELY-ABLE) Study. Circulation (2013) 2.64

China's facility-based birth strategy and neonatal mortality: a population-based epidemiological study. Lancet (2011) 2.64

Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics (2005) 2.61

QTLNetwork: mapping and visualizing genetic architecture of complex traits in experimental populations. Bioinformatics (2008) 2.57

CsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae. Mol Microbiol (2005) 2.56

Dabigatran versus warfarin: effects on ischemic and hemorrhagic strokes and bleeding in Asians and non-Asians with atrial fibrillation. Stroke (2013) 2.52

Attenuation of noise in ultrasensitive signaling cascades. Biophys J (2002) 2.42

Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet (2010) 2.41

Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins. Proc Natl Acad Sci U S A (2013) 2.33

ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients. Proc Natl Acad Sci U S A (2003) 2.29

Mapping the genetic architecture of complex traits in experimental populations. Bioinformatics (2007) 2.27

Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J Hepatol (2005) 2.21

Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Blood (2010) 2.15

Elevated ATPase activity of KaiC applies a circadian checkpoint on cell division in Synechococcus elongatus. Cell (2010) 2.15

Validating transcripts with probes and imaging technology. Nat Methods (2011) 2.15

A paired-end sequencing strategy to map the complex landscape of transcription initiation. Nat Methods (2010) 2.14

A multistep epigenetic switch enables the stable inheritance of DNA methylation states. Nat Genet (2007) 2.14

Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Blood (2013) 2.12

Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures. Mol Cell (2010) 2.12

Heritable stochastic switching revealed by single-cell genealogy. PLoS Biol (2007) 2.11

Detection of minor drug-resistant populations by parallel allele-specific sequencing. Nat Methods (2007) 2.09

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res (2010) 2.06

Nuclear export and retention signals in the RS domain of SR proteins. Mol Cell Biol (2002) 2.04

Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. J Neurochem (2006) 2.00

Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science (2011) 1.97

Genetic and phenotypic diversity in breast tumor metastases. Cancer Res (2014) 1.96

Probing polymerization forces by using actin-propelled lipid vesicles. Proc Natl Acad Sci U S A (2003) 1.92

Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell (2012) 1.88

Metabolism of bile salts in mice influences spore germination in Clostridium difficile. PLoS One (2010) 1.87

Disentangling molecular relationships with a causal inference test. BMC Genet (2009) 1.84

A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans. PLoS Biol (2011) 1.84

A new Vibrio cholerae sRNA modulates colonization and affects release of outer membrane vesicles. Mol Microbiol (2008) 1.83

Genetic and phenotypic diversity of quorum-sensing systems in clinical and environmental isolates of Vibrio cholerae. Infect Immun (2006) 1.82

A system of counteracting feedback loops regulates Cdc42p activity during spontaneous cell polarization. Dev Cell (2005) 1.81

A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing. Proc Natl Acad Sci U S A (2006) 1.78

Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease. Genome Biol (2009) 1.77

Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol Cancer Res (2011) 1.76

Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock. Nature (2007) 1.74

Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis. Cancer Res (2011) 1.71

Predicting stochastic gene expression dynamics in single cells. Proc Natl Acad Sci U S A (2006) 1.70

Synthetic biology: understanding biological design from synthetic circuits. Nat Rev Genet (2009) 1.70

Long-range polony haplotyping of individual human chromosome molecules. Nat Genet (2006) 1.69

Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nat Genet (2010) 1.69

Optimality in the development of intestinal crypts. Cell (2012) 1.67

A Bayesian partition method for detecting pleiotropic and epistatic eQTL modules. PLoS Comput Biol (2010) 1.66

PML nuclear bodies and apoptosis. Oncogene (2004) 1.66

Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing. Proc Natl Acad Sci U S A (2008) 1.63

Circadian gating of the cell cycle revealed in single cyanobacterial cells. Science (2010) 1.62

Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast. Cell (2012) 1.61

A general mechanism for network-dosage compensation in gene circuits. Science (2010) 1.59

Transcription factor AtMYB103 is required for anther development by regulating tapetum development, callose dissolution and exine formation in Arabidopsis. Plant J (2007) 1.58

A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies. Am J Hum Genet (2008) 1.57