Published in Mol Cell on May 27, 2005
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell (2008) 4.33
Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics. Mol Cell Proteomics (2010) 3.44
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell (2006) 3.08
Structure of the mitotic checkpoint complex. Nature (2012) 2.72
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science (2009) 2.69
Identification of a physiological E2 module for the human anaphase-promoting complex. Proc Natl Acad Sci U S A (2009) 2.65
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell (2009) 2.45
Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. Genes Dev (2007) 2.32
An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev (2006) 2.16
Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature (2010) 2.11
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell (2010) 2.08
Panta rhei: the APC/C at steady state. J Cell Biol (2013) 1.62
The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C). J Biol Chem (2008) 1.61
Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell (2007) 1.53
Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol (2009) 1.51
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nat Struct Mol Biol (2010) 1.50
How APC/C-Cdc20 changes its substrate specificity in mitosis. Nat Cell Biol (2011) 1.48
APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Nat Neurosci (2010) 1.43
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol (2012) 1.40
Molecular architecture and mechanism of the anaphase-promoting complex. Nature (2014) 1.36
Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding. Proc Natl Acad Sci U S A (2006) 1.33
Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol Cell Biol (2007) 1.32
CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Plant Physiol (2009) 1.31
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc Natl Acad Sci U S A (2012) 1.31
Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol (2011) 1.29
Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat Rev Mol Cell Biol (2015) 1.25
Atomic structure of the APC/C and its mechanism of protein ubiquitination. Nature (2015) 1.22
Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. EMBO Rep (2005) 1.21
Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol Cell (2013) 1.21
The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27. EMBO J (2010) 1.19
Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast. Mol Cell Biol (2006) 1.17
Structural insights into anaphase-promoting complex function and mechanism. Philos Trans R Soc Lond B Biol Sci (2011) 1.17
Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation. J Cell Biol (2012) 1.14
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature (2014) 1.12
The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit. J Cell Biol (2010) 1.11
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol (2011) 1.10
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae. Mol Biol Cell (2008) 1.09
Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex. J Biol Chem (2008) 1.08
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol (2012) 1.08
Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C. EMBO J (2012) 1.07
A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo. Genes Dev (2005) 1.07
State of the APC/C: organization, function, and structure. Crit Rev Biochem Mol Biol (2011) 1.02
Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1. EMBO J (2011) 1.01
Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. EMBO J (2013) 1.01
CDC20 overexpression predicts a poor prognosis for patients with colorectal cancer. J Transl Med (2013) 0.98
Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol (2009) 0.96
Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7. J Biol Chem (2008) 0.96
Mechanism of APC/CCDC20 activation by mitotic phosphorylation. Proc Natl Acad Sci U S A (2016) 0.96
Processive ubiquitin chain formation by the anaphase-promoting complex. Semin Cell Dev Biol (2011) 0.95
RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. Proc Natl Acad Sci U S A (2015) 0.95
The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast. J Biol Chem (2009) 0.94
Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency. Curr Biol (2014) 0.94
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol Cell Biol (2009) 0.90
Cyclin B3 controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. Cell Cycle (2015) 0.89
A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony. PLoS Biol (2013) 0.88
Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem (2010) 0.87
The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix. J Mol Biol (2013) 0.86
Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation. Proc Natl Acad Sci U S A (2013) 0.85
Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A. Mol Biol Cell (2008) 0.84
Control the host cell cycle: viral regulation of the anaphase-promoting complex. J Virol (2013) 0.84
Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. J Mol Biol (2014) 0.84
biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes. Proc Natl Acad Sci U S A (2016) 0.83
Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II. Mol Biol Cell (2010) 0.82
REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1. Cell Cycle (2012) 0.82
The biochemistry of mitosis. Cold Spring Harb Perspect Biol (2015) 0.82
APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint. J Biol Chem (2013) 0.82
Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation. Proc Natl Acad Sci U S A (2016) 0.81
Acm1 contributes to nuclear positioning by inhibiting Cdh1-substrate interactions. Cell Cycle (2012) 0.80
Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate. Biol Open (2014) 0.80
The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells. Eukaryot Cell (2006) 0.79
The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. FEBS Open Bio (2014) 0.79
Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages. Mol Biol Cell (2015) 0.79
Identification of anaphase promoting complex substrates in S. cerevisiae. PLoS One (2012) 0.79
Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1. Oncogene (2011) 0.79
Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit. Nat Commun (2016) 0.76
FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest. Cell Cycle (2010) 0.76
A structural model of the anaphase promoting complex co-activator (Cdh1) and in silico design of inhibitory compounds. Res Pharm Sci (2015) 0.76
Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated Proteolysis. J Biol Chem (2016) 0.76
Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2. BMC Biochem (2010) 0.76
The Non-Canonical Role of Aurora-A in DNA Replication. Front Oncol (2015) 0.75
Ubiquitin ligases: Taming the APC. Nat Chem Biol (2012) 0.75
An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition. PLoS One (2016) 0.75
Understanding the structural basis for controlling chromosome division. Philos Trans A Math Phys Eng Sci (2015) 0.75
Dual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1. Mol Biol Cell (2016) 0.75
Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain. J Mol Biol (2015) 0.75
Transcriptional and post-transcriptional regulation of Cdc20 during the spindle assembly checkpoint in S. cerevisiae. Cell Signal (2017) 0.75
Noise cancellation: viral fine tuning of the cellular environment for its own genome replication. PLoS Pathog (2010) 0.75
Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast. Cell Div (2013) 0.75
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discov (2017) 0.75
APC/C(CDC20) and APC/C play pivotal roles in the process of embryonic development in Artemia sinica. Sci Rep (2016) 0.75
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 9.95
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science (2004) 8.58
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol (2003) 8.32
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol (2007) 6.17
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci (2003) 5.19
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo. Curr Biol (2007) 5.17
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (2010) 4.69
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature (2005) 4.57
Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1. Dev Cell (2008) 4.01
Wapl controls the dynamic association of cohesin with chromatin. Cell (2006) 3.83
Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. PLoS Biol (2005) 3.72
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J (2003) 3.54
Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS Biol (2005) 3.33
Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr Biol (2004) 3.29
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS Genet (2009) 3.25
Distinct functions of condensin I and II in mitotic chromosome assembly. J Cell Sci (2004) 3.14
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol (2009) 2.98
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol (2002) 2.97
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol (2010) 2.91
Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev Cell (2007) 2.72
TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. Curr Biol (2003) 2.71
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science (2009) 2.69
Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells. Curr Biol (2006) 2.69
Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication. Curr Biol (2006) 2.47
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev (2004) 2.33
Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II. Curr Biol (2004) 2.28
The STIR-domain superfamily in signal transduction, development and immunity. Trends Biochem Sci (2003) 2.24
N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence. J Mol Biol (2002) 2.18
Regulation of sister chromatid cohesion between chromosome arms. Curr Biol (2004) 2.16
Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell (2010) 2.12
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Mol Cell (2005) 2.09
Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol (2006) 2.04
Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr Biol (2002) 2.04
Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs. Mol Cell Proteomics (2008) 2.01
Polo and Aurora kinases: lessons derived from chemical biology. Curr Opin Cell Biol (2008) 1.92
Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature (2013) 1.92
Regulation of human separase by securin binding and autocleavage. Curr Biol (2002) 1.86
Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners. Mol Cell (2003) 1.85
Refinement and prediction of protein prenylation motifs. Genome Biol (2005) 1.84
Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence. J Mol Biol (2003) 1.83
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol (2006) 1.80
Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. Curr Biol (2007) 1.79
Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. J Cell Sci (2007) 1.78
Glycosylphosphatidylinositol lipid anchoring of plant proteins. Sensitive prediction from sequence- and genome-wide studies for Arabidopsis and rice. Plant Physiol (2003) 1.72
N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences. J Mol Biol (2002) 1.72
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites. Biol Direct (2009) 1.70
SNPeffect v2.0: a new step in investigating the molecular phenotypic effects of human non-synonymous SNPs. Bioinformatics (2006) 1.69
Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae. Curr Biol (2005) 1.65
How cohesin and CTCF cooperate in regulating gene expression. Chromosome Res (2009) 1.62
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
The ring between ring fingers (RBR) protein family. Genome Biol (2007) 1.59
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J (2009) 1.58
Towards complete sets of farnesylated and geranylgeranylated proteins. PLoS Comput Biol (2007) 1.57
Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences. J Mol Biol (2003) 1.51
Myristoylation of viral and bacterial proteins. Trends Microbiol (2004) 1.49
pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model. Biol Direct (2007) 1.46
Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. Bioessays (2003) 1.45
SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants. Nucleic Acids Res (2011) 1.44
Joint annotation of coding and non-coding single nucleotide polymorphisms and mutations in the SNPeffect and PupaSuite databases. Nucleic Acids Res (2007) 1.43
Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proc Natl Acad Sci U S A (2004) 1.43
MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins. Genome Biol (2004) 1.42
Cohesin and DNA damage repair. Exp Cell Res (2006) 1.41
Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A. Curr Biol (2003) 1.41
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol (2012) 1.40
The complete removal of cohesin from chromosome arms depends on separase. J Cell Sci (2007) 1.40
TM or not TM: transmembrane protein prediction with low false positive rate using DAS-TMfilter. Bioinformatics (2004) 1.37
A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus. PLoS Curr (2010) 1.37
On filtering false positive transmembrane protein predictions. Protein Eng (2002) 1.35
RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells. J Cell Sci (2010) 1.33
The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA. Virol J (2013) 1.33
S. pombe meiotic linear elements contain proteins related to synaptonemal complex components. J Cell Sci (2004) 1.31
Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal (2011) 1.31
A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database. Genome Biol (2007) 1.29
Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. BMC Bioinformatics (2005) 1.29
More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology. PLoS Comput Biol (2010) 1.26
Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis. Nat Protoc (2006) 1.21
Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia. Hum Mutat (2007) 1.20
Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model. PLoS Pathog (2013) 1.20
ANNIE: integrated de novo protein sequence annotation. Nucleic Acids Res (2009) 1.19
Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. Genome Biol (2005) 1.16
Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. EMBO J (2003) 1.16
Beware of moving targets: reference proteome content fluctuates substantially over the years. J Bioinform Comput Biol (2012) 1.16
Extending Asia Pacific bioinformatics into new realms in the "-omics" era. BMC Genomics (2009) 1.15