Published in Curr Biol on September 02, 2003
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat Cell Biol (2008) 4.08
Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J (2003) 3.54
Structure of the mitotic checkpoint complex. Nature (2012) 2.72
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell (2009) 2.45
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO J (2010) 2.33
An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27
Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature (2010) 2.11
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell (2010) 2.08
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. Cell Cycle (2009) 1.94
Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Mol Syst Biol (2010) 1.91
Structural basis for the subunit assembly of the anaphase-promoting complex. Nature (2011) 1.80
The ubiquitin system, disease, and drug discovery. BMC Biochem (2008) 1.73
Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species. Mol Cell Biol (2006) 1.65
Panta rhei: the APC/C at steady state. J Cell Biol (2013) 1.62
Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell (2007) 1.53
The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC. Mol Cell (2008) 1.52
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nat Struct Mol Biol (2010) 1.50
How APC/C-Cdc20 changes its substrate specificity in mitosis. Nat Cell Biol (2011) 1.48
Mammalian Cdh1/Fzr mediates its own degradation. EMBO J (2004) 1.42
LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C. PLoS One (2015) 1.42
Molecular architecture and mechanism of the anaphase-promoting complex. Nature (2014) 1.36
The e3 ubiquitin ligase gene family in plants: regulation by degradation. Curr Genomics (2006) 1.29
Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes. Nat Cell Biol (2007) 1.24
The CRY box: a second APCcdh1-dependent degron in mammalian cdc20. EMBO Rep (2006) 1.21
Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships. Breast Cancer Res (2005) 1.20
The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27. EMBO J (2010) 1.19
APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. J Cell Sci (2010) 1.18
Structural insights into anaphase-promoting complex function and mechanism. Philos Trans R Soc Lond B Biol Sci (2011) 1.17
Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast. Mol Cell Biol (2006) 1.17
Two classes of the CDh1-type activators of the anaphase-promoting complex in plants: novel functional domains and distinct regulation. Plant Cell (2004) 1.15
Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation. J Cell Biol (2012) 1.14
Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. Nat Struct Mol Biol (2009) 1.13
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature (2014) 1.12
The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53. Genes Dev (2004) 1.11
Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27. Mol Cell Biol (2004) 1.10
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol (2011) 1.10
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae. Mol Biol Cell (2008) 1.09
Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome. Plant Cell (2011) 1.08
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol (2012) 1.08
Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C. EMBO J (2012) 1.07
Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator. PLoS Genet (2007) 1.06
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores. Structure (2009) 1.05
The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. Development (2007) 1.04
Regulation of ciliary polarity by the APC/C. Proc Natl Acad Sci U S A (2009) 1.03
State of the APC/C: organization, function, and structure. Crit Rev Biochem Mol Biol (2011) 1.02
Emi2 inhibition of the anaphase-promoting complex/cyclosome absolutely requires Emi2 binding via the C-terminal RL tail. Mol Biol Cell (2010) 1.01
Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. EMBO J (2013) 1.01
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. Biochim Biophys Acta (2014) 1.00
Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol Ther (2015) 0.97
Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol (2009) 0.96
Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1. J Biol Chem (2010) 0.96
Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7. J Biol Chem (2008) 0.96
Mechanism of APC/CCDC20 activation by mitotic phosphorylation. Proc Natl Acad Sci U S A (2016) 0.96
Structural, bioinformatic, and in vivo analyses of two Treponema pallidum lipoproteins reveal a unique TRAP transporter. J Mol Biol (2012) 0.94
The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast. J Biol Chem (2009) 0.94
Molecular mechanism of APC/C activation by mitotic phosphorylation. Nature (2016) 0.92
Regulation of APC/C-Cdh1 and its function in neuronal survival. Mol Neurobiol (2012) 0.91
Cyclin B3 controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. Cell Cycle (2015) 0.89
Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint. EMBO Rep (2014) 0.87
The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix. J Mol Biol (2013) 0.86
Meiotic control of the APC/C: similarities & differences from mitosis. Cell Div (2011) 0.85
In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p. Genetics (2005) 0.84
Control the host cell cycle: viral regulation of the anaphase-promoting complex. J Virol (2013) 0.84
Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. J Mol Biol (2014) 0.84
Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex. Am J Pathol (2007) 0.84
Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling. J Biol Chem (2011) 0.83
The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation. Nat Commun (2016) 0.82
Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II. Mol Biol Cell (2010) 0.82
Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae. Eukaryot Cell (2005) 0.81
Acm1 contributes to nuclear positioning by inhibiting Cdh1-substrate interactions. Cell Cycle (2012) 0.80
The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. FEBS Open Bio (2014) 0.79
Structural biology: a new look for the APC. Nature (2011) 0.79
A structural model of the anaphase promoting complex co-activator (Cdh1) and in silico design of inhibitory compounds. Res Pharm Sci (2015) 0.76
The Non-Canonical Role of Aurora-A in DNA Replication. Front Oncol (2015) 0.75
Dual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1. Mol Biol Cell (2016) 0.75
Structural Insight into Anaphase Promoting Complex 3 Structure and Docking with a Natural Inhibitory Compound. Adv Biomed Res (2017) 0.75
Understanding the structural basis for controlling chromosome division. Philos Trans A Math Phys Eng Sci (2015) 0.75
APC-targeted RAA1 degradation mediates the cell cycle and root development in plants. Plant Signal Behav (2010) 0.75
The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in C. elegans. PeerJ (2016) 0.75
APC/C(CDC20) and APC/C play pivotal roles in the process of embryonic development in Artemia sinica. Sci Rep (2016) 0.75
Composition, roles, and regulation of cullin-based ubiquitin e3 ligases. Arabidopsis Book (2014) 0.75
Transcriptional and post-transcriptional regulation of Cdc20 during the spindle assembly checkpoint in S. cerevisiae. Cell Signal (2017) 0.75
Ubiquitin ligases: Taming the APC. Nat Chem Biol (2012) 0.75
Anaphase-Promoting Complex 7 is a Prognostic Factor in Human Colorectal Cancer. Ann Coloproctol (2017) 0.75
The mitotic checkpoint complex (MCC): looking back and forth after 15 years. AIMS Mol Sci (2016) 0.75
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 9.95
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science (2004) 8.58
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol (2003) 8.32
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol (2007) 6.17
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci (2003) 5.19
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo. Curr Biol (2007) 5.17
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (2010) 4.69
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature (2005) 4.57
Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1. Dev Cell (2008) 4.01
Wapl controls the dynamic association of cohesin with chromatin. Cell (2006) 3.83
Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. PLoS Biol (2005) 3.72
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J (2003) 3.54
Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS Biol (2005) 3.33
Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr Biol (2004) 3.29
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS Genet (2009) 3.25
Distinct functions of condensin I and II in mitotic chromosome assembly. J Cell Sci (2004) 3.14
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol (2009) 2.98
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol (2002) 2.97
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol (2010) 2.91
The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates. Mol Cell (2005) 2.77
Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev Cell (2007) 2.72
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science (2009) 2.69
Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells. Curr Biol (2006) 2.69
Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication. Curr Biol (2006) 2.47
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev (2004) 2.33
Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II. Curr Biol (2004) 2.28
The STIR-domain superfamily in signal transduction, development and immunity. Trends Biochem Sci (2003) 2.24
Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell (2008) 2.21
N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence. J Mol Biol (2002) 2.18
Regulation of sister chromatid cohesion between chromosome arms. Curr Biol (2004) 2.16
Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell (2010) 2.12
The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell (2009) 2.11
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Mol Cell (2005) 2.09
Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol (2006) 2.04
Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr Biol (2002) 2.04
Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs. Mol Cell Proteomics (2008) 2.01
Polo and Aurora kinases: lessons derived from chemical biology. Curr Opin Cell Biol (2008) 1.92
Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature (2013) 1.92
Regulation of human separase by securin binding and autocleavage. Curr Biol (2002) 1.86
Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners. Mol Cell (2003) 1.85
Refinement and prediction of protein prenylation motifs. Genome Biol (2005) 1.84
Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence. J Mol Biol (2003) 1.83
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol (2006) 1.80
Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. Curr Biol (2007) 1.79
Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. J Cell Sci (2007) 1.78
Glycosylphosphatidylinositol lipid anchoring of plant proteins. Sensitive prediction from sequence- and genome-wide studies for Arabidopsis and rice. Plant Physiol (2003) 1.72
N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences. J Mol Biol (2002) 1.72
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites. Biol Direct (2009) 1.70
SNPeffect v2.0: a new step in investigating the molecular phenotypic effects of human non-synonymous SNPs. Bioinformatics (2006) 1.69
Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae. Curr Biol (2005) 1.65
How cohesin and CTCF cooperate in regulating gene expression. Chromosome Res (2009) 1.62
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
The ring between ring fingers (RBR) protein family. Genome Biol (2007) 1.59
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J (2009) 1.58
Towards complete sets of farnesylated and geranylgeranylated proteins. PLoS Comput Biol (2007) 1.57
Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences. J Mol Biol (2003) 1.51
Myristoylation of viral and bacterial proteins. Trends Microbiol (2004) 1.49
pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model. Biol Direct (2007) 1.46
Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. Bioessays (2003) 1.45
SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants. Nucleic Acids Res (2011) 1.44
Joint annotation of coding and non-coding single nucleotide polymorphisms and mutations in the SNPeffect and PupaSuite databases. Nucleic Acids Res (2007) 1.43
Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proc Natl Acad Sci U S A (2004) 1.43
MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins. Genome Biol (2004) 1.42
Cohesin and DNA damage repair. Exp Cell Res (2006) 1.41
Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A. Curr Biol (2003) 1.41
The complete removal of cohesin from chromosome arms depends on separase. J Cell Sci (2007) 1.40
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol (2012) 1.40
TM or not TM: transmembrane protein prediction with low false positive rate using DAS-TMfilter. Bioinformatics (2004) 1.37
A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus. PLoS Curr (2010) 1.37
On filtering false positive transmembrane protein predictions. Protein Eng (2002) 1.35
RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells. J Cell Sci (2010) 1.33
The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA. Virol J (2013) 1.33
S. pombe meiotic linear elements contain proteins related to synaptonemal complex components. J Cell Sci (2004) 1.31
Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal (2011) 1.31
Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. BMC Bioinformatics (2005) 1.29
A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database. Genome Biol (2007) 1.29
More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology. PLoS Comput Biol (2010) 1.26
Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis. Nat Protoc (2006) 1.21
Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model. PLoS Pathog (2013) 1.20
Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia. Hum Mutat (2007) 1.20
ANNIE: integrated de novo protein sequence annotation. Nucleic Acids Res (2009) 1.19
Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. Genome Biol (2005) 1.16
Beware of moving targets: reference proteome content fluctuates substantially over the years. J Bioinform Comput Biol (2012) 1.16