Published in Curr Opin Cell Biol on August 01, 2005
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol (2010) 2.98
Autophagy: a forty-year search for a missing membrane source. PLoS Biol (2006) 2.64
CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest (2006) 2.59
Salt stress-induced cell death in the unicellular green alga Micrasterias denticulata. J Exp Bot (2009) 2.39
Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. J Cell Biol (2006) 2.35
Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae. Proc Natl Acad Sci U S A (2007) 2.27
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol (2010) 2.12
Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy. EMBO J (2010) 2.12
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.94
Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP. EMBO J (2009) 1.91
Arp2 links autophagic machinery with the actin cytoskeleton. Mol Biol Cell (2008) 1.80
Polyubiquitin chains: functions, structures, and mechanisms. Cell Mol Life Sci (2008) 1.75
Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J Biol Chem (2011) 1.74
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta (2008) 1.73
Modification of cellular autophagy protein LC3 by poliovirus. J Virol (2007) 1.71
The multiple roles of autophagy in cancer. Carcinogenesis (2011) 1.63
Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. Chem Biol (2011) 1.50
Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy (2008) 1.49
Multiple roles of the cytoskeleton in autophagy. Biol Rev Camb Philos Soc (2009) 1.43
Rapid hair cell loss: a mouse model for cochlear lesions. J Assoc Res Otolaryngol (2007) 1.41
Autophagy-physiology and pathophysiology. Histochem Cell Biol (2008) 1.31
CD47 deficiency confers cell and tissue radioprotection by activation of autophagy. Autophagy (2012) 1.27
Atg19 mediates a dual interaction cargo sorting mechanism in selective autophagy. Mol Biol Cell (2006) 1.19
Autophagy: a pathway that contributes to connexin degradation. J Cell Sci (2011) 1.17
Inhibition of autophagosome formation by the benzoporphyrin derivative verteporfin. J Biol Chem (2010) 1.15
Protein turnover and differentiation in Leishmania. Int J Parasitol (2007) 1.14
Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy (2012) 1.12
TOR is a negative regulator of autophagy in Arabidopsis thaliana. PLoS One (2010) 1.11
M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models. PLoS One (2008) 1.10
Glutathione participates in the regulation of mitophagy in yeast. J Biol Chem (2009) 1.08
RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats. Acta Pharmacol Sin (2009) 1.07
Curvature of double-membrane organelles generated by changes in membrane size and composition. PLoS One (2012) 1.06
Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy. Cell Death Dis (2011) 1.04
Atg9 sorting from mitochondria is impaired in early secretion and VFT-complex mutants in Saccharomyces cerevisiae. J Cell Sci (2006) 1.03
Metabolism addiction in pancreatic cancer. Cell Death Dis (2014) 1.02
The emerging role of acetylation in the regulation of autophagy. Autophagy (2013) 1.01
Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells. Toxicol Appl Pharmacol (2011) 1.01
Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries. Autophagy (2013) 0.97
A type IV secretion system contributes to intracellular survival and replication of Burkholderia cenocepacia. Infect Immun (2008) 0.97
Oligopeptidase B deficient mutants of Leishmania major. Mol Biochem Parasitol (2010) 0.95
CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells. Neoplasia (2009) 0.95
The TOR complex 1 is distributed in endosomes and in retrograde vesicles that form from the vacuole membrane and plays an important role in the vacuole import and degradation pathway. J Biol Chem (2010) 0.94
Review on recent advances in the analysis of isolated organelles. Anal Chim Acta (2012) 0.91
Autophagy in pancreatic cancer. Int J Cell Biol (2012) 0.90
An interrelationship between autophagy and filamentous growth in budding yeast. Genetics (2007) 0.89
Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor. Mol Cancer Ther (2009) 0.89
Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung. Am J Respir Cell Mol Biol (2014) 0.89
The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradation. J Biol Chem (2009) 0.87
A selective autophagy pathway that degrades gluconeogenic enzymes during catabolite inactivation. Commun Integr Biol (2009) 0.85
The role of α-synuclein and tau hyperphosphorylation-mediated autophagy and apoptosis in lead-induced learning and memory injury. Int J Biol Sci (2012) 0.82
Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells. Oncol Rep (2015) 0.82
The many faces of mitochondrial autophagy: making sense of contrasting observations in recent research. Int J Cell Biol (2012) 0.81
Basal Autophagy Is Required for Herpes simplex Virus-2 Infection. Sci Rep (2015) 0.80
Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences. Front Neurosci (2015) 0.78
Distinct requirements of Autophagy-related genes in programmed cell death. Cell Death Differ (2015) 0.78
Role of oxidative stress in cytotoxicity of grape seed extract in human bladder cancer cells. Food Chem Toxicol (2013) 0.78
β-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy. Aging Cell (2015) 0.78
Optimization of filaggrin expression and processing in cultured rat keratinocytes. J Dermatol Sci (2010) 0.78
Herpes Simplex Virus-1 Fine-Tunes Host's Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models. PLoS One (2015) 0.78
MicroRNAs: an emerging player in autophagy. ScienceOpen Res (2014) 0.77
ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei. PLoS One (2015) 0.77
Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy. Int J Nanomedicine (2016) 0.76
Enhanced antitumor effect of lower-dose and longer-term CPT-11 treatment in combination with low-dose celecoxib against neuroblastoma xenografts. Int J Clin Oncol (2011) 0.76
Ubiquitinated proteins enriched from tumor cells by a ubiquitin binding protein Vx3(A7) as a potent cancer vaccine. J Exp Clin Cancer Res (2015) 0.76
Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles. PLoS One (2016) 0.75
Autophagy as a regulator of cardiovascular redox homeostasis. Free Radic Biol Med (2016) 0.75
Autophagy-associated alpha-arrestin signaling is required for conidiogenous cell development in Magnaporthe oryzae. Sci Rep (2016) 0.75
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy (2016) 0.75
Autophagy is associated with chemoresistance in neuroblastoma. BMC Cancer (2016) 0.75
Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1. Oncotarget (2017) 0.75
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Autophagy in health and disease: a double-edged sword. Science (2004) 13.69
Autophagosome formation: core machinery and adaptations. Nat Cell Biol (2007) 13.59
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Potential therapeutic applications of autophagy. Nat Rev Drug Discov (2007) 8.56
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75
Endoplasmic reticulum stress triggers autophagy. J Biol Chem (2006) 5.05
The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell (2004) 4.72
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell (2002) 4.49
Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell (2008) 4.41
In search of an "autophagomometer". Autophagy (2009) 4.31
Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem (2001) 3.90
Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. J Biol Chem (2004) 3.86
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
Autophagy in the eukaryotic cell. Eukaryot Cell (2002) 3.61
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 3.52
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res (2007) 3.49
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy (2008) 3.47
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Autophagy and human disease. Cell Cycle (2007) 3.22
A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 3.10
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol (2010) 2.98
Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae. Mol Biol Cell (2004) 2.84
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Mitophagy in yeast occurs through a selective mechanism. J Biol Chem (2008) 2.80
The regulation of autophagy - unanswered questions. J Cell Sci (2011) 2.73
Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol Biol Cell (2005) 2.73
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2010) 2.66
The molecular mechanism of autophagy. Mol Med (2003) 2.63
Eating the endoplasmic reticulum: quality control by autophagy. Trends Cell Biol (2007) 2.60
Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A (2010) 2.53
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts. Autophagy (2005) 2.52
Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol Biol Cell (2004) 2.51
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.45
The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J Biol Chem (2004) 2.40
Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. J Cell Biol (2006) 2.35
Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast. J Biol Chem (2005) 2.33
Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem (2006) 2.32
The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26
The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy. Dev Cell (2013) 2.24
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol (2010) 2.12
Autophagy in yeast: a review of the molecular machinery. Cell Struct Funct (2002) 2.09
How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) (2008) 2.08
A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell (2009) 2.04
Mitochondria removal by autophagy. Autophagy (2011) 2.04
An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal (2013) 2.04
Atg27 is required for autophagy-dependent cycling of Atg9. Mol Biol Cell (2006) 1.98
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.94
Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell (2006) 1.85
Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J Cell Biol (2003) 1.81
Arp2 links autophagic machinery with the actin cytoskeleton. Mol Biol Cell (2008) 1.80
Autophagic processes in yeast: mechanism, machinery and regulation. Genetics (2013) 1.78
Biochemical methods to monitor autophagy-related processes in yeast. Methods Enzymol (2008) 1.68
Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. J Biol Chem (2002) 1.66
Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy (2007) 1.62
A cycling protein complex required for selective autophagy. Autophagy (2007) 1.60
Molecular machinery required for autophagy and the cytoplasm to vacuole targeting (Cvt) pathway in S. cerevisiae. Curr Opin Cell Biol (2002) 1.60
Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy. Mol Biol Cell (2008) 1.58
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy (2009) 1.57
Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy. J Cell Biol (2008) 1.55
Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol (2010) 1.51
The molecular mechanism of mitochondria autophagy in yeast. Mol Microbiol (2010) 1.51
The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem (2002) 1.50
Receptor protein complexes are in control of autophagy. Autophagy (2012) 1.49
In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol (2008) 1.48
Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction. J Cell Sci (2012) 1.45
Autophagy in organelle homeostasis: peroxisome turnover. Mol Aspects Med (2006) 1.44
The role of autophagy in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.44
The quantitative Pho8Delta60 assay of nonspecific autophagy. Methods Enzymol (2008) 1.44
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Nature (2013) 1.43
Multiple roles of the cytoskeleton in autophagy. Biol Rev Camb Philos Soc (2009) 1.43
Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy. J Biol Chem (2003) 1.39
Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol (2011) 1.37
A role for Atg8-PE deconjugation in autophagosome biogenesis. Autophagy (2012) 1.35
In the beginning there was babble... Autophagy (2012) 1.35
Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae. Autophagy (2005) 1.32
Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy. J Biol Chem (2010) 1.28
Cell biology: regulated self-cannibalism. Nature (2004) 1.26
Positive or negative roles of different cyclin-dependent kinase Pho85-cyclin complexes orchestrate induction of autophagy in Saccharomyces cerevisiae. Mol Cell (2010) 1.23
The regulation of aging: does autophagy underlie longevity? Trends Cell Biol (2009) 1.22
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase. Autophagy (2011) 1.20
Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiae. J Biol Chem (2011) 1.17
Relieving autophagy and 4EBP1 from rapamycin resistance. Mol Cell Biol (2011) 1.16
The variability of autophagy and cell death susceptibility: Unanswered questions. Autophagy (2013) 1.15
Monitoring mitophagy in yeast: the Om45-GFP processing assay. Autophagy (2009) 1.14
Dual roles of Atg8-PE deconjugation by Atg4 in autophagy. Autophagy (2012) 1.14
The quiz factor. CBE Life Sci Educ (2008) 1.13
Artophagy: the art of autophagy--the Cvt pathway. Autophagy (2010) 1.13
Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy. Autophagy (2009) 1.12
Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation. Proc Natl Acad Sci U S A (2013) 1.10
Mitochondria autophagy in yeast. Antioxid Redox Signal (2011) 1.10
A genomic screen for yeast mutants defective in mitophagy. Autophagy (2010) 1.08