Published in Cell Res on October 01, 2007
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A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. Cell Death Dis (2013) 1.11
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Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci (2012) 1.02
Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. Carcinogenesis (2009) 1.00
Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. J Biol Chem (2012) 1.00
Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1. Cell Death Dis (2010) 0.99
Autophagy has a key role in the pathophysiology of schizophrenia. Mol Psychiatry (2013) 0.99
Age-related changes in the function of autophagy in rat kidneys. Age (Dordr) (2011) 0.96
Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes. Mol Biol Cell (2011) 0.96
Autophagy is active in normal colon mucosa. Autophagy (2012) 0.96
Interleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathway. Virology (2013) 0.95
Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination. Autophagy (2014) 0.95
Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress. Toxicol Appl Pharmacol (2012) 0.95
Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma. J Mol Med (Berl) (2012) 0.94
Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments. Cancer Res (2012) 0.94
Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy. FASEB J (2011) 0.94
A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast. J Cell Biol (2014) 0.93
Systematic cloning and analysis of autophagy-related genes from the silkworm Bombyx mori. BMC Mol Biol (2009) 0.93
MAPK/JNK signalling: a potential autophagy regulation pathway. Biosci Rep (2015) 0.93
Mitochondrial Ca(2+) signals in autophagy. Cell Calcium (2012) 0.92
RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways. J Biol Chem (2012) 0.92
The intricacy of nuclear membrane dynamics during nucleophagy. Nucleus (2010) 0.92
Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells. Curr Cancer Drug Targets (2013) 0.92
Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy. Cell Commun Signal (2012) 0.92
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Targeting autophagic pathways for cancer drug discovery. Chin J Cancer (2012) 0.91
Foot-and-mouth disease virus nonstructural protein 2C interacts with Beclin1, modulating virus replication. J Virol (2012) 0.90
ATRA-induced upregulation of Beclin 1 prolongs the life span of differentiated acute promyelocytic leukemia cells. Autophagy (2011) 0.90
PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent. PLoS One (2012) 0.90
The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone. Cell Death Dis (2014) 0.89
Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state. J Biol Chem (2010) 0.89
Autophagosomes contribute to intracellular lipid distribution in enterocytes. Mol Biol Cell (2013) 0.89
RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. Oncotarget (2014) 0.89
Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis. J Toxicol (2009) 0.88
Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells. PLoS One (2011) 0.88
Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors. Commun Integr Biol (2012) 0.88
Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro. Oncol Rep (2011) 0.87
Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae. Traffic (2012) 0.87
Dramatic antitumor effects of the dual mTORC1 and mTORC2 inhibitor AZD2014 in hepatocellular carcinoma. Am J Cancer Res (2014) 0.87
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease. Mt Sinai J Med (2010) 0.87
Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro. Asian J Androl (2010) 0.86
DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells. Autophagy (2014) 0.86
TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation. Mol Cell Biochem (2012) 0.85
A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy (2015) 0.85
The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression. J Genomics (2015) 0.84
Regulation of Abeta pathology by beclin 1: a protective role for autophagy? J Clin Invest (2008) 0.84
Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling. Br J Cancer (2009) 0.84
The pleiotropic roles of sphingolipid signaling in autophagy. Cell Death Dis (2014) 0.84
Quiescent fibroblasts are protected from proteasome inhibition-mediated toxicity. Mol Biol Cell (2012) 0.83
Hypoxia-induced autophagic response is associated with aggressive phenotype and elevated incidence of metastasis in orthotopic immunocompetent murine models of head and neck squamous cell carcinomas (HNSCC). Exp Mol Pathol (2011) 0.83
Impaired autophagic function in rat islets with aging. Age (Dordr) (2012) 0.82
Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras-transformed NIH 3T3 cells. Mol Cells (2011) 0.82
New insights into autophagy using a multiple knockout strain. Autophagy (2008) 0.82
Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases. Mol Neurobiol (2014) 0.81
Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro model. J Cell Commun Signal (2015) 0.81
Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction. PLoS One (2013) 0.81
Functional role of autophagy in gastric cancer. Oncotarget (2016) 0.81
New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophrenia. Autophagy (2014) 0.81
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
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A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
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Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75
Endoplasmic reticulum stress triggers autophagy. J Biol Chem (2006) 5.05
The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell (2004) 4.72
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell (2002) 4.49
Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell (2008) 4.41
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Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. J Biol Chem (2004) 3.86
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
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The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 3.52
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy (2008) 3.47
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Autophagy and human disease. Cell Cycle (2007) 3.22
A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 3.10
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol (2010) 2.98
Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae. Mol Biol Cell (2004) 2.84
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Mitophagy in yeast occurs through a selective mechanism. J Biol Chem (2008) 2.80
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Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol Biol Cell (2005) 2.73
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2010) 2.66
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Eating the endoplasmic reticulum: quality control by autophagy. Trends Cell Biol (2007) 2.60
Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A (2010) 2.53
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts. Autophagy (2005) 2.52
Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol Biol Cell (2004) 2.51
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.45
Autophagosomes: biogenesis from scratch? Curr Opin Cell Biol (2005) 2.42
The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J Biol Chem (2004) 2.40
Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. J Cell Biol (2006) 2.35
Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast. J Biol Chem (2005) 2.33
Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem (2006) 2.32
The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26
The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy. Dev Cell (2013) 2.24
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol (2010) 2.12
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How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) (2008) 2.08
A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell (2009) 2.04
Mitochondria removal by autophagy. Autophagy (2011) 2.04
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Atg27 is required for autophagy-dependent cycling of Atg9. Mol Biol Cell (2006) 1.98
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.94
Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell (2006) 1.85
Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J Cell Biol (2003) 1.81
Arp2 links autophagic machinery with the actin cytoskeleton. Mol Biol Cell (2008) 1.80
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Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. J Biol Chem (2002) 1.66
Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy (2007) 1.62
A cycling protein complex required for selective autophagy. Autophagy (2007) 1.60
Molecular machinery required for autophagy and the cytoplasm to vacuole targeting (Cvt) pathway in S. cerevisiae. Curr Opin Cell Biol (2002) 1.60
Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy. Mol Biol Cell (2008) 1.58
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy (2009) 1.57
Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy. J Cell Biol (2008) 1.55
Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol (2010) 1.51
The molecular mechanism of mitochondria autophagy in yeast. Mol Microbiol (2010) 1.51
The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem (2002) 1.50
Receptor protein complexes are in control of autophagy. Autophagy (2012) 1.49
In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol (2008) 1.48
Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction. J Cell Sci (2012) 1.45
Autophagy in organelle homeostasis: peroxisome turnover. Mol Aspects Med (2006) 1.44
The role of autophagy in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.44
The quantitative Pho8Delta60 assay of nonspecific autophagy. Methods Enzymol (2008) 1.44
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Nature (2013) 1.43
Multiple roles of the cytoskeleton in autophagy. Biol Rev Camb Philos Soc (2009) 1.43
Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy. J Biol Chem (2003) 1.39
Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol (2011) 1.37
A role for Atg8-PE deconjugation in autophagosome biogenesis. Autophagy (2012) 1.35
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Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae. Autophagy (2005) 1.32
Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy. J Biol Chem (2010) 1.28
Cell biology: regulated self-cannibalism. Nature (2004) 1.26
Positive or negative roles of different cyclin-dependent kinase Pho85-cyclin complexes orchestrate induction of autophagy in Saccharomyces cerevisiae. Mol Cell (2010) 1.23
The regulation of aging: does autophagy underlie longevity? Trends Cell Biol (2009) 1.22
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase. Autophagy (2011) 1.20
Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiae. J Biol Chem (2011) 1.17
Relieving autophagy and 4EBP1 from rapamycin resistance. Mol Cell Biol (2011) 1.16
The variability of autophagy and cell death susceptibility: Unanswered questions. Autophagy (2013) 1.15
Monitoring mitophagy in yeast: the Om45-GFP processing assay. Autophagy (2009) 1.14
Dual roles of Atg8-PE deconjugation by Atg4 in autophagy. Autophagy (2012) 1.14
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Artophagy: the art of autophagy--the Cvt pathway. Autophagy (2010) 1.13
Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy. Autophagy (2009) 1.12
Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation. Proc Natl Acad Sci U S A (2013) 1.10
Mitochondria autophagy in yeast. Antioxid Redox Signal (2011) 1.10
A genomic screen for yeast mutants defective in mitophagy. Autophagy (2010) 1.08