Published in Mol Biol Cell on October 04, 2006
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (2008) 5.43
Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res (2011) 5.40
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26
The yeast lysosome-like vacuole: endpoint and crossroads. Biochim Biophys Acta (2008) 2.22
A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell (2009) 2.04
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Arp2 links autophagic machinery with the actin cytoskeleton. Mol Biol Cell (2008) 1.80
Autophagic processes in yeast: mechanism, machinery and regulation. Genetics (2013) 1.78
Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell (2009) 1.74
Autophagy: for better or for worse. Cell Res (2011) 1.65
Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae. Genetics (2012) 1.64
Genome-wide functional analysis reveals that infection-associated fungal autophagy is necessary for rice blast disease. Proc Natl Acad Sci U S A (2009) 1.53
Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol (2010) 1.51
The role of autophagy in tumour development and cancer therapy. Expert Rev Mol Med (2009) 1.43
Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterology (2011) 1.35
Francisella tularensis harvests nutrients derived via ATG5-independent autophagy to support intracellular growth. PLoS Pathog (2013) 1.34
Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurol (2008) 1.31
A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. PLoS One (2009) 1.26
Positive or negative roles of different cyclin-dependent kinase Pho85-cyclin complexes orchestrate induction of autophagy in Saccharomyces cerevisiae. Mol Cell (2010) 1.23
Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. Am J Physiol Renal Physiol (2009) 1.22
Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila. Development (2013) 1.20
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner. J Neurosci (2011) 1.18
Review: autophagy and neurodegeneration: survival at a cost? Neuropathol Appl Neurobiol (2010) 1.17
The variability of autophagy and cell death susceptibility: Unanswered questions. Autophagy (2013) 1.15
Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy. Autophagy (2009) 1.12
Molecular mechanisms of autophagy in the cardiovascular system. Circ Res (2015) 1.10
Mitochondria autophagy in yeast. Antioxid Redox Signal (2011) 1.10
DangER: protein ovERload. Targeting protein degradation to treat myeloma. Haematologica (2012) 1.06
Lipid binding requirements for oxysterol-binding protein Kes1 inhibition of autophagy and endosome-trans-Golgi trafficking pathways. J Biol Chem (2010) 1.01
Autophagy in unicellular eukaryotes. Philos Trans R Soc Lond B Biol Sci (2010) 1.01
Posttranslational modification of autophagy-related proteins in macroautophagy. Autophagy (2015) 1.01
Macroautophagy-mediated degradation of whole nuclei in the filamentous fungus Aspergillus oryzae. PLoS One (2010) 1.00
Cellular and Molecular Connections between Autophagy and Inflammation. Mediators Inflamm (2015) 0.96
The late stage of autophagy: cellular events and molecular regulation. Protein Cell (2010) 0.94
The role of autophagy in genome stability through suppression of abnormal mitosis under starvation. PLoS Genet (2013) 0.94
An interrelationship between autophagy and filamentous growth in budding yeast. Genetics (2007) 0.89
14-3-3 protects against stress-induced apoptosis. Cell Death Dis (2012) 0.86
The intriguing life of autophagosomes. Int J Mol Sci (2012) 0.83
Autophagy in Plasmodium, a multifunctional pathway? Comput Struct Biotechnol J (2013) 0.82
Saccharomyces cerevisiae Rot1 is an essential molecular chaperone in the endoplasmic reticulum. Mol Biol Cell (2008) 0.82
Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases. Int J Mol Sci (2016) 0.82
The many faces of mitochondrial autophagy: making sense of contrasting observations in recent research. Int J Cell Biol (2012) 0.81
Chaperone-mediated autophagy: roles in neurodegeneration. Transl Neurodegener (2014) 0.81
The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation. Elife (2015) 0.81
Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae. Eukaryot Cell (2012) 0.81
Autophagy: machinery and regulation. Microb Cell (2016) 0.80
The role of autophagy in intracellular pathogen nutrient acquisition. Front Cell Infect Microbiol (2015) 0.80
The yeast Saccharomyces cerevisiae: an overview of methods to study autophagy progression. Methods (2014) 0.80
Autophagy is required for G₁/G₀ quiescence in response to nitrogen starvation in Saccharomyces cerevisiae. Autophagy (2014) 0.80
Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling. Cell Discov (2016) 0.79
Avoidance and Subversion of Eukaryotic Homeostatic Autophagy Mechanisms by Bacterial Pathogens. J Mol Biol (2016) 0.79
Autophagic signaling and proteolytic enzyme activity in cardiac and skeletal muscle of spontaneously hypertensive rats following chronic aerobic exercise. PLoS One (2015) 0.79
A late form of nucleophagy in Saccharomyces cerevisiae. PLoS One (2012) 0.78
An Overview of Autophagy and Yeast Pseudohyphal Growth: Integration of Signaling Pathways during Nitrogen Stress. Cells (2012) 0.78
Role of macroautophagy in nutrient homeostasis during fungal development and pathogenesis. Cells (2012) 0.78
Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1. PLoS One (2015) 0.77
Autophagy in toxicology: self-consumption in times of stress and plenty. J Appl Toxicol (2012) 0.77
Oxidative stress and carbon metabolism influence Aspergillus flavus transcriptome composition and secondary metabolite production. Sci Rep (2016) 0.76
Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling. Lipids (2016) 0.76
A lysosome-centered view of nutrient homeostasis. Autophagy (2016) 0.76
Dying to protect: cell death and the control of T-cell homeostasis. Immunol Rev (2017) 0.75
Functional Expression and Characterization of Schizosaccharomyces pombe Avt3p as a Vacuolar Amino Acid Exporter in Saccharomyces cerevisiae. PLoS One (2015) 0.75
Autophagy is dispensable to overcome ER stress in the filamentous fungus Aspergillus niger. Microbiologyopen (2016) 0.75
Myocardial stress and autophagy: mechanisms and potential therapies. Nat Rev Cardiol (2017) 0.75
Large-scale inference of gene function through phylogenetic annotation of Gene Ontology terms: case study of the apoptosis and autophagy cellular processes. Database (Oxford) (2016) 0.75
Assays to Monitor Autophagy in Saccharomyces cerevisiae. Cells (2017) 0.75
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells. PLoS One (2017) 0.75
Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell (2000) 36.09
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol (1988) 13.27
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway. Cell (1990) 8.98
The molecular machinery of autophagy: unanswered questions. J Cell Sci (2005) 6.67
Isolation of autophagocytosis mutants of Saccharomyces cerevisiae. FEBS Lett (1994) 6.35
Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun (1995) 5.89
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell (2002) 4.49
The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J Biol Chem (2000) 3.97
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu Rev Biochem (2000) 3.44
Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways. Mol Biol Cell (1999) 3.30
Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae. Mol Biol Cell (2004) 2.84
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem (2005) 2.64
Changes induced in the permeability barrier of the yeast plasma membrane by cupric ion. J Bacteriol (1988) 2.03
Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae. FEMS Microbiol Rev (1997) 1.77
Degradation of lipid vesicles in the yeast vacuole requires function of Cvt17, a putative lipase. J Biol Chem (2000) 1.75
Aut5/Cvt17p, a putative lipase essential for disintegration of autophagic bodies inside the vacuole. J Bacteriol (2001) 1.56
A family of yeast proteins mediating bidirectional vacuolar amino acid transport. J Biol Chem (2001) 1.40
Intravacuolar membrane lysis in Saccharomyces cerevisiae. Does vacuolar targeting of Cvt17/Aut5p affect its function? J Biol Chem (2002) 1.33
bmr3, a third multidrug transporter gene of Bacillus subtilis. J Bacteriol (1997) 1.32
An arginine/histidine exchange transport system in vacuolar-membrane vesicles of Saccharomyces cerevisiae. J Biol Chem (1984) 1.26
The breakdown of autophagic vesicles inside the vacuole depends on Aut4p. J Cell Sci (2000) 1.12
A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. J Biol Chem (2004) 1.02
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Autophagy in health and disease: a double-edged sword. Science (2004) 13.69
Autophagosome formation: core machinery and adaptations. Nat Cell Biol (2007) 13.59
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Potential therapeutic applications of autophagy. Nat Rev Drug Discov (2007) 8.56
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75
Endoplasmic reticulum stress triggers autophagy. J Biol Chem (2006) 5.05
The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell (2004) 4.72
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell (2002) 4.49
Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell (2008) 4.41
In search of an "autophagomometer". Autophagy (2009) 4.31
Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem (2001) 3.90
Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. J Biol Chem (2004) 3.86
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
Autophagy in the eukaryotic cell. Eukaryot Cell (2002) 3.61
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 3.52
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res (2007) 3.49
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy (2008) 3.47
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Autophagy and human disease. Cell Cycle (2007) 3.22
A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 3.10
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol (2010) 2.98
Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae. Mol Biol Cell (2004) 2.84
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Mitophagy in yeast occurs through a selective mechanism. J Biol Chem (2008) 2.80
The regulation of autophagy - unanswered questions. J Cell Sci (2011) 2.73
Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol Biol Cell (2005) 2.73
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2010) 2.66
The molecular mechanism of autophagy. Mol Med (2003) 2.63
Eating the endoplasmic reticulum: quality control by autophagy. Trends Cell Biol (2007) 2.60
Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A (2010) 2.53
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts. Autophagy (2005) 2.52
Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol Biol Cell (2004) 2.51
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.45
Autophagosomes: biogenesis from scratch? Curr Opin Cell Biol (2005) 2.42
The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J Biol Chem (2004) 2.40
Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. J Cell Biol (2006) 2.35
Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast. J Biol Chem (2005) 2.33
Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem (2006) 2.32
The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26
The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy. Dev Cell (2013) 2.24
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol (2010) 2.12
Autophagy in yeast: a review of the molecular machinery. Cell Struct Funct (2002) 2.09
How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) (2008) 2.08
A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell (2009) 2.04
Mitochondria removal by autophagy. Autophagy (2011) 2.04
An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal (2013) 2.04
Atg27 is required for autophagy-dependent cycling of Atg9. Mol Biol Cell (2006) 1.98
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.94
Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J Cell Biol (2003) 1.81
Arp2 links autophagic machinery with the actin cytoskeleton. Mol Biol Cell (2008) 1.80
Autophagic processes in yeast: mechanism, machinery and regulation. Genetics (2013) 1.78
Biochemical methods to monitor autophagy-related processes in yeast. Methods Enzymol (2008) 1.68
Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. J Biol Chem (2002) 1.66
Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy (2007) 1.62
A cycling protein complex required for selective autophagy. Autophagy (2007) 1.60
Molecular machinery required for autophagy and the cytoplasm to vacuole targeting (Cvt) pathway in S. cerevisiae. Curr Opin Cell Biol (2002) 1.60
Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy. Mol Biol Cell (2008) 1.58
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy (2009) 1.57
Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy. J Cell Biol (2008) 1.55
Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol (2010) 1.51
The molecular mechanism of mitochondria autophagy in yeast. Mol Microbiol (2010) 1.51
The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem (2002) 1.50
Receptor protein complexes are in control of autophagy. Autophagy (2012) 1.49
In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol (2008) 1.48
Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction. J Cell Sci (2012) 1.45
Autophagy in organelle homeostasis: peroxisome turnover. Mol Aspects Med (2006) 1.44
The role of autophagy in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.44
The quantitative Pho8Delta60 assay of nonspecific autophagy. Methods Enzymol (2008) 1.44
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Nature (2013) 1.43
Multiple roles of the cytoskeleton in autophagy. Biol Rev Camb Philos Soc (2009) 1.43
Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy. J Biol Chem (2003) 1.39
Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol (2011) 1.37
The many roles of NOX2 NADPH oxidase-derived ROS in immunity. Semin Immunopathol (2010) 1.36
A role for Atg8-PE deconjugation in autophagosome biogenesis. Autophagy (2012) 1.35