Published in Autophagy on July 29, 2009
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics (2011) 3.28
TOR-dependent control of autophagy: biting the hand that feeds. Curr Opin Cell Biol (2009) 2.17
Autophagic processes in yeast: mechanism, machinery and regulation. Genetics (2013) 1.78
The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy (2013) 1.71
Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae. Curr Genet (2010) 1.65
mTOR's role in ageing: protein synthesis or autophagy? Aging (Albany NY) (2009) 1.59
Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol (2010) 1.51
Mitochondria regulate autophagy by conserved signalling pathways. EMBO J (2011) 1.45
The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants. Plant Cell (2011) 1.20
CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation. J Cell Biol (2014) 1.04
Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation. J Biol Chem (2013) 0.98
A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy. J Biol Chem (2012) 0.94
State transitions in the TORC1 signaling pathway and information processing in Saccharomyces cerevisiae. Genetics (2014) 0.91
Advances in Autophagy Regulatory Mechanisms. Cells (2016) 0.90
From signal transduction to autophagy of plant cell organelles: lessons from yeast and mammals and plant-specific features. Protoplasma (2010) 0.87
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy (2015) 0.84
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
Identification of lung-cancer-related genes with the shortest path approach in a protein-protein interaction network. Biomed Res Int (2013) 0.82
Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. J Biol Chem (2012) 0.82
Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging. Ageing Res Rev (2014) 0.80
An Overview of Autophagy and Yeast Pseudohyphal Growth: Integration of Signaling Pathways during Nitrogen Stress. Cells (2012) 0.78
Heavy metal-induced metallothionein expression is regulated by specific protein phosphatase 2A complexes. J Biol Chem (2014) 0.78
Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation. Genetics (2016) 0.75
Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress. Autophagy (2017) 0.75
Orchestrated Action of PP2A Antagonizes Atg13 Phosphorylation and Promotes Autophagy after the Inactivation of TORC1. PLoS One (2016) 0.75
Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation. J Cell Mol Med (2017) 0.75
Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing. Microb Cell (2014) 0.75
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast (1998) 48.29
TOR signaling in growth and metabolism. Cell (2006) 35.29
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Elevated recombination rates in transcriptionally active DNA. Cell (1989) 17.42
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem (1998) 10.77
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol (2000) 9.61
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature (1999) 9.29
Autophagy: molecular machinery for self-eating. Cell Death Differ (2005) 8.46
Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun (1995) 5.89
A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast. Nucleic Acids Res (2002) 5.38
Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev (1996) 4.92
Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex. J Cell Biol (2001) 4.18
The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J Biol Chem (2000) 3.97
Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. J Biol Chem (2004) 3.86
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J (1999) 3.63
Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J Biol Chem (2000) 3.25
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 3.10
Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie (2007) 2.95
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev (2005) 2.56
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.45
Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast. J Biol Chem (2005) 2.33
B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A. Proc Natl Acad Sci U S A (1997) 2.30
Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast. Mol Cell Biol (2004) 2.26
Cell growth control: little eukaryotes make big contributions. Oncogene (2006) 2.19
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol Cell (2001) 2.18
Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes. EMBO J (1990) 2.15
Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast. Mol Cell (2003) 1.98
Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell (2006) 1.85
Rapamycin activates Tap42-associated phosphatases by abrogating their association with Tor complex 1. EMBO J (2006) 1.40
Mutations in the Saccharomyces cerevisiae type 2A protein phosphatase catalytic subunit reveal roles in cell wall integrity, actin cytoskeleton organization and mitosis. Genetics (1997) 1.38
Lucifer's labyrinth--ten years of path finding in cell death. Mol Cell (2007) 1.28
Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. Oncogene (2007) 1.22
Regulation of APG14 expression by the GATA-type transcription factor Gln3p. J Biol Chem (2000) 1.09
The Tap42-protein phosphatase type 2A catalytic subunit complex is required for cell cycle-dependent distribution of actin in yeast. Mol Cell Biol (2003) 1.03
Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells. Biochem J (2001) 1.02
Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, alpha4 and the mammalian ortholog of yeast Tip41 (TIPRL). FEBS J (2007) 0.95
The association of Tap42 phosphatase complexes with TORC1: another level of regulation in Tor signaling. Cell Cycle (2006) 0.89
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Autophagy in health and disease: a double-edged sword. Science (2004) 13.69
Autophagosome formation: core machinery and adaptations. Nat Cell Biol (2007) 13.59
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Potential therapeutic applications of autophagy. Nat Rev Drug Discov (2007) 8.56
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75
Endoplasmic reticulum stress triggers autophagy. J Biol Chem (2006) 5.05
The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell (2004) 4.72
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell (2002) 4.49
Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell (2008) 4.41
In search of an "autophagomometer". Autophagy (2009) 4.31
PSORT-B: Improving protein subcellular localization prediction for Gram-negative bacteria. Nucleic Acids Res (2003) 4.25
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem (2001) 3.90
Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. J Biol Chem (2004) 3.86
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
Autophagy in the eukaryotic cell. Eukaryot Cell (2002) 3.61
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 3.52
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res (2007) 3.49
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy (2008) 3.47
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Autophagy and human disease. Cell Cycle (2007) 3.22
A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 3.10
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol (2010) 2.98
Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae. Mol Biol Cell (2004) 2.84
Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem (2002) 2.80
Mitophagy in yeast occurs through a selective mechanism. J Biol Chem (2008) 2.80
The regulation of autophagy - unanswered questions. J Cell Sci (2011) 2.73
Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol Biol Cell (2005) 2.73
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2010) 2.66
The molecular mechanism of autophagy. Mol Med (2003) 2.63
Eating the endoplasmic reticulum: quality control by autophagy. Trends Cell Biol (2007) 2.60
Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A (2010) 2.53
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts. Autophagy (2005) 2.52
Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol Biol Cell (2004) 2.51
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.45
Autophagosomes: biogenesis from scratch? Curr Opin Cell Biol (2005) 2.42
The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J Biol Chem (2004) 2.40
Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. J Cell Biol (2006) 2.35
Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast. J Biol Chem (2005) 2.33
Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem (2006) 2.32
The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26
The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy. Dev Cell (2013) 2.24
Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis. Respir Med (2008) 2.21
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol (2010) 2.12
Autophagy in yeast: a review of the molecular machinery. Cell Struct Funct (2002) 2.09
How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) (2008) 2.08
A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell (2009) 2.04
Mitochondria removal by autophagy. Autophagy (2011) 2.04
An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal (2013) 2.04
Atg27 is required for autophagy-dependent cycling of Atg9. Mol Biol Cell (2006) 1.98
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.94
Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell (2006) 1.85
Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J Cell Biol (2003) 1.81
Arp2 links autophagic machinery with the actin cytoskeleton. Mol Biol Cell (2008) 1.80
Autophagic processes in yeast: mechanism, machinery and regulation. Genetics (2013) 1.78
Antibacterial drug leads targeting isoprenoid biosynthesis. Proc Natl Acad Sci U S A (2012) 1.69
Biochemical methods to monitor autophagy-related processes in yeast. Methods Enzymol (2008) 1.68
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med (2008) 1.68
Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. J Biol Chem (2002) 1.66
Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy (2007) 1.62
A cycling protein complex required for selective autophagy. Autophagy (2007) 1.60
Molecular machinery required for autophagy and the cytoplasm to vacuole targeting (Cvt) pathway in S. cerevisiae. Curr Opin Cell Biol (2002) 1.60
Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy. Mol Biol Cell (2008) 1.58
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy (2009) 1.57
Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci U S A (2012) 1.56
Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy. J Cell Biol (2008) 1.55
Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci U S A (2010) 1.54
Regulation of macroautophagy in Saccharomyces cerevisiae. Semin Cell Dev Biol (2010) 1.51
The molecular mechanism of mitochondria autophagy in yeast. Mol Microbiol (2010) 1.51
The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem (2002) 1.50
Receptor protein complexes are in control of autophagy. Autophagy (2012) 1.49
In vivo reconstitution of autophagy in Saccharomyces cerevisiae. J Cell Biol (2008) 1.48
Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2/Bax signal pathway. Folia Neuropathol (2012) 1.47
Profile-based string kernels for remote homology detection and motif extraction. J Bioinform Comput Biol (2005) 1.46
Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction. J Cell Sci (2012) 1.45
Autophagy in organelle homeostasis: peroxisome turnover. Mol Aspects Med (2006) 1.44
The role of autophagy in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.44
The quantitative Pho8Delta60 assay of nonspecific autophagy. Methods Enzymol (2008) 1.44
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Nature (2013) 1.43
Profile-based string kernels for remote homology detection and motif extraction. Proc IEEE Comput Syst Bioinform Conf (2004) 1.43
Multiple roles of the cytoskeleton in autophagy. Biol Rev Camb Philos Soc (2009) 1.43