Published in Dev Cell on August 01, 2005
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High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science (2003) 5.19
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science (2005) 4.70
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Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science (2004) 3.73
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MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol Cell (2005) 2.29
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Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev (2003) 2.10
Tissue-specific alternative splicing remodels protein-protein interaction networks. Mol Cell (2012) 2.08
Turning it up a Notch: cross-talk between TGF beta and Notch signaling. Bioessays (2005) 1.95
The disparate role of BMP in stem cell biology. Oncogene (2005) 1.92
Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development (2005) 1.88
Foxh1 is essential for development of the anterior heart field. Dev Cell (2004) 1.74
A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network. Cell Stem Cell (2012) 1.72
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J (2004) 1.70
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
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Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway. J Biol Chem (2005) 1.47
Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Curr Biol (2007) 1.40
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci U S A (2009) 1.29
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Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev Cell (2008) 1.19
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High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer. Proc Natl Acad Sci U S A (2013) 1.16
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Regulation of Par6 by extracellular signals. Curr Opin Cell Biol (2006) 1.12
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The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. J Biol Chem (2009) 1.10
Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Cancer Res (2011) 1.10
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A (2004) 1.10
Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity. Proc Natl Acad Sci U S A (2010) 1.08
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A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Res (2007) 1.02
Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA. J Biol Chem (2008) 1.01
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UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nat Neurosci (2009) 1.00
An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. J Biol Chem (2006) 1.00
TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs. EMBO J (2011) 0.99
Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. EMBO Mol Med (2010) 0.98
Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling. PLoS Genet (2010) 0.96
Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Mol Syst Biol (2009) 0.94
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J (2007) 0.93
Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation. Mol Cell Biol (2011) 0.92
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Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity. J Biol Chem (2004) 0.91
A high-throughput induction gene trap approach defines C4ST as a target of BMP signaling. Mech Dev (2002) 0.90
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The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning. Biochem J (2009) 0.87
A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis (2008) 0.87
Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget (2011) 0.86
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The TGFbeta-Par6 polarity pathway: linking the Par complex to EMT and breast cancer progression. Cell Cycle (2010) 0.85
C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome. Eur J Hum Genet (2012) 0.84
Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest (2016) 0.80
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Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth. Cancer Res (2006) 0.78
Cell biology: an unexpected social servant. Nature (2004) 0.77
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Mol Cell Proteomics (2013) 0.77
The return of Dr Jekyll in cancer metastasis. EMBO J (2012) 0.75
Structural biology: On the wings of inhibition. Nature (2002) 0.75
Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev (2015) 0.75